scholarly journals Alcohol and dietary fibre intakes affect circulating sex hormones among premenopausal women

2006 ◽  
Vol 9 (7) ◽  
pp. 875-881 ◽  
Author(s):  
Gertraud Maskarinec ◽  
Yukiko Morimoto ◽  
Yumie Takata ◽  
Suzanne P Murphy ◽  
Frank Z Stanczyk
Keyword(s):  
Breast Cancer ◽  
Dietary Fibre ◽  
Premenopausal Women ◽  
Serum Levels ◽  
Sex Hormone ◽  
Least Square ◽  
Sex Hormone Binding Globulin ◽  
Hormone Levels ◽  
Fibre Intake ◽  
Dietary Fibre Intake

AbstractBackgroundThe association of alcohol and fibre intake with breast cancer may be mediated by circulating sex hormone levels, which are predictors of breast cancer risk.ObjectiveTo evaluate the relationship of alcohol and dietary fibre intake with circulating sex hormone levels among premenopausal women.MethodsA total of 205 premenopausal women completed a validated food-frequency questionnaire at baseline and after 2 years; blood samples taken at the same time were analysed for circulating sex hormone concentrations, including oestrone (E1), oestradiol (E2), free E2, progesterone, androstenedione and sex hormone-binding globulin, by radioimmunoassay. We used mixed models to estimate least-square means of sex hormone concentrations for alcohol intake categories and quartiles of dietary intake.ResultsAfter adjustment for covariates, alcohol consumption was moderately associated with higher circulating oestrogen levels; those who consumed more than one drink per day had 20% higher E2 (Ptrend = 0.07) levels than non-drinkers. In contrast, higher dietary fibre intake was associated with lower serum levels of androstenedione (−8% between the lowest and highest quartiles of intake, Ptrend = 0.06), but not oestrogens. Similarly, consumption of fruits (−12%, Ptrend = 0.03), vegetables (−9%, Ptrend = 0.15) and whole grains (−7%, Ptrend = 0.07) showed inverse associations with androstenedione levels.ConclusionsThe consistency of the observed differences in sex hormone levels associated with alcohol and fibre-rich foods indicates that these nutritional factors may affect sex hormone concentrations and play a role in breast cancer aetiology and prevention.

Serum Steroid Hormone Levels, Sex Hormone-Binding Globulin, and Body Mass Index in the Etiology of Postmenopausal Breast Cancer

Epidemiology ◽  
1996 ◽  
Vol 7 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Loren Lipworth ◽  
Hans-Olov Adami ◽  
Dimitrios Trichopoulos ◽  
Kjell Cartström ◽  
Christos Mantzoros
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Steroid Hormone ◽  
Postmenopausal Breast Cancer ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Hormone Levels

scholarly journals Dietary fibre intake and risk of breast cancer: A systematic review and meta-analysis of epidemiological studies

Oncotarget ◽  
2016 ◽  
Vol 7 (49) ◽  
pp. 80980-80989 ◽  
Author(s):  
Sumei Chen ◽  
Yuanyuan Chen ◽  
Shenglin Ma ◽  
Ruzhen Zheng ◽  
Pengjun Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Dietary Fibre Intake Is Associated with Serum Levels of Uraemic Toxins in Children with Chronic Kidney Disease

Toxins ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 225
Author(s):  
Amina El Amouri ◽  
Evelien Snauwaert ◽  
Aurélie Foulon ◽  
Charlotte Vande Moortel ◽  
Maria Van Dyck ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Dietary Fibre ◽  
Serum Levels ◽  
Total Serum ◽  
Inverse Association ◽  
Fibre Intake ◽  
Dietary Choices ◽  
Potential Benefits ◽  
Dietary Fibre Intake

Imbalanced colonic microbial metabolism plays a pivotal role in generating protein-bound uraemic toxins (PBUTs), which accumulate with deteriorating kidney function and contribute to the uraemic burden of children with chronic kidney disease (CKD). Dietary choices impact the gut microbiome and metabolism. The aim of this study was to investigate the relation between dietary fibre and gut-derived PBUTs in paediatric CKD. Sixty-one (44 male) CKD children (9 ± 5 years) were prospectively followed for two years. Dietary fibre intake was evaluated by either 24-h recalls (73%) or 3-day food records (27%) at the same time of blood sampling for assessment of total and free serum levels of different PBUTs using liquid chromatography. We used linear mixed models to assess associations between fibre intake and PBUT levels. We found an inverse association between increase in fibre consumption (g/day) and serum concentrations of free indoxyl sulfate (−3.1% (−5.9%; −0.3%) (p = 0.035)), free p-cresyl sulfate (−2.5% (−4.7%; −0.3%) (p = 0.034)), total indole acetic acid (IAA) (−1.6% (−3.0%; −0.3%) (p = 0.020)), free IAA (−6.6% (−9.3%; −3.7%) (p < 0.001)), total serum p-cresyl glucuronide (pCG) (−3.0% (−5.6%; −0.5%) (p = 0.021)) and free pCG levels (−3.3% (−5.8%; −0.8%) (p = 0.010)). The observed associations between dietary fibre intake and the investigated PBUTs highlight potential benefits of fibre intake for the paediatric CKD population. The present observational findings should inform and guide adaptations of dietary prescriptions in children with CKD.

scholarly journals Endogenous sex hormone levels and breast cancer risk

1987 ◽  
Vol 4 (4) ◽  
pp. 233-247 ◽  
Author(s):  
Lisa Begg ◽  
Lewis H. Kuller ◽  
James P. Gutai ◽  
Arlene G. Caggiula ◽  
Norman Wolmark ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sex Hormone ◽  
Hormone Levels

scholarly journals Intake of dietary fibre and lifetime non-steroidal anti-inflammatory drug (NSAID) use and the incidence of colorectal polyps in a population screened for colorectal cancer

2017 ◽  
Vol 71 (10) ◽  
pp. 961-969 ◽  
Author(s):  
Eileen Shaw ◽  
Matthew T Warkentin ◽  
S Elizabeth McGregor ◽  
Susanna Town ◽  
Robert J Hilsden ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dietary Fibre ◽  
Cross Sectional Study ◽  
Colorectal Polyps ◽  
Cross Sectional ◽  
Fibre Intake ◽  
Screening Population ◽  
Lifestyle Questionnaire ◽  
Dietary Fibre Intake ◽  
Anti Inflammatory

BackgroundThere is suggestive evidence that increased intake of dietary fibre and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are generally associated with decreased colorectal cancer risk. However, the effects on precursors of colorectal cancer, such as adenomatous polyps, are mixed. We present the associations between dietary fibre intake and NSAID use on the presence and type of colorectal polyps in a screening population.MethodsA cross-sectional study of 2548 individuals undergoing colonoscopy at the Forzani & MacPhail Colon Cancer Screening Centre (Calgary, Canada) was conducted. Dietary fibre intake and NSAID use were assessed using the Diet History Questionnaire I or II and the Health and Lifestyle Questionnaire. Colorectal outcomes were documented as a polyp or high-risk adenomatous polyp (HRAP; villous histology, high-grade dysplasia, ≥10 mm or ≥3 adenomas). Crude and ORs and 95% CIs were estimated using unconditional logistic regression.ResultsThere were 1450 negative colonoscopies and 1098 patients with polyps, of which 189 patients had HRAPs. Total dietary fibre intake was associated with a decreased presence of HRAPs (OR=0.50, 95% CI: 0.29 to 0.86) when comparing the highest to lowest quartiles and was observed with both soluble (OR=0.51, 95% CI: 0.30 to 0.88) and insoluble (OR=0.51, 95% CI: 0.30 to 0.86) fibres. Ever use of NSAIDs was also inversely associated with HRAPs (OR=0.65, 95% CI: 0.47 to 0.89), observed with monthly (OR=0.60, 95% CI: 0.37 to 0.95) and daily (OR=0.53, 95% CI: 0.32 to 0.86) use.ConclusionsDietary fibre intake and NSAID use were associated with a decreased risk of having a HRAP at screening.

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