P111 CT-signs and the effectiveness of surgical treatment of sinonasal disease in children with cystic fibrosis

2021 ◽  
Vol 20 ◽  
pp. S73
Author(s):  
Y. Gorinova ◽  
U. Malyavina ◽  
Y. Rusetsky ◽  
O. Simonova ◽  
A. Zudilin
Keyword(s):  
Cystic Fibrosis ◽  
Surgical Treatment ◽  
Sinonasal Disease

scholarly journals Chronic rhinosinusitis in adult patients with cystic fibrosis: clinical manifestation and therapeutic approaches

2019 ◽  
Vol 29 (3) ◽  
pp. 311-320
Author(s):  
G. L. Shumkova ◽  
E. L. Amelina ◽  
V. M. Svistushkin ◽  
E. V. Sin’kov ◽  
S. A. Krasovskiy ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Surgical Treatment ◽  
Treatment Group ◽  
Chronic Rhinosinusitis ◽  
Paranasal Sinuses ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyps ◽  
Adult Patients ◽  
Sinus Surgery ◽  
Markers Of Inflammation

The aim of this study was to evaluate prevalence of chronic rhinosinusitis (CRS) and nasal polyps in adult patients with cystic fibrosis (CF) in Russian Federation. Additionally, we investigated the clinical course of CRS and developed the optimal therapeutic strategy.Methods. Three hundred and forty eight CF patients were involved in the study. Physical examination, computed tomography (CT) of paranasal sinuses and audiometry, if needed, were used. CRS and bilateral nasal polyps were diagnosed in 28 patients. Nasal endoscopy, SNOT-20 questionnaire, rhinomanometry, micro - biological examination of sputum and mucus from paranasal sinuses (obtained during puncture or surgery), spirometry, and measurement of serum markers of inflammation were used. Endoscopic sinus surgery was used in 14 patients (the group 1) and others were treated non-surgically (the group 2). Both group were treated during 6 months using intranasal mometasone, mucolytics and antibiotics via PARI SINUSTM nebulizer.Results. An improvement in symptoms, CT signs, rhinomanometry parameters and endoscopic signs was seen in both groups after treatment and was more prominent in the surgical treatment group compared to the non-surgical treatment group. Bacterial load reduction in nasal sinuses, decrease in the rate of pulmonary disease exacerbations, and an improvement in oxygen blood saturation were found in the surgical treatment group only. Treatment of CRS did not affect lung function, sputum microbiology and serum inflammatory markers.Conclusion. Endoscopic sinus surgery followed by intranasal mucolytics and antibacterials is an effective and well-tolerated treatment in adult CF patients with CRS. 

scholarly journals Dornase Alfa as Postoperative Therapy in Cystic Fibrosis Sinonasal Disease

2005 ◽  
Vol 131 (12) ◽  
pp. 1097 ◽  
Author(s):  
Mariano Cimmino ◽  
Massimiliano Nardone ◽  
Matteo Cavaliere ◽  
Angela Plantulli ◽  
Angela Sepe ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Postoperative Therapy ◽  
Dornase Alfa ◽  
Sinonasal Disease

scholarly journals Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis

Diagnostics ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 222 ◽  
Author(s):  
Alice Castaldo ◽  
Paola Iacotucci ◽  
Vincenzo Carnovale ◽  
Roberta Cimino ◽  
Renato Liguori ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Healthy Subjects ◽  
Inferior Turbinate ◽  
Lavage Fluid ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Cytokine Levels ◽  
Inferior Turbinate Hypertrophy ◽  
Sinonasal Disease

About 50% of patients with cystic fibrosis (CF) have sinonasal complications, which include inferior turbinate hypertrophy (NTH) and/or nasal polyposis (NP), and different degrees of lung disease, which represents the main cause of mortality. Monitoring of sinonasal disease requires complex instrumental procedures, while monitoring of lung inflammation requires invasive collection of bronchoalveolar lavage fluid. The aim of this study was to investigate the associations between salivary cytokines levels and CF-related airway diseases. Salivary biochemical parameters and cytokines, i.e., interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-α), were analyzed in resting saliva from healthy subjects and patients with CF. Patients with CF showed significantly higher levels of salivary chloride, IL-6, IL-8, and TNF-α and lower calcium levels than healthy subjects. Among patients with CF, IL-6 and IL-8 were significantly higher in patients with NTH, while TNF-α was significantly lower in patients with NP. A decreasing trend of TNF-α in patients with severe lung disease was also observed. On the other hand, we did not find significant correlation between cytokine levels and Pseudomonas aeruginosa or Stenotrophomonas maltophilia colonization. These preliminary results suggest that salivary IL-6 and IL-8 levels increase during the acute phase of sinonasal disease (i.e., NTH), while the end stages of pulmonary disease and sinonasal disease (i.e., NP) show decreased TNF-α levels.

Cystic Fibrosis and the Sinonasal Tract

1996 ◽  
Vol 105 (4) ◽  
pp. 329-330 ◽  
Author(s):  
John G. Batsakis ◽  
Adel K. El-Naggar
Keyword(s):  
Cystic Fibrosis ◽  
Surgical Treatment ◽  
Respiratory Tract ◽  
Paranasal Sinuses ◽  
Lower Respiratory Tract ◽  
Sinonasal Tract ◽  
Inherited Diseases ◽  
Radiologic Examination ◽  
Sinonasal Symptoms ◽  
All Treatment

Cystic fibrosis is considered to be one of the most common fatal inherited diseases. Sinonasal manifestations are not outstanding as compared with those in the lower respiratory tract. Panopacification of the paranasal sinuses is, however, almost universal on radiologic examination of patients, although many of these patients do not have sinonasal symptoms. Approximately 10% to 20% of cystic fibrosis patients will eventually require surgical treatment of their sinuses. All treatment, including surgery, is transiently effective; none is curative.

Respiratory Viral Detection in the Paranasal Sinuses of Patients with Cystic Fibrosis

2017 ◽  
Vol 31 (2) ◽  
pp. 105-108 ◽  
Author(s):  
Nicholas R. Rowan ◽  
Eric W. Wang ◽  
Alyssa Kanaan ◽  
Nivedita Sahu ◽  
John V. Williams ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Paranasal Sinuses ◽  
Viral Infections ◽  
Respiratory Viruses ◽  
Clinical Severity ◽  
Healthy Controls ◽  
Viral Detection ◽  
Respiratory Viral Infections ◽  
Clinical Measures ◽  
Sinonasal Disease

Background Pulmonary colonization with antibiotic-resistant organisms in patients with cystic fibrosis (CF) is often preceded by upper-airway infections. Although there is a well-described relationship between pulmonary respiratory viral infections and overall disease progression of CF, the pathogenicity of respiratory viral infections in the paranasal sinuses of patients with CF remains unknown. With recent advances in respiratory virus detection techniques, this study sought to detect the presence of respiratory viruses in the paranasal sinuses of patients with CF in comparison with healthy controls and to correlate the viral presence with clinical measures of sinonasal disease. Methods This prospective individual cohort study compared 24 patients with CF with 14 healthy controls. Basic demographics, clinical measures of disease and respiratory viral screens (commercial multiplex) obtained directly from the paranasal sinuses were compared between the two groups. Results Respiratory viruses were detected in 33% of patients with CF (8/24) compared with 0% of the healthy controls (0/14) (p = 0.017). Respiratory viruses were only detected during the winter months, and the most commonly identified were influenza A and human rhinovirus strains. There was no statistical difference in the 22-Item Sino-Nasal Outcome Test (SNOT-22) scores (p = 0.93) or modified Lund-Kennedy scores (p = 0.74) between patients with CF with a positive viral test and those without a positive result. Conclusions Respiratory viral detection is more commonly detected in the paranasal sinuses of patients with CF compared with healthy controls. Although respiratory viral presence did not correlate with a worse clinical severity of sinonasal disease, these findings may provide insight into the pathophysiology of CF and open new avenues for potential targeted therapy.

Hepatolithiasis in Cystic Fibrosis: A Special Condition for Surgical Treatment

2014 ◽  
Vol 92 (9) ◽  
pp. 634-635
Author(s):  
Fuensanta Mon Martín ◽  
Antonio Isaac Martín Malagón ◽  
Iván Jesús Arteaga González ◽  
Hermógenes Díaz Luís ◽  
Ángel Luís Carrillo Pallares
Keyword(s):  
Cystic Fibrosis ◽  
Surgical Treatment

Surgical treatment of non-cystic fibrosis bronchiectasis in Brazilian children

2013 ◽  
Vol 30 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Cristiano Feijó Andrade ◽  
Iury Andrade Melo ◽  
Arthur Rodrigo Ronconi Holand ◽  
Éverton Franco Silva ◽  
Gilberto Bueno Fischer ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Surgical Treatment ◽  
Brazilian Children

Cystic fibrosis - general review on sinonasal complications and case report

2017 ◽  
Vol 7 (25) ◽  
pp. 33-37
Author(s):  
Claudiu Manea ◽  
Alina Diaconescu
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Case Report ◽  
Life Expectancy ◽  
Multiple Organ ◽  
Lower Airway ◽  
General Review ◽  
Organ Systems ◽  
Sinonasal Disease

Abstract An irreversible disease, cystic fibrosis (CF), is responsible for affecting multiple organ systems containing epithelia. It is well known that the sinonasal disease caused by CF has consequences for the incidence of the lower airway exacerbations, as well as affecting the quality of life of those patients. This review provides an update by evaluating the available literature regarding pathogenesis, management and treatment of cystic fibrosis patients. To gain a better view of the disease and obtain a higher life expectancy, further studies are needed.

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