Job Type, Neighborhood Prevalence, and Risk of COVID-19 Among Healthcare Workers in New York City

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2021.163 ◽

2021 ◽

pp. 1-12

Author(s):

Fran A. Ganz-Lord ◽

Kathryn R. Segal

Keyword(s):

New York ◽

New York City ◽

York City ◽

Healthcare Workers ◽

Environmental Services ◽

Infection Rates ◽

Job Type ◽

Increased Risk

NARRATIVE ABSTRACT This study compared the risk of COVID-19 between clinical and non-clinical HCWs while adjusting for home zip codes. Clinical HCWs did not have higher risk of COVID-19, but living in higher-risk zip codes was associated with increased infection rates. However, environmental services workers showed increased risk of COVID-19.

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Dynamic Management of Lung Cancer Care During Surging COVID-19

Frontiers in Surgery ◽

10.3389/fsurg.2021.663364 ◽

2021 ◽

Vol 8 ◽

Author(s):

Annie Wang ◽

Stephanie H. Chang ◽

Eric J. Kim ◽

Jamie L. Bessich ◽

Joshua K. Sabari ◽

...

Keyword(s):

Lung Cancer ◽

New York ◽

New York City ◽

Cancer Patients ◽

York City ◽

Healthcare Workers ◽

New York University ◽

Lung Cancer Patients ◽

Increased Risk ◽

Review Current

Management of patients with lung cancer continues to be challenging during the COVID-19 pandemic, due to the increased risk of complications in this subset of patients. During the COVID-19 surge in New York City, New York University Langone Health adopted triage strategies to help with care for lung cancer patients, with good surgical outcomes and no transmission of COVID-19 to patients or healthcare workers. Here, we will review current recommendations regarding screening and management of lung cancer patients during both a non-surge phase and surge phase of COVID-19.

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143. Opioid Use and Hospitalizations for Endocarditis, Osteomyelitis, and Central Nervous System Abscess among Adults — New York City, 2001–2014

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.218 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S99-S99

Author(s):

Chaorui Huang ◽

David Lucero ◽

Denise Paone ◽

Ellenie Tuazon ◽

Demetre Daskalakis

Keyword(s):

New York ◽

Central Nervous System ◽

New York City ◽

Nervous System ◽

York City ◽

Opioid Epidemic ◽

Opioid Use ◽

Increased Risk ◽

Opioid Users ◽

Discharge Record

Abstract Background Along with a growing opioid epidemic nationwide, opioid users often have an increased risk of severe infectious diseases including endocarditis, osteomyelitis, and central nervous system (CNS) abscess. As the largest city in the United States, New York City (NYC) may serve as a study model for opioid use and infectious diseases. We investigated the association between opioid use and hospitalizations for endocarditis, osteomyelitis, and CNS abscess in NYC. Methods Data for NYC residents aged ≥18 years discharged from New York State hospitals during 2001–2014 were analyzed using a hospital discharge dataset. We defined a hospitalization for endocarditis, osteomyelitis, and CNS abscess as one with a principal or secondary diagnosis for these conditions within the discharge record. We identified opioid users by examining principal or secondary diagnoses for opioid use within the discharge record at the time of hospitalization for endocarditis, osteomyelitis, and CNS abscess. Log-binomial model was applied among all hospitalized patients using endocarditis, osteomyelitis, and CNS abscess as the outcome, adjusting for age, sex, race, and borough. Results During 2001–2014, there were 139,392 hospitalizations in total for endocarditis, osteomyelitis, or CNS abscess, of which 8,823 (6.3%) were among opioid users. There was an increased risk of hospitalization for endocarditis [RR: 2.6 (95% CI: 2.5–2.7)], osteomyelitis [RR: 1.1 (95% CI: 1.1–1.1)], and CNS abscesses [RR: 1.9 (95% CI: 1.8–2.1)] among hospitalized opioid users compared with hospitalized nonopioid users, adjusted by age, sex, race, and borough. Hospitalized opioid users had four times the risk for endocarditis hospitalization compared with hospitalized nonopioid users in the 18–44 year age group (RR: 4.2 [95% CI: 3.9–4.5]) (Table 1). Conclusion These results provide further evidence that opioid use is associated with an increased risk of endocarditis, osteomyelitis, and CNS abscess. Efforts to combat the opioid epidemic might lower the overall incidence of endocarditis, osteomyelitis, and CNS abscess. Disclosures All authors: No reported disclosures.

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Carbapenemase-producing Enterobacterales causing secondary infections during the COVID-19 crisis at a New York City hospital

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkaa466 ◽

2020 ◽

Author(s):

Angela Gomez-Simmonds ◽

Medini K Annavajhala ◽

Thomas H McConville ◽

Donald E Dietz ◽

Sherif M Shoucri ◽

...

Keyword(s):

New York ◽

New York City ◽

York City ◽

Bacterial Infections ◽

Antibiotic Resistance Gene ◽

City Hospital ◽

Nanopore Sequencing ◽

Sequencing Data ◽

Secondary Infections ◽

Increased Risk

Abstract Background Patients with COVID-19 may be at increased risk for secondary bacterial infections with MDR pathogens, including carbapenemase-producing Enterobacterales (CPE). Objectives We sought to rapidly investigate the clinical characteristics, population structure and mechanisms of resistance of CPE causing secondary infections in patients with COVID-19. Methods We retrospectively identified CPE clinical isolates collected from patients testing positive for SARS-CoV-2 between March and April 2020 at our medical centre in New York City. Available isolates underwent nanopore sequencing for rapid genotyping, antibiotic resistance gene detection and phylogenetic analysis. Results We identified 31 CPE isolates from 13 patients, including 27 Klebsiella pneumoniae and 4 Enterobacter cloacae complex isolates. Most patients (11/13) had a positive respiratory culture and 7/13 developed bacteraemia; treatment failure was common. Twenty isolates were available for WGS. Most K. pneumoniae (16/17) belonged to ST258 and encoded KPC (15 KPC-2; 1 KPC-3); one ST70 isolate encoded KPC-2. E. cloacae isolates belonged to ST270 and encoded NDM-1. Nanopore sequencing enabled identification of at least four distinct ST258 lineages in COVID-19 patients, which were validated by Illumina sequencing data. Conclusions While CPE prevalence has declined substantially in New York City in recent years, increased detection in patients with COVID-19 may signal a re-emergence of these highly resistant pathogens in the wake of the global pandemic. Increased surveillance and antimicrobial stewardship efforts, as well as identification of optimal treatment approaches for CPE, will be needed to mitigate their future impact.

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Prevalence of Adult Male Circumcision in the General Population and a Population at Increased Risk for HIV/AIDS in New York City

Sexually Transmitted Diseases ◽

10.1097/olq.0b013e318175d899 ◽

2008 ◽

Vol 35 (9) ◽

pp. 814-817 ◽

Cited By ~ 9

Author(s):

Christy M. McKinney ◽

Ellen J. Klingler ◽

Rachel Paneth-Pollak ◽

Julia A. Schillinger ◽

R Charon Gwynn ◽

...

Keyword(s):

New York ◽

New York City ◽

General Population ◽

Adult Male ◽

Male Circumcision ◽

York City ◽

Increased Risk ◽

Adult Male Circumcision ◽

Hiv Aids

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Lynch Syndrome–Associated Variants and Cancer Rates in an Ancestrally Diverse Biobank

JCO Precision Oncology ◽

10.1200/po.20.00290 ◽

2020 ◽

pp. 1429-1444

Author(s):

Rachel E. Rosenblum ◽

Celina Ang ◽

Sabrina A. Suckiel ◽

Emily R. Soper ◽

Meenakshi R. Sigireddi ◽

...

Keyword(s):

New York ◽

New York City ◽

Lynch Syndrome ◽

York City ◽

Sequence Data ◽

African Ancestry ◽

European Ancestry ◽

Electronic Health Record Data ◽

Increased Risk ◽

Cancer Rates

PURPOSE Limited data are available on the prevalence and clinical impact of Lynch syndrome (LS)–associated genomic variants in non-European ancestry populations. We identified and characterized individuals harboring LS-associated variants in the ancestrally diverse Bio Me Biobank in New York City. PATIENTS AND METHODS Exome sequence data from 30,223 adult Bio Me participants were evaluated for pathogenic, likely pathogenic, and predicted loss-of-function variants in MLH1, MSH2, MSH6, and PMS2. Survey and electronic health record data from variant-positive individuals were reviewed for personal and family cancer histories. RESULTS We identified 70 individuals (0.2%) harboring LS-associated variants in MLH1 (n = 12; 17%), MSH2 (n = 13; 19%), MSH6 (n = 16; 23%), and PMS2 (n = 29; 41%). The overall prevalence was 1 in 432, with higher prevalence among individuals of self-reported African ancestry (1 in 299) than among Hispanic/Latinx (1 in 654) or European (1 in 518) ancestries. Thirteen variant-positive individuals (19%) had a personal history, and 19 (27%) had a family history of an LS-related cancer. LS-related cancer rates were highest in individuals with MSH6 variants (31%) and lowest in those with PMS2 variants (7%). LS-associated variants were associated with increased risk of colorectal (odds ratio [OR], 5.0; P = .02) and endometrial (OR, 30.1; P = 8.5 × 10−9) cancers in Bio Me. Only 2 variant-positive individuals (3%) had a documented diagnosis of LS. CONCLUSION We found a higher prevalence of LS-associated variants among individuals of African ancestry in New York City. Although cancer risk is significantly increased among variant-positive individuals, the majority do not harbor a clinical diagnosis of LS, suggesting underrecognition of this disease.

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Nosocomial Rotavirus in a Pediatric Hospital

Infection Control and Hospital Epidemiology ◽

10.1086/501904 ◽

2001 ◽

Vol 22 (5) ◽

pp. 299-301 ◽

Cited By ~ 12

Author(s):

Adam J. Ratner ◽

Natalie Neu ◽

Kathleen Jakob ◽

Surah Grumet ◽

Nora Adachi ◽

...

Keyword(s):

New York ◽

New York City ◽

Infection Control ◽

York City ◽

Healthcare Workers ◽

Pediatric Cardiology ◽

Case Finding ◽

Surveillance Program ◽

Pediatric Hospital ◽

The Impact

AbstractWe describe a nosocomial rotavirus outbreak among pediatric cardiology patients and the impact of a prospective, laboratory-based surveillance program for rotavirus in our university-affiliated, quartenary-care pediatric hospital in New York City. Improved compliance with infection control and case-finding among patients and healthcare workers halted the outbreak.

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Seroepidemiology among Employees of New York City Health and Hospitals during the First Wave of the SARS-CoV-2 Epidemic

10.1101/2021.04.12.21255344 ◽

2021 ◽

Author(s):

Alexander D Bryan ◽

Kathleen Tatem ◽

Jillian Diuguid-Gerber ◽

Caroline Cooke ◽

Anya Romanoff ◽

...

Keyword(s):

New York ◽

New York City ◽

York City ◽

Healthcare Workers ◽

Close Contact ◽

Self Report ◽

Antibody Testing ◽

Serological Tests ◽

Cross Sectional ◽

Community Factors

Objective: Estimate the seroprevalence of SARS-CoV-2 antibodies among New York City Health + Hospitals healthcare workers, and identify demographic and occupational factors associated with SARS-CoV-2 antibodies among healthcare workers. Methods: This was an observational, cross-sectional study using data from SARS-CoV-2 serological tests accompanied by a demographic and occupational survey administered to healthcare workers. Participants were employed by New York City Health + Hospitals (NYC H+H) and either completed serologic testing at NYC H+H between April 30 and June 30, 2020, or completed SARS-CoV-2 antibody testing outside of NYC H+H and were able to self-report results. Results: Seven hundred twenty-seven survey respondents were included in analysis. Participants had a mean age of 46 years (SD= 12.19) and 543 (75%) were women. Two hundred fourteen (29%) participants tested positive or reported testing positive for the presence of SARS-CoV-2 antibodies (IgG+). Characteristics associated with positive SARS-CoV-2 serostatus were Black race (25% IgG+ vs. 15% IgG-, p=0.001), having someone in the household with COVID symptoms (49% IgG+ vs. 21% IgG-, p<0.001), or having a confirmed COVID-19 case in the household (25% IgG+ vs 5% IgG-, p<0.001). Characteristics associated with negative SARS-CoV-2 serostatus included working on a COVID patient floor (27% IgG+ vs. 36% IgG-, p=0.02), working in the ICU (20% IgG+ vs. 28% IgG-, p=0.03), or having close contact with a patient with COVID-19 (51% IgG+ vs. 62% IgG-, p=0.03). Conclusions: Results underscore the significance of community factors and inequities might have on SARS-CoV-2 exposure for healthcare workers.

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Safe tracheostomy in COVID-19 patients: a case series

International Surgery Journal ◽

10.18203/2349-2902.isj20203257 ◽

2020 ◽

Vol 7 (8) ◽

pp. 2702

Author(s):

Melissa K. Meghpara ◽

Bhavana Devanabanda ◽

Mercy Jimenez ◽

Martine A. Louis ◽

Neil Mandava

Keyword(s):

New York ◽

New York City ◽

York City ◽

Healthcare Workers ◽

Case Series ◽

The Elderly ◽

Optimal Timing ◽

Hispanic Males ◽

Prolonged Intubation ◽

Operating Room Staff

The coronavirus (COVID-19) pandemic has led to a critical need in treating severe respiratory disease while providing adequate protection to healthcare workers. Critically ill COVID-19 patients have required prolonged intubation and mechanical ventilation, not limited to those with multiple comorbidities or the elderly. At the height of the pandemic in New York City; our institution intubated 192 COVID-19 patients. Many institutions have avoided performing tracheostomy in this population due to high risk of virus aerosolization. This study is a retrospective, IRB approved, single center case series of 14 consecutive tracheostomies in COVID-19 patients at a community hospital in Flushing, New York City. Data from 1 March to 31 May 2020 was collected from electronic medical records. All COVID-19 positive patients undergoing tracheostomy were included; patients undergoing tracheostomy that were not COVID-19 positive were excluded. Fourteen patients underwent tracheostomy during the study period. Average age was 62 and 64.3% were male (n=9). Hispanic males represented 50% of patients undergoing tracheostomy and 71.4% were from home. Average days from initial intubation to tracheostomy was 20.6, ranging from 12 to 43 days. With the exception of two patients, all underwent a single intubation. No involved operating room staff became ill during or after these procedures. Tracheostomy may be safely performed in COVID-19 patients while minimizing risk to staff; however, patient outcomes may not be significantly altered. Further research is needed to determine the optimal timing and overall benefit of tracheostomy in this population.

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