P11-9 Cortical excitability changes in high-frequency rTMS for central post-stroke pain

2010 ◽  
Vol 121 ◽  
pp. S167
Author(s):  
K. Hosomi ◽  
Y. Saitoh ◽  
H. Kishima ◽  
M. Hirata ◽  
S. Oshino ◽  
...  
Keyword(s):  
High Frequency ◽  
Cortical Excitability ◽  
Post Stroke

scholarly journals High-frequency rTMS with two different inter-train intervals improves upper limb motor function at the early stage of stroke

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092873 ◽  
Author(s):  
Jiaqia Ke ◽  
Xiaopei Zou ◽  
Mei Huang ◽  
Qiaotian Huang ◽  
Hongzhan Li ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Motor Function ◽  
Upper Limb ◽  
High Frequency ◽  
Sham Group ◽  
Cortical Excitability ◽  
Early Period ◽  
Cortical Region ◽  
Post Stroke ◽  
Significant Difference

Objective This study aimed to explore the therapeutic effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) with two different inter-train intervals (ITIs) on upper limb motor function in the early period of stroke. Methods We recruited 48 post-stroke patients in the early period and randomly divided them into three cohorts: the sham group, the short ITI (8 s) group, and the long ITI (28 s) group. HF-rTMS was delivered at 20 Hz. The amplitude of motor evoked potentials at the affected cortical region, representing the abductor pollicis brevis muscle, reflected cortical excitability. At baseline, immediately after treatment, and 1 month after treatment, we evaluated the recovery of upper limb motor function using Brunnstrom recovery stages (BRSs) and the Fugl–Meyer Assessment for upper extremity (FMA-UE), and assessed functional independence using the Barthel Index (BI). Results HF-rTMS with two different ITIs significantly improved upper limb functional recovery relative to the sham group, but there was no significant difference in cortical excitability changes or BRS, FMA-UE, or BI scores between the different ITI groups. Conclusions At the early post-stroke stage, HF-rTMS with short ITIs generates a similar therapeutic effect to HF-rTMS with long ITIs, suggesting that treatment times can be decreased.

P367: High frequency deep rTMS over the right homologous Broca’s region improves naming in chronic post-stroke aphasia: a pilot study

2014 ◽  
Vol 125 ◽  
pp. S145
Author(s):  
R. Chieffo ◽  
F. Ferrari ◽  
P. Battista ◽  
E. Houdayer ◽  
A. Nuara ◽  
...  
Keyword(s):  
Pilot Study ◽  
High Frequency ◽  
Post Stroke ◽  
Broca’S Region ◽  
The Right

scholarly journals A Short Bout of High-intensity Exercise Alters Ipsilesional Motor Cortical Excitability Post-stroke

2019 ◽  
Author(s):  
Xin Li ◽  
Charalambos C. Charalambous ◽  
Darcy S. Reisman ◽  
Susanne M. Morton
Keyword(s):  
High Intensity ◽  
Acute Exercise ◽  
Cortical Excitability ◽  
Motor Evoked Potentials ◽  
High Intensity Exercise ◽  
Exercise Protocol ◽  
Post Stroke ◽  
Motor Cortical Excitability ◽  
Motor Cortical ◽  
Lactate Levels

AbstractBackgroundAcute exercise can increase motor cortical excitability and enhance motor learning in healthy individuals, an effect known as exercise priming. Whether it has the same effects in people with stroke is unclear.ObjectivesThe objective of this study was to investigate whether a short, clinically-feasible high-intensity exercise protocol can increase motor cortical excitability in non-exercised muscles of chronic stroke survivors.MethodsThirteen participants with chronic, unilateral stroke participated in two sessions, at least one week apart, in a crossover design. In each session, they underwent either high-intensity lower extremity exercise or quiet rest. Motor cortical excitability of the extensor carpi radialis muscles was measured bilaterally with transcranial magnetic stimulation before and immediately after either exercise or rest. Motor cortical excitability changes (post-exercise or rest measures normalized to pre-test measures) were compared between exercise vs. rest conditions.ResultsAll participants were able to reach the target high-intensity exercise level. Blood lactate levels increased significantly after exercise (p < 0.001, d = 2.85). Resting motor evoked potentials from the lesioned hemisphere increased after exercise compared to the rest condition (p = 0.046, d = 2.76), but this was not the case for the non-lesioned hemisphere (p = 0.406, d = 0.25).ConclusionsHigh-intensity exercise can increase lesioned hemisphere motor cortical excitability in a non-exercised muscle post-stroke. Our short and clinically-feasible exercise protocol shows promise as a potential priming method in stroke rehabilitation.

Abstract 123: Effects Of High-frequency RTMS Applied Over Bilateral Leg Motor Areas Using A Double Cone Coil On Walking Function In Post-stroke Patients

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Wataru Kakuda ◽  
Masahiro Abo ◽  
Ryo Momosaki
Keyword(s):  
High Frequency ◽  
Sham Group ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Double Cone ◽  
Anatomical Location ◽  
Cost Index ◽  
Magnetic Current ◽  
Post Stroke ◽  
Walking Velocity ◽  
Motor Areas

Objective: It is difficult to stimulate leg motor areas with magnetic current using a figure-of-eight coil due to the deep anatomical location of the areas. However, a double cone coil is useful for stimulating deep brain regions. We postulated that the use of the same coil may allow repetitive transcranial magnetic stimulation (rTMS) to modulate the neural activity of the same areas. The purpose of this study is to investigate the effect of high-frequency rTMS applied over bilateral leg motor areas with a double cone coil on walking function after stroke. Materials and methods: Eighteen post-stroke hemiparetic patients with gait disturbances attended two experimental sessions with more than 24 hours apart, in a cross-over, double-blind paradigm. In one session, high-frequency rTMS of 10 Hz was applied over the leg motor area bilaterally in a 10-sec train using a double cone coil for 20 minutes (total 2,000 pulses). In the other session, sham stimulation was applied for 20 minutes at the same site. To assess walking function, walking velocity and Physiological Cost Index (PCI) were evaluated serially before, immediately after, and 10 and 20 minutes after each intervention. Results: The walking velocity was significantly higher for 20 minutes after stimulation in the high-frequency rTMS group than the sham group. PCI was lower in the high-frequency rTMS group than the sham group, but this was significant only immediately after stimulation. Conclusions: High-frequency rTMS of bilateral motor areas using a double cone coil can potentially improve walking function in post-stroke hemiparetic patients.

scholarly journals Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Beatrice Moret ◽  
Rita Donato ◽  
Massimo Nucci ◽  
Giorgia Cona ◽  
Gianluca Campana
Keyword(s):  
Frequency Band ◽  
High Frequency ◽  
Primary Motor Cortex ◽  
Cortical Excitability ◽  
Motor Evoked Potentials ◽  
Random Noise ◽  
High Frequency Band ◽  
Neural Excitability ◽  
Transcranial Random Noise Stimulation ◽  
Wide Range

Abstract Transcranial random noise stimulation (tRNS) is a recent neuromodulation protocol. The high-frequency band (hf-tRNS) has shown to be the most effective in enhancing neural excitability. The frequency band of hf-tRNS typically spans from 100 to 640 Hz. Here we asked whether both the lower and the higher half of the high-frequency band are needed for increasing neural excitability. Three frequency ranges (100–400 Hz, 400–700 Hz, 100–700 Hz) and Sham conditions were delivered for 10 minutes at an intensity of 1.5 mA over the primary motor cortex (M1). Single-pulse transcranial magnetic stimulation (TMS) was delivered over the same area at baseline, 0, 10, 20, 30, 45 and 60 minutes after stimulation, while motor evoked potentials (MEPs) were recorded to evaluate changes in cortical excitability. Only the full-band condition (100–700 Hz) was able to modulate excitability by enhancing MEPs at 10 and 20 minutes after stimulation: neither the higher nor the lower sub-range of the high-frequency band significantly modulated cortical excitability. These results show that the efficacy of tRNS is strictly related to the width of the selected frequency range.

Cortical excitability changes after high-frequency repetitive transcranial magnetic stimulation for central poststroke pain

Pain ◽  
2013 ◽  
Vol 154 (8) ◽  
pp. 1352-1357 ◽  
Author(s):  
Koichi Hosomi ◽  
Haruhiko Kishima ◽  
Satoru Oshino ◽  
Masayuki Hirata ◽  
Naoki Tani ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Cortical Excitability ◽  
Repetitive Transcranial Magnetic Stimulation

THE EFFECT OF HIGH AND LOW FREQUENCY CORTICAL STIMULATION WITH A FIXED OR A POISSON DISTRIBUTED INTERPULSE INTERVAL ON CORTICAL EXCITABILITY IN RATS

2014 ◽  
Vol 24 (02) ◽  
pp. 1430005 ◽  
Author(s):  
INE BUFFEL ◽  
ALFRED MEURS ◽  
ROBRECHT RAEDT ◽  
VEERLE DE HERDT ◽  
LEEN DECORTE ◽  
...  
Keyword(s):  
High Frequency ◽  
Refractory Epilepsy ◽  
Cortical Excitability ◽  
Low Frequency ◽  
Cortical Stimulation ◽  
Interpulse Interval ◽  
Motor Cortex Stimulation ◽  
Low Intensity ◽  
Promising Treatment ◽  
Neocortical Epilepsy

Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response - 100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 μA) and/or low frequency (5 Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.

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