Therapeutic effect of human fibroblast interferon on premalignant lesions arising in oral mucosa

Invasive oral squamous cell carcinoma is often preceded by the presence of clinically identifiable premalignant changes of the oral mucosa, including white lesions. We conducted a cross-sectional, observational study to assess the clinicopathologic and epidemiologic aspects of chronic oral mucosal white lesions to determine the necessity of early biopsy in these cases. Our study population was made up of 77 patients—50 males and 27 females, aged 15 to 70 years (mean: 42.9)—who presented with white lesions persisting for at least 4 weeks. All but 3 patients underwent a biopsy; the 3 exceptions were diagnosed with smear-proven candidiasis. Patients with moderate or severe dysplasia underwent an excision biopsy. The buccal mucosa was the single most common site of white lesions, occurring in 15 patients (19.5%), although 21 patients (27.3%) exhibited a diffuse involvement of the oral mucosa. Of the 77 patients, 59 (76.6%) had concerning findings: premalignant lesions in 45 patients (58.4%) and malignant lesions in 14 (18.2%). Also, dysplasia was seen in 8 patients (10.4%), all of whom had premalignant lesions. Tobacco chewing (p = 0.008) and betel quid chewing (p = 0.029) were significantly associated with the development of premalignant and malignant lesions; a longer duration of tobacco chewing (≥10 yr) was significantly associated with a higher risk of malignant but not premalignant lesions (p = 0.031). Finally, illiteracy was a significant risk factor for premalignant and malignant lesions (p = 0.03). Our findings support the necessity of biopsy in every case. Early detection of oral carcinoma by biopsy of all oral white lesions would not only prevent patients from undergoing disfiguring surgery and chemoradiation, but it also would increase the 5-year survival rate.

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Use of the carbon dioxide laser in the Management of premalignant lesions of the oral Mucosa

The Journal of Laryngology & Otology ◽

10.1017/s0022215100148364 ◽

1984 ◽

Vol 98 (12) ◽

pp. 1251-1260 ◽

Cited By ~ 41

Author(s):

J. W. Frame ◽

A. R. Das Gupta ◽

G. A. Dalton ◽

P. H. Rhys Evans

Keyword(s):

Carbon Dioxide ◽

Oral Mucosa ◽

Carbon Dioxide Laser ◽

Premalignant Lesions

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Regulation of Collagen Synthesis in Tobacco/Pan-Masala Induced Oral Sub-Mucosal Fibrosis and Diagnostic Approach - Review Article

International Journal of Scientific Research in Science and Technology ◽

10.32628/ijsrst218114 ◽

2021 ◽

pp. 134-143

Author(s):

Shraddha Awasthi ◽

Ausaf Ahmad ◽

Anand Narain Srivastava

Keyword(s):

Oral Mucosa ◽

Collagen Synthesis ◽

Oral Submucous Fibrosis ◽

Malignant Lesion ◽

Life Quality ◽

Premalignant Lesions ◽

Reference List ◽

Transformation Rate ◽

Dental Services ◽

Submucous Fibrosis

Introduction : oral submucosal fibrosis (OSMF) is related to juxta epithelial inflammatory response followed by a fibroelastic change of the lamina propria, with epithelial atrophy leading to stiffness of the oral mucosa, causing trismus and inability to eat. Methods and Materials: The suitability standards for studies were: Research Articles that studied the metabolic activities in oral submucous fibrosis mainly caused by some carcinogenic substances or chemicals which may present in tobacco, alcohol, cigarettes, pan-masala etc Reference list of selected articles and reviews on the topic also were searched. studies were extracted, A total of 90-100 studies were extracted, using the keywords oral submucous fibrosis, oral potentially malignant lesion and diagnosis, collagen synthesis etc., Results: cancer risk among these patients, periodic biopsies of suspicious regions of the oral mucosa are essential for the early detection and management of high?risk oral premalignant lesions and prevention of cancer. Conclusion: OSMF is hardly recognized and is poorly understood across the globe. significant improvement in management, nor reduction in its high malignant transformation rate. Better integration of medical and dental services, especially in developing countries, may reduce patients’ suffering and improve their life quality.

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Interferon activity and its characterization in the sera of patients with premalignant lesions arising in oral mucosa

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/s0300-9785(86)80133-8 ◽

1986 ◽

Vol 15 (2) ◽

pp. 134-147 ◽

Cited By ~ 11

Author(s):

Mitsuru Urata ◽

Hideo Yoshida ◽

Tetsuo Yanagawa ◽

Yoshiaki Yura ◽

Nanayo Furumoto ◽

...

Keyword(s):

Oral Mucosa ◽

Premalignant Lesions ◽

Interferon Activity

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Leucoplasia: revisão de literatura e apresentação de caso clínico

Revista da Faculdade de Odontologia de Porto Alegre ◽

10.22456/2177-0018.111098 ◽

2021 ◽

Vol 35 (2) ◽

pp. 20-22

Author(s):

João Jorge Diniz Barbachan ◽

Pantelis Varvaki Rados ◽

Manoel Sant'Ana Fllho ◽

Manoela Gallicchio Domingues

Keyword(s):

Literature Review ◽

Malignant Transformation ◽

Oral Mucosa ◽

Clinical Case ◽

Premalignant Lesions ◽

Early Diagnose

Leucoplakia is a clinica' term that refers to an alteration on the oral mucosa with the appearance of white patchers that are firmly adhered and cannot be classified as any other diagnosable discase. They are considered premalignant lesions due to the increase in the risk of malignant transformation. In this case, around 4% to 6% of the lesions evolve to cancer. Then, it is necessary to estabilish a correct and early diagnose and also a precise treatment to reach good results. The periodical control of the patients that show this kind of alteration is extremely important. The aim of this study is to discuss the possible ethiological agents, clinical and histopathological aspects as well as, the treatment and prognoses through literature review, illustrating with a clinical case.

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Correlation of Clinical and Histopathological Diagnosis of Oral Mucosa Lesions at the University of Costa Rica Between 2008 and 2015

Odovtos - International Journal of Dental Sciences ◽

10.15517/ijds.2021.44521 ◽

2020 ◽

pp. 407-415

Author(s):

Yadira V. Boza Oreamuno ◽

Andrea López Soto

Keyword(s):

Costa Rica ◽

Oral Mucosa ◽

Premalignant Lesions ◽

Histopathological Diagnosis ◽

Substantial Agreement ◽

Kappa Test ◽

A Value ◽

Autoimmune Conditions ◽

Diagnostic Hypothesis ◽

The University

The objective of this study is to determine the existing concordance between the clinical and histopathological diagnosis of lesions in the oral mucosa at the Faculty of Dentistry of the University of Costa Rica (UCR). A retrospective study of 261 reports of oral lesions recovered from the biopsy archive of the UCR Faculty of Dentistry from 2008 to 2015. Of the total reports 165 were included in the analysis, 96 (36.8%) did not have any diagnostic hypotheses. The concordance between the clinical and histopathological diagnosis was verified by the Kappa test. Concordance with the first diagnostic hypothesis was presented in 114 (69.1%) cases, the value of kappa was 0.663 (substantial agreement) and 36.8% without clinical diagnosis only a description of the lesion. The premalignant lesions presented an excellent concordance (kappa=0.902). The concordance of the group of non-neoplastic proliferative lesions was moderate (kappa=0.504) and the dermatological and autoimmune conditions with negligible concordance (0.157). Concordance occurred in the majority of the patients investigated with a value corresponding to a substantial agreement, however, the percentage of reports that did not have a clinical hypothesis should be improved.

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Common premalignant lesions of the oral mucosa

Ortadoğu Tıp Dergisi ◽

10.21601/ortadogutipdergisi.340599 ◽

2018 ◽

Vol 10 (2) ◽

pp. 190-200

Author(s):

İnci Rana Karaca ◽

Hümeyra Yazar

Keyword(s):

Oral Mucosa ◽

Premalignant Lesions

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Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions

Oral Oncology ◽

10.1016/j.oraloncology.2011.07.008 ◽

2011 ◽

Vol 47 (11) ◽

pp. 1055-1061 ◽

Cited By ~ 51

Author(s):

Ewan A. Gibb ◽

Katey S.S. Enfield ◽

Greg L. Stewart ◽

Kim M. Lonergan ◽

Raj Chari ◽

...

Keyword(s):

Oral Mucosa ◽

Premalignant Lesions ◽

Non Coding Rnas

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Mast Cells and Angiogenesis in Oral Malignant and Premalignant Lesions

The Open Dentistry Journal ◽

10.2174/1874210600802010126 ◽

2008 ◽

Vol 2 (1) ◽

pp. 126-132 ◽

Cited By ~ 18

Author(s):

E.Z Michailidou ◽

A.K Markopoulos ◽

D.Z Antoniades

Keyword(s):

Squamous Cell Carcinoma ◽

Mast Cell ◽

Mast Cells ◽

Cell Carcinoma ◽

Oral Mucosa ◽

Squamous Cell ◽

Premalignant Lesions ◽

Angiogenic Switch ◽

Normal Oral Mucosa ◽

Human Cd34

Mast cell contribution to neoangiogenesis during tumorigenesis in oral squamous cell carcinoma is not determined yet. Objectives: To associate numerical mast cell density (MCD) to numerical microvessel density (MVD) during the progression of oral leukoplakia without dysplasia and leukoplakia with dysplasia to squamous cell carcinoma (OSCC). Materials and methods: MVD was analysed immunohistochemically (mouse monoclonal anti-human CD34) in 49 paraffin-embedded specimens, 35 OSCCs, 9 leukoplakias and 5 normal oral tissues. Toluidine blue counterstaining revealed mast cells. MCD and MVD were assessed at the same optical field. Results: MVD increased between: normal oral mucosa, dysplasia (p=0.004), OSCC (p=0.001), leukoplakia and OSCC (p=0.041). MCD increased between: normal oral mucosa, dysplasia (p=0.003), OSCC (p=0.000), leukoplakia and OSCC (p=0.007). MVD was found to depend on MCD (p=0.000) in a percent 28.3% (power curve fit model). Conclusions: Mast cells are attracted at the lesion site and may turn on an angiogenic switch during tumorigenesis in OSCC.

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