Lack of correlation between serum corticosterone level and immune functions in undernourished mice

1993 ◽  
Vol 13 (7) ◽  
pp. 801-813
Author(s):  
S.M. Filteau ◽  
T.J. Kaido ◽  
Maureen P. O'Grady ◽  
Robert A. Menzies ◽  
Nicholas R.S. Hall
Keyword(s):  
Corticosterone Level ◽  
Immune Functions ◽  
Serum Corticosterone

scholarly journals GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior

2020 ◽  
Vol 2020 ◽  
pp. 1-22 ◽  
Author(s):  
Yi Zheng ◽  
Meimei Wu ◽  
Ting Gao ◽  
Li Meng ◽  
Xiaowei Ding ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Corticosterone Level ◽  
Brain Structures ◽  
Ample Evidence ◽  
Genetic Ablation ◽  
Serum Corticosterone ◽  
Underlying Mechanisms ◽  
G Protein Coupled ◽  
Prolonged Stress

Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain structures critically involved in mood control. Genetic ablation of GPER in the rat resulted in significantly lower basal serum corticosterone level but enhanced ACTH release in response to acute restraint stress, especially in the female. GPER-/- rats of either sex displayed increased anxiety-like behaviors and deficits in learning and memory. Additionally, GPER deficiency led to aggravation of anxiety-like behaviors following single-prolonged stress (SPS). SPS caused significant decreases in serum corticosterone in WT but not in GPER-deficient rats. The results highlight an important role of GPER at multiple sites in regulation of the HPA axis and mood.

scholarly journals Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 682
Author(s):  
Yasmina K. Mahmoud ◽  
Ahmed A. Ali ◽  
Heba M. A. Abdelrazek ◽  
Tahany Saleh Aldayel ◽  
Mohamed M. Abdel-Daim ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Histopathological Examination ◽  
Memory Performance ◽  
Elevated Serum ◽  
Corticosterone Level ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Serum Corticosterone ◽  
Group I ◽  
Ameliorative Effect

The ameliorative effect of L-arginine (LA) and L-carnitine (LC) against fipronil (FPN)-induced neurotoxicity was explored. In this case, 36 adult male rats were randomly divided into six groups: group I received distilled water, group II received 500 mg/kg LA, group III received 100 mg/kg LC, group IV received 4.85 mg/kg FPN, group V received 4.85 mg/kg FPN and 500 mg/kg LA and group VI received 4.85 mg/kg FPN and 100 mg/kg LC for 6 weeks. Cognitive performance was assessed using Barnes maze (BM). Serum corticosterone, brain total antioxidant capacity (TAC), malondialdehyde (MDA) and dopamine were measured. Histopathology and immunohistochemistry of ionized calcium-binding adaptor (Iba-1), doublecortin (DCX) and serotonin (S-2A) receptors were performed. Fipronil induced noticeable deterioration in spatial learning and memory performance. In addition, FPN significantly (p < 0.05) diminished brain antioxidant defense system and dopamine coincide with elevated serum corticosterone level. Histopathological examination revealed degenerative and necrotic changes. Furthermore, Iba-1 and DCX were significantly expressed in cortex and hippocampus whereas S-2A receptors were significantly lowered in FPN group. However, administration of LA or LC alleviated FPN-induced deteriorations. In conclusion, LA and LC could be prospective candidates for mitigation of FPN-induced neurotoxicity via their antioxidant, anti-inflammatory and neuropotentiating effects.

scholarly journals Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them

2022 ◽  
Vol 19 (1) ◽  
Author(s):  
Alzahra J. Al Omran ◽  
Amy S. Shao ◽  
Saki Watanabe ◽  
Zeyu Zhang ◽  
Jifeng Zhang ◽  
...  
Keyword(s):  
Social Isolation ◽  
Mental Health Treatment ◽  
Morphological Changes ◽  
Signal Transmission ◽  
Corticosterone Level ◽  
Treatment Resistance ◽  
Mental Illnesses ◽  
Serum Corticosterone ◽  
Pathway Activation ◽  
Socially Isolated

Abstract Background Anxiety disorders are the most prevalent mental illnesses in the U.S. and are estimated to consume one-third of the country’s mental health treatment cost. Although anxiolytic therapies are available, many patients still exhibit treatment resistance, relapse, or substantial side effects. Further, due to the COVID-19 pandemic and stay-at-home order, social isolation, fear of the pandemic, and unprecedented times, the incidence of anxiety has dramatically increased. Previously, we have demonstrated dihydromyricetin (DHM), the major bioactive flavonoid extracted from Ampelopsis grossedentata, exhibits anxiolytic properties in a mouse model of social isolation-induced anxiety. Because GABAergic transmission modulates the immune system in addition to the inhibitory signal transmission, we investigated the effects of short-term social isolation on the neuroimmune system. Methods Eight-week-old male C57BL/6 mice were housed under absolute social isolation for 4 weeks. The anxiety-like behaviors after DHM treatment were examined using elevated plus-maze and open field behavioral tests. Gephyrin protein expression, microglial profile changes, NF-κB pathway activation, cytokine level, and serum corticosterone were measured. Results Socially isolated mice showed increased anxiety levels, reduced exploratory behaviors, and reduced gephyrin levels. Also, a dynamic alteration in hippocampal microglia were detected illustrated as a decline in microglia number and overactivation as determined by significant morphological changes including decreases in lacunarity, perimeter, and cell size and increase in cell density. Moreover, social isolation induced an increase in serum corticosterone level and activation in NF-κB pathway. Notably, DHM treatment counteracted these changes. Conclusion The results suggest that social isolation contributes to neuroinflammation, while DHM has the ability to improve neuroinflammation induced by anxiety.

CAN OCIMUM BASILICUM (BASIL) RELIEF THE IMPACT OF CHRONIC UNPREDICTABLE MILD STRESS ON THE MICE SALIVARY GLANDS?

2018 ◽  
Vol 15 (2) ◽  
pp. 1
Author(s):  
Nasra Naeim Ayuob ◽  
Soad Shaker Ali ◽  
Manal Galal Abd El Wahab
Keyword(s):  
Salivary Glands ◽  
Smooth Muscle Actin ◽  
Corticosterone Level ◽  
Ocimum Basilicum ◽  
Mild Stress ◽  
Parotid Glands ◽  
Alpha Smooth Muscle Actin ◽  
Serum Corticosterone ◽  
Neurotropic Factor ◽  
The Impact

Background: Salivary glands are affected in acute and chronic stressful conditions. Ocimum basilicum (OB), basil, possesses anxiolytic and antidepressant like effect so this study aimed to evaluate the effect of the chronic unpredictable mild stress (CUMS) on the structure of salivary glands of mice and the efficacy of OB in relieving this effect. Material and Methods: Forty male mice were distributed equally into four groups; the control, CUMS (exposed to the CUMS for 4 weeks), CUMS+Fluoxetine (treated with Fluoxetine after exposure to CUMS), CUMS+OB (treated with OB after exposure to CUMS). Treatments continued for 2 weeks. Behavioral changes and serum corticosterone level were assessed at the end of the experiment. Submandibular and parotid glands were histopathologically examined and stained with anti-alpha smooth muscle actin (ASMA) and anti-brain derived neurotropic factor (BDNF) antibodies. Results: A depressive behavior was observed in mice exposed to the CUMS. Serum corticosterone level significantly increased in these mice compared to the control (130.9±8.8 versus 21.03±2.1, p

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