P02-118 - Student career choice in psychiatry - Phase 1 - a systematic review

BACKGROUND Effective screening is required to facilitate the early identification of central auditory processing disorder (CAPD) - a deficit within the central auditory nervous system, which can have a significant effect on a child’s listening, learning and communication. While several screening tools have been proposed, there is a lack of contextually appropriate tools that take the needs of a multilingual society, like South Africa (SA), into consideration. OBJECTIVE This study aims to develop a contextually appropriate CAPD screening protocol for children (aged 7 to 12 years) in SA. The specific study aims are: (1) to develop a contextually appropriate screening protocol for CAPD in primary school children in SA, and (2) to evaluate the feasibility of implementing the developed protocol in primary school children in SA. METHODS The study will follow a developmental, mixed methods research design, implemented in two phases. Phase 1 will be applied to address aim 1. The aim will be achieved by (i) conducting a systematic review (i.e. objective 1.1); (ii) applying the nominal group technique (NGT) on experts to identify criteria for an appropriate protocol (i.e. objective 1.2); and (iii) using a combination of expert consultations, questionnaires and rating scales (administered to experts) to devise an appropriate screening protocol (i.e. objective 1.3). Once the protocol is developed, it will be implemented by the recommended end-users. Thereafter, a feasibility study will be conducted in Phase 2 to evaluate the implementation of the protocol. This phase will include field testing the protocol and a focus group discussion with end-users. For Phase 1, the narrative synthesis approach will be used to analyse systematic review data. For the NGT the researcher will tally the participants’ ratings to identify the list of criteria for an appropriate protocol. Content analysis and descriptive statistics will be performed to analyse the expert ratings of the protocols. For Phase 2, descriptive statistics will be performed to summarise features of the study sample and measures used. Thematic analysis will be conducted to analyse the focus group data. RESULTS Ethical clearance was obtained from the university’s Human Research Ethics Committee (HREC reference number 636/2020) and the Western Cape Education Department granted the researchers permission to recruit educators and learners from primary schools in the area. The systematic review for objective 1.1. was completed and findings outlined the test properties, benefits, and limitations of existing CAPD screening tools. Face-to-face data collection was postponed due to the global COVID-19 pandemic. Participant recruitment for objective 1.2 is currently underway and the anticipated completion date for data collection is July 2022. CONCLUSIONS The present study will aim to advance CAPD screening practice by proposing a process to develop a contextually appropriate protocol. The researcher will apply this process in the South African context to develop a CAPD screening protocol for primary school children in SA. CLINICALTRIAL Not applicable.

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Psychosocial Distress of Patients with Psoriasis: Protocol for an Assessment of Care Needs and the Development of a Supportive Intervention (Preprint)

10.2196/preprints.8490 ◽

2017 ◽

Author(s):

Jördis Maria Zill ◽

Jörg Dirmaier ◽

Matthias Augustin ◽

Sarah Dwinger ◽

Eva Christalle ◽

...

Keyword(s):

Systematic Review ◽

Supportive Care ◽

Psychosocial Support ◽

Meta Analysis ◽

Phase 1 ◽

Psychosocial Distress ◽

Supportive Care Needs ◽

Phase 2 ◽

Care Needs ◽

Supportive Intervention

BACKGROUND Psoriasis is a chronic inflammatory disease that is often associated with a number of somatic and mental comorbidity. Patients with psoriasis show an increased risk of depression and (social) anxiety. OBJECTIVE The aims of this study are 1) to explore the psychosocial distress of patients with psoriasis and to assess their care needs; and 2) to develop a supportive intervention based on the prior results. METHODS A multi-stage design with four phases combining quantitative and qualitative methodology will be used and conducted in two centers. 1) A scoping review and focus groups will be used to design a questionnaire to assess the psychosocial distress and care needs of the patients. 2) The questionnaire developed in phase 1 will be used in a cross-sectional survey to assess the extent of psychosocial distress and supportive care needs in 400 patients with psoriasis. 3) A systematic review and meta-analysis will be conducted to identify psychosocial and psychoeducational interventions for patients with psoriasis and to describe their effectiveness. 4) Based on the results of the phases 2 and 3 a manualized supportive intervention will be developed and the feasibility and acceptance of the intervention will be assessed. RESULTS Currently, phase 1 of the project has been completed and the recruitment for phase 2 has been started. The systematic review and meta-analysis of phase 3 are conducted simultaneously to phase 2 and results are expected soon. Phase 4 has not been started yet. CONCLUSIONS The expected results of this study will show the extent of psychosocial distress of patients with psoriasis in Germany and supplement previous research with findings about the supportive care needs of this patient group. Moreover, the developed intervention will help to address the psychosocial support needs of patients with psoriasis. Research shows that psychosocial support is strongly needed.

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Nervous and Muscular Adverse Events after COVID-19 Vaccination: A Systematic Review and Meta-Analysis of Clinical Trials

Vaccines ◽

10.3390/vaccines9080939 ◽

2021 ◽

Vol 9 (8) ◽

pp. 939

Author(s):

Jiaxin Chen ◽

Yuangui Cai ◽

Yicong Chen ◽

Anthony P. Williams ◽

Yifang Gao ◽

...

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Adverse Events ◽

Fixed Effects ◽

Meta Analysis ◽

Phase 1 ◽

Cochrane Library ◽

Categorical Variables ◽

Control Group ◽

Open Label

Background: Nervous and muscular adverse events (NMAEs) have garnered considerable attention after the vaccination against coronavirus disease (COVID-19). However, the incidences of NMAEs remain unclear. We aimed to calculate the pooled event rate of NMAEs after COVID-19 vaccination. Methods: A systematic review and meta-analysis of clinical trials on the incidences of NMAEs after COVID-19 vaccination was conducted. The PubMed, Medline, Embase, Cochrane Library, and Chinese National Knowledge Infrastructure databases were searched from inception to 2 June 2021. Two independent reviewers selected the study and extracted the data. Categorical variables were analyzed using Pearson’s chi-square test. The pooled odds ratio (OR) with the corresponding 95% confidence intervals (CIs) were estimated and generated with random or fixed effects models. The protocol of the present study was registered on PROSPERO (CRD42021240450). Results: In 15 phase 1/2 trials, NMAEs occurred in 29.2% vs. 21.6% (p < 0.001) vaccinated participants and controls. Headache and myalgia accounted for 98.2% and 97.7%, and their incidences were 16.4% vs. 13.9% (OR = 1.97, 95% CI = 1.28–3.06, p = 0.002) and 16.0% vs. 7.9% (OR = 3.31, 95% CI = 2.05–5.35, p < 0.001) in the vaccine and control groups, respectively. Headache and myalgia were more frequent in the newly licensed vaccines (OR = 1.97, 95% CI = 1.28–3.06, p = 0.02 and OR = 3.31, 95% CI = 2.05–5.35, p < 0.001) and younger adults (OR = 1.40, 95% CI = 1.12–1.75, p = 0.003 and OR = 1.54, 95% CI = 1.20–1.96, p < 0.001). In four open-label trials, the incidences of headache, myalgia, and unsolicited NMAEs were 38.7%, 27.4%, and 1.5%. Following vaccination in phase 3 trials, headache and myalgia were still common with a rate of 29.5% and 19.2%, although the unsolicited NMAEs with incidence rates of ≤ 0.7% were not different from the control group in each study. Conclusions: Following the vaccination, NMAEs are common of which headache and myalgia comprised a considerable measure, although life-threatening unsolicited events are rare. NMAEs should be continuously monitored during the ongoing global COVID-19 vaccination program.

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Towards the development of a system-wide quality improvement maturity model: a synthesis using systematic review and expert opinion

International Journal of Lean Six Sigma ◽

10.1108/ijlss-06-2021-0107 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Adeel Akmal ◽

Nataliya Podgorodnichenko ◽

Richard Greatbanks ◽

Jeff Foote ◽

Tim Stokes ◽

...

Keyword(s):

Systematic Review ◽

Quality Improvement ◽

New Zealand ◽

Phase 1 ◽

Successful Implementation ◽

Maturity Model ◽

True Nature ◽

Content Type ◽

Current State ◽

Full Control

Purpose The various quality improvement (QI) frameworks and maturity models described in the health services literature consider some aspects of QI while excluding others. This paper aims to present a concerted attempt to create a quality improvement maturity model (QIMM) derived from holistic principles underlying the successful implementation of system-wide QI programmes. Design/methodology/approach A hybrid methodology involving a systematic review (Phase 1) of over 270 empirical research articles and books developed the basis for the proposed QIMM. It was followed by expert interviews to refine the core constructs and ground the proposed QIMM in contemporary QI practice (Phase 2). The experts included academics in two academic conferences and 59 QI managers from the New Zealand health-care system. In-depth interviews were conducted with QI managers to ascertain their views on the QIMM and its applicability in their respective health organisations (HOs). Findings The QIMM consists of four dimensions of organisational maturity, namely, strategic, process, supply chain and philosophical maturity. These dimensions progress through six stages, namely, identification, ad-hoc, formal, process-driven, optimised enterprise and finally a way of life. The application of the QIMM by the QI managers revealed that the scope of QI and the breadth of the principles adopted by the QI managers and their HOs in New Zealand is limited. Practical implications The importance of QI in health systems cannot be overstated. The proposed QIMM can help HOs diagnose their current state and provide a guide to action achieving a desirable state of quality improvement maturity. This QIMM avoids reliance on any single QI methodology. HOs – using the QIMM – should retain full control over the process of selecting any QI methodology or may even cherry-pick principles to suit their needs as long as they understand and appreciate the true nature and scope of quality overstated. The proposed QIMM can help HOs diagnose their current state and provide a guide to action achieving a desirable state of quality improvement maturity. This QIMM avoids reliance on any single QI methodology. HOs – using the QIMM – should retain full control over the process of selecting any QI methodology or may even cherry-pick principles to suit their needs as long as they understand and appreciate the true nature and scope of quality. Originality/value This paper contributes new knowledge by presenting a maturity model with an integrated set of quality principles for HOs and their extended supply networks.

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Immunogenicity and Safety Analysis of Inactivated Virus Vaccine against SARS-CoV-2: A Systematic Review of Phase 1/2 Clinical Trials

Journal of Asian Medical Students' Association ◽

10.52629/jamsa.v9i1.258 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Muhammad Mikail Athif Zhafir Asyura ◽

Angelina Patricia Chandra ◽

Achmad Agussalim ◽

Garry Soloan

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Virus Vaccine ◽

Seroconversion Rate ◽

Phase 1 ◽

Safety Analysis ◽

Inactivated Vaccine ◽

Online Databases ◽

Dependent Relation ◽

Tract Infections

Introduction: The lingering Severe Acute Respiratory System-Coronavirus-2 (SARS-CoV-2) pandemic worldwide has called scientists to accelerate vaccine production and reduce the spread of the virus. The inactivated virus vaccine has been administered widely due to its potency. Following its recent public use, we aim to summarize the efficacy and safety of the inactivated vaccine, especially following Indonesia’s settlement on the SinoVac vaccine. Materials and Methods: A systematic review was performed, searching for randomized controlled trials, according to the PRISMA statement throughout four online databases with studies published up to 2 February 2021. Critical appraisal was further conducted utilizing the Cochrane Risk of Bias Tool 2.0. Results and Discussions: The search yielded six phase ½ clinical trials with a total of 3251 subjects. The outcome was obtained in seroconversion rates (%) after two doses of vaccine. Four studies administered the CoronaVac inactivated vaccine and resulted in a high seroconversion rate, ranging from 89—90%. The other two studies administered the BBV152 and BBIBP-CorV inactivated vaccine and showed similar results. Furthermore, a dose dependent relation is shown with higher doses showing higher seroconversion rates. The safety analysis reported injection site pain as an insignificant but most prevalent local adverse reaction, with other adverse reactions being mild to moderate respiratory tract infections Conclusion: The inactivated vaccine’s efficacy has been proven to stimulate antibody response regardless of dosage, period of administration, and age, with insignificant adverse effects. Further phase 3 clinical trials and widespread administration with the help of non-governmental and medical student organizations are recommended

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Dynamics of career choice among students in undergraduate medical courses. A BEME systematic review: BEME Guide No. 33

Medical Teacher ◽

10.3109/0142159x.2015.1074990 ◽

2015 ◽

Vol 38 (1) ◽

pp. 18-29 ◽

Cited By ~ 46

Author(s):

Sophie J. Querido ◽

David Vergouw ◽

Lode Wigersma ◽

Ronald S. Batenburg ◽

Marlies E. J. De Rond ◽

...

Keyword(s):

Systematic Review ◽

Career Choice

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Patient information in phase 1 trials: A systematic review

Psycho-Oncology ◽

10.1002/pon.4559 ◽

2017 ◽

Vol 27 (3) ◽

pp. 768-780 ◽

Cited By ~ 3

Author(s):

Katrine Toubro Gad ◽

Ulrik Lassen ◽

Morten Mau-Søerensen ◽

Mette Terp Høybye ◽

Christoffer Johansen

Keyword(s):

Systematic Review ◽

Patient Information ◽

Phase 1 ◽

Phase 1 Trials

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A systematic review protocol of medical and clinical research landscapes and quality in Malaysia and Indonesia [REALQUAMI]

10.21203/rs.3.rs-40583/v1 ◽

2020 ◽

Author(s):

Boon How Chew ◽

Shaun Wen Huey Lee ◽

Poh Ying Lim ◽

Soo Huat Teoh ◽

Aneesa Abdul Rashid ◽

...

Keyword(s):

Systematic Review ◽

Biomedical Research ◽

Phase 1 ◽

Research Performance ◽

Health Conditions ◽

Research Quality ◽

Independent Effect ◽

Responsible Conduct Of Research ◽

And Performance

Abstract Background Research landscapes and quality may change in many ways. Much research waste has been increasingly reported. Poorly conducted clinical and biomedical researches are detrimental to the health of the people and healthcare performance with misleading clinical evidence. Efforts to improve research performance will need good data on the profiles and performance of past research. This systematic review aims to describe the characteristics and examine the quality of clinical and biomedical research in Malaysia and Indonesia. Methods A search will be conducted in PubMed, EMBASE, CINAHL and PsycINFO to identify for published clinical and biomedical research from 1962 to 2019 from Malaysia and/or Indonesia. Additional search will also be conducted in MyMedR (Malaysian only). Studies found will be independently screened by a team of reviewers, relevant information will be extracted and the quality of articles will be assessed. In Phase 1, the characteristics of the research including the profiles of the researchers and the journals in which they are published will be reported descriptively. In Phase 2, a research quality screening tool will be validated to assess the research quality based on three domains of relevance, the credibility of the methods and usefulness of the results. Associations between the research characteristics and quality will be analysed. The independent effect of each of the determinant will be quantified in multivariable regression analysis. Longitudinal trends of the research characteristics, health conditions studied and settings, among others will be explored. Discussion Results of this study will serve as the 'baseline' data for future evaluation and within the country and between countries comparison. This review may also provide informative results to stakeholders of the evolution of research conduct and performance from the past until now. The longitudinal and prospective trends of the research characteristics and quality could provide suggestions on improvement initiatives. Additionally, information on health conditions, research settings, and whether they are over- or under-studied may help future prioritization of research initiatives and resources. Registration: CRD42020152907 (PROSPERO) and https://osf.io/w85ce (Open Science Framework’s registry for Research on the Responsible Conduct of Research).

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LO58: Long-term outcomes among emergency department syncope patients: a systematic review

CJEM ◽

10.1017/cem.2018.120 ◽

2018 ◽

Vol 20 (S1) ◽

pp. S27-S27

Author(s):

C. Leafloor ◽

P. Jiho Hong ◽

L. Sikora ◽

J. Elliot ◽

M. Mukarram ◽

...

Keyword(s):

Systematic Review ◽

Emergency Department ◽

Phase 1 ◽

Adverse Outcomes ◽

Cochrane Central Register ◽

Phase 2 ◽

Long Term Outcomes ◽

One Year

Introduction: Approximately 50% of patients discharged from the Emergency Department (ED) after syncope have no cause found. Long-term outcomes among syncope patients are not well studied, to guide physicians regarding outpatient testing and follow-up. The objective of this study was to conduct a systematic review for long-term (one year) outcomes among ED patients with syncope. We aim to use the results of this review to guide us in prospective analysis of one year outcomes with our large database of syncope patients. Methods: We searched Cochrane Central Register of Controlled Trials, Medline and Medline in Process, PubMed, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) from the inception to June, 2017. We included studies that reported long-term outcomes among adult ED patients (16 years or older) with syncope. We excluded studies on pediatric patients, and studies that included syncope mimickers: pre-syncope, seizure, intoxication, loss of consciousness after head trauma. We also excluded case reports, letters to the editor and review articles. Outcomes included death, syncope recurrence requiring hospitalization, arrhythmias and procedural interventions for arrhythmias. We selected articles based on title and abstract review during phase-1 and conducted full article review during phase-2. Meta-analysis was performed by pooling the outcomes using random effects model (RevMan v.5.3; Cochrane Collaboration). Results: Initial literature search generated 2094 articles after duplicate removal. 50 articles remained after phase-1 (=0.85) and 16 articles were included in the systematic review after phase-2 (=0.86). The 16 included studies enrolled a total of 44,755 patients. Pooled analysis at 1-year follow-up showed the following outcomes: 7% mortality; 14% recurrence of syncope requiring hospitalization; one study reported that 0.6% of patients had a pacemaker inserted; and two studies reported 0.8 11.5% of patients suffered new arrhythmias. Conclusion: An important proportion of ED patients with syncope suffer outcomes at 1-year. Appropriate follow-up is needed to prevent long-term adverse outcomes. Further prospective research to identify patients at risk for long-term important cardiac outcomes and death is needed.

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Systematic Review of Common Factors Used to Measure Individuals’ Career Choice

10.1007/978-3-030-90235-3_10 ◽

2021 ◽

pp. 111-126

Author(s):

Feninferina Azman ◽

Azimah Abdul Ghapar ◽

Masyura Ahmad Faudzi ◽

Hasventhran Baskaran ◽

Fiza Abdul Rahim

Keyword(s):

Systematic Review ◽

Career Choice ◽

Common Factors

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