Efficacy trends of the acorn cardiac support device in patients with heart failure: a one year follow-up

Abstract Background Catheter ablation improves clinical outcomes in symptomatic atrial fibrillation (AF) patients with heart failure (HF) with reduced ejection fraction (HFrEF). However, the role of catheter ablation in HF patients with a preserved ejection fraction (HFpEF) is less clear. Purpose To determine the efficacy of catheter ablation of AF in patients with HFpEF relative to those with HFrEF. Methods We performed an extensive literature search and systematic review of studies that compared AF recurrence at one year after catheter ablation of AF in patients with HFpEF versus those with HFrEF. Risk ratio (RR) 95% confidence intervals were measured using the Mantel-Haenszel method for dichotomous variables, where a RR<1.0 favors the HFpEF group. Results Four studies with a total of 563 patients were included, of which 312 had HFpEF and 251 had HFrEF. All patients included were undergoing first time catheter ablation of AF. Patients with HFpEF experienced similar recurrence of AF one year after ablation on or off antiarrhythmic drugs compared to those with HFrEF (RR 0.87; 95% CI 0.69–1.10, p=0.24), as shown in Figure 1. Recurrence of AF was assessed with electrocardiography, Holter monitoring, and/or event monitoring at scheduled follow-up visits and final follow-up. Conclusion Based on the results of this meta-analysis, catheter ablation of AF in patients with HFpEF appears as efficacious in maintaining sinus rhythm as in those with HFrEF. Funding Acknowledgement Type of funding source: None

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Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure

Scientific Reports ◽

10.1038/s41598-021-91368-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Daichi Maeda ◽

Nobuyuki Kagiyama ◽

Kentaro Jujo ◽

Kazuya Saito ◽

Kentaro Kamiya ◽

...

Keyword(s):

Heart Failure ◽

Older Patients ◽

Early Recognition ◽

Walk Distance ◽

Failure Data ◽

Patients With Heart Failure ◽

All Cause Mortality ◽

One Year ◽

Independent Marker

AbstractFrailty is a common comorbidity associated with adverse events in patients with heart failure, and early recognition is key to improving its management. We hypothesized that the AST to ALT ratio (AAR) could be a marker of frailty in patients with heart failure. Data from the FRAGILE-HF study were analyzed. A total of 1327 patients aged ≥ 65 years hospitalized with heart failure were categorized into three groups based on their AAR at discharge: low AAR (AAR < 1.16, n = 434); middle AAR (1.16 ≤ AAR < 1.70, n = 487); high AAR (AAR ≥ 1.70, n = 406). The primary endpoint was one-year mortality. The association between AAR and physical function was also assessed. High AAR was associated with lower short physical performance battery and shorter 6-min walk distance, and these associations were independent of age and sex. Logistic regression analysis revealed that high AAR was an independent marker of physical frailty after adjustment for age, sex and body mass index. During follow-up, all-cause death occurred in 161 patients. After adjusting for confounding factors, high AAR was associated with all-cause death (low AAR vs. high AAR, hazard ratio: 1.57, 95% confidence interval, 1.02–2.42; P = 0.040). In conclusion, AAR is a marker of frailty and prognostic for all-cause mortality in older patients with heart failure.

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Depression risk in patients with heart failure in primary care practices in Germany

International Psychogeriatrics ◽

10.1017/s1041610216000867 ◽

2016 ◽

Vol 28 (11) ◽

pp. 1889-1894

Author(s):

Marcel Konrad ◽

Jens Bohlken ◽

Michael A Rapp ◽

Karel Kostev

Keyword(s):

Heart Failure ◽

Primary Care ◽

Health Insurance ◽

Control Group ◽

Patients With Heart Failure ◽

Study Population ◽

Care Practices ◽

One Year ◽

Primary Care Practices

ABSTRACTBackground:The goal of this study was to estimate the prevalence of and risk factors for diagnosed depression in heart failure (HF) patients in German primary care practices.Methods:This study was a retrospective database analysis in Germany utilizing the Disease Analyzer® Database (IMS Health, Germany). The study population included 132,994 patients between 40 and 90 years of age from 1,072 primary care practices. The observation period was between 2004 and 2013. Follow-up lasted up to five years and ended in April 2015. A total of 66,497 HF patients were selected after applying exclusion criteria. The same number of 66,497 controls were chosen and were matched (1:1) to HF patients on the basis of age, sex, health insurance, depression diagnosis in the past, and follow-up duration after index date.Results:HF was a strong risk factor for diagnosed depression (p < 0.0001). A total of 10.5% of HF patients and 6.3% of matched controls developed depression after one year of follow-up (p < 0.001). Depression was documented in 28.9% of the HF group and 18.2% of the control group after the five-year follow-up (p < 0.001). Cancer, dementia, osteoporosis, stroke, and osteoarthritis were associated with a higher risk of developing depression. Male gender and private health insurance were associated with lower risk of depression.Conclusions:The risk of diagnosed depression is significantly increased in patients with HF compared to patients without HF in primary care practices in Germany.

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ONE YEAR FOLLOW-UP ASSESSMENT OF PATIENTS WITH HEART FAILURE

Journal of Hypertension ◽

10.1097/01.hjh.0000539604.92640.e0 ◽

2018 ◽

Vol 36 (Supplement 1) ◽

pp. e214

Author(s):

A.M. Gonzalez Gonzalez ◽

A.M. Garcia Bellon ◽

P. Guardia Martinez ◽

M. De Mora Martin

Keyword(s):

Heart Failure ◽

Patients With Heart Failure ◽

One Year

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Results of a multicenter randomized clinical trial for the assessment of a cardiac support device in patients with heart failure

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2004.11.119 ◽

2005 ◽

Vol 24 (2) ◽

pp. S74 ◽

Cited By ~ 2

Author(s):

D.L. Mann ◽

M.A. Acker ◽

M. Jessup ◽

H.N. Sabbah ◽

R.C. Starling ◽

...

Keyword(s):

Heart Failure ◽

Clinical Trial ◽

Randomized Clinical Trial ◽

Patients With Heart Failure ◽

Support Device ◽

Cardiac Support Device

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128Change in geriatric nutritional risk index predicts one-year mortality in patients with heart failure with preserved ejection fraction

European Heart Journal ◽

10.1093/eurheartj/ehz747.0044 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

A Sunaga ◽

S Hikoso ◽

T Yamada ◽

Y Yasumura ◽

M Uematsu ◽

...

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Risk Index ◽

Patient Characteristics ◽

Nutritional Risk ◽

Preserved Ejection Fraction ◽

Nutritional Risk Index ◽

Patients With Heart Failure ◽

One Year

Abstract Background Malnutrition is associated with adverse prognosis in heart failure patients. However, in patients with heart failure with preserved ejection fraction (HFpEF), the effects of change in nutritional status during hospitalization on prognosis is unknown. Geriatric nutritional risk index (GNRI) is a widely used objective index for evaluating nutritional status. Low GNRI (<92) has moderate or severe nutritional risk and high GNRI (≥92) has no or low nutritional risk. Purpose The purpose of this study was to clarify the effect of change in GNRI during hospitalization on one-year mortality and the association between the value of GNRI and one-year mortality in patients with HFpEF. Methods We prospectively registered patients with HFpEF in PURSUIT-HFpEF registry when they were hospitalized for heart failure in 29 hospitals. Preserved ejection fraction was defined as more than 50% of left ventricular ejection fraction. Of the 486 patients who registered PURSUIT-HFpEF, 228 cases with one-year follow-up data were examined. GNRI was calculated as follows: 14.89 × serum albumin (g/dl) + 41.7 × body mass index/22. Results Mean age was 81±10 years and 100 patients (44%) were male. During a median [interquartile range] follow-up period of 374 [342, 400] days, 28 patients (12%) died. Mortality was significantly higher in patients with low GNRI at admission (n=65) than those with high GNRI at admission (n=163) (26% vs. 9%, log-rank P=0.011) and higher in patients with low GNRI at discharge (n=109) than those with high GNRI at discharge (n=119) (22% vs. 6%, log-rank P=0.002). Multivariate analysis with Cox proportional hazard model with patient characteristics at admission revealed that low GNRI at admission was independently associated with mortality (hazard ratio: 0.96, 95% CI: 0.93–0.99, P=0.035) and that with patient characteristics at discharge revealed that low GNRI at discharge was independently associated with mortality (hazard ratio: 0.94, 95% CI: 0.91–0.97, P<0.001). We also compared mortality by dividing patients into 4 group according to whether GNRI was high or low at the time of admission and discharge. Patients with low GNRI at admission and at discharge (n=59) exhibited the highest mortality, on the other hand, patients with high GNRI at admission and low GNRI at discharge (n=50) exhibited higher mortality than those with high GNRI both at admission and at discharge (n=113) (Low and low: 28% vs. High and low: 14% vs. High and high: 6% vs. Low and high: 0%, log-rank P=0.010). All cause mortality Conclusion GNRI at admission or at discharge was independently associated with one-year mortality in patients with HFpEF. Moreover, worsening GNRI during hospitalization is associated with the worse prognosis. It is important to prevent lowering GNRI during treatment of acute decompensated HFpEF. Acknowledgement/Funding Roche Diagnostics, FUJIFILM Toyama Chemical

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Gender Differences in the Influence of Social Support on One-Year Changes in Functional Status in Older Patients with Heart Failure

Cardiology Research and Practice ◽

10.1155/2012/616372 ◽

2012 ◽

Vol 2012 ◽

pp. 1-10 ◽

Cited By ~ 15

Author(s):

Danielle M. Berard ◽

Elizabeth G. VanDenKerkhof ◽

Margaret Harrison ◽

Joan E. Tranmer

Keyword(s):

Heart Failure ◽

Social Support ◽

Gender Differences ◽

Kansas City ◽

Functional Decline ◽

Self Report ◽

Functional Health ◽

Patients With Heart Failure ◽

One Year

The purpose of this study was to determine the combined effects of gender and levels of social support on 1-year functional health outcomes in older persons diagnosed with heart failure (HF). Persons ≥ 65 years of age with an acute HF exacerbation (164 females; 271 males) were enrolled and followed for a year. Participants completed baseline and 12-month questionnaires containing clinical and demographic descriptive information and validated self-report measures of: (1) physical functioning (Medical Outcome Study [MOS] SF12 and Kansas City Cardiomyopathy Questionnaire [KCCQ]) and (2) social support (MOS- Social Support Survey). Women were more likely to be single, widowed or divorced, living alone and earning less annual income. At baseline, women reported significantly lower support and physical function scores. However, at 1 year there were no significant gender differences in the proportion of men or women who experienced clinically meaningful functional decline or death across the year of follow-up. In multivariable modeling, men with lower levels of social support were more likely to experience functional decline. This was not the case for women. Our findings suggest that gender-directed strategies to promote optimization of function for both men and women living with HF in their community are warranted.

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