Serum Steroid Hormone Levels, Sex Hormone-Binding Globulin, and Body Mass Index in the Etiology of Postmenopausal Breast Cancer

Epidemiology ◽  
1996 ◽  
Vol 7 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Loren Lipworth ◽  
Hans-Olov Adami ◽  
Dimitrios Trichopoulos ◽  
Kjell Cartström ◽  
Christos Mantzoros
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Steroid Hormone ◽  
Postmenopausal Breast Cancer ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Hormone Levels

Concentrations of sex-hormone binding globulin and corticosteroid binding globulin in serum in relation to cardiovascular risk factors and to 12-year incidence of cardiovascular disease and overall mortality in postmenopausal women.

1986 ◽  
Vol 32 (1) ◽  
pp. 146-152 ◽  
Author(s):  
L Lapidus ◽  
G Lindstedt ◽  
P A Lundberg ◽  
C Bengtsson ◽  
T Gredmark
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Significant Risk ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Corticosteroid Binding Globulin ◽  
Overall Mortality

Abstract We determined sex-hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) by radioimmunoassay of serum samples from a group of 253 women, who were 54 or 60 years old when first studied in 1968-69. The SHBG concentration was highly significantly and inversely related to body mass, body mass index, waist-to-hip circumference ratio, and serum triglyceride concentration; CBG concentration was inversely related to body mass and body mass index. The concentration of neither protein was related to whether or not the subject smoked. Decrease in the concentration of SHBG, but not of CBG, was a significant risk factor for 12-year overall mortality. The plot of the 12-year incidence of myocardial infarction vs SHBG concentration was U-shaped. We recommend that SHBG be included when serum androgens or estrogens are being evaluated as risk factors for cardiovascular disease and death.

Relationship of high density lipoprotein cholesterol with total and free testosterone and sex hormone binding globulin

1983 ◽  
Vol 104 (2) ◽  
pp. 253-256 ◽  
Author(s):  
R. F. Heller ◽  
M. J. Wheeler ◽  
J. Micallef ◽  
N. E. Miller ◽  
B. Lewis
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding

Abstract. A cross-sectional study was performed to see if the previously described association between high density lipoprotein (HDL) cholesterol and plasma total testosterone concentration reflected a relationship with free testosterone or with sex hormone binding globulin (SHBG). In 295 employed middle-aged men, measurements were made of total testosterone and SHBG in serum and of testosterone in saliva, and also of plasma total and HDL cholesterol, plasma triglycerides and other factors which might influence HDL cholesterol levels such as body mass index, alcohol and smoking habits and thyroid hormone levels. In a multiple regression analysis using the GLIM package programme total testosterone concentrations had a persistent positive association with HDL cholesterol (t = 3.5, P < 0.001) – this association was independent of SHBG (which had a negative association with HDL: t = −1.8, P <0.07. The association of HDL cholesterol with testosterone was independent of and stronger than the association of HDL cholesterol with body mass index, alcohol intake and cigarette smoking. Salivary testosterone (a measure of the circulating free hormone) also had a positive independent association with HDL cholesterol. The relationship between HDL cholesterol and testosterone thus appears to reflect an association with circulating hormone levels rather than with the hormone binding globulin.

Effects of aromatase inhibitors and body mass index on steroid hormone levels in women with early and advanced breast cancer

2014 ◽  
Vol 101 (8) ◽  
pp. 939-948 ◽  
Author(s):  
K. M. Elliott ◽  
J. Dent ◽  
F. Z. Stanczyk ◽  
L. Woodley ◽  
R. C. Coombes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Advanced Breast Cancer ◽  
Body Mass ◽  
Aromatase Inhibitors ◽  
Steroid Hormone ◽  
Advanced Breast ◽  
Hormone Levels

Total testosterone and sex hormone-binding globulin are associated with metabolic syndrome independent of age and body mass index in Korean men

Maturitas ◽  
2013 ◽  
Vol 74 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Doohee Hong ◽  
Young-Sang Kim ◽  
Eun Soo Son ◽  
Kyu-Nam Kim ◽  
Bom-Taeck Kim ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding

Physical Activity and Sex Hormone–Binding Globulin in Older Adults

2019 ◽  
Vol 27 (5) ◽  
pp. 621-624
Author(s):  
Dietrich Rothenbacher ◽  
Dhayana Dallmeier ◽  
Michael D. Denkinger ◽  
Bernhard O. Boehm ◽  
Wolfgang Koenig ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Body Mass Index ◽  
Body Mass ◽  
Serum Levels ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Glutamyl Transferase ◽  
Relationship Of

Besides its known function as a transport protein for testosterone and other steroid hormones, sex hormone–binding globulin (SHBG) is a biomarker associated with many adverse health effects. The aim of this study was to investigate the association of physical activity with SHBG serum levels in older adults. The physical activity and SHBG values for 1,259 older adults (43.4% female; 56.6% male) with a mean age of 75.6 ± 6.5 years were included in the analysis. The average daily walking duration was 104.2 ± 40.4 (mean ± SD) min. A positive dose–response relationship of daily walking duration with quartiles of SHBG was seen after adjustment for age, sex, history of cardiovascular diseases, diabetes, smoking, γ-glutamyl transferase, and C-reactive protein (p for trend = .010). However, this relationship disappeared after adjustment for body mass index (p for trend = .977). Body mass index seems to be an important determinant of SHBG and a possible confounding factor in the relationship of physical activity and SHBG.

scholarly journals Sex hormone binding globulin and risk of breast cancer: a Mendelian randomization study

2019 ◽  
Vol 48 (3) ◽  
pp. 807-816 ◽  
Author(s):  
Niki L Dimou ◽  
Nikos Papadimitriou ◽  
Dipender Gill ◽  
Sofia Christakoudi ◽  
Neil Murphy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genome Wide Association Study ◽  
Mendelian Randomization ◽  
Postmenopausal Breast Cancer ◽  
Positive Association ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sensitivity Analyses ◽  
Inverse Association ◽  
Hormone Binding

Abstract Background There are observational data suggesting an inverse association between circulating concentrations of sex hormone binding globulin (SHBG) and risk of postmenopausal breast cancer. However, causality is uncertain and few studies have investigated this association by tumour receptor status. We aimed to investigate these associations under the causal framework of Mendelian randomization (MR). Methods We used summary association estimates extracted from published genome-wide association study (GWAS) meta-analyses for SHBG and breast cancer, to perform two-sample MR analyses. Summary statistics were available for 122 977 overall breast cancer cases, of which 69 501 were estrogen receptor positive (ER+ve) and 21 468 were ER-ve, and 105 974 controls. To control for potential horizontal pleiotropy acting via body mass index (BMI), we performed multivariable inverse-variance weighted (IVW) MR as the main analysis, with the robustness of this approach further tested in sensitivity analyses. Results The multivariable IVW MR analysis indicated a lower risk of overall (odds ratio [OR]: 0.94; 95% confidence interval [CI]: 0.90, 0.98; P: 0.006) and ER+ve (OR: 0.92; 95% CI: 0.87, 0.97; P: 0.003) breast cancer, and a higher risk of ER-ve disease (OR: 1.09; 95% CI: 1.00, 1.18; P: 0.047) per 25 nmol/L higher SHBG levels. Sensitivity analyses were consistent with the findings of the main analysis. Conclusions We corroborated the previous literature evidence coming from observational studies for a potentially causal inverse association between SHBG concentrations and risk of ER+ve breast cancer, but our findings also suggested a potential novel positive association with ER-ve disease that warrants further investigation, given the low prior probability of being true.

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