scholarly journals Regulation of Collagen Synthesis in Tobacco/Pan-Masala Induced Oral Sub-Mucosal Fibrosis and Diagnostic Approach - Review Article

2021 ◽  
pp. 134-143
Author(s):  
Shraddha Awasthi ◽  
Ausaf Ahmad ◽  
Anand Narain Srivastava
Keyword(s):  
Oral Mucosa ◽  
Collagen Synthesis ◽  
Oral Submucous Fibrosis ◽  
Malignant Lesion ◽  
Life Quality ◽  
Premalignant Lesions ◽  
Reference List ◽  
Transformation Rate ◽  
Dental Services ◽  
Submucous Fibrosis

<p><strong>Introduction :</strong> oral submucosal fibrosis (OSMF) is related to juxta epithelial inflammatory response followed by a fibroelastic change of the lamina propria, with epithelial atrophy leading to stiffness of the oral mucosa, causing trismus and inability to eat.</p> <p><strong>Methods and Materials:</strong> The suitability standards for studies were: Research Articles that studied the metabolic activities in oral submucous fibrosis mainly caused by some carcinogenic substances or chemicals which may present in tobacco, alcohol, cigarettes, pan-masala etc Reference list of selected articles and reviews on the topic also were searched. studies were extracted, A total of 90-100 studies were extracted, using the keywords oral submucous fibrosis, oral potentially malignant lesion and diagnosis, collagen synthesis etc.,</p> <p><strong>Results: </strong>cancer risk among these patients, periodic biopsies of suspicious regions of the oral mucosa are essential for the early detection and management of high?risk oral premalignant lesions and prevention of cancer.</p> <p><strong>Conclusion</strong>: OSMF is hardly recognized and is poorly understood across the globe. significant improvement in management, nor reduction in its high malignant transformation rate. Better integration of medical and dental services, especially in developing countries, may reduce patients’ suffering and improve their life quality.</p>

Carcinogenesis of Male Oral Submucous Fibrosis Alters Salivary Microbiomes

2020 ◽  
pp. 002203452096875
Author(s):  
M.Y. Chen ◽  
J.W. Chen ◽  
L.W. Wu ◽  
K.C. Huang ◽  
J.Y. Chen ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Oral Microbiome ◽  
Premalignant Lesions ◽  
Rrna Gene ◽  
Transformation Rate ◽  
Validation Data ◽  
Oral Carcinogenesis ◽  
Key Species ◽  
Submucous Fibrosis

Most oral squamous cell carcinoma (OSCC) tumors arise from oral premalignant lesions. Oral submucous fibrosis (OSF), usually occurring in male chewers of betel quid, is a premalignant stromal disease characterized by a high malignant transformation rate and high prevalence. Although a relationship between the inhabited microbiome and carcinogenesis has been proposed, no detailed information regarding the oral microbiome of patients with OSF exists; the changes of the salivary microbiome during cancer formation remain unclear. This study compared the salivary microbiomes of male patients with OSCC and a predisposing OSF background (OSCC-OSF group) and those with OSF only (OSF group). The results of high-throughput sequencing of the bacterial 16S rRNA gene indicated that OSF-related carcinogenesis and smoking status significantly contributed to phylogenetic composition variations in the salivary microbiome, leading to considerable reductions in species richness and phylogenetic diversity. The microbiome profile of OSF-related malignancy was associated with increased microbial stochastic fluctuation, which dominated the salivary microbiome assembly and caused species co-occurrence network collapse. Artificial intelligence selection algorithms consistently identified 5 key species in the OSCC-OSF group: Porphyromonas catoniae, Prevotella multisaccharivorax, Prevotella sp. HMT-300, Mitsuokella sp. HMT-131, and Treponema sp. HMT-927. Robust accuracy in predicting oral carcinogenesis was obtained with our exploratory and validation data sets. In functional analysis, the microbiome of the OSCC-OSF group had greater potential for S-adenosyl-l-methionine and norspermidine synthesis but lower potential for l-ornithine and pyrimidine deoxyribonucleotide synthesis and formaldehyde metabolism. These findings indicated that the salivary microbiome plays important roles in modulating microbial metabolites during oral carcinogenesis. In conclusion, our results provided new insights into salivary microbiome alterations during the malignant transformation of OSF.

scholarly journals Premalignant lesions of the oral cavity: current perspectives

2021 ◽  
Vol 9 (6) ◽  
pp. 1816
Author(s):  
Santosh Kumar Swain
Keyword(s):  
Oral Cavity ◽  
Treatment Options ◽  
Oral Submucous Fibrosis ◽  
Current Treatment ◽  
Premalignant Lesions ◽  
Transformation Rate ◽  
Etiological Factors ◽  
Life Saving ◽  
Potentially Malignant ◽  
Submucous Fibrosis

Premalignant lesions of the oral cavity are also called as potentially malignant disorders. The common premalignant lesions of the oral cavity include leukoplakia, oral submucous fibrosis (OSMF) and oral erythroplakia. These lesions have a very high malignant transformation rate. The exact etiological factors for development of the premalignant lesions of the oral cavity are not fully understood till date. Use of tobacco, alcohol drinking, chewing betel quid containing areca nut and solar rays are important etiological factors for resulting the premalignant lesions of the oral cavity. Early diagnosis is an important step for preventing the malignant transformations of these lesions and can be also life-saving. There are several treatment options including conservative to surgical for eliminating the premalignant lesions of the oral cavity. The aim of this study was to discuss the details of epidemiology, etiopathology, clinical presentations, diagnosis and current treatment of the premalignant lesions of the oral cavity.  

scholarly journals Egr-1 mediates low dose Arecoline induced human oral mucosa fibroblasts proliferation by transaction the expression of Wnt5a

2020 ◽  
Author(s):  
Qiang Chen ◽  
Jiuyang Jiao ◽  
Youyuan Wang ◽  
Zhihui Mai ◽  
Jing Ren ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Collagen Synthesis ◽  
Low Dose ◽  
Oral Submucous Fibrosis ◽  
High Dose ◽  
Areca Nut ◽  
Therapeutic Drugs ◽  
Submucous Fibrosis ◽  
Oral Submucosal Fibrosis ◽  
Submucosal Fibrosis

Abstract Background Arecoline is the main carcinogens in Areca nut that induce oral submucous fibrosis to develop into cancer. However, many previous studies have showed that Arecoline may inhibit proliferation and prevent collagen synthesis of fibroblasts. Results High dose Arecoline (> 32 µg/ml) could inhibit but low dose Arecoline (< 16 µg/ml) could promote the proliferation of human oral fibroblasts. Wnt5a was both sufficient and necessary for the promotion of fibrobasts proliferation. Egr-1, but not NF-κB, FOXO1, Smad2 or Smad3, mediated the expression of Wnt5a in fibrobasts. The specific siRNAs of Egr-1, Egr inhibitors or Wnt5a antibodies treatment blocked Arecoline induced Wnt5a upregulation and fibroblasts proliferation. Conclusions Egr-1 mediates low dose Arecoline induced human oral mucosa fibroblasts proliferation by transaction the expression of Wnt5a, and Egr inhibitors or Wnt5a antibodies are potential therapeutic drugs of oral submucosal fibrosis and oral cancer.

scholarly journals Comparative Study of Intralesional Dexamethasone Plus Hyaluronidase & Oral Colchicine in Patients with Oral Submucous Fibrosis

2018 ◽  
Vol 14 (2) ◽  
pp. 60-65
Author(s):  
Ganesh Prasad Neupane ◽  
Maya Rai ◽  
R. S. Rathore ◽  
V. K. Bhargava ◽  
A. K. Mahat ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Study Groups ◽  
T Test ◽  
Significant Difference ◽  
Intralesional Injections ◽  
Submucous Fibrosis ◽  
Larger Sample

Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition of the oral mucosa. It is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium.Aim and objective: To evaluate the efficacy of oral Colchicine in comparison to intralesional injections of Dexamethasone plus Hyaluronidase in the management of OSMF patients.Materials and Methods: Fourty patients with OSMF were randomly divided equally into two groups. 20 patients in Dexamethasone group received biweekly intralesional injections of Dexamethasone (4mg/ml) plus Hyaluronidase 1500 IU in buccal mucosa for a period of 12 weeks. Other 20 patients in Colchicine group received oral Colchicine 0.5 mg tablets twice daily for 12 weeks. Parameters taken in the study were burning sensation, and mouth opening. Descriptive statistics, paired t test and unpaired t test were used for statistical analysis.Results and Conclusions: The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, statistically highly significant difference was noted (p <0.001) only in mouth opening but not in burning sensation.These encouraging results should prompt further clinical trials with Colchicine on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSMF. JNGMC,  Vol. 14 No. 2 December 2016, Page: 60-65

scholarly journals Association of Blood Groups with Oral Submucous Fibrosis and if any of the Blood Group is Related with an Increased Risk for Oral Submucous Fibrosis

2021 ◽  
Vol 15 (10) ◽  
pp. 2776-2778
Author(s):  
Sobia Siddique ◽  
Syed Muhammad Razi Zaidi ◽  
Shahida Maqbool ◽  
Madiha Insha ◽  
Muhammad Abul Hasan Ali ◽  
...  
Keyword(s):  
Blood Group ◽  
Oral Submucous Fibrosis ◽  
Malignant Lesion ◽  
Oral Pathology ◽  
Blood Groups ◽  
P Value ◽  
Blood Group System ◽  
Increased Risk ◽  
Submucous Fibrosis ◽  
B Blood Group

Objective: To assess any association of blood groups with oral submucous fibrosis and if any of the blood group is related with an increased risk for oral submucous fibrosis. Study Design: Comparative study Place and Duration of Study: Department Of Oral Pathology, Fatima Jinnah Dental College & Hospital Karachi, Pakistan from Jan to Dec 2018. Patients and Methods: Total 100 patients were enrolled in the study in which half were cases where oral sub mucous fibrosis had been diagnosed clinically while remaining half were the controls that were involved in the habit of using tobacco/nuts but had no oral pre malignant lesion. For investigation of blood, samples of blood were taken from both the groups. Odd ration and chi-square test was used to analyze data. A p-value of <0.05 was considered statistically significant. Results: Majority of the individuals in experimental group had “B” blood group followed by “O” “AB” and “A” blood groups. Conclusion: This study showed that ABO blood groups have considerable relation with oral submucous fibrosis. Individuals having “B” blood group had 2.18 times increased tendency of having oral submucous fibrosis in contrast with patients who belong to any other blood group. Keywords: ABO blood group system, Oral Submucous fibrosis, Oral lesions, Oral Squamous Cell Carcinoma

scholarly journals Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study

2016 ◽  
Vol 7 (5) ◽  
pp. 10-16 ◽  
Author(s):  
Devishree V Rai ◽  
Kruthika S Guttal ◽  
Bhusan B Kulkarni ◽  
Shivaprakash Hiremath ◽  
Krishna N Burde
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Control Group ◽  
Transformation Rate ◽  
Significant Finding ◽  
Vegf Gene ◽  
Oral Potentially Malignant Disorders ◽  
Male Predominance ◽  
Submucous Fibrosis

Background: Oral Submucous Fibrosis is one of the oral potentially malignant disorders presenting with progressive restriction in mouth opening. The condition having a high malignant transformation rate necessitates identification of biomarkers to be employed for early detection of malignant change. This will influence the prognosis in addition to adding better quality of life to patients.Aims and Objectives: To relate the association of VEGF -460C/T polymorphism in patients with OSMF and to compare the same among healthy subjects.Materials and Methods: Thirty patients with Oral submucous fibrosis and 20 controls free from habits and any form of lesions were included in the study. The polymorphism of VEGF gene was detected by polymerase chain reaction-based restriction analysis.Results: Sixty-four percent of the population in the study was in the age group of 21-40 yrs suggesting the prominence of disease in younger individuals with male predominance. With reference to polymorphism, 6.67% of the subjects from OSMF group showed CT polymorphism and 16.67% showed TT polymorphism. There were no statistically significant differences in the polymorphism between the study group and controls. However the frequency of T allele in the patient group 12 (20%) was greater than that in the control group 1 (2.5%), which was a significant finding. There was no association between the habits, frequency of habits, duration of quid placement, site of quid placement and style of chewing with the nature of polymorphism. Conclusion: VEGF 460C/T has the potential to be used as a prognostic marker in predicting the malignant transformation of OSMF.Asian Journal of Medical Sciences Vol.7(5) 2016 10-16

scholarly journals Hearing Efficiency in Oral Submucous Fibrosis: A Clinical Study

2020 ◽  
Author(s):  
J. S. Shah ◽  
Nutan Lunagariya
Keyword(s):  
Oral Mucosa ◽  
Conductive Hearing Loss ◽  
Oral Submucous Fibrosis ◽  
Hearing Threshold ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Areca Nut ◽  
Gradual Reduction ◽  
Submucous Fibrosis ◽  
Conductive Hearing

Abstract Oral Submucous fibrosis (OSMF) is a chronic insidious disease of oral mucosa that occurs due to areca-nut chewing, consumption of chillies, autoimmunity and genetic predisposition. The disease starts with burning sensation and inability to tolerate spicy foods with gradual reduction in mouth opening due to fibrosis of the oral mucosa. The extension of fibrosis into the naso pharynx leads to reduction in hearing efficiency. As very few studies had been done to evaluate the hearing disability in OSMF patients, this study had been undertaken to prove the same. To evaluate hearing efficiency in patients with Oral Submucous Fibrosis of various grades of severity. Presentation includes 30 patients of osmf with various grades and evaluated for hearing efficacy by audiometry. Hearing threshold was compared in different grades of osmf. The present study revealed a significant association between OSMF and hearing deficit. Involvement of the palatal muscles with OSMF may decrease the patency of the Eustachian tube, leading to conductive hearing loss. Therefore, the protocol for managing OSMF patients should include ENT consultation and treatment for hearing deficit in order to increase the success rate of treatment.

scholarly journals Aberrant DKK3 expression in the oral leukoplakia and oral submucous fibrosis: a comparative immunohistochemical study

2016 ◽  
Author(s):  
T. Al-dhohorah ◽  
M. Mashrah ◽  
Z. Yao ◽  
J. Huang
Keyword(s):  
Histological Grade ◽  
Oral Submucous Fibrosis ◽  
Suppressor Gene ◽  
Oral Leukoplakia ◽  
Premalignant Lesions ◽  
Severe Dysplasia ◽  
Normal Oral Mucosa ◽  
Significant Difference ◽  
Risk Of Progression ◽  
Submucous Fibrosis

We aimed to assess and compare the expression of Dickkopf homolog 3 (DKK3), a possible tumor suppressor gene (TSG), in oral leukoplakia (OLK) and oral submucous fibrosis (OSF) using immunohistochemistry. Seventy-five cases of normal oral mucosa (NOM), OLK, OSF, and squamous cell carcinoma (OSCC) were studied. DKK3 was expressed in all cases of NOM, OLK and OSCC. There was steady increases in the percentage of the positive cells progressing toward OSCC. The expression was localized in the cytoplasm and cell membrane of cell affected by OLK with mild dysplasia and OLK with severe dysplasia. No significant association was observed between DKK3 expression and dysplastic status of OLK. Loss of DKK3 expression was observed in 15 of 30 cases in the OSF group, which was significantly associated with histological grade of OSF (P<0.0001). The percentage of positive cells gradually declined with the increasing severity of epithelial atrophy. A significant difference (P<0.01) was observed when comparing DKK3 expression among different groups of OLK and OSF cases. DKK3 may have diverse expressions in oral premalignant lesions. Loss of DKK3 expression in dysplastic/advanced stage of OSF may imply a high risk of progression to oral cancer.

scholarly journals Use of buccal fat pad flap for premalignant buccal mucosa defect reconstruction

2020 ◽  
Vol 7 (11) ◽  
pp. 3769
Author(s):  
Pankaj Kshirsagar ◽  
Prabhat B. Nichkaode ◽  
Saicharan Reddy ◽  
Manichandra Reddy C.
Keyword(s):  
Buccal Mucosa ◽  
Postoperative Morbidity ◽  
Oral Submucous Fibrosis ◽  
Premalignant Lesions ◽  
Fast Method ◽  
Fat Pad ◽  
Medical College ◽  
Operative Complications ◽  
Submucous Fibrosis ◽  
Buccal Pad Of Fat

Premalignant lesions over buccal mucosa are very common in India, some of these lesions require excision leaving behind defects and various techniques can be used in reconstruction of these defects. Small palatal defect, oroantral fistulas have been successfully closed by buccal pad of fat flap. Aim of this study was to evaluate reconstruction of defects after excision of premalignant lesion over buccal mucosa using buccal pad of fat. 20 patients were selected for this study who presented with different premalignant lesions like erythroplakia, proliferative verrucous leukoplakia, chronic hyperplastic candidiasis, Oral submucous fibrosis over buccal mucosa in Dr. DY Patil medical college surgery unit 4 and 7. Excision of lesion followed by reconstruction with buccal pad of fat was done. Patients were followed up every 14 days for 14 weeks, and was evaluated for epithelisation of flap and post-operative complications like infection and flap necrosis and also the functionality of the flap. In this study we have observed complete epithelisation of the flap in most of our patients. Dehiscence of the wound was observed in 3 of the patients with large defects (>4×5 cm). No postoperative morbidity was in postoperative patients. Buccal pad of fat is an excellent technique for reconstruction of small defects of buccal mucosa. It is a reliable and a fast method which has easy accessibility less complications and minimal morbidity.

scholarly journals Distribution of Oral Submucous Fibrosis Cases and Malignant Transformation Rate among Bhutanese Patients Treated at Jigme Dorji Wangchuck National Referral Hospital, Bhutan

2021 ◽  
Vol 4 (12) ◽  
pp. OR7-OR10
Author(s):  
Pratap Singh Tamang ◽  
Gyan Prasad Bajgai ◽  
Hari Prasad Pokhrel
Keyword(s):  
Retrospective Study ◽  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Referral Hospital ◽  
Transformation Rate ◽  
Limited Mouth Opening ◽  
High Burden ◽  
Submucous Fibrosis ◽  
National Referral Hospital

BACKGROUND: Oral Submucous Fibrosis (OSMF) is a chronic, insidious, scarring disease of the mouth often involving the palate, oro-pharynx, pharynx, esophagus, tongue and the buccal mucosa which leads to ulceration, blanching and ultimately limited mouth opening. The aim of the study is to describe the age, gender and district-wise distribution of oral submucous fibrosis cases and to assess the malignant transformation rate among the patients with oral submucous fibrosis who were treated at Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.MATERIALS AND METHOD: This is a descriptive retrospective study. The patients were clinically diagnosed by examining their mouth and by measuring their mouth opening (Inter-incisal height). Patients who had less than 3 fingers mouth opening and diagnosed as Oral submucous fibrosis (OSMF) during these three-year period from 2018 to 2020 were considered for the study.RESULTS: There were 278 cases in total. Thimphu district had the maximum number of cases followed by Wangduephodrang and Samtse. Gasa and Haa districts had the minimum cases. More males were affected than females. The malignant transformation rate among these patients was 4.3%.CONCLUSION: Thimphu district had the highest proportion of OSMF cases and was almost equally distributed among genders. Over 90% of the patients reported improvement without surgery while the malignancy transformation rate was 4.3%. The study recommends conducting screening in districts with high burden of OSMF cases for early diagnosis and treatment.

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