Transforming growth factor-alpha overexpression in proliferative verrucous leukoplakia and oral squamous cell carcinoma

1996 ◽  
Vol 82 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Ranganathan Kannan ◽  
Gautam N. Bijur ◽  
Susan R. Mallery ◽  
F. Michael Beck ◽  
Carol L.K. Sabourin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Proliferative Verrucous Leukoplakia ◽  
Factor Alpha

In vitro secretion of transforming growth factor alpha (TGF-α): A comparison of the A431 cell line with three human oesophageal squamous cell carcinoma lines

1992 ◽  
Vol 12 (4) ◽  
pp. 293-302 ◽  
Author(s):  
A. L. Thornley ◽  
G. J. Jones
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Squamous Cell ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Factor Alpha ◽  
A431 Cell Line

Transforming growth factor alpha (TGF-α) is a single chain polypeptide which exists in a variety of forms differing in molecular weight. These forms are variously present in normal and neoplastic cells. Of particular interest are TGF-α's well-known mitogenic properties. The transition from a normal to a neoplastic cellular state results from signalling defects that may depend upon, iter alia, abonormal levels of expression and secretion of TGF-α. It is known that the secretion of TGF-α may be enhanced appreciably by agents such as phorbol 12-myristate 13-acetate (PMA), serum factors and epidermal growth factor (EGF). Here, we compare the efficacy of these three agents in the elevation of TGF-α secretion in the well studied A431 cell line with their previously undocumented efficacy in certain interesting, but little known, human oesophageal squamous cell carcinoma (SCC) lines.

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