476 ACUTE CORONARY SYNDROME AND LOW-HDL CHOLESTEROL. RELATIONSHIP WITH LIPOPROTEIN (A)

Objective: Acute coronary syndrome is frequently complicated by rhythm disturbances, yet any association between high-density lipoprotein (HDL) cholesterol levels and arrhythmias in the setting of non-ST-segment elevation myocardial infarction (non-STEMI) is uncertain. The goal of this study was to evaluate any association between HDL-cholesterol levels and arrhythmias in the setting of non-STEMI. Methods: Retrospective data from Phoenix Veterans Affair Medical Center records were utilized for our study. A total of 6881 patients were found who presented during 2000 to 2003 with non-STEMI with available fasting lipid panels collected within the first 24 hours of admission. Patients were followed for the development of rhythm disturbances up to 6 years after initial presentation, with a mean follow up of 1269 days. Results: We found that high triglycerides/HDL and low-density lipid/HDL ratios were predictive of arrhythmias. However, low HDL levels had strongest association with highest odds ratio (OR) for development of arrhythmias (for HDL <31 mg/dL, OR = 3.72, 95% confidence interval [CI] = 2.55-5.44, P < .05) in patients with diabetes and (for HDL < 31 mg/dL, OR = 3.69, 95% CI = 2.85-4.71, P < .05) in patients without diabetes. Using multivariate analysis adjusting for comorbidities, low HDL level remained independently associated with arrhythmias. Conclusions: Patients with low HDL levels during hospitalization with non-STEMI have a greater risk of developing cardiac rhythm disturbances independent of other risk factors. These data suggest a possible protective role of HDL in preventing arrhythmias in the setting of acute coronary syndrome.

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Association of HDL Cholesterol with In-Hospital Outcome of Patients with Acute Coronary Syndrome

Bangladesh Heart Journal ◽

10.3329/bhj.v32i2.36098 ◽

2018 ◽

Vol 32 (2) ◽

pp. 114-118

Author(s):

Chowdhury Muhammad Omar Faruque ◽

Abdul Wadud Chowdhury ◽

Miftaul Jannath Chowdhury ◽

Abu Thaher Mohammad Mahfuzul Hoque ◽

Md Solaiman Mia ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Cross Sectional ◽

Hospital Outcome ◽

Coronary Syndrome ◽

Group I ◽

Low Hdl ◽

Biochemical Evaluation ◽

Cardiac Emergency

Background:Acute coronary syndrome is a cardiac emergency. It is increasing dramatically and becoming a major burden in our health care system. Relation between serum lipid profile and acute coronary syndrome is well established. Our study tried to reveal association of high density lipoprotein cholesterol (HDL-C) with in-hospital outcome of patients with acute coronary syndrome.Methods: The study was a cross sectional comparative study. Clinical & biochemical evaluation was done in hospital settings. A total number of 271 patients were included in the study and divided into two groups. Patients with low HDL-C level were in group I and patients with normal HDL-C were in group II.Results: Group I populations had more complications & more in- hospital stay than group II (74.3% vs 28.9%, P<0.001 and 6.65±2.04 days vs 5.09±1.44 days, p<0.001 respectively).Conclusion: The study revealed significant association of HDL-C with outcome of acute coronary syndrome patients. Complications of acute coronary syndrome were more in patients with low HDLC level.Bangladesh Heart Journal 2017; 32(2) : 114-118

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Prevalence of metabolic syndrome and its different components in patients with acute coronary syndrome

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20195664 ◽

2019 ◽

Vol 7 (1) ◽

pp. 161

Author(s):

Gaurav Jain ◽

Balaji D. More

Keyword(s):

Metabolic Syndrome ◽

Acute Coronary Syndrome ◽

International Diabetes Federation ◽

Hdl Cholesterol ◽

Coronary Syndrome ◽

The Metabolic Syndrome ◽

High Prevalence ◽

Low Hdl ◽

Male Patients ◽

Very High

Background: Several components of the Metabolic Syndrome (MetS) are risk factor for cardiovascular diseases. So, this study was conducted to evaluate the prevalence of MetS and its components in patients with CAD.Methods: Author included all patients admitted with Acute Coronary Syndrome (ACS), who had CAD confirmed by coronary angiography. They were divided into two groups according to presence or absence of MetS based on International Diabetes Federation criteria. The prevalence of MetS and its individual components was estimated.Results: It was observed that there is a high prevalence of MetS (66%) in patients admitted with ACS. Metabolic syndrome is more prevalent in female patients (82.4%) than in male patients (57.6%) with ACS. Hypertension is the most prevalent (87.9) component of MetS. Diabetes Mellitus (DM) is the 2nd most prevalent (83.3%) component of MetS. About 65.2% patients with MetS had abnormally raised triglyceride levels and 32(48.5%) had abnormally low HDL-cholesterol level. Among the MetS 38(57.6%) had abnormal waist circumference. Among the study group, the most common triad of MetS components was DM + HTN + abnormal TG. There is significant association between MetS and microalbuminuria, with incidence of 22(33.3%) in this study. Similarly, a significant association between DM and microalbuminuria, 23(33.8%) was observed.Conclusions: This study confirms a very high prevalence of MetS in Indian patients with CAD. The prevalence of the risk factors was higher in CAD patients with MetS.

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Acute Coronary Syndrome in the Young: Clinical Characteristics, Risk Factors and Prognosis

The Open Cardiovascular Medicine Journal ◽

10.2174/1874192401408010061 ◽

2014 ◽

Vol 8 (1) ◽

pp. 61-67 ◽

Cited By ~ 14

Author(s):

Marcos R Esteban ◽

Sara M Montero ◽

José J. A Sánchez ◽

Horacio P Hernández ◽

José J. G Pérez ◽

...

Keyword(s):

Risk Factors ◽

Acute Coronary Syndrome ◽

Ejection Fraction ◽

Odds Ratio ◽

Hdl Cholesterol ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Ventricular Ejection Fraction ◽

Coronary Syndrome ◽

Low Hdl

Background: To describe the characteristics of patients ≤40 years of age hospitalized for acute coronary syndrome, analyze the risk factors and identify the variables associated with prognosis. Methods: Case series of patients admitted between 2003 and 2012 inclusive in a tertiary hospital (123 consecutive cases admitted between 2003 and 2012), and case-control study (369 controls selected from the general population matched for sex and age with cases, at a ratio of 3:1). Outcome variables: Mortality, likelihood of survival without readmission for heart-related problems, extent of coronary disease as determined by coronary angiography and cardiovascular risk factors. Results: Mean age was 35.4±4.8 years and 83.7% of the participants were men. Myocardial infarction with abnormal Q wave (48%) and single-vessel involvement (44.7%) predominated. Intrahospital mortality was 1.6%. For the 108 patients eventually included in the follow-up, likelihood of readmission-free survival after 60 months was 69.3±4.8%. In the case group 36% of the patients admitted to using cocaine. Compared to controls, the prevalence in patients was higher for smoking (74.8 vs 33.1%, p<0001), diabetes (14.6% vs 5.1%, p=0.001), low HDL-cholesterol (82.9 vs 34.1%, p<0.001) and obesity (30.0 vs 20.3%, p=0.029). Decreased left ventricular ejection fraction (odds ratio=2.2, p=0.033) and smoking (odds ratio=7.8, p=0.045) were associated with readmission for coronary syndrome. Conclusion: Acute coronary syndrome in people younger than 40 years is associated with diabetes and unhealthy lifestyle: smoking, sedentary behavior (low HDL-cholesterol), cocaine use and obesity. The readmission rate is high, and readmission is associated with smoking and decreased ejection fraction.

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200 ARE HDL PARTICLES DYSFUNCTIONAL IN ACUTE CORONARY SYNDROME PATIENTS WITH STEMI AND LOW HDL-CHOLESTEROL LEVELS: IMPACT OF STATIN?

Atherosclerosis Supplements ◽

10.1016/s1567-5688(11)70201-x ◽

2011 ◽

Vol 12 (1) ◽

pp. 44-45

Author(s):

F.H. Rached ◽

C.V. Serrano ◽

L. Camont ◽

A.L. Pinto ◽

M. Barros ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Hdl Cholesterol ◽

Coronary Syndrome ◽

Cholesterol Levels ◽

Low Hdl

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GAMBARAN PROFIL LIPID PADA PENDERITA SINDROM KORONER AKUT DI RSUP. PROF. DR. R. D. KANDOU PERIODE JANUARI – SEPTEMBER 2015

e-CliniC ◽

10.35790/ecl.4.1.2016.11023 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

Eva Nur Faridah ◽

Janry A. Pangemanan ◽

Starry H. Rampengan

Keyword(s):

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Ldl Cholesterol ◽

Plaque Rupture ◽

Hdl Cholesterol ◽

St Elevation Myocardial Infarction ◽

Coronary Syndrome ◽

Cholesterol Levels ◽

Low Hdl ◽

St Elevation

Abstract: Acute coronary syndrome (ACS) is due to plaque rupture or erosion of atherosklerosis, including unstable angina pectoris, non-ST elevation myocardial infarction, and ST-elevation myocardial infarction. In indonesia, ACS is still regarded as the highest death contributor. One of the risk factors of ACS is dyslipidemia, that is abnormality condition of lipid in blood. Objective: This study aims to determine description of lipid profile in patients with acute coronary syndrome. Methods: This was a descriptive observational method, based on the secondary data from patients in CVBC Prof. Dr. R. D. Kandou Hospital during January to September 2015. Result: The result showed that from 80 patients of ACS were 37 patients (46,25%) with high total cholsterol levels (≥ 200 mg/dL), 70 patients (87,5%) with low HDL cholesterol levels (≤ 40 - 50 mg/dL), there are 58 patients (72,5%) with high LDL cholesterol levels (> 100 mg/dL) and 32 patients (40%) with high triglycerides levels (≥ 150 mg/dL). Conclusion: Most of ACS patients in this research had high LDL cholesterol levels and low HDL cholesterol levels.Keywords: Acute coronary syndrome, dyslipidemia, lipid profileAbstrak: Sindrom koroner Akut ( SKA ) terjadi karena adanya ruptur atau erosi dari plak aterosklerosis, termasuk angina pektoris tidak stabil, non-ST elevasi miokard infark, dan ST elevasi miokard infark. Di Indonesia, SKA masih di anggap sebagai penyumbang angka kematian tertinggi. Salah satu faktor risiko SKA adalah dislipidemia, yaitu berupa gangguan metabolisme lipid. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran profil lipid pada penderita sindrom koroner akut. Metode: Penelitian ini bersifat deskriptif observasional dengan menggunakan data sekunder dari penderita SKA di CVBC RSUP. Prof. Dr. R. D. Kandou periode januari – september 2015. Hasil: Hasil penelitian ini menunjukkan dari 80 penderita SKA didapatkan 37 orang (46,25%) adalah penderita yang memiliki kadar kolesterol total tinggi (≥ 200 mg/dL), sebanyak 70 orang (87,5%) memiliki kadar HDL rendah (≤ 40 – 50 mg/dL), adapun yang memiliki kadar LDL tinggi (> 100 mg/dL) yaitu 58 orang (72,5%) dan 32 orang (40%) adalah penderita yang memiliki kadar trigliserida tinggi (≥ 150 mg/dL). Kesimpulan: Penderita sindrom koroner akut dalam penelitian ini sebagian besar memiliki kadar kolesterol LDL yang tinggi dan kadar kolesterol HDL yang rendah.Kata kunci: Sindrom koroner akut, dislipidemia, profil lipid

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Evaluation of remnant cholesterol levels and monocyte-to-hdl-cholesterol ratio in south asian patients with acute coronary syndrome

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2021.04.007 ◽

2021 ◽

Author(s):

Vincenzo Sucato ◽

Giuseppe Coppola ◽

Gabriella Testa ◽

Francesco Amata ◽

Marco Martello ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

South Asian ◽

Hdl Cholesterol ◽

Cholesterol Ratio ◽

Coronary Syndrome ◽

Asian Patients ◽

Cholesterol Levels ◽

Remnant Cholesterol

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Elevated lipoprotein(a) as a predictor for multivessel disease in patients with premature acute coronary syndrome

Atherosclerosis ◽

10.1016/j.atherosclerosis.2021.06.158 ◽

2021 ◽

Vol 331 ◽

pp. e55

Author(s):

U.V. Chubykina ◽

E.A. Klesareva ◽

N.A. Tmoyan

Keyword(s):

Acute Coronary Syndrome ◽

Multivessel Disease ◽

Lipoprotein A ◽

Coronary Syndrome

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Complex lipid-lowering treatment options in patients with a history of acute coronary syndrome

Orvosi Hetilap ◽

10.1556/oh.2011.29036 ◽

2011 ◽

Vol 152 (8) ◽

pp. 296-302 ◽

Cited By ~ 1

Author(s):

Győző Dani ◽

László Márk ◽

András Katona

Keyword(s):

Acute Coronary Syndrome ◽

Serum Lipid ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Lipid Lowering ◽

Coronary Syndrome ◽

Target Values ◽

History Of ◽

Lipid Parameters

Authors aimed to assess how target values in serum lipid concentrations (LDL- and HDL-cholesterol, triglyceride) can be achieved in patients with a history of acute coronary syndrome during follow up in an outpatient cardiology clinic. Methods: 201 patients with a history of acute coronary syndrome were included and were followed up between January 1 and May 31, 2007.Authors analyzed serum lipid parameters of the patients and the lipid-lowering medications at the time of the first meeting and during follow up lasting two years. Results: During the enrollment visit only 26.4% of the patients had serum LDL cholesterol at target level, whereas high triglycerides and low HDL cholesterol levels were observed in 40.3% and 33.3% of the patients, respectively. Only 22 patients (10.9%) achieved the target levels in all three lipid parameters. Of the 201 patients, 179 patients participated in the follow up, and data obtained from these patients were analyzed. There was a positive trend toward better lipid parameters; 42.5% of the patients reached the desired LDL-cholesterol target value and 17.3% of the patients had HDL-cholesterol and triglycerides target values. Conclusions: These findings are consistent with those published in the literature. Beside the currently used therapeutic options for achieving optimal LDL-cholesterol, efforts should be made to reduce the so-called “residual cardiovascular risk” with the use of a widespread application of combination therapy. Orv. Hetil., 2011, 152, 296–302.

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