155 SERUM LEVELS OF ANGIOPOIETIN-LIKE PROTEIN 4 (ANGPTL4) ARE INVERSELY CORRELATED WITH OBESITY IN HEALTHY YOUNG ADULT TWINS

2011 ◽  
Vol 12 (1) ◽  
pp. 35
Author(s):  
M.R. Robciuc ◽  
J. Naukkarinen ◽  
H. Tyynismaa ◽  
T. Raivio ◽  
A. Ortega-Alonso ◽  
...  
Keyword(s):  
Young Adult ◽  
Serum Levels ◽  
Healthy Young Adult ◽  
Adult Twins

scholarly journals Spatial Similarity of MRI-Visible Perivascular Spaces in Healthy Young Adult Twins

2021 ◽  
Author(s):  
Boeun Lee ◽  
Na-Young Shin ◽  
Chang-hyun Park ◽  
Yoonho Nam ◽  
Soo Mee Lim ◽  
...  
Keyword(s):  
Young Adult ◽  
Genetic Factors ◽  
Perivascular Spaces ◽  
Healthy Young Adult ◽  
Sibling Pairs ◽  
Spatial Similarity ◽  
Human Connectome Project ◽  
Significant Difference ◽  
Adult Twins ◽  
Mz Twins

Abstract Purpose This study aims to determine whether genetic factors affect the location of dilated perivascular spaces (dPVS) by comparing healthy young twins and non-twin (NT) siblings. Methods A total of 700 healthy young adult twins and NT siblings (138 monozygotic (MZ) twin pairs, 79 dizygotic (DZ) twin pairs, and 133 NT sibling pairs) were collected from the Human Connectome Project dataset. dPVS was automatically segmented and normalized to standard space. Then, spatial similarity indices (mean squared error [MSE], structural similarity [SSIM], and dice similarity [DS]) were calculated for dPVS in the basal ganglia (BGdPVS) and white matter (WMdPVS) between paired subjects before and after propensity score matching of dPVS volumes between groups. Within-pair correlations for the regional volumes of dVPS were also assessed using the intraclass correlation coefficient (ICC). Results The spatial similarity of dPVS was significantly higher in MZ twins (higher DS [median, 0.382 and 0.310] and SSIM [0.963 and 0.887] and lower MSE [0.005 and 0.005] for BGdPVS and WMdPVS, respectively) than DZ twins (DS [0.121 and 0.119], SSIM [0.941 and 0.868], and MSE [0.010 and 0.011]) and NT siblings (DS [0.106 and 0.097], SSIM [0.924 and 0.848], and MSE [0.016 and 0.017]). No significant difference was found between DZ twins and NT siblings. Similar results were found even after subjects were matched according to dPVS volume. Regional dPVS volumes were also more correlated within pairs in MZ twins than DZ twins and NT siblings. Conclusion Our results suggest that genetic factors affect the location of dPVS.

scholarly journals Liver Fat But Not Other Adiposity Measures Influence Circulating FGF21 Levels in Healthy Young Adult Twins

2011 ◽  
Vol 96 (2) ◽  
pp. E351-E355 ◽  
Author(s):  
Henna Tyynismaa ◽  
Taneli Raivio ◽  
Antti Hakkarainen ◽  
Alfredo Ortega-Alonso ◽  
Nina Lundbom ◽  
...  
Keyword(s):  
Young Adult ◽  
Body Fat ◽  
Genetic Factors ◽  
Fat Content ◽  
Liver Fat ◽  
Fibroblast Growth Factor 21 ◽  
Oral Glucose ◽  
Model Assessment ◽  
Healthy Young Adult ◽  
Adult Twins

abstract Context: Emerging as an important metabolic regulator, fibroblast growth factor 21 (FGF21) has gained considerable interest in diabetes and obesity research. The circulating FGF21 concentration is fairly low in normal individuals, but elevated hormone levels may associate with obesity. The determining factors of FGF21 levels in humans are not clear. Objective: Our objective was to study the influence of genetic and acquired components to serum FGF21 variability in healthy young adult twins. Design and Participants: Fasting serum FGF21, lipids, body fat, and oral glucose tolerance test were investigated in 46 monozygotic (MZ) and 75 dizygotic twin pairs aged 22.8–33.1 yr. Subcutaneous, intraabdominal, and liver fat content were measured by magnetic resonance imaging/spectroscopy in a subsample of 24 MZ pairs. Results: Genetic factors contributed moderately (heritability 40%) to circulating serum FGF21 levels. Subjects with high FGF21 concentrations (≥ 250 pg/ml, n = 30) had higher fasting triglycerides, insulin, homeostasis model assessment index, and area under the curve glucose and lower high-density lipoprotein cholesterol but similar measures of overall adiposity (body mass index, body fat percent) than subjects with lower FGF21 (<100 pg/ml, n = 148). Importantly, in the MZ subsample, higher liver fat but not sc or intraabdominal fat content was found in subjects with high FGF21. Furthermore, in analyses controlling for genetic/familial effects in twin pairs, within-pair differences in liver fat (MZ) and triglycerides (dizygotic pairs) were the major acquired factors that correlated with differences in FGF21 concentrations. Conclusions: Genetic factors influence serum FGF21 levels. Of the acquired components, high liver fat and triglycerides rather than overall adiposity associate with high FGF21 levels.

A Single-Dose Bioequivalence and Food Effect Study With Aprepitant and Fosaprepitant Dimeglumine in Healthy Young Adult Subjects

2012 ◽  
Vol 1 (3) ◽  
pp. 93-101 ◽  
Author(s):  
C. R. Shadle ◽  
M. G. Murphy ◽  
Y. Liu ◽  
M. Ho ◽  
D. Tatosian ◽  
...  
Keyword(s):  
Single Dose ◽  
Young Adult ◽  
Food Effect ◽  
Effect Study ◽  
Healthy Young Adult

scholarly journals Effectiveness of nasopalatine nerve block for anesthesia of maxillary central incisors after failure of the anterior superior alveolar nerve block technique

2007 ◽  
Vol 18 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Tufi Neder Meyer ◽  
Leonardo Lima Lemos ◽  
Carolina Neder Matuck do Nascimento ◽  
William Ricardo Ribeiro de Lellis
Keyword(s):  
Young Adult ◽  
Nerve Block ◽  
Thermal Sensitivity ◽  
Dental Students ◽  
Sensitivity Test ◽  
Healthy Young Adult ◽  
Cold Stimulus ◽  
Single Operator ◽  
The University ◽  
Adult Volunteers

The purpose of this study was to assess the effectiveness of nasopalatine nerve block for anesthesia of maxillary central incisors after failure of the anterior superior alveolar nerve (ASAN) block technique. Secondarily, the possible innervation of the maxillary central incisors by the nasopalatine nerve was also investigated. Twenty-seven healthy, young adult volunteers (age: 17-26 years; gender: 9 males and 18 females) were enrolled in this study. All participants were undergraduate dental students of the University of Vale do Rio Verde de Três Corações. The volunteers had the anterior superior alveolar nerves anesthetized and a thermal sensitivity test (cold) was performed on the maxillary central incisors. The volunteers that responded positively to cold stimulus received a nasopalatine nerve block and the thermal sensitivity test was repeated. All participants were anesthetized by a single operator. Three patients presented sensitivity after both types of bilateral blocks and were excluded from the percentage calculations. In the remaining 24 patients, 16 had their maxillary central incisors anesthetized by the anterior superior alveolar block and 8 remained with sensitivity after the ASAN block. All these 8 patients had their maxillary central incisors successfully anesthetized by the nasopalatine block. In this study, 33.3% of the subjects had the innervation of one or both maxillary central incisors derived from the nasopalatine nerve, whilst most subjects (66.7%) had such teeth innervated by the anterior superior alveolar nerve. The nasopalatine nerve block was effective in anesthetizing the maxillary central incisors when the anterior superior alveolar nerve block failed.

scholarly journals Suicidal Ideation, Depression, and Conduct Disorder in a Sample of Adolescent and Young Adult Twins

2012 ◽  
Vol 42 (4) ◽  
pp. 426-436 ◽  
Author(s):  
Julie Linker ◽  
Nathan A. Gillespie ◽  
Hermine Maes ◽  
Lindon Eaves ◽  
Judy L. Silberg
Keyword(s):  
Young Adult ◽  
Suicidal Ideation ◽  
Conduct Disorder ◽  
Adolescent And Young Adult ◽  
Adult Twins

Voice Onset Time of Velar Stop Productions in Aged Speakers

1993 ◽  
Vol 76 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Linda Petrosino ◽  
Roger D. Colcord ◽  
Karen B. Kurcz ◽  
Robert J. Yonker
Keyword(s):  
Standard Deviation ◽  
Young Adult ◽  
Voice Onset Time ◽  
Onset Time ◽  
Stop Consonants ◽  
Physiological Changes ◽  
Healthy Young Adult ◽  
Apparent Increase ◽  
Older Subjects

Voice onset time (VOT) was measured for voiced and voiceless velar stop consonants across three vowel contexts (/i, a, u/) in healthy young adult and older subjects. Analysis showed that mean VOT values for both /k/ and /g/ across the three vowel contexts did not differ between the two groups; however, differences in VOT variability (standard deviation) approached significance; the older subjects exhibited increased variability. This apparent increase in variability may be related to the subtle anatomical and physiological changes with age.

P4-251: Validation of a telephone version of the Memory Alteration Test in healthy young adult volunteers

2013 ◽  
Vol 9 ◽  
pp. P798-P798
Author(s):  
Mirian Ecay-Torres ◽  
Ainara Estanga ◽  
Andrea Izagirre ◽  
Arrate Barrenetxea ◽  
Ellemarije Altena ◽  
...  
Keyword(s):  
Young Adult ◽  
Healthy Young Adult ◽  
Adult Volunteers
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