242 Acute exercise response of blood glucose to short-term exercise training in patients with type 2 diabetes

2007 ◽  
Vol 10 ◽  
pp. 84
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Exercise Training ◽  
Acute Exercise ◽  
Short Term ◽  
Exercise Response

Determinants of changes in blood glucose response to short-term exercise training in patients with Type 2 diabetes

2008 ◽  
Vol 115 (9) ◽  
pp. 273-281 ◽  
Author(s):  
Matthew D. Hordern ◽  
Louise M. Cooney ◽  
Elaine M. Beller ◽  
Johannes B. Prins ◽  
Thomas H. Marwick ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Cardiorespiratory Fitness ◽  
Training Group ◽  
Moderate Intensity ◽  
Model Assessment ◽  
Short Term

The aim of the present study was to determine the effects of a 4-week exercise training intervention on blood glucose, insulin sensitivity, BMI (body mass index) and cardiorespiratory fitness in patients with Type 2 diabetes, and to identify and establish criteria for patients who are more likely to improve their blood glucose from short-term exercise training. A randomized, controlled trial of exercise training, comprising two supervised and one non-supervised sessions of individualized cardiorespiratory and resistance exercise per week, was performed in 132 healthy patients with Type 2 diabetes (exercise training group, n=68), with the aim of accumulating a minimum of 150 min of moderate-intensity exercise for 4 weeks. BMI, waist circumference, blood pressure, blood lipid profile, blood glucose, insulin, insulin sensitivity [calculated by HOMAIR (homoeostasis model assessment of insulin resistance) and QUICKI (quantitative insulin check index)], β-cell function (calculated by HOMAβ-Cell), HbA1c (glycated haemoglobin) and V̇O2max (maximal oxygen consumption) were measured at baseline and at 4 weeks. The exercise training group had significant improvements in V̇O2max, BMI and triacylglycerols (triglycerides). There were no significant changes in blood glucose, HOMAIR, QUICKI or HOMAβ-Cell. Decreases in blood glucose were significantly predicted by baseline blood glucose and HbA1c, with these variables accounting for 15.9% of the change in blood glucose (P<0.001). ROC (receiver operator characteristic) curve analysis revealed that patients with a blood glucose >8.85 mmol/l (sensitivity=73%, specificity=78%) and HbA1c >7.15% (sensitivity=79%, specificity=60%) were more likely to achieve a clinically significant decrease in blood glucose. In conclusion, in apparently healthy patients with Type 2 diabetes, a 4-week exercise intervention improved cardiorespiratory fitness, BMI and triacylglycerols. Elevated blood glucose and HbA1c predicted improvements in blood glucose.

Acute response of blood glucose to short-term exercise training in patients with type 2 diabetes

2011 ◽  
Vol 14 (3) ◽  
pp. 238-242 ◽  
Author(s):  
Matthew D. Hordern ◽  
Thomas H. Marwick ◽  
Peter Wood ◽  
Louise M. Cooney ◽  
Johannes B. Prins ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Exercise Training ◽  
Short Term ◽  
Acute Response

scholarly journals Long-standing, insulin-treated type 2 diabetes patients with complications respond well to short-term resistance and interval exercise training

2008 ◽  
Vol 158 (2) ◽  
pp. 163-172 ◽  
Author(s):  
S F E Praet ◽  
R A M Jonkers ◽  
G Schep ◽  
C D A Stehouwer ◽  
H Kuipers ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Exercise Training ◽  
Muscle Function ◽  
Whole Body ◽  
Short Term ◽  
Interval Exercise ◽  
Arterial Blood ◽  
Diabetes Outcome

ObjectiveTo determine the feasibility and the benefits of combined resistance and interval exercise training on phenotype characteristics and skeletal muscle function in deconditioned, type 2 diabetes (T2D) patients with polyneuropathy.DesignShort-term, single-arm intervention trial.MethodsEleven male T2D patients (age: 59.1±7.5 years; body mass index: 32.2±4.0 kg/m2) performed progressive resistance and interval exercise training thrice a week for 10 weeks. Besides primary diabetes outcome measures, muscle strength (MUST), maximal workload capacity (Wmax), whole-body peak oxygen uptake (VO2peak) and muscle oxidative capacity (MUOX), intramyocellular lipid (IMCL) and glycogen (IMCG) storage, and systemic inflammation markers were determined before and after training. Daily exogenous insulin requirements (EIR) and historic individualized EIR were gathered and analysed.ResultsMUST and Wmax increased with 17% (90% confidence intervals 9–24%) and 14% (6–21) respectively. Furthermore, mean arterial blood pressure declined with 5.5 mmHg (−9.7 to −1.4). EIR dropped with 5.0 IU/d (−11.5 to 1.5) compared with baseline. A decline of respectively −0.7 mmol/l (−2.9 to 1.5) and −147 μmol/l (−296 to 2) in fasting plasma glucose and non-esterified fatty acids concentrations were observed following the intervention, but these were not accompanied by changes in VO2peak, MUOX, IMCL or IMCG, and blood glycolysated haemoglobin, adiponectin, tumor necrosis factor-α and/or cholesterol concentrations.ConclusionShort-term resistance and interval exercise training is feasible in deconditioned T2D patients with polyneuropathy and accompanied by moderate improvements in muscle function and blood pressure. Such a specific exercise regimen may provide a better framework for future exercise intervention programmes in the treatment of deconditioned T2D patients.

scholarly journals Impact of Glucose Fluctuation on Acute Cerebral Infarction in Type 2 Diabetes

2014 ◽  
Vol 41 (4) ◽  
pp. 486-492 ◽  
Author(s):  
Jinxin Huang ◽  
Xingguang Zhang ◽  
Juan Li ◽  
Liya Tang ◽  
Xiumin Jiao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Cerebral Infarction ◽  
Acute Cerebral Infarction ◽  
Short Term ◽  
Group A ◽  
Glucose Fluctuations ◽  
The Impact ◽  
Group D

Objective:This study aimed to describe the frequency and temporal profile of acute cerebral infarction (ACI) using a continuous glucose monitoring system (CGMS) in patients with and without type 2 diabetes mellitus (T2DM) and explore the impact of blood glucose fluctuations on the short-term prognosis of ACI.Methods:The subjects were divided into four groups: T2DM with acute cerebral infarction (DMCI, Group A, n=56); T2DM without acute cerebral infarction (DM-NCI, Group B, n=36); Acute cerebral infarction patients without T2DM (NDM-CI, Group C, n=54); Healthy control group (NG, Group D, n=36). The National Institutes of Health Stoke Scale (NIHSS) and modified Rankin scale (mRs) were collected in Group A and C. All subjects were monitored for 72 hours using the CGMS. Indices such as fasting blood glucose (FBG) and mean amplitude of glycemic excursions (MAGE) were calculated. Glycemic excursions were compared between Group A, B, C and Group D, respectively. Multiple linear regression analysis and logistic analysis was applied.Results:MAGE is related to NIHSS, homocysteine (HCY), HOMA-IR, FBG, CRP and IMT, while NIHSS is related to CRP, HCY, HOMA-IR, IMT. The factors impacting the short-term prognosis of ACI were NIHSS, HBA1C and MAGE.Conclusion:Larger glucose fluctuations are associated with more stroke risk factors and are associated with a poorer short-term prognosis. More attention should be paid to glucose fluctuations in patients with ACI and a history of T2DM.

scholarly journals Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes

Diabetes ◽  
2009 ◽  
Vol 58 (6) ◽  
pp. 1333-1341 ◽  
Author(s):  
G. Kacerovsky-Bielesz ◽  
M. Chmelik ◽  
C. Ling ◽  
R. Pokan ◽  
J. Szendroedi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Atp Synthesis ◽  
Short Term

scholarly journals Endurance, interval sprint, and resistance exercise training: impact on microvascular dysfunction in type 2 diabetes

2016 ◽  
Vol 310 (3) ◽  
pp. H337-H350 ◽  
Author(s):  
T. Dylan Olver ◽  
M. Harold Laughlin
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Blood Glucose ◽  
Exercise Training ◽  
Blood Glucose Control ◽  
Microvascular Dysfunction ◽  
Skeletal Muscle Fiber ◽  
Microvascular Function ◽  
Capillary Rarefaction

Type 2 diabetes (T2D) alters capillary hemodynamics, causes capillary rarefaction in skeletal muscle, and alters endothelial and vascular smooth muscle cell phenotype, resulting in impaired vasodilatory responses. These changes contribute to altered blood flow responses to physiological stimuli, such as exercise and insulin secretion. T2D-induced microvascular dysfunction impairs glucose and insulin delivery to skeletal muscle (and other tissues such as skin and nervous), thereby reducing glucose uptake and perpetuating hyperglycemia and hyperinsulinemia. In patients with T2D, exercise training (EX) improves microvascular vasodilator and insulin signaling and attenuates capillary rarefaction in skeletal muscle. EX-induced changes subsequently augment glucose and insulin delivery as well as glucose uptake. If these adaptions occur in a sufficient amount of tissue, and skeletal muscle in particular, chronic exposure to hyperglycemia and hyperinsulinemia and the risk of microvascular complications in all vascular beds will decrease. We postulate that EX programs that engage as much skeletal muscle mass as possible and recruit as many muscle fibers within each muscle as possible will generate the greatest improvements in microvascular function, providing that the duration of the stimulus is sufficient. Primary improvements in microvascular function occur in tissues (skeletal muscle primarily) engaged during exercise, and secondary improvements in microvascular function throughout the body may result from improved blood glucose control. We propose that the added benefit of combined resistance and aerobic EX programs and of vigorous intensity EX programs is not simply “more is better.” Rather, we believe the additional benefit is the result of EX-induced adaptations in and around more muscle fibers, resulting in more muscle mass and the associated microvasculature being changed. Thus, to acquire primary and secondary improvements in microvascular function and improved blood glucose control, EX programs should involve upper and lower body exercise and modulate intensity to augment skeletal muscle fiber recruitment. Under conditions of limited mobility, it may be necessary to train skeletal muscle groups separately to maximize whole body skeletal muscle fiber recruitment.

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