Population-based lipid screening in the era of a childhood obesity epidemic: The importance of non-HDL cholesterol assessment

Experimental studies have suggested that tea consumption could lower the risk of dyslipidaemia. However, epidemiological evidence is limited, especially in southern China, where oolong tea is the most widely consumed beverage. We conducted a population-based case–control study to evaluate the association between consumption of tea, especially oolong tea, and risk of dyslipidaemia in Shantou, southern China, from 2010 to 2011. Information on tea consumption, lifestyle characteristics and food consumption frequency of 1651 patients with newly diagnosed dyslipidaemia and 1390 controls was obtained using a semi-quantitative questionnaire. Anthropometric variables and serum biochemical indices were determined. Drinking more than 600 ml (2 paos) of green, oolong or black tea daily was found to be associated with the lowest odds of dyslipidaemia risk (P< 0·001) when compared with non-consumption, but only oolong tea consumption was found to be associated with low HDL-cholesterol levels. A dose–response relationship between duration of tea consumption and risk of dyslipidaemia (OR 0·10, 95 % CI 0·06, 0·16), as well as that between amount of dried tea leaves brewed and risk of dyslipidaemia (OR 0·34, 95 % CI 0·24, 0·48), was found. Moreover, consumption of oolong tea for the longest duration was found to be associated with 3·22, 11·99 and 6·69 % lower blood total cholesterol, TAG and LDL-cholesterol levels, respectively. In conclusion, the present study indicates that long-term oolong tea consumption may be associated with a lower risk of dyslipidaemia in the population of Shantou in southern China.

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Prevalence of Metabolic Syndrome Among Adolescents in India: a Population-Based Study

10.21203/rs.3.rs-902711/v1 ◽

2021 ◽

Author(s):

Sowmya Ramesh ◽

Ransi Ann Abraham ◽

Avina Sarna ◽

Harshpal S Sachdev ◽

Nizamuddin Khan ◽

...

Keyword(s):

Metabolic Syndrome ◽

Urban Areas ◽

Census Data ◽

Healthy Lifestyle ◽

Hdl Cholesterol ◽

Population Based ◽

Multivariate Logistic Regression Model ◽

Public Health Issue ◽

Bivariate Analysis ◽

Nutrition Survey

Abstract Background: In India, the prevalence of overweight among adolescents is on the rise, setting the stage for an increase in metabolic syndrome (MS). This paper presents the national prevalence of MS in adolescents in India. Methods: A nationally representative data of adolescents (10–19 years) from the Comprehensive National Nutrition Survey was used. MS was defined based on the NCEP–ATP III criteria for adolescents. Bivariate analysis was used to report socio-demographic differentials in prevalence and to assess interstate variability. Multivariate logistic regression model was constructed to measure the association between socio-demographic characteristics and prevalence of MS. Census data from 2011 was projected to 2017 to calculate burden.Results: The prevalence of MS was 5.2% among adolescents. 11.9%, 15.4%, 26.0%, 31.9% and 3.7% had central obesity, high blood pressure, hypertriglyceridemia, low HDL-cholesterol and high fasting glucose, respectively. The prevalence was higher among males (5.7% vs. 4.7%, adjusted odds ratio (AOR): 1.3, 95% confidence interval [CI]: 1.0, 1.6), those residing in urban areas (7.9% vs 4.2%, AOR: 1.4, 95% CI: 1.1, 1.8), and from wealthier households as compared to their counterparts (8.3% vs. 2.4%, AOR: 3.4, 95% CI: 2.1, 5.5). There was wide interstate variability in the prevalence of MS (0.5% – 16.5%). In 2017, 14.2 million adolescents had MS in India.Conclusions: The prevalence of MS among adolescents in India is low and clustered in urban areas and richer households. Early prevention interventions promoting a healthy lifestyle, especially in high prevalence areas, are needed to keep MS from becoming a public health issue.

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Serum paraoxonase-1 activity is associated with light to moderate alcohol consumption: the PREVEND cohort study

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqy217 ◽

2018 ◽

Vol 108 (6) ◽

pp. 1283-1290 ◽

Cited By ~ 5

Author(s):

Eke G Gruppen ◽

Stephan J L Bakker ◽

Richard W James ◽

Robin P F Dullaart

Keyword(s):

Alcohol Consumption ◽

Linear Regression Analysis ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Sensitivity ◽

Population Based ◽

Cross Sectional Study ◽

Paraoxonase 1 ◽

Phenyl Acetate ◽

Cross Sectional

ABSTRACT Background Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-associated enzyme with antioxidative properties, which may protect against the development of cardiovascular disease. Alcohol consumption increases HDL cholesterol, but the extent to which alcohol consumption gives rise to higher serum PON-1 activity is uncertain. Objective In a population-based study, we determined the relation of serum PON-1 activity with alcohol consumption when taking account of HDL cholesterol and apolipoprotein A-I (apoA-I), its major apolipoprotein. Design A cross-sectional study was performed in 8224 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort. Alcohol consumption was categorized as 1) no/rarely (25.3%); 2) 0.1–10 g/d (49.3%); 3) 10–30 g/d (20.1%); and 4) >30 g/d (5.2%) with 1 drink equivalent to 10 g alcohol. Serum PON-1 activity was measured as its arylesterase activity (phenyl acetate as substrate). Results Median serum PON-1 activity was 50.8, 53.1, 54.4, and 55.7 U/L in the 4 categories of alcohol consumption, respectively (P < 0.001). Its increase paralleled the increments in HDL cholesterol and apoA-I. Notably, there was no further increase in PON-1 activity, HDL cholesterol, and apoA-I when alcohol consumption was increased from 10–30 g/d to >30 g/d. Multivariable linear regression analysis demonstrated that PON-1 activity was related to alcohol consumption independently from clinical covariates, high sensitivity C-reactive protein, and lipid concentrations, including HDL cholesterol (P < 0.001 for each category of alcohol consumption with no alcohol consumption as the reference category). Notably, as inferred from standardized β-coefficients, there was no difference in PON-1 activity between 10–30 g alcohol/d and >30 g alcohol/d. Conclusions Alcohol consumption is associated with an increase in serum PON-1 activity, but its effect seems to reach a plateau with alcohol consumption of 10–30 g/d.

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Dealing with the childhood obesity epidemic: a public health approach

Abdominal Radiology ◽

10.1007/s00261-012-9861-y ◽

2012 ◽

Vol 37 (5) ◽

pp. 719-724 ◽

Cited By ~ 15

Author(s):

Leslie A. Lytle

Keyword(s):

Public Health ◽

Childhood Obesity ◽

Public Health Approach ◽

Obesity Epidemic

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Abstract 5017: An Insertion/Deletion Polyporphism in α 2 -Adrenergic Receptor Gene is a Novel Genetic Risk Factors Sudden Cardiac Death

Circulation ◽

10.1161/circ.118.suppl_18.s_1132-a ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Jari Laukkanen

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Sudden Cardiac Death ◽

Genetic Risk ◽

Cardiac Death ◽

Cox Model ◽

Receptor Gene ◽

Hdl Cholesterol ◽

Population Based ◽

Coronary Risk Factors

α 2B -adrenoceptors mediate contraction of vascular smooth muscle and induce coronary vasoconstriction in humans. A variant of the human α 2B -adrenoceptor gene that encodes a D of three residues in an intracellular acidic motif has been shown to confer decreased receptor desensitization. This receptor variant could, therefore, be involved in cardiovascular diseases associated with enhanced vasoconstriction. Our aim was to study whether an insertion/deletion (I/D) polymorphism in the α 2B -adrenoceptor gene is associated with the risk for sudden cardiac death. This study was part of a prospective population-based study investigating risk factors for cardiovascular diseases in a cohort of middle-aged men from eastern Finland. The study is based on 1606 men 42 to 60 years of age followed for an average time of 17 years. In this study population, 338 men (21%) had the D/D genotype; 467 (29 %) had the I/I genotype, and 801 (50%) had a heterozygous genotype. There were 76 sudden cardiac deaths during follow-up. In a Cox model adjusting for other coronary risk factors (age, systolic blood pressure, smoking, diabetes, serum LDL and HDL cholesterol, body mass index and exercise-induced myocardial ischemia), men with the D/D or I/D genotype had 1.95 time (95% confidence interval, 1.07 to 3.55, P = 0.029) higher risk to experience sudden cardiac death (20 events for D/D genotype, 13 events for I/I genotype and 43 events for I/D genotype) compared with men carrying the I/I genotype. The α 2B -adrenoceptor genotype was associated with coronary heart disease death but not with hypertension. The D/D and I/D genotypes of the α 2B -adrenoceptor are novel genetic risk predictors for sudden cardiac death.

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Virtual Junk Food Playgrounds in Europe: Advergames in the UK and Hungary

Journal of Virtual Worlds Research ◽

10.4101/jvwr.v3i2.1893 ◽

1970 ◽

Vol 3 (2) ◽

Cited By ~ 1

Author(s):

Arhlene A. Flowers ◽

Katalin Lustyik ◽

Emese Gulyás

Keyword(s):

Childhood Obesity ◽

Online Advertising ◽

Food Advertising ◽

The Internet ◽

Communist Country ◽

Junk Food ◽

Obesity Epidemic ◽

Number Of Children ◽

The Media ◽

The Uk

Unhealthy foods and drinks are among the top products advertised to young children. Considering the growing childhood obesity epidemic and the soaring number of children accessing the Internet, even online junk food advertising has come under increasing scrutiny. Many countries are in the process of expanding and revising existing regulation to account for the realities of the digital age and to respond to health and other social concerns. This paper focuses on two European countries in particular to examine and compare these processes through the lens of junk food advergames aimed at children. Our questions are: 1) Given the differences in the media landscapes of the UK and Hungary, what types of junk food advergames target children?; and 2) In light of the growing childhood obesity problem faced by both nations, how have government bodies, advocacy groups, and advertisers approached junk food advertising targeting children in general and online advertising including advergames in particular? The United Kingdom represents a country with the highest Internet usage by children and the most developed online advertising market in Europe, while Hungary, a post-communist country, represents an emerging media market where young people have less access to the Internet and buying power but constitute a crucial “entry point” for food advertisers.

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