MS104 THE RELATIONSHIP BETWEEN LEPTIN SERUM CONCENTRATIONS AND PRODUCTION OF SMALL, DENSE LDL PARTICLES

2010 ◽  
Vol 11 (2) ◽  
pp. 131
Author(s):  
Z. Vogrinc ◽  
M. Trbojevic-Cepe ◽  
J. Sertic ◽  
Z. Reiner
Keyword(s):  
Serum Concentrations ◽  
Small Dense Ldl ◽  
Ldl Particles ◽  
The Relationship

Do Extra-Platelet Sources Contribute to the Plasma Level of Thrombospondin?

1988 ◽  
Vol 59 (02) ◽  
pp. 273-276 ◽  
Author(s):  
J Dawes ◽  
D A Pratt ◽  
M S Dewar ◽  
F E Preston
Keyword(s):  
Platelet Count ◽  
Background Concentration ◽  
Serum Concentrations ◽  
Bone Marrow Depression ◽  
Serial Sampling ◽  
Control Serum ◽  
Platelet Release ◽  
Highly Correlated ◽  
The Relationship

SummaryThrombospondin, a trimeric glycoprotein contained in the platelet α-granules, has been proposed as a marker of in vivo platelet activation. However, it is also synthesised by a range of other cells. The extraplatelet contribution to plasma levels of thrombospondin was therefore estimated by investigating the relationship between plasma thrombospondin levels and platelet count in samples from profoundly thrombocytopenic patients with marrow hypoplasia, using the platelet-specific α-granule protein β-thromboglobulin as control. Serum concentrations of both proteins were highly correlated with platelet count, but while plasma β-thromboglobulin levels and platelet count also correlated, there was no relationship between the number of platelets and thrombospondin concentrations in plasma. Serial sampling of patients recovering from bone marrow depression indicated that the plasma thrombospondin contributed by platelets is superimposed on a background concentration of at least 50 ng/ml probably derived from a non-platelet source, and plasma thrombospondin levels do not simply reflect platelet release.

A Prospective, Multicentric Study to Evaluate the Effects of Saroglitazar on Non-HDL Cholesterol and Small Dense LDL Particles in Patients with Diabetic Dyslipidemia

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 38-LB
Author(s):  
UPENDRA KAUL ◽  
PEEYUSH JAIN ◽  
RANJAN KACHRU ◽  
VINEET BHATIA ◽  
PRIYADARSHINI ARAMBAM ◽  
...  
Keyword(s):  
Hdl Cholesterol ◽  
Diabetic Dyslipidemia ◽  
Multicentric Study ◽  
Small Dense Ldl ◽  
Ldl Particles

scholarly journals Serotonin and Tryptophan Serum Concentrations in Shelter Dogs Showing Different Behavioural Responses to a Potentially Stressful Procedure

2020 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Giacomo Riggio ◽  
Chiara Mariti ◽  
Valeria Sergi ◽  
Silvana Diverio ◽  
Angelo Gazzano
Keyword(s):  
Behavioural Response ◽  
Blood Collection ◽  
Stressful Situation ◽  
Serum Concentrations ◽  
Chi Square ◽  
Significant Difference ◽  
Relaxation Stress ◽  
Shelter Dogs ◽  
Stress Signals ◽  
The Relationship

In mammals, serotonin (5-HT) levels depend on the availability of tryptophan (TRP). Low 5-HT concentrations have been linked to behavioural disorders in dogs. This study aimed at investigating possible differences in dogs’ serum TRP and 5-HT concentrations according to their behavioural response to a potentially stressful procedure. Thirty-nine physically healthy shelter dogs, 15 females and 24 males, mean age = 5.6 years, were categorized by a certified veterinary behaviourist according to their behavioural response to medical examination and blood collection, in: relaxation, stress signals, tension without growling, tension with growling, escape attempts, and aggression attempts. Extraction and quantification of 5-HT and TRP were performed using a HLPC method. Data were statistically analysed, applying Chi-square and Spearman tests. Results showed no significant difference in TRP (χ2 = 2.084, p = 0.555) nor 5-HT (χ2 = 0.972, p = 0.808) serum concentrations among different categories of dogs; however, some categories were underrepresented (relaxation = 20.5%, stress signals = 30.8%, tension without growling = 43.6%, tension with growling = 5.1%, escape attempts = 0%, aggression attempts = 0%). No correlation between serum TRP and 5-HT concentrations was found (ρ = 0.086, p = 0.602). Serum 5-HT levels do not seem to be associated with dogs’ behavioural response to a stressful situation nor with serum TRP concentrations. The relationship between serum TRP and 5-HT concentrations and behaviour needs further research.

Small dense LDL particles occur in NIDDM patients with mild hyperlipidaemia

1993 ◽  
Vol 103 (2) ◽  
pp. 300
Author(s):  
M.W. Stewart ◽  
R.G. Dyer ◽  
M.F. Laker
Keyword(s):  
Small Dense Ldl ◽  
Ldl Particles ◽  
Niddm Patients

scholarly journals Effects of Armolipid Plus on small dense LDL particles in a sample of patients affected by familial combined hyperlipidemia

2015 ◽  
Vol 10 (6) ◽  
pp. 475-480 ◽  
Author(s):  
Marco Gentile ◽  
Ilenia Calcaterra ◽  
Alfonso Strazzullo ◽  
Carmen Pagano ◽  
Delia Pacioni ◽  
...  
Keyword(s):  
Familial Combined Hyperlipidemia ◽  
Small Dense Ldl ◽  
Ldl Particles

scholarly journals Small, Dense LDL Particles Predict Changes in Intima Media Thickness and Insulin Resistance in Men with Type 2 Diabetes and Prediabetes – A Prospective Cohort Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72763 ◽  
Author(s):  
Philipp A. Gerber ◽  
Christoph Thalhammer ◽  
Christian Schmied ◽  
Silviana Spring ◽  
Beatrice Amann-Vesti ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Intima Media Thickness ◽  
Small Dense Ldl ◽  
Media Thickness ◽  
Ldl Particles

SERUM IMMUNOGLOBULINS: I. LEVELS IN NORMAL CHILDREN AND IN UNCOMPLICATED CHILDHOOD ALLERGY

PEDIATRICS ◽  
1968 ◽  
Vol 41 (3) ◽  
pp. 600-611
Author(s):  
Rebecca H. Buckley ◽  
Susan C. Dees ◽  
W. Michael O'Fallon
Keyword(s):  
Statistical Analysis ◽  
Geometric Mean ◽  
Serum Concentrations ◽  
Normal Children ◽  
Mean Values ◽  
Serum Immunoglobulins ◽  
Normal Individuals ◽  
Contrast Analysis ◽  
Relationship Of ◽  
The Relationship

In 201 normal individuals from infancy to adulthood, serum concentrations of immunoglobulins G, A, and M are presented as geometric mean values (mg/l00 ml) and as percents of adult mean values for each of these proteins. A statistical analysis revealed a significant relationship between age and both IgG and IgA concentrations up to ages 6 and 7 years. No correlation was present between age and immunoglobulin concentrations beyond that time, suggesting that the adult concentrations of IgG and IgA are normally reached and maintained after ages 6 and 7 years. In contrast, analysis of the IgM data suggested that the adult value is reached by age 1 year. No truly significant differences were found in immunoglobulin concentrations which could be attributed to sex. Significantly higher concentrations of IgG were found in normal Negro than in normal Caucasian subjects after age 6 years, but no significant differences were found below this age for IgG or at any age for IgA and IgM. Similarly determined serum immunoglobulins in 85 allergic children, selected because they had no complicating illnesses, were compared with the normal group according to the age of the child. No significant differences were found in concentrations of either IgG or IgA. Some differences were found in IgM, but these were small and were primarily associated with the relationship of IgM to age in the allergic group.

Relevance of hepatic lipase to the metabolism of triacylglycerol-rich lipoproteins

2003 ◽  
Vol 31 (5) ◽  
pp. 1070-1074 ◽  
Author(s):  
A. Zambon ◽  
S. Bertocco ◽  
N. Vitturi ◽  
V. Polentarutti ◽  
D. Vianello ◽  
...  
Keyword(s):  
Arterial Wall ◽  
Disease Risk ◽  
Lipolytic Activity ◽  
Hepatic Lipase ◽  
Heparan Sulphate ◽  
Genetic Regulation ◽  
Density Lipoprotein ◽  
Hepatic Uptake ◽  
Small Dense Ldl ◽  
Ldl Particles

HL (hepatic lipase) is a glycoprotein that is synthesized and secreted by the liver, and which binds to heparan sulphate proteoglycans on the surface of sinusoidal endothelial cells and on the external surface of parenchymal cells in the space of Disse. HL catalyses the hydrolysis of triacylglycerols and phospholipids in different lipoproteins, contributing to the remodelling of VLDL (very-low-density lipoprotein) remnants, as well as IDL, LDL and HDL (intermediate-, low- and high-density lipoprotein respectively). HL deficiency in humans is associated with diminished conversion of VLDL remnants into IDL and a near-complete absence of IDL-to-LDL conversion. Remnant lipoproteins and IDL are major determinants of coronary artery disease risk, and accumulation of these lipoproteins in the presence of low HL activity might lead to increased atherosclerosis. In addition to and independently of its lipolytic activity, HL participates as a ligand in promoting the hepatic uptake of remnants and IDL particles, and the latter may represent an additional mechanism linking low HL levels to plasma accumulation of these atherogenic lipoproteins. On the other hand, high HL activity may also result in an increased atherosclerotic risk by promoting the formation of atherogenic small, dense LDL particles. Finally, HL is also synthesized by human macrophages, suggesting that, at the arterial wall site, HL may also contribute locally to promote atherosclerosis by enhancing the formation and retention in the subendothelial space of the arterial wall of VLDL remnants, IDL and small, dense LDL. In conclusion, by interfering with the metabolism of apolipoprotein B100-containing lipoproteins, HL may have pro- as well as anti-atherogenic effects. The anti- or pro-atherogenic role of HL is likely to be modulated by the concurrent presence of other lipid abnormalities (i.e. LDL-cholesterol levels), as well as by the genetic regulation of other enzymes involved in lipoprotein metabolism.

scholarly journals The analog free testosterone assay: are the results in men clinically useful?

1998 ◽  
Vol 44 (10) ◽  
pp. 2178-2182 ◽  
Author(s):  
Stephen J Winters ◽  
David E Kelley ◽  
Bret Goodpaster
Keyword(s):  
Free Testosterone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Serum Concentrations ◽  
Testosterone Concentration ◽  
Low Testosterone ◽  
Relationship Of ◽  
The Relationship ◽  
Constant Percentage

Abstract Men with low testosterone concentrations are usually hypogonadal. However, because variations in the testosterone transport protein, sex hormone-binding globulin (SHBG), directly influence the total testosterone concentration, confirmation of a low testosterone with a measurement of free testosterone or “bioavailable” testosterone (BAT) is recommended. In the present study, we examined the relationship of SHBG with free testosterone (Coat-A-Count assay, Diagnostic Products) and with BAT in men (n = 29) and women (n = 28) who participated in a study of the metabolic determinants of body composition. As expected, total testosterone was strongly positively correlated with SHBG among men (r = 0.68; P <0.01). Although the BAT was independent of SHBG in men (r = 0.02), SHBG was an important predictor of free testosterone (r = 0. 62; P <0.01). In contrast, in women serum concentrations of total testosterone (r = −0.26; P = 0.17), free testosterone (r = −0.30; P = 0.17), and BAT (r = −0.46; P = 0.013) all tended to be lower with increasing SHBG. Free testosterone was nearly perfectly positively correlated with total testosterone (r = 0.97) in men, among whom free testosterone represented a relatively constant percentage of the total testosterone (0.5–0.65%), and the percentage of free testosterone was unrelated to SHBG. Thus the Coat-A-Count free testosterone concentration in men, like the total testosterone concentration, is determined in part by plasma SHBG. Accordingly, androgen deficiency may be misclassified with this assay in men with low SHBG. Moreover, the previous findings of reduced free testosterone concentrations with hypertension or hyperinsulinemia or as a risk factor for developing type 2 diabetes, conditions in which SHBG is reduced, may have been methodology-related.

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