Long-term results of total mesorectal excision for rectal cancer: prospective single-center study

2017 ◽  
Vol 72 ◽  
pp. S63
Author(s):  
D. Sidorov ◽  
L. Petrov ◽  
M. Lozhkin ◽  
A. Troitskiy ◽  
A. Isaeva
2009 ◽  
Vol 75 (1) ◽  
pp. 33-38
Author(s):  
QuintÍN H. GonzÁLez ◽  
Homero A. RodrÍGuez-Zentner ◽  
J. Manuel Moreno-Berber ◽  
Omar Vergara-FernÁNdez ◽  
HÉCtor Tapia-Cid De LeÓN ◽  
...  

Because definitive long-term results are not yet available, the oncologic safety of laparoscopic surgery in rectal cancer remains controversial. Laparoscopic total mesorectal excision (LTME) for rectal cancer has been proposed to have several short-term advantages in comparison with open total mesorectal excision (OTME). However, few prospective randomized studies have been performed. The main purpose of our study was to evaluate whether relevant differences in safety and efficacy exist after elective LTME for the treatment of rectal cancer compared with OTME in a tertiary referral medical center. This comparative nonrandomized prospective study analyzes data in 56 patients with middle and lower rectal cancer treated with low anterior resection or abdominoperineal resection from November 2005 to November 2007. Follow-up was determined through office charts or direct patient contact. Statistical analysis was performed using χ2 test and Student's t test. Twenty-eight patients underwent LTME and 28 patients were in the OTME group. No conversion was required in the LTME group. Mean operating time was shorter in the laparoscopic group (LTME) (181.3 vs 206.1 min, P < 0.002). Less intraoperative blood loss and fewer postoperative complications were seen in the LTME group. Return of bowel motility was observed earlier after laparoscopic surgery. There was no 30-day mortality and the overall morbidity was 17 per cent in the LTME group versus 32 per cent in the OTME group. The mean number of harvested lymph nodes was greater in the laparoscopic group than in the OTME group (12.1 ± 2 vs 9.3 ± 3). Mean follow-up time was 12 months (range 9-24 months). No local recurrence was found. LTME is a feasible procedure with acceptable postoperative morbidity and low mortality, however it is technically demanding. This series confirms its safety, although oncologic results are at present comparable with the OTME published series with the limitation of a short follow-up period. Further randomized studies are necessary to evaluate long-term clinical outcome.


2014 ◽  
Vol 18 (4) ◽  
pp. 796-807 ◽  
Author(s):  
Riccardo Brachet Contul ◽  
Manuela Grivon ◽  
Massimiliano Fabozzi ◽  
Paolo Millo ◽  
Mario Junior Nardi ◽  
...  

2020 ◽  
Vol 36 (5) ◽  
pp. 381-387
Author(s):  
Stefan Fichtner-Feigl

<b><i>Background:</i></b> The surgical approach in rectal cancer treatment has evolved in the last decades and a standardized surgical technique for tumor resection – total mesorectal excision – has been established. <b><i>Summary:</i></b> In a multidisciplinary effort with the use of total mesorectal excision in combination with adjuvant and neoadjuvant treatments to compliment surgery disease management can achieve excellent long-term local control and improved patient survival. Further improvements in imaging techniques and the ability to identify prognostic factors such as tumor regression, extramural venous invasion, and threatened margins have introduced the concept of decision-making based on preoperative staging information. <b><i>Key Message:</i></b> Therefore, in the modern era treatment algorithms are based on high-resolution imaging to plan neoadjuvant therapy and precision surgery followed by pathological and molecular analysis to stratify patients for the need of adjuvant chemotherapy. Despite excellent results with guideline structured treatment pathways, there is still a need to improve long-term results especially for individuals with locally advanced or metastatic tumors.


Surgery ◽  
2015 ◽  
Vol 157 (6) ◽  
pp. 1121-1129 ◽  
Author(s):  
Min Soo Cho ◽  
Chang Woo Kim ◽  
Se Jin Baek ◽  
Hyuk Hur ◽  
Byung Soh Min ◽  
...  

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