scholarly journals Spirulina can increase total-body vitamin A stores of Chinese school-age children as determined by a paired isotope dilution technique

2012 ◽  
Vol 1 ◽  
Author(s):  
Lei Li ◽  
Xianfeng Zhao ◽  
Jie Wang ◽  
Tawanda Muzhingi ◽  
Paolo M. Suter ◽  
...  
Keyword(s):  
Vitamin A ◽  
Rural Areas ◽  
Enrichment Analysis ◽  
School Age Children ◽  
School Age ◽  
Serum Samples ◽  
Retinyl Acetate ◽  
Chinese School ◽  
Total Body ◽  
Β Carotene

AbstractSpirulina is an alga rich in high-quality protein and carotenoids. It is unclear whether spirulina can improve the total-body vitamin A stores of school-age children in China with a high prevalence of vitamin A malnutrition. We aimed to evaluate the efficacy of spirulina in improving the total-body vitamin A stores of school-age children in rural areas of China when they consumed spirulina in their daily meals. A total of 228 children (6–11 years) were recruited and randomly divided into three groups supplemented with 4 g (containing 4·18 µg β-carotene), 2 g (containing 2·54 µg β-carotene) or 0 g spirulina 5 d/week for 10 weeks, respectively. Before and after the intervention period, each child was given 0·5 mg [2H4]retinyl acetate and [2H8]retinyl acetate, respectively. To assess vitamin A stores, blood samples (3 ml) were collected on the third and the twenty-first day after each labelled retinyl acetate dose for a retinol enrichment analysis using a GC mass spectrometer. The concentrations of retinol and β-carotene in serum samples were also determined by using HPLC. After the 10-week intervention, serum β-carotene concentrations of children with 2 or 4 g spirulina supplement increased by 0·160 and 0·389 µmmol/l, respectively. Total-body vitamin A stores increased significantly, with a median increase of 0·160 mmol in children taking 2 g spirulina and of 0·279 mmol in children taking 4 g spirulina. Spirulina is a good dietary source of β-carotene, which may effectively increase the total-body vitamin A stores of Chinese school-age children.

scholarly journals Updated Estimates of Vitamin a Total Body Stores in Healthy Young Adults Determined by Compartmental Modeling with Vitamin a Intake Added as Data (FS06-07-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jennifer Ford ◽  
Georg Lietz ◽  
Anthony Oxley ◽  
Joanne Green ◽  
Michael Green
Keyword(s):  
Young Adults ◽  
Vitamin A ◽  
Model Prediction ◽  
Simulation Analysis ◽  
Geometric Mean ◽  
Compartmental Analysis ◽  
Science Research ◽  
European Ancestry ◽  
Retinyl Acetate ◽  
Total Body

Abstract Objectives We applied a new modeling approach to generate estimates of vitamin A total body stores (TBS) for previously-studied subjects (Green et al. J Nutr 2016;146:2129–36) who were consuming moderate amounts of preformed vitamin A. Based on recent work, we hypothesized that inclusion of an estimate of vitamin A dietary intake (DI) during modeling would help compensate for the less-than-optimal study duration (14 d). Methods We reanalyzed retinol kinetic data collected after ingestion of [13C10]retinyl acetate by 26 young adults of European ancestry for whom estimates of DI were available. To predict TBS by compartmental analysis, geometric mean (GM) data on fraction of dose in plasma versus time plus estimated intake (2.9 µmol retinol activity equivalents/d) were analyzed using the Simulation, Analysis and Modeling software in light of previously-established models. We also used modeling to estimate coefficients (“FaS”) used in retinol isotope dilution (RID) equations and calculated TBS for the group and individuals. Results TBS predicted by the model without DI data included was 98 µmol; when the GM DI was included in the modeling data stream, predicted TBS was 273 µmol. Including DI data during modeling also resulted in lower predictions of intake [2.9 versus 8.7 µmol/d without DI, compared with the average RDA for adults (2.8 µmol/d)] and longer predicted days of vitamin A stores (125 versus 15 d). Using the FaS at 7 d (0.90) predicted by the model with DI, RID-predicted TBS agreed with the model prediction (GM, 274 µmol, range 106–889 µmol). Conclusions Results indicate that including an estimate of DI during modeling provides more realistic predictions of TBS for studies of short duration and improves confidence in model prediction of vitamin A status. Funding Sources Original human studies were supported by Biotechnology and Biological Science Research Council (grant BB/G004056/1 to GL) and Cancer Research UK; current analyses were supported by College of Health and Human Development, Penn State University.

Prevalence of vitamin A deficiency and dietary inadequacy in Indian school-age children and adolescents

2021 ◽  
Author(s):  
Geereddy Bhanuprakash Reddy ◽  
Tattari Shalini ◽  
Santu Ghosh ◽  
Raghu Pullakhandam ◽  
Boiroju Naveen Kumar ◽  
...  
Keyword(s):  
Vitamin A ◽  
Children And Adolescents ◽  
Vitamin A Deficiency ◽  
School Age Children ◽  
School Age ◽  
Indian School

Vitamin A status and factors associated in healthy school-age children

2014 ◽  
Vol 33 (3) ◽  
pp. 509-512 ◽  
Author(s):  
Dogus Vuralli ◽  
Leyla Tumer ◽  
Alev Hasanoglu ◽  
Gürsel Biberoglu ◽  
Hatice Pasaoglu
Keyword(s):  
Vitamin A ◽  
School Age Children ◽  
School Age ◽  
Factors Associated ◽  
Vitamin A Status

scholarly journals Risk factors for Toxocara spp. seroprevalence and its association with atopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil

Acta Tropica ◽  
2017 ◽  
Vol 174 ◽  
pp. 158-164 ◽  
Author(s):  
Márcia B. Silva ◽  
Ana L.M. Amor ◽  
Leonardo N. Santos ◽  
Alana A. Galvão ◽  
Aida V. Oviedo Vera ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rural Areas ◽  
Small Town ◽  
School Age Children ◽  
Northeast Brazil ◽  
School Age ◽  
Asthma Phenotypes

scholarly journals THE RELATONSHIP BETWEEN THE INTAKE OF ENERGY,PROTEIN, VITAMIN A AND ZINC (Zn) AND STUNTING IN THE AGE OF EARLY PERIOD IN ENTERING SCHOOL IN CANDIREJO VILLAGE

2015 ◽  
Vol 7 (16) ◽  
pp. 47-56
Author(s):  
Desy Kumaladewi ◽  
Sugeng Maryanto ◽  
Galeh Septiar Pontang
Keyword(s):  
Vitamin A ◽  
Early Period ◽  
Average Energy ◽  
School Age Children ◽  
Bivariate Analysis ◽  
School Age ◽  
Cross Sectional ◽  
Zinc Intake ◽  
First Year Students ◽  
Average Intake

Stunting is one of the effects of lack of nutrients that lasts a long time. Stunting can occur due to deficiency of macronutrients and macronutrients that play a role in the growth, such as energy, protein, vitamin A and zinc (Zn). The aim of this study was determine the relationship between the intake of energy, protein, vitamin A and zinc (Zn) and the incidences of stunting in children of school age in Candirejo Village This research was The study correlation with cross sectional approach. The population in this study were all first year students in Candirejo village. It obtained 56 children with total sampling method. Method of data taking used microtoise, digital scale and FFQ. Bivariate analysis used Pearson product moment and alternative test of Spearman rho (α=0,05) The average energy intake in children was 86.5% RDA. The average protein intake in children was 106.3% RDA. The average intake of vitamin A in children was 111.9% RDA. The average intake of zinc in children was 64.4% RDA. From 56 childs 37,5% was stunting and 62,5% no stunting. There was no relationship between the intake of energy, protein and vitamin A with the incidences of stunting (p = 0.129, p = 0.139, p = 0.200), and there was a correlation between zinc intake with the incidences of stunting (p = 0.014) There was no relationship between the intake of energy, protein and vitamin A with the incidences of stunting in children of school-age in Candirejo village. There was a relationship between zinc intake with the incidences of stunting in school-age children in the Candirejo village.

Vitamin D status in Mexican children 1 to 11 years of age: an update from the Ensanut 2018-19

2021 ◽  
Vol 63 (3 May-Jun) ◽  
pp. 382-393
Author(s):  
Mario E Flores ◽  
Marta Rivera-Pasquel ◽  
Andrys Valdez-Sánchez ◽  
Vanessa De la Cruz-Góngora ◽  
Alejandra Contreras-Manzano ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Dairy Products ◽  
The Body ◽  
School Age Children ◽  
School Age ◽  
Vitamin D Status ◽  
Serum Samples ◽  
Related Factors ◽  
Mexican Children

Objective. To evaluate vitamin D status and deficiency in Mexican children and related factors, with updated data from a representative national survey. Materials and methods. Data and serum samples of child participants were collected in the Ensanut 2018-19. The measurement 25-(OH)-D was obtained through chemiluminescence. Height and weight, as well as dietary information, were measured using a semi-quan­titative food frequency questionnaire and sociodemographic information. Results. Data of 4 691 children aged 1-11 years were analyzed. Vitamin D deficiency (25-OH-D<50 nmol/L) was found in 27.3% of pre-school-age children and 17.2% of school-age children, and was positively associated with the body mass index (BMI). Main dietary sources were milk, eggs and dairy products, which in combination provided >70% of vitamin D intake. Conclusions. Vitamin D deficiency is important in Mexican children. Actions and programs to fight this deficiency are required.

scholarly journals The “Super-Child” Approach Is Applied To Estimate Retinol Kinetics and Vitamin A Total Body Stores in Mexican Preschoolers

2020 ◽  
Vol 150 (6) ◽  
pp. 1644-1651 ◽  
Author(s):  
Veronica Lopez-Teros ◽  
Jennifer L Ford ◽  
Michael H Green ◽  
Brianda Monreal-Barraza ◽  
Lilian García-Miranda ◽  
...  
Keyword(s):  
Vitamin A ◽  
Corn Oil ◽  
Compartmental Analysis ◽  
Whole Body ◽  
Retinyl Acetate ◽  
Data Set ◽  
Mexican Children ◽  
Model Predictions ◽  
Total Body ◽  
Composite Data

ABSTRACT Background Retinol isotope dilution (RID) and model-based compartmental analysis are recognized techniques for assessing vitamin A (VA) status. Recent studies have shown that RID predictions of VA total body stores (TBS) can be improved by using modeling and that VA kinetics and TBS in children can be effectively studied by applying population modeling (“super-child” approach) to a composite data set. Objectives The objectives were to model whole-body retinol kinetics and predict VA TBS in a group of Mexican preschoolers using the super-child approach and to use model predictions of RID coefficients to estimate TBS by RID in individuals. Methods Twenty-four healthy Mexican children (aged 3–6 y) received an oral dose (2.96 μmol) of [13C10]retinyl acetate in corn oil. Blood samples were collected from 8 h to 21 d after dosing, with each child sampled at 4 d and at 1 other time. Composite data for plasma labeled retinol compared with time were analyzed using a 6-component model to obtain group retinol kinetic parameters and pool sizes. Model-predicted TBS was compared with mean RID predictions at 4 d; RID estimates at 4 d were compared with those calculated at 7–21 d. Results Model-predicted TBS was 1097 μmol, equivalent to ∼2.4 y-worth of VA; using model-derived coefficients, group mean RID-predicted TBS was 1096 μmol (IQR: 836–1492 μmol). TBS at 4 d compared with a later time was similar (P = 0.33). The model predicted that retinol spent 1.5 h in plasma during each transit and recycled to plasma 13 times before utilization. Conclusions The super-child modeling approach provides information on whole-body VA kinetics and can be used with RID to estimate TBS at any time between 4 and 21 d postdose. The high TBS predicted for these children suggests positive VA balance, likely due to large-dose VA supplements, and warrants further investigation.

scholarly journals A new approach to the assessment of marginal vitamin A deficiency in children in suburban Guwahati, India: hydrolysis of retinoyl glucuronide to retinoic acid

2008 ◽  
Vol 101 (6) ◽  
pp. 794-797 ◽  
Author(s):  
Pulin C. Sarma ◽  
Bhabesh C. Goswami ◽  
Krishna Gogoi ◽  
Harsha Bhattacharjee ◽  
Arun B. Barua
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Serum Retinol ◽  
Serum Samples ◽  
Group I ◽  
High Prevalence ◽  
Hydrolysis Of ◽  
Β Carotene

The objective of the present study was to determine marginal vitamin A deficiency (VAD) by testing the hydrolysis of retinoyl glucuronide (RAG) to retinoic acid (RA) in children. Previous studies in rats showed that hydrolysis occurred when rats were vitamin A deficient. Children (n 61) aged 3–18 years, were divided into two groups, I and II. Blood was collected from the children in Group I (n 19) who were not dosed with RAG. Children in Group II (n 42) were administered all-trans retinoyl glucuronide (RAG) orally, and blood was collected 4 h after the dose. All serum samples were analysed for retinoids and carotenoids. RA was detected in serum only when serum retinol was < 0·85 μmol/l. Thus, hydrolysis of RAG to RA occurred in children with VAD or marginal VAD. Serum retinol was < 0·35 μmol/l in twenty-one children, 0·35–0·7 μmol/l in twenty-three children, 0·7–0·9 μmol/l in eleven children and >1 μmol/l in six children. Mean serum retinol in sixty-one children was 0·522 (sd 0·315) μmol/l. Mean β-carotene (0·016 (sd 0·015) μmol/l) was far below normal compared to the level of lutein (0·176 (sd 0·10) μmol/l) in sixty-one children. A low β-carotene level might be due to a low intake of carotene but high demand for vitamin A. The RAG hydrolysis test may prove to be a useful approach for the determination of marginal VAD with no clinical or subclinical signs of VAD. High prevalence of VAD amongst certain communities in Assam cannot be ruled out.

scholarly journals Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon

2018 ◽  
Vol 12 (8) ◽  
pp. e0006663 ◽  
Author(s):  
Jean Claude Dejon-Agobé ◽  
Jeannot Fréjus Zinsou ◽  
Yabo Josiane Honkpehedji ◽  
Ulysse Ateba-Ngoa ◽  
Jean-Ronald Edoa ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Rural Areas ◽  
Schistosoma Haematobium ◽  
Falciparum Infection ◽  
School Age Children ◽  
School Age ◽  
Soil Transmitted Helminths ◽  
Plasmodium Falciparum Infection
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