scholarly journals Severe necrotizing myelopathy from toxacariasis

2015 ◽  
Vol 42 (S1) ◽  
pp. S29-S29
Author(s):  
R Magun ◽  
JE Silva
Keyword(s):  
Cervical Spinal Cord ◽  
Transverse Myelitis ◽  
Elisa Test ◽  
Minimal Improvement ◽  
Oligoclonal Banding ◽  
Leg Weakness ◽  
Necrotizing Myelopathy ◽  
Serum Elisa ◽  
Post Infectious ◽  
Spinal Cord Edema

We present a 25 year old female veterinarian technician presenting with rapidly progressive quadriplegia in less then 12 hours. Her symptoms occurred at work with initially bilateral hand weakness followed by arm and leg weakness. Before the end of the day she was on a ventilator in the ICU. MRI showed a hyperintense longitudinal T2 signal extending from the cervical medullary junction to T1. Extensive cervical spinal cord edema with cord expansion was noted. CSF showed normal protein and cell count with no oligoclonal banding. A post-infectious inflammatory process causing transverse myelitis was presumed and she was given IVIG, steroids, and plasmapheresis with no improvement. A serum ELISA test for IgG to Toxocara was reactive at titre of 1:800 at 3 weeks after her initial presentation. Her serum IgE levels was elevated at 169 x 10x3 U/L (Normal <87 x 10x3 U/L). At 4 weeks, she was commenced on albendazole at 800 mg per day for two months. A repeat serum ELISA test at 6 weeks and 2 weeks into her treatment with albendazole showed a declining titre of 1:200 consistent with recent Toxocara infection. At 10 weeks, her ELISA test was non-reactive. Unfortunately she did not respond to albendazole treatment and she shows minimal improvement now 1.5 years later.

scholarly journals Predictors of outcome in a large retrospective cohort of patients with transverse myelitis

2017 ◽  
Vol 24 (13) ◽  
pp. 1743-1752 ◽  
Author(s):  
Matteo Gastaldi ◽  
Enrico Marchioni ◽  
Paola Banfi ◽  
Valeria Mariani ◽  
Laura Di Lodovico ◽  
...  
Keyword(s):  
Nervous System ◽  
Connective Tissue ◽  
Autoimmune Diseases ◽  
Inflammatory Diseases ◽  
Univariate Analysis ◽  
Transverse Myelitis ◽  
Inflammatory Disorder ◽  
Prognostic Assessment ◽  
Lumbar Mri ◽  
Post Infectious

Background: Transverse myelitis (TM) is an inflammatory disorder that can be idiopathic or associated with central nervous system autoimmune/dysimmune inflammatory diseases, connective tissue autoimmune diseases, or post-infectious neurological syndromes. Prognosis of initial TM presentations is uncertain. Objective: To identify outcome predictors in TM. Methods: Retrospective study on isolated TM at onset. Scores ⩾3 on the modified Rankin scale (mRS) marked high disability. Results: A total of 159 patients were identified. TM was classified as follows: idiopathic (I-TM, n = 53), post-infectious (PI-TM, n = 48), associated with multiple sclerosis (MS-TM, n = 51), or neuromyelitis optica spectrum disorders/connective tissue autoimmune diseases/neurosarcoidosis ( n = 7). At follow-up (median, 55 months; interquartile range, 32–80), 42 patients were severely disabled, and patients with I-TM or PI-TM showed the worst outcomes. Predictors of disability were infectious antecedents, sphincter and pyramidal symptoms, high mRS scores, blood–cerebrospinal fluid barrier damage, lumbar magnetic resonance imaging (MRI) lesions on univariate analysis, and older age (odds ratio (OR), 1.1; 95% confidence interval (CI), 1.0–1.1), overt/subclinical involvement of the peripheral nervous system (PNS) (OR, 9.4; 95% CI, 2.2–41.0), complete TM (OR, 10.8; 95% CI, 3.4–34.5) on multivariate analysis. Conclusion: Our findings help define prognosis and therapies in TM at onset. Infectious antecedents and PNS involvement associate with severe prognosis. Nerve conduction studies and lumbar MRI could improve the prognostic assessment of this condition.

scholarly journals Covid-19 post-infectious acute transverse myelitis responsive to corticosteroid therapy: report of two clinical cases

2021 ◽  
Author(s):  
Thaís de Maria Frota Vasconcelos ◽  
Danilo Nunes Oliveira ◽  
Glauber de Menezes Ferreira ◽  
Fabrícia Carneiro Torres ◽  
José Daniel Vieira de Castro ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Transverse Myelitis ◽  
Acute Transverse Myelitis ◽  
Post Infectious ◽  
Clinical Cases

scholarly journals Comparative Diagnosis of Serum IgG1 and Coproantigen ELISA for Fasciolosis Detection of Goats in Mexico

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Abel Villa-Mancera ◽  
Pedro Molina-Mendoza ◽  
Karina Hernández-Guzmán ◽  
Jaime Olivares-Pérez ◽  
Jorge Sarracent-Pérez ◽  
...  
Keyword(s):  
Serological Test ◽  
Sandwich Elisa ◽  
Correlation Coefficients ◽  
Economic Loss ◽  
Elisa Test ◽  
Current Status ◽  
Antigen Elisa ◽  
Faecal Samples ◽  
Diagnostic Sensitivity And Specificity ◽  
Serum Elisa

The objective of present study was to determine the prevalence of natural caprine fasciolosis in the Mixteca region of Mexico using coproantigen and serum IgG1 ELISA tests for comparative purposes. A total of 1070 serum and faecal samples were analyzed for IgG1 antibodies and coproantigens, using ELISA with E/S products as antigen and a monoclonal antibody-based sandwich ELISA. Prevalence of 73.46% was found using the serological ELISA and a percentage of 77.20 was found for coproantigen ELISA. The diagnostic sensitivity and specificity for serum ELISA were 86.7% and 96.4%, and for the coproantigen ELISA they were 93.1% and 97.8%, respectively. The seropositive samples were further categorized as low, medium, or high positivity. Results show a great proportion of low and medium positive goats when the serum ELISA test was used. Correlation coefficients between coproantigens and seropositivity were statistically significant (P<0.01) for low seropositivity (r=0.93) and medium seropositivity (r=0.84). The accuracy of faecal antigen ELISA was higher compared to indirect ELISA serological test. Two ELISAs were shown to be useful for demonstrating the current status ofF. hepaticainfection in the endemic areas and can be employed in studies on epidemiology as well as anthelmintics treatment for preventing economic loss and the risk of transmission to humans.

scholarly journals Vaccine Induced Acute Transverse Myelitis: A Case Report

2016 ◽  
Vol 13 (2) ◽  
pp. 89-91 ◽  
Author(s):  
Avinash Chandra ◽  
Reema Rajbhandari ◽  
Samir Acharya ◽  
Priya Gurung ◽  
Basant Pant
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Adverse Reactions ◽  
Transverse Myelitis ◽  
Active Immunization ◽  
Acute Transverse Myelitis ◽  
Autoimmune Phenomenon ◽  
Improve Accuracy ◽  
Post Traumatic ◽  
Post Infectious

Acute transverse myelitis is a focal infl ammatory disorder of the spinal cord. One of the main etiologic factors include, multiple sclerosis, post-infectious and post-traumatic events although autoimmune phenomenon is the most common cause. Transverse Myelitis (TM) due to etiology other than Multiple Sclerosis has shown spinal cord involvement of two or more segments. Annually millions of active immunization with vaccines is carried out globally with few transverse myelitis caused because of the adverse reactions due to these vaccinations. In order to improve accuracy of reporting, research and diagnosis, the Transverse Myelitis Consortium Working Group (TMCWG) have produced criteria for the diagnosis of ATM. Here we report a case of TM in adult, diagnosed as TM consistent with the TMCWG criteria and probably this is the first ever been reported case from Nepal. Nepal Journal of Neuroscience. Vol. 13, No. 2, 2016, Page: 89-91 

Development of a milk and serum ELISA test for the detection of Teladorsagia circumcincta antibodies in goats using experimentally and naturally infected animals

2014 ◽  
Vol 113 (10) ◽  
pp. 3651-3660 ◽  
Author(s):  
Eleni Malama ◽  
Peggy Hoffmann-Köhler ◽  
Insa Biedermann ◽  
Regine Koopmann ◽  
Jürgen Krücken ◽  
...  
Keyword(s):  
Elisa Test ◽  
Teladorsagia Circumcincta ◽  
Serum Elisa

scholarly journals CLINICAL EVALUATION OF PANCHKARMA MANAGEMENT ALONG WITH PHYSIOTHERAPY IN TRANSVERSE MYELITIS - A CASE STUDY

2020 ◽  
Vol p4 (05) ◽  
pp. 2453-2457
Author(s):  
Mishra Meenu ◽  
Shivhare Shwetal
Keyword(s):  
Involuntary Movement ◽  
Symptomatic Relief ◽  
Transverse Myelitis ◽  
Lower Limbs ◽  
Sensory Level ◽  
Spastic Paraplegia ◽  
Demyelinating Disorder ◽  
Bowel Movements ◽  
Post Infectious

Introduction: Transverse Myelitis is an acute, usually monophasic, demyelinating disorder affecting the spinal cord. It is usually thought to be post infectious in origin. It occurs at any age and present with a subacute paraparesis with a sensory level, accompanied by severe pain in the neck or back at the onset. The annual incidence of Transverse Myelitis ranges from 1.34 to 4.60 cases per million. In Ayurveda there is no description of a single disease which can exactly resemble with Transverse Myelitis. It can be correlated with Adhrangghata, which comes under Vatavyadhi. Aim: To study the effect of Panchkarma management with Physiotherapy in Transverse Myelitis and to find out effective Panchkarma management in Transverse Myelitis. Material & Methods: A 30-year-old male patient Vikas Dubey was visited unit OPD 31767 Kayachikitsa Govt. Ayurveda Hospital Bhopal. On 3rd June 2019 presented with Spastic Paraplegia, had involuntary movement in bilateral lower limbs along with moderate pain off and on and irregular bladder bowel movements. The patient was treated with Panchkarma along with Physiotherapy for 76 days. Assessment was done on the basis of symptomatic relief. Observation: The Panchkarma procedures along with physiotherapy yielded improvement in sensory & motor functions of patient. Conclusion: On the basis of result obtained, it can be concluded that Panchkarma along with physiotherapy can be used as effective treatment in management of Transverse Myelitis.

Post-infectious transverse myelitis in an older adult: A rare complication of Klebsiella bacteremia

2018 ◽  
Vol 18 (7) ◽  
pp. 1135-1136
Author(s):  
Jasmine S Lim ◽  
S Navya Putta ◽  
Surinder Pada ◽  
J En Lee
Keyword(s):  
Older Adult ◽  
Rare Complication ◽  
Transverse Myelitis ◽  
Post Infectious

scholarly journals Acute Flaccid Myelitis in COVID-19

2020 ◽  
Vol 6 (3) ◽  
pp. 20200098
Author(s):  
Mohamed Abdelhady ◽  
Ahmed Elsotouhy ◽  
Surjith Vattoth
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Case Reports ◽  
Transverse Myelitis ◽  
Acute Disseminated Encephalomyelitis ◽  
Imaging Findings ◽  
Metabolic Complications ◽  
Acute Flaccid Myelitis ◽  
Post Infectious ◽  
Spinal Cord Imaging

Spinal cord imaging findings in COVID-19 are evolving with the increasing frequency of neurological symptoms among COVID-19 patients. Several mechanisms are postulated to be the cause of central nervous system affection including direct virus neuroinvasive potential, post infectious secondary immunogenic hyperreaction, hypercoagulability, sepsis and possible vasculitis as well as systemic and metabolic complications associated with critical illness. Only a few case reports of spinal cord imaging findings are described in COVID-19, which include transverse myelitis, acute disseminated encephalomyelitis and post-infectious Guillain Barre’ syndrome. We are describing a case of myelitis which, to the best of our knowledge, is the first reported case of myelitis in COVID-19.

scholarly journals Spinal Cord Injury from Fluoroscopically Guided Intercostal Blocks with Phenol

2014 ◽  
Vol 2;17 (2;3) ◽  
pp. E219-E224
Author(s):  
Ruple S. Laughlin
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Case Report ◽  
Lower Extremity ◽  
Transverse Myelitis ◽  
Signal Abnormality ◽  
Modifiable Factors ◽  
Cord Injury ◽  
Leg Weakness ◽  
Chemical Denervation

Background: Image guided intercostal blocks are commonly performed and considered relatively safe. Chemical denervation is commonly used in clinical practice for treatment of chronic noncancer associated pain. Objective: To report a case of spinal cord injury resulting from fluoroscopically guided intercostal blocks with phenol. Study Design: Case report. Setting: Inpatient hospital service. Results/Case Report: A 53 year-old women was transferred from her local facility for acute onset of lower extremity paresis beginning shortly after right intercostal nerve injections of 2 mL of preservative-free phenol at the T7, 8, 9 levels. She had previous intercostal blocks for chronic rightsided mid thoracic/abdominal pain every 3 months for at least one year without sequelae. Within 20 minutes of the injection, she developed a sensation of right leg weakness and heaviness. Over several hours she developed worsening right leg weakness, and then left leg weakness, followed by urinary retention. Admission examination revealed severe right greater than left leg weakness, right lower extremity hyperesthesia to T10, absent lower extremity reflexes, and bilateral extensor plantar responses. Magnetic resonance imaging (MRI) of the entire spine demonstrated extensive T2/DWI hyperintensity in the central spinal cord from T1 to L1 with mild cord enlargement and enhancement at T7-9 (sites of injection). Extensive serum and cerebrospinal fluid (CSF) evaluation did not show any evidence of an infectious, inflammatory, or metabolic cause to her myelopathy. Repeat MRI of the entire spine demonstrated near complete resolution of the T2 signal abnormality. One month after presentation, despite radiographic improvement, the patient showed some clinical improvement, but remained walker dependent and with neurogenic bowel and bladder. Limitations: This report describes a single case report. Conclusion: This case offers several lessons for a pain specialist including 1) the potential for a neurologic catastrophe (spinal cord injury) from aqueous neurolytic intercostal blocks despite “safe” contrast spread; 2) potential mechanisms of neurogenic injury with intercostal blocks; 3) review of modifiable factors to decrease the risk of neurogenic injury; and 4) review of potential interventions (steroids, lumbar drain) to improve outcome in the setting of iatrogenic procedural related spinal cord injury. Key words: Phenol, myelopathy, paraparesis, chemical denervation, neurolysis, intercostal block, epidural spread, chronic pain, complication, transverse myelitis

scholarly journals Spectrum of spinal cord involvement in COVID-19: A systematic review

2020 ◽  
Author(s):  
Ritwick Mondal ◽  
Shramana Deb ◽  
Gourav Shome ◽  
Upasana Ganguly ◽  
Durjoy Lahiri ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Clinical Laboratory ◽  
Case Reports ◽  
Transverse Myelitis ◽  
Systemic Review ◽  
Cochrane Library ◽  
Imaging Data ◽  
Spinal Cord Involvement ◽  
Imaging Characteristics ◽  
Post Infectious

Background and aims- Recent reports reveal incidences of spinal cord involvement in form of para-infectious or post-infectious myelitis raising potential concerns about the possibilities of SARS-CoV-2 behind the pathogenesis of spinal cord demyelination. In this study, we intend to summarise so far available pieces of evidence documenting SARS-CoV-2 mediated spinal demyelination in terms of clinical, laboratory parameters and imaging characteristics. Methodology- This review was carried out based on the existing PRISMA (Preferred Report for Systemic Review and Meta-analyses) consensus statement. Data was collected from four databases: Pubmed/Medline, NIH Litcovid, Embase and Cochrane library and Preprint servers up till 10th September, 2020. Search strategy comprised of a range of keywords from relevant medical subject headings which includes "SARS-COV-2", "COVID-19", "demyelination" etc. Results- A total of 21 cases were included from 21 case reports after screening from various databases and preprint servers. Biochemical analysis reveals that the majority of cases showed elevated CSF protein as well as lymphocytic pleocytosis. Interestingly, a majority of cases were found to be associated with long extensive transverse myelitis (LETM), and remaining cases were found to be associated with isolated patchy involvement or isolated short segment involvement or combined LETM and patchy involvement. Few cases were also found with significant co-involvement of the brain and spine based on the imaging data. Conclusion- It can be interpreted that SARS-CoV-2 may play a potential role in spinal demyelinating disorders in both para-infectious and post-infectious forms.

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