The importance of serum vitamin D and parameters of calcium-phosphate metabolism in renal cell carcinoma

2017 ◽  
Vol 16 (11) ◽  
pp. e2843
Author(s):  
R. Sobotka ◽  
O.Č. Čapoun ◽  
T. Hanuš ◽  
M. Kalousová ◽  
T. Zima ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Vitamin D ◽  
Calcium Phosphate ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Serum Vitamin ◽  
Phosphate Metabolism ◽  
Serum Vitamin D ◽  
Calcium Phosphate Metabolism

scholarly journals Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D3

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Natalia Niedziela ◽  
Krystyna Pierzchała ◽  
Jolanta Zalejska-Fiolka ◽  
Jacek T. Niedziela ◽  
Ewa Romuk ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Calcium Phosphate ◽  
Serum Level ◽  
Clinical Stage ◽  
Phosphate Metabolism ◽  
Disability Status ◽  
Relapsing Remitting ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Calcium Phosphate Metabolism

Background. In addition to the widely known effect of vitamin D3 (vitD3) on the skeleton, its role in the regulation of the immune response was also confirmed. Aim. The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosis (RRMS) selected due to the serum level of vitamin D3. Methods. The concentrations of biochemical markers and indices of lumbar spine bone densitometry (DXA) were determined in 82 patients divided into vitamin D3 deficiency (VitDd), insufficiency (VitDi), and normal vitamin D3 level (VitDn) subgroups. Results. The highest level of the parathyroid hormone (PTH) and the highest prevalence of hypophosphatemia and osteopenia were demonstrated in VitDd group compared to VitDi and VitDn. However, in VitDd, VitDi, and VitDn subgroups no significant differences were observed in the levels of alkaline phosphatase (ALP) and ionized calcium (Ca2+) and in DXA indices. A negative correlation was observed between the level of vitamin D3 and the Expanded Disability Status Scale (EDSS) in the whole MS group. The subgroups were significantly different with respect to the EDSS scores and the frequency of complaints related to walking according to the EQ-5D. Conclusions. It is necessary to assess calcium-phosphate metabolism and supplementation of vitamin D3 in RRMS patients. The higher the clinical stage of the disease assessed with the EDSS, the lower the level of vitamin D3 in blood serum. Subjectively reported complaints related to difficulties with walking were reflected in the EDSS in VitDd patients.

scholarly journals Thecomparisonofserumbiomarkersin patients with osteoarthritisand rheumatoidarthritis

2018 ◽  
Vol 6 (2) ◽  
pp. 1-11
Author(s):  
Almandlawi S G ◽  
Ahmed A S
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Calcium Phosphate ◽  
Serum Vitamin ◽  
Type Ii Collagen ◽  
Healthy Controls ◽  
Type Ii ◽  
Serum Vitamin D

Introduction: This study aims to assess the status of serum vitamin D, parathyroid hormone, type II collagen, calcium, phosphate,albumin, and alkaline phosphatase in osteoarthritis and rheumatoidarthritis patients and to study their association with rheumatoid arthritis disease activity. Materials and Methods: This prospectivecross-sectional study was conducted at the clinical analysis department, College of Pharmacy, Hawler Medical University in 2017.They study samples were collected at Rizgary Teaching Hospitalduring the period September 2015 to January 2016. A total of(N=156) participants were included: (N=53) patients with rheumatoid arthritis (RA), (N=53) with osteoarthritis (OA), and (N=50)healthy controls. Enzyme Linked Immuno Sorbent Assay kits determined serum vitamin D, parathyroid hormone, and type II collagen; and serum albumin, calcium, phosphate and alkaline phosphatase, were determined by standard colorimetric methods. Resultsand Discussion: Statistically significant higher levels of parathyroid hormone and type II collagen, with lower levels of Vitamin D,were found in the osteoarthritis group than the rheumatoid arthritisgroup and the healthy controls (P=0.007, P<0.001, P= 0.005) respectively. Multiple linear regression showed a statistically significant difference in serum type II collagen as a dependent variable, inpatients suffering from RA or OA compared to the healthy controlgroup; after adjusting for the effect of other independent studyvariables, there was a mean increase of (45.90 nmol/L, P<0.001)in RA patients, and OA patients showed greater levels of type IIcollagen (73.950 nmol/L) than the health control group (P<0.001).Conclusions: Elevated type II collagen levels, in conjunction witha low vitamin D status, may be strong discriminator between osteoarthritis and rheumatoid arthritis patients.

Effects of cabozantinib on bone turnover markers in patients with metastatic renal cell carcinoma.

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 638-638 ◽  
Author(s):  
Raffaele Ratta ◽  
Elena Verzoni ◽  
Francesco Pantano ◽  
Paolo Grassi ◽  
Antonia Martinetti ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Vitamin D ◽  
Bone Resorption ◽  
Bone Turnover ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Bone Turnover Markers ◽  
Tracp 5B ◽  
Turnover Markers

638 Background: In-vitro studies have shown that cabozantinib has a strong inhibitory action on osteoclast differentiation and bone-resorption activity. The aim of this analysis was to investigate the effects of cabozantinib on bone turnover markers in patients (pts) with metastatic renal cell carcinoma (mRCC). Methods: We included mRCC pts treated with cabozantinib within the Italian Managed Access Program (MAP) at the Istituto Nazionale Tumori of Milan (Italy). Plasma samples from every patient were collected at baseline and after 3 and 6 months of treatment. The bone resorption markers C-terminal telopeptide of type I collagen (CTx) and tartrate-resistant acid phosphatase isoenzyme 5b (TRACP 5b), the osteoclastogenesis markers osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL), vitamin D and parathormone (PTH) were measured by immunometric assay techniques. Data were analyzed using the RM One-Way ANOVA test with Greenhouse-Geisser correction followed by uncorrected Fisher’s LSD multiple comparison tests with individual variances computed for each comparison. Statistical tests were performed using the program GraphPad Prism (San Diego, CA). Results: Twenty-two pts have been treated with cabozantinib. Mature data were available for 11 pts. Analysis of TRACP 5b, OPG, RANKL and vitamin D did not show any significant variations during treatment with cabozantinib. CTx showed a significant reduction after 6 months of treatment (MV 171.5 pg/mL, STD 208.4) from baseline (mean value [MV] 352.2 pg/mL, standard deviation [STD] 210.1) (p = 0.0439) in the whole study population. PTH levels significantly increased after 3 months of treatment (MV 86.79 pg/mL, STD 34.99) from baseline (MV 30.77 pg/mL, STD 12.64) (p = 0.0003), while significantly decreased after 6 months (MV 75.01 pg/mL, STD 53.1) (p = 0.0174). Conclusions: Our data suggested that cabozantinib significantly reduced bone resorption as demonstrated by the decrease of CTx; it was also associated with an asymptomatic transient secondary increase of parathormone. This is the first clinical evidence on effects of cabozantinib on bone metabolism in a small population of mRCC pts.

Decreased Expression of the Epithelial Ca 2+ Channel TRPV5 and TRPV6 in Human Renal Cell Carcinoma Associated With Vitamin D Receptor

2011 ◽  
Vol 186 (6) ◽  
pp. 2419-2425 ◽  
Author(s):  
Yongyang Wu ◽  
Tatsuya Miyamoto ◽  
Kai Li ◽  
Hiroshi Nakagomi ◽  
Norifumi Sawada ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Vitamin D ◽  
Cell Carcinoma ◽  
Vitamin D Receptor ◽  
Renal Cell ◽  
Human Renal Cell Carcinoma

scholarly journals Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
S. Karami ◽  
P. Brennan ◽  
M. Navratilova ◽  
D. Mates ◽  
D. Zaridze ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Vitamin D ◽  
Dietary Intake ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Central And Eastern Europe ◽  
Positive Association ◽  
Inverse Association ◽  
Ultraviolet Exposure ◽  
Vitamin D Intake

Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk. Therefore, we investigated whetherVDRandRXRApolymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe. A positive association was observed in this population between increasing dietary intake frequency of yogurt, while an inverse association was observed with egg intake frequency.RXRApolymorphisms, located3′of the coding sequence, modified associations between specific vitamin D rich foods and RCC risk, whileRXRApolymorphisms, located in introns 1 and 4, modified associations with specific calcium rich foods. Results suggest that variants in theRXRAgene modified the associations observed between RCC risk and calcium and vitamin D intake.

scholarly journals Association of Prediagnostic Serum Vitamin D Levels with the Development of Basal Cell Carcinoma

2010 ◽  
Vol 130 (5) ◽  
pp. 1438-1443 ◽  
Author(s):  
Maryam M. Asgari ◽  
Jean Tang ◽  
Margaret E. Warton ◽  
Mary-Margaret Chren ◽  
Charles P. Quesenberry ◽  
...  
Keyword(s):  
Vitamin D ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Association of Methylenetetrahydrofolate Reductase, Vitamin D Receptor, and Interleukin-16 Gene Polymorphisms With Renal Cell Carcinoma Risk

2019 ◽  
Vol 18 ◽  
pp. 153303381985941 ◽  
Author(s):  
Tianbiao Zhou ◽  
Hongyan Li ◽  
Wei-Ji Xie ◽  
Zhiqing Zhong ◽  
Hongzhen Zhong ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Vitamin D ◽  
Cell Carcinoma ◽  
Vitamin D Receptor ◽  
Renal Cell ◽  
Gene Polymorphisms ◽  
Methylenetetrahydrofolate Reductase ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Carcinoma Risk

In this meta-analysis, we investigated the association of methylenetetrahydrofolate reductase, vitamin D receptor, and interleukin-16 gene polymorphisms with the risk of renal cell carcinoma. We searched the PubMed and Cochrane Library databases up to July 1, 2017, and included 12 eligible case–control studies in our analysis. The vitamin D receptor ApaI A allele, ApaI AA and aa genotypes, BsmI B allele, and Fok1 FF genotype were all associated with the risk of renal cell carcinoma in Asian populations. However, methylenetetrahydrofolate reductase (rs1801133 and rs1801131), vitamin D receptor (TaqI and Fok1), and interleukin-16 (rs4778889 and rs11556218) gene polymorphisms were not associated with the risk of renal cell carcinoma. Our study indicates that the vitamin D receptor ApaI A allele, ApaI AA and aa genotypes, BsmI B allele, and Fok1 FF genotype are associated with renal cell carcinoma risk.

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