EPA-0184 - New treatment options in obsessive compulsive disorder

2014 ◽  
Vol 29 ◽  
pp. 1
Author(s):  
N. Fineberg ◽  
S. Reghunandanan ◽  
A. Brown
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Treatment Options ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
New Treatment

scholarly journals Drug treatment of obsessive-compulsive disorder

2010 ◽  
Vol 12 (2) ◽  
pp. 187-197 ◽  
Keyword(s):  
Drug Treatment ◽  
Obsessive Compulsive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Treatment Options ◽  
Future Research ◽  
Considerable Proportion ◽  
Preliminary Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Rational Drug

Knowledge of pharmacotherapeutic treatment options in obsessive-compulsive disorder (OCD) has grown considerably over the past 40 years. Serotonergic antidepressants, such as selective serotonin reuptake inhibitors (SSRls) and clomipramine, are the established pharmacologic first-line treatment of OCD. Medium to large dosages and acute treatment for at least 3 months are recommended until efficacy is assessed. In case of significant improvement, maintenance treatment is necessary, Unfortunately, about half of the patients do not respond sufficiently to oral serotonergic antidepressants; augmentation with atypical antipsychotics is an established second-line drug treatment strategy. Alternatives include intravenous serotonergic antidepressants and combination with or switch to cognitive behavioral psychotherapy. Remarkably, a considerable proportion of OCD patients still do not receive rational drug treatment. Novel research approaches, such as preliminary treatment studies with glutamatergic substances, and trials with further drugs, as well as needed aspects of future research, are reviewed.

Obsessive Compulsive Disorder: A Vocational Perspective

1997 ◽  
Vol 28 (1) ◽  
pp. 28-30
Author(s):  
Robert Miranda ◽  
Carolyn W. Rollins
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Age Of Onset ◽  
Negative Impact ◽  
Treatment Options ◽  
Life Time ◽  
The United States ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Academic History ◽  
The Impact

In recent years the number of individuals diagnosed with obsessive compulsive disorder (OCD) has increased. With a life time prevalence of 2.5%, OCD is more prevalent than schizophrenia, bipolar disorder, or panic disorder. Undiagnosed and untreated, OCD can have negative effects on many aspects of an individual's life, including vocation. With the mean age of onset in the United States being approximately 16 years of age, the impact of OCD on an individual's vocational development can be considerable. Additionally, individuals with this disorder may present a poor work or academic history. Their vocational performance may be incorrectly interpreted as indicative of irresponsibility or a poor work ethic rather than as a consequence of the disease. Therefore, rehabilitation counselors should be cognizant of the symptoms associated with OCD and the negative impact of the disorder on an individual's life. This article outlines symptoms of the disorder, explores current treatment options, and discusses vocational implications associated with OCD.

scholarly journals The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?

2019 ◽  
Vol 4 (2) ◽  
pp. 77-87 ◽  
Author(s):  
Reilly R. Kayser ◽  
Ivar Snorrason ◽  
Margaret Haney ◽  
Francis S. Lee ◽  
H. Blair Simpson
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Endocannabinoid System ◽  
Obsessive Compulsive ◽  
Treatment Target ◽  
Compulsive Disorder ◽  
System A ◽  
New Treatment

A Review of the Treatment for Refractory Obsessive-Compulsive Disorder: From Medicine to Deep Brain Stimulation

CNS Spectrums ◽  
2004 ◽  
Vol 9 (11) ◽  
pp. 833-847 ◽  
Author(s):  
David S. Husted ◽  
Nathan A. Shapira
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Treatment Options ◽  
Invasive Procedure ◽  
Obsessive Compulsive ◽  
Pharmacological Agents ◽  
Compulsive Disorder ◽  
Definition Of ◽  
Deep Brain

ABSTRACTThis article provides an overview of the etiology, epidemiology, and first-line treatment options for obsessive-compulsive disorder (OCD). The subject of treatment-resistant and treatment-refractory OCD is the discussed, including a definition of these often-debated terms, and the latest treatment options delineated. This includes a review of the latest research concerning the pharmacological agents that have been studied as monotherapy or augmenting agents for the treatment of OCD, the use of experimental medications and procedures, treatment with reversible, minimally invasive procedure, such as vagal nerve stimulation and transcranial magnetic stimulation, invasive but the potentially reversible deep brain stimulation, and irreversible lesioning with ablative psychosurgery. A discussion of the role of psychotherapy in the treatment of OCD is also included.

scholarly journals Lithium: a potential therapeutic strategy in obsessive–compulsive disorder by targeting the canonical WNT/β pathway

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexandre Vallée ◽  
Jean-Noël Vallée ◽  
Yves Lecarpentier
Keyword(s):  
Oxidative Stress ◽  
Obsessive Compulsive Disorder ◽  
Therapeutic Strategy ◽  
Behavioral Therapy ◽  
First Line ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Line Therapy ◽  
New Treatment ◽  
Gsk 3Β

AbstractObsessive–compulsive disorder (OCD) is a neuropsychiatric disorder characterized b–y recurrent and distinctive obsessions and/or compulsions. The etiologies remain unclear. Recent findings have shown that oxidative stress, inflammation, and the glutamatergic pathway play key roles in the causes of OCD. However, first-line therapies include cognitive–behavioral therapy but only 40% of the patients respond to this first-line therapy. Research for a new treatment is mandatory. This review focuses on the potential effects of lithium, as a potential therapeutic strategy, on OCD and some of the presumed mechanisms by which lithium provides its benefit properties. Lithium medication downregulates GSK-3β, the main inhibitor of the WNT/β-catenin pathway. The activation of the WNT/β-catenin could be associated with the control of oxidative stress, inflammation, and glutamatergic pathway. Future prospective clinical trials could focus on lithium and its different and multiple interactions in OCD.

The Medical Treatment of Obsessive-Compulsive Disorder and Anxiety

CNS Spectrums ◽  
2008 ◽  
Vol 13 (S14) ◽  
pp. 37-46 ◽  
Author(s):  
Borwin Bandelow
Keyword(s):  
Anxiety Disorders ◽  
Obsessive Compulsive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Behavioral Therapy ◽  
Treatment Options ◽  
First Line ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
History Of ◽  
Higher Doses

AbstractSelective serotonin reuptake inhibitors (SSRIs) are first-line pharmacotherapy treatments for obsessive-compulsive disorder (OCD). Clomipramine is effective in OCD but associated with more adverse events. Typically, higher doses of antidepressants are required for OCD. Up to 50% of patients do not respond to initial treatment of OCD. Treatment options for nonresponders include augmentation of antidepressants with atypical antipsychotics, among other strategies. First-line treatments for anxiety disorders include SSRIs, serotonin norepinephrine reuptake inhibitors, and pregabalin. Tricyclic antidepressants are equally effective as SSRIs, but are less well tolerated. In treatment-resistant cases, benzodiazepines may be used when the patient does not have a history of dependency and tolerance. Other treatment options include irreversible and reversible monoamine oxidase inhibitors, the atypical antipsychotic quetiapine, and other medications. Cognitive-behavioral therapy has been sufficiently investigated in controlled studies of OCD and anxiety disorders and is recommended alone or in combination with the above medications.

scholarly journals Stuck song syndrome

2020 ◽  
Author(s):  
Brynn Petras Charron ◽  
Jordan Ho
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Treatment Options ◽  
Differential Diagnoses ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Past

The article presents a case of a 32-year-old woman who has been experiencing episodes of musical obsessions for the past 12 years. The case highlights the importance of addressing stuck song syndrome due to its effects on the functioning of the patient. The psychopathological expressions of this condition in relation to obsessive-compulsive disorder (OCD) are described. The discussion provides distinction between the differential diagnoses of palinacousis, musical hallucinations, and musical obsessions. Lastly, the recognized treatment options for musical obsessions are explored.

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