Aloe vera gel and sea-buckthorn oil protect human fibroblasts against silver nanoparticles cytotoxicity

2021 ◽  
Vol 350 ◽  
pp. S238-S239
Author(s):  
A.-M. Enciu ◽  
E. Codrici ◽  
D.I. Popescu ◽  
P. Preda ◽  
D. Stan ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Human Fibroblasts ◽  
Aloe Vera ◽  
Sea Buckthorn ◽  
Aloe Vera Gel ◽  
Sea Buckthorn Oil

scholarly journals EVALUATION OF BIOLOGICAL ACTIVITY OF GREENLY SYNTHESIZED SILVER NANOPARTICLES USING ALOE VERA GEL EXTRACT AS ANTIBACTERIAL AGENT IN-VITRO AND IN-VIVO

2020 ◽  
Vol 51 (6) ◽  
pp. 1706-1715
Author(s):  
Ibrahim & et al.
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Methicillin Resistance ◽  
Aloe Vera ◽  
Dilution Method ◽  
Lesion Volume ◽  
Aloe Vera Gel ◽  
Complicated Skin

The present study was carried out to synthesis silver nanoparticles by using Aloe Vera gel and evaluates antibacterial activity in vitro and in vivo. The synthesis and characterization of silver nanoparticles was confirmed by Ultra Violet Visible- spectrophotometer, X-ray diffraction, Fourier Transmission Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy. Reduction of the Ag+ to Ag0 during exposure to the Aloe Vera gel extract was followed by color change of the solution from colorless, yellow to dark brown within 24 hours. It is observed that surface Plasmon resonance peaks of the maximum absorbance of silver-nanoparticles occur at 425 nm, indicating that AgNPs were produced. Later on, using agar well diffusion and tube dilution method against pathogenic methicillin resistance staphylococcus aureus, (MRSA). Pseudomonas. aeruginosa and Escherichia coli, the antimicrobial properties of synthesised AgNPs were investigated. To confirm in-vivo antibacterial activity, after inducing complicated skin and soft tissue infection in mice by injecting S.aureus subcutaneously. 16µg/gm AgNPs were applied skin infected daily for three days. Silver nanoparticles were as succeeded to reduce the lesion volume in infected mice and reduce the acute inflammation symptoms as clindamycin, In conclusion, A new approach can be used to combat serious infections caused by MRSA by Aloe Vera AgNPs.

scholarly journals Determination of antioxidant potential of biochemically synthesized silver nanoparticles using Aloe vera gel extract

2019 ◽  
Vol 6 (2) ◽  
pp. 208-217 ◽  
Author(s):  
Jasmeet Kaur Sohal ◽  
Ashish Saraf ◽  
Kamlesh Shukla ◽  
Meghna Shrivastava
Keyword(s):  
Silver Nanoparticles ◽  
Aqueous Extract ◽  
Average Particle Size ◽  
Radical Scavenging ◽  
Aloe Vera ◽  
Reducing Power ◽  
Antioxidant Potential ◽  
Average Particle ◽  
Aloe Vera Gel ◽  
Before And After

Biosynthesis of nanoparticles by using plant extracts is presently under development. The study has been focused on the biosynthesis of silver nanoparticles (AgNPs) using aqueous extract of Aloe vera gel as well as to determine their antioxidant potential. UV-Vis spectrophotometeric analysis showed surface plasmonic resonance (SPR) band at 440 nm, which is specific for AgNPs. The Transmission Electron Microscopy (TEM) revealed that the synthesized AgNPs were spherical in shape with an average particle size of 66.6 nm. Fourier Transform Infrared Spectroscopic (FTIR) analysis of the aqueous extract before and after the synthesis of AgNPs revealed the presence of different functional groups related to phenolic and polyphenolic compounds such as tannins and flavonoids, and other metabolites like proteins, which may be responsible for the synthesis and stabilization of AgNPs. The antioxidant potential of the synthesized AGAgNPs was determined by using 2, 2 Diphenyl-1- Picryl Hydrazyl (DPPH) radical scavenging, metal chelating and reducing power assay. Antioxidant assessment showed enhanced dose dependent antioxidant potential of the synthesized AgNPs as compared to the crude extract, which can gain attention of the pharmaceutical industry for preparation of antioxidants of natural origin as the synthetic ones are suspected to be carcinogenic. Present study also supports the advantages of green method for the nanoparticles synthesis.

Effect of Aloe Vera Gel on Severity of Radiation Induced Dermatitis among Patients after Mastectomy

2020 ◽  
Vol 11 (2) ◽  
pp. 1499
Author(s):  
Eman Tharwat Mohamed ◽  
Nawal Ebeid Hanna ◽  
Dalia Salah El-Deen ◽  
Soad Hanna Tadros ◽  
Noha Yehia Ibrahim
Keyword(s):  
Aloe Vera ◽  
Aloe Vera Gel ◽  
Radiation Induced

Evaluation of Isolated Fractions of Aloe vera Gel Materials on Indinavir Pharmacokinetics: In vitro and in vivo Studies

2016 ◽  
Vol 13 (3) ◽  
pp. 471-480 ◽  
Author(s):  
Lonette Wallis ◽  
Maides Malan ◽  
Chrisna Gouws ◽  
Dewald Steyn ◽  
Suria Ellis ◽  
...  
Keyword(s):  
Aloe Vera ◽  
In Vivo Studies ◽  
Aloe Vera Gel

Gastrointestinal Region Specific Insulin Permeation Enhancement by Aloe vera Gel

2020 ◽  
Vol 10 (2) ◽  
pp. 117-122
Author(s):  
Elizca Pretorius ◽  
Clarissa Willers ◽  
Josias H. Hamman ◽  
Johan D. Steyn
Keyword(s):  
Gastrointestinal Tract ◽  
Ex Vivo ◽  
Aloe Vera ◽  
Diffusion Chamber ◽  
Proximal Jejunum ◽  
Absorption Enhancers ◽  
Permeation Enhancement ◽  
Insulin Transport ◽  
Aloe Vera Gel ◽  
Specific Insulin

Background: The oral administration route is still the most preferred by patients for drug treatment, but is unfortunately not suitable for all drug compounds. For example, protein and peptide drugs (e.g. insulin) are typically administered via injection seeing as they are unstable in the gastrointestinal luminal environment and have poor membrane permeation properties. To overcome this problem, functional excipients such as drug absorption enhancers can be co-administered. Although Aloe vera gel has the ability to improve the permeation of drugs across the intestinal epithelium, its drug permeation enhancing effect has not been investigated in the different regions of the gastrointestinal tract yet. Objective: The aim of this study was to investigate the insulin permeation enhancing effects of A. vera gel material across excised pig intestinal tissues from different regions of the gastrointestinal tract and to identify the gastrointestinal region where the highest insulin permeation enhancement was achieved. : Insulin transport across excised pig intestinal tissues from the duodenum, proximal jejunum, medial jejunum, distal jejunum, ileum and colon was measured in the absence and presence of A. vera gel (0.5% w/v) using both the Sweetana-Grass diffusion chamber and everted sac techniques. Results: The insulin permeation results obtained from both ex vivo techniques showed varied permeation enhancing effects of A. vera gel as a function of the different regions of the gastrointestinal tract. The colon was identified as the gastrointestinal region where A. vera gel was the most effective in terms of insulin permeation enhancement in the Sweetana-Grass diffusion chamber technique with a Papp value of 5.50 x 10-7 cm.s-1, whereas the ileum was the region where the highest permeation enhancement occurred in the everted sac technique with a Papp value of 5.45 x 10-7 cm.s-1. Conclusion: The gastrointestinal permeation enhancing effects of A. vera gel on insulin is region specific with the highest effect observed in the ileum and colon.

scholarly journals Synthesis of BMA NPs using aloe vera gel for their electrochemical, biological and photocatalytic studies

2021 ◽  
Vol 6 ◽  
pp. 100017
Author(s):  
M. Vasudha ◽  
Devaraja Gayathri ◽  
Soundarya S Gurum ◽  
MR Kavya ◽  
HP Nagaswarupa ◽  
...  
Keyword(s):  
Aloe Vera ◽  
Aloe Vera Gel

scholarly journals Green synthesis of silver nanoparticles: Characterization and its potential biomedical applications

2021 ◽  
Vol 10 (1) ◽  
pp. 412-420
Author(s):  
Mona S. Alwhibi ◽  
Dina A. Soliman ◽  
Manal A. Awad ◽  
Asma B. Alangery ◽  
Horiah Al Dehaish ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Aloe Vera ◽  
Inhibition Zone ◽  
Biologically Active ◽  
Noble Metal Nanoparticles ◽  
Biological Synthesis ◽  
Ag Nps ◽  
Mouse Melanoma ◽  
Therapeutic Benefits ◽  
Vis Spectroscopy

Abstract In recent times, research on the synthesis of noble metal nanoparticles (NPs) has developed rapidly and attracted considerable attention. The use of plant extracts is the preferred mode for the biological synthesis of NPs due to the presence of biologically active constituents. Aloe vera is a plant endowed with therapeutic benefits especially in skincare due to its unique curative properties. The present study focused on an environmental friendly and rapid method of phytosynthesis of silver nanoparticles (Ag-NPs) using A. vera gel extract as a reductant. The synthesized Ag-NPs were characterized by transmission electron microscopy (TEM), UV-Vis spectroscopy, Fourier transform infrared (FTIR), and dynamic light scattering (DLS). TEM micrographs showed spherical-shaped synthesized Ag-NPs with a diameter of 50–100 nm. The UV-Vis spectrum displayed a broad absorption peak of surface plasmon resonance (SPR) at 450 nm. The mean size and size distribution of the formed Ag-NPs were investigated using the DLS technique. Antibacterial studies revealed zones of inhibition by Ag-NPs of A. vera (9 and 7 mm) against Pseudomonas aeruginosa and Escherichia coli, respectively. Furthermore, the antifungal activity was screened, based on the diameter of the growth inhibition zone using the synthesized Ag-NPs for different fungal strains. Anticancer activity of the synthesized Ag-NPs against the mouse melanoma F10B16 cell line revealed 100% inhibition with Ag-NPs at a concentration of 100 µg mL−1. The phytosynthesized Ag-NPs demonstrated a marked antimicrobial activity and also exhibited a potent cytotoxic effect against mouse melanoma F10B16 cells. The key findings of this study indicate that synthesized Ag-NPs exhibit profound therapeutic activity and could be potentially ideal alternatives in medicinal applications.

scholarly journals Green Synthesized Silver Nanoparticles Immobilized on Activated Carbon Nanoparticles: Antibacterial Activity Enhancement Study and Its Application on Textiles Fabrics

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3790
Author(s):  
Pratama Jujur Wibawa ◽  
Muhammad Nur ◽  
Mukhammad Asy’ari ◽  
Wijanarka Wijanarka ◽  
Heru Susanto ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Activated Carbon ◽  
Aloe Vera ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
E Coli ◽  
Transmission Electron ◽  
Average Size ◽  
Green Synthesized Silver Nanoparticles

This research aimed to enhance the antibacterial activity of silver nanoparticles (AgNPs) synthesized from silver nitrate (AgNO3) using aloe vera extract. It was performed by means of incorporating AgNPs on an activated carbon nanoparticle (ACNPs) under ultrasonic agitation (40 kHz, 2 × 50 watt) for 30 min in an aqueous colloidal medium. The successful AgNPs synthesis was clarified with both Ultraviolet-Visible (UV-Vis) and Fourier Transform Infrared (FTIR) spectrophotometers. The successful AgNPs–ACNPs incorporation and its particle size analysis was performed using Transmission Electron Microscope (TEM). The brown color suspension generation and UV-Vis’s spectra maximum wavelength at around 480 nm confirmed the existence of AgNPs. The particle sizes of the produced AgNPs were about 5 to 10 nm in the majority number, which collectively surrounded the aloe vera extract secondary metabolites formed core-shell like nanostructure of 8.20 ± 2.05 nm in average size, while ACNPs themselves were about 20.10 ± 1.52 nm in average size formed particles cluster, and 48.00 ± 8.37 nm in average size as stacking of other particles. The antibacterial activity of the synthesized AgNPs and AgNPs-immobilized ACNPs was 57.58% and 63.64%, respectively (for E. coli); 61.25%, and 93.49%, respectively (for S. aureus). In addition, when the AgNPs-immobilized ACNPs material was coated on the cotton and polyester fabrics, the antibacterial activity of the materials changed, becoming 19.23% (cotton; E. coli), 31.73% (polyester; E. coli), 13.36% (cotton; S. aureus), 21.15% (polyester; S. aureus).

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