scholarly journals Effects of Armolipid Plus on small dense LDL particles in a sample of patients affected by familial combined hyperlipidemia

2015 ◽  
Vol 10 (6) ◽  
pp. 475-480 ◽  
Author(s):  
Marco Gentile ◽  
Ilenia Calcaterra ◽  
Alfonso Strazzullo ◽  
Carmen Pagano ◽  
Delia Pacioni ◽  
...  
Keyword(s):  
Familial Combined Hyperlipidemia ◽  
Small Dense Ldl ◽  
Ldl Particles

A Prospective, Multicentric Study to Evaluate the Effects of Saroglitazar on Non-HDL Cholesterol and Small Dense LDL Particles in Patients with Diabetic Dyslipidemia

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 38-LB
Author(s):  
UPENDRA KAUL ◽  
PEEYUSH JAIN ◽  
RANJAN KACHRU ◽  
VINEET BHATIA ◽  
PRIYADARSHINI ARAMBAM ◽  
...  
Keyword(s):  
Hdl Cholesterol ◽  
Diabetic Dyslipidemia ◽  
Multicentric Study ◽  
Small Dense Ldl ◽  
Ldl Particles

Small dense LDL particles occur in NIDDM patients with mild hyperlipidaemia

1993 ◽  
Vol 103 (2) ◽  
pp. 300
Author(s):  
M.W. Stewart ◽  
R.G. Dyer ◽  
M.F. Laker
Keyword(s):  
Small Dense Ldl ◽  
Ldl Particles ◽  
Niddm Patients

MS104 THE RELATIONSHIP BETWEEN LEPTIN SERUM CONCENTRATIONS AND PRODUCTION OF SMALL, DENSE LDL PARTICLES

2010 ◽  
Vol 11 (2) ◽  
pp. 131
Author(s):  
Z. Vogrinc ◽  
M. Trbojevic-Cepe ◽  
J. Sertic ◽  
Z. Reiner
Keyword(s):  
Serum Concentrations ◽  
Small Dense Ldl ◽  
Ldl Particles ◽  
The Relationship

Rat model of familial combined hyperlipidemia as a result of comparative mapping

2004 ◽  
Vol 17 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Takahiro Ueno ◽  
Johanne Tremblay ◽  
Jaroslav Kunes ◽  
Josef Zicha ◽  
Zdenka Dobesova ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Comparative Mapping ◽  
Clinical Characteristics ◽  
Syntenic Region ◽  
Chromosome 2 ◽  
Familial Combined Hyperlipidemia ◽  
Small Dense Ldl ◽  
Plasma Triglycerides ◽  
The Metabolic Syndrome ◽  
Close Relationship

Total genome scan was carried out in 266 F2 intercrosses from the Prague hypertriglyceridemic (HTG) rat that shares several clinical characteristics with human metabolic syndrome. Two loci for plasma triglycerides (TG) were localized on chromosome 2 (Chr 2) (LOD 4.4, 3.2). The first locus overlapped with the rat syntenic region of the human locus for the metabolic syndrome and for small, dense LDL, while the second overlapped with the syntenic region of another locus for small, dense LDL in humans by the comparative mapping approach. Loci for TG on rat Chr 13 (LOD 3.3) and Chr 1 (LOD 2.7) overlapped with the syntenic region of loci for human familial combined hyperlipidemia (FCHL) in Finnish and Dutch populations, respectively. The concordances of loci for TG localized in this study with previously reported loci for FCHL and its related phenotypes are underlying the generalized importance of these loci in dyslipidemia. These data suggest the close relationship between dyslipidemia in HTG rats and human FCHL, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants.

scholarly journals Small, Dense LDL Particles Predict Changes in Intima Media Thickness and Insulin Resistance in Men with Type 2 Diabetes and Prediabetes – A Prospective Cohort Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72763 ◽  
Author(s):  
Philipp A. Gerber ◽  
Christoph Thalhammer ◽  
Christian Schmied ◽  
Silviana Spring ◽  
Beatrice Amann-Vesti ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Intima Media Thickness ◽  
Small Dense Ldl ◽  
Media Thickness ◽  
Ldl Particles

Relevance of hepatic lipase to the metabolism of triacylglycerol-rich lipoproteins

2003 ◽  
Vol 31 (5) ◽  
pp. 1070-1074 ◽  
Author(s):  
A. Zambon ◽  
S. Bertocco ◽  
N. Vitturi ◽  
V. Polentarutti ◽  
D. Vianello ◽  
...  
Keyword(s):  
Arterial Wall ◽  
Disease Risk ◽  
Lipolytic Activity ◽  
Hepatic Lipase ◽  
Heparan Sulphate ◽  
Genetic Regulation ◽  
Density Lipoprotein ◽  
Hepatic Uptake ◽  
Small Dense Ldl ◽  
Ldl Particles

HL (hepatic lipase) is a glycoprotein that is synthesized and secreted by the liver, and which binds to heparan sulphate proteoglycans on the surface of sinusoidal endothelial cells and on the external surface of parenchymal cells in the space of Disse. HL catalyses the hydrolysis of triacylglycerols and phospholipids in different lipoproteins, contributing to the remodelling of VLDL (very-low-density lipoprotein) remnants, as well as IDL, LDL and HDL (intermediate-, low- and high-density lipoprotein respectively). HL deficiency in humans is associated with diminished conversion of VLDL remnants into IDL and a near-complete absence of IDL-to-LDL conversion. Remnant lipoproteins and IDL are major determinants of coronary artery disease risk, and accumulation of these lipoproteins in the presence of low HL activity might lead to increased atherosclerosis. In addition to and independently of its lipolytic activity, HL participates as a ligand in promoting the hepatic uptake of remnants and IDL particles, and the latter may represent an additional mechanism linking low HL levels to plasma accumulation of these atherogenic lipoproteins. On the other hand, high HL activity may also result in an increased atherosclerotic risk by promoting the formation of atherogenic small, dense LDL particles. Finally, HL is also synthesized by human macrophages, suggesting that, at the arterial wall site, HL may also contribute locally to promote atherosclerosis by enhancing the formation and retention in the subendothelial space of the arterial wall of VLDL remnants, IDL and small, dense LDL. In conclusion, by interfering with the metabolism of apolipoprotein B100-containing lipoproteins, HL may have pro- as well as anti-atherogenic effects. The anti- or pro-atherogenic role of HL is likely to be modulated by the concurrent presence of other lipid abnormalities (i.e. LDL-cholesterol levels), as well as by the genetic regulation of other enzymes involved in lipoprotein metabolism.

scholarly journals Small, Dense LDL and Elevated Apolipoprotein B Are the Common Characteristics for the Three Major Lipid Phenotypes of Familial Combined Hyperlipidemia

2003 ◽  
Vol 23 (7) ◽  
pp. 1289-1294 ◽  
Author(s):  
Amir F. Ayyobi ◽  
Sandra H. McGladdery ◽  
Marguerite J. McNeely ◽  
Melissa A. Austin ◽  
Arno G. Motulsky ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Familial Combined Hyperlipidemia ◽  
Small Dense Ldl ◽  
The Common

scholarly journals Combined effects of a dietary portfolio of plant sterols, vegetable protein, viscous fibre and almonds on LDL particle size

2004 ◽  
Vol 92 (4) ◽  
pp. 657-663 ◽  
Author(s):  
Benoît Lamarche ◽  
Sophie Desroches ◽  
David J. A. Jenkins ◽  
Cyril W. C. Kendall ◽  
Augustine Marchie ◽  
...  
Keyword(s):  
Particle Size ◽  
Blood Lipids ◽  
Saturated Fat ◽  
Plant Sterols ◽  
Ldl Particle Size ◽  
Small Dense Ldl ◽  
Ldl Particles ◽  
Dietary Components ◽  
Dietary Portfolio ◽  
Combined Impact

Studies conducted in the last 20 years have led to the identification of small dense LDL as an important risk factor for CVD. Consumption of plant sterols, soyabean proteins, viscous fibre and nuts are known to modulate the risk of CVD favourably through their cholesterol (Chol)-lowering properties, both independently and more recently in combination. Nevertheless, their combined impact on the LDL particle size phenotype has never been tested. In the present study, we assessed the effect of incorporating concurrently plant sterols (1 g/4·2 MJ), soyabean protein (23 g/4·2 MJ), viscous fibre (9 g/4·2 MJ) and almonds (15 g/4·2 MJ) into a diet very low in saturated fat in twelve patients with mildly elevated plasma LDL-Chol levels. Fasting blood lipids were obtained at the start of the study and at 2-week intervals during the 4-week study. The diet-induced reduction in plasma LDL-Chol of 30·0 (SE 3·0) % (P<0·0001) was attributed to concurrent reductions in the serum Chol concentrations of large (>26.0 nm−30 (SE 8) %,P<0·001), medium (25·5–26·0 nm−29 (SE 3) %,P<0·001) and small (<25·5 nm − 21 (SD 6) %,P<0·01) LDL particles, with near maximal reductions seen by week 2. These results indicate that foods and dietary components advocated for their potential to reduce the risk of CVD are effective in reducing serum concentrations of all LDL fractions including small dense LDL, thus potentially further contributing to an overall lower risk of CVD.

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