The role of ARF and Rab GTPases in membrane transport

Tumor progression involves invasion, migration, metabolism, autophagy, exosome secretion, and drug resistance. Cargos transported by membrane vesicle trafficking underlie all of these processes. Rab GTPases, which, through coordinated and dynamic intracellular membrane trafficking alongside cytoskeletal pathways, determine the maintenance of homeostasis and a series of cellular functions. The mechanism of vesicle movement regulated by Rab GTPases plays essential roles in cancers. Therefore, targeting Rab GTPases to adjust membrane trafficking has the potential to become a novel way to adjust cancer treatment. In this review, we describe the characteristics of Rab GTPases; in particular, we discuss the role of their activation in the regulation of membrane transport and provide examples of Rab GTPases regulating membrane transport in tumor progression. Finally, we discuss the clinical implications and the potential as a cancer therapeutic target of Rab GTPases.

Download Full-text

The role of phosphoinositides in membrane transport

Current Opinion in Cell Biology ◽

10.1016/s0955-0674(00)00240-4 ◽

2001 ◽

Vol 13 (4) ◽

pp. 485-492 ◽

Cited By ~ 345

Author(s):

Anne Simonsen ◽

Andrew E Wurmser ◽

Scott D Emr ◽

Harald Stenmark

Keyword(s):

Membrane Transport

Download Full-text

Monitoring HSVtk suicide gene therapy: the role of [18F]FHPG membrane transport

British Journal of Cancer ◽

10.1038/sj.bjc.6602216 ◽

2004 ◽

Vol 91 (12) ◽

pp. 2079-2085 ◽

Cited By ~ 9

Author(s):

A R Buursma ◽

I J van Dillen ◽

A van Waarde ◽

W Vaalburg ◽

G A P Hospers ◽

...

Keyword(s):

Gene Therapy ◽

Membrane Transport ◽

Suicide Gene ◽

Suicide Gene Therapy

Download Full-text

The role of host cell Rab GTPases in influenza A virus infections

Future Microbiology ◽

10.2217/fmb-2020-0092 ◽

2021 ◽

Author(s):

Jing Wu ◽

Jiaqi Gu ◽

Li Shen ◽

Xiaonan Jia ◽

Yiqian Yin ◽

...

Keyword(s):

Influenza A Virus ◽

Influenza A ◽

Respiratory Infections ◽

Small Gtpase ◽

Regulatory Mechanisms ◽

Rab Proteins ◽

Rab Gtpases ◽

Virus Infections ◽

Adaptation Mechanisms

Influenza A virus (IAV) is a crucial cause of respiratory infections in humans worldwide. Therefore, studies should clarify adaptation mechanisms of IAV and critical factors of the viral pathogenesis in human hosts. GTPases of the Rab family are the largest branch of the Ras-like small GTPase superfamily, and they regulate almost every step during vesicle-mediated trafficking. Evidence has shown that Rab proteins participate in the lifecycle of IAV. In this mini-review, we outline the regulatory mechanisms of different Rab proteins in the lifecycle of IAV. Understanding the role of Rab proteins in IAV infections is important to develop broad-spectrum host-targeted antiviral strategies.

Download Full-text