A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 μg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults

Many types of vitamin supplements are available on the market, but little is known about whether cholecalciferol obtained from fat-containing capsules differs in bioavailability from that of solid tablets. Our objective was to test whether 4 weeks of daily supplementation with 10 μg cholecalciferol given as a fish oil capsule produces a larger increase in serum 25-hydroxyvitamin D (s-25(OH)D) concentration compared with the same dose of cholecalciferol given as a multivitamin tablet. A total of seventy-four healthy subjects aged 19–49 years were initially included and fifty-five of these completed the study and fulfilled the inclusion criteria. After completing a self-administered questionnaire about diet and sunshine exposure and having a non-fasting venous blood sample drawn, participants were randomised to receive daily multivitamin tablets (n 28) or fish oil capsules (n 27), each containing equal doses of cholecalciferol. A second blood sample was drawn after 28 d. Mean baseline s-25(OH)D was 40·3 (sd 22·0) nmol/l in the multivitamin group and 48·5 (24·8) nmol/l in the fish oil group. When controlling for baseline s-25(OH)D, mean 4-week increase in s-25(OH)D was 35·8 (95 % CI 30·9, 40·8) nmol/l in the multivitamin group and 32·3 (95 % CI 27·3, 37·4) nmol/l in the fish oil group; the mean difference was 3·5 (95 % CI − 3·6, 10·6) nmol/l (P = 0·33). The results were unaltered by statistical adjustment for BMI, ethnic background, age and sex. We conclude that fish oil capsules and multivitamin tablets containing 10 μg cholecalciferol administered over a 4-week period produced a similar mean increase in s-25(OH)D concentration.

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Vitamin D Status among Young Children Aged 6 to 23 Months from 4 Different Ethnic Groups in Yunnan, China

Food and Nutrition Bulletin ◽

10.1177/0379572118765825 ◽

2018 ◽

Vol 39 (2) ◽

pp. 260-265

Author(s):

Yanhong Li ◽

Yan Li ◽

Xian Zhang ◽

Lin Zhao ◽

Liqin Chen ◽

...

Keyword(s):

Vitamin D ◽

Young Children ◽

Vitamin D Deficiency ◽

Ethnic Groups ◽

Venous Blood ◽

Hydroxyvitamin D ◽

Significant Difference ◽

25 Hydroxyvitamin D ◽

The Mean ◽

Venous Blood Sampling

Objectives: To determine the prevalence of vitamin D deficiency in 6- to 23-month-old children from 4 different ethnic groups, Han, Lisu, Hani, and Bai, in Yunnan Province of China. Methods: A large cohort of 938 young children aged 6 to 23 months who were living in Yunnan, China (23°28′-27°52′ N), were selected and recruited in this study. Venous-blood sampling was conducted in all the participants, and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. The children’s physical status was measured. Results: General mean serum 25(OH)D level was 21.46 ± 7.95 ng/mL, which was obtained from a total of 938 cases. No significant difference was found in age, gender, height, and weight of participants from different ethnic groups. The mean 25(OH)D level was significantly lower in children of Lisu ethnic groups compared with that of Han and Hani participants, respectively ( P < .05). In addition, Bai children had lower 25(OH)D content than Hani children ( P < .001). Among the children with 25(OH)D sufficiency, the number of Lisu participants was significantly lower than Han children ( P < .001). Conclusion: The prevalence of vitamin D deficiency varied among the ethnically different children in Yunnan, China, and significantly fewer Lisu children maintained vitamin D sufficiency compared with other ethnic children. Recognizing these ethnic differences in treating children with vitamin D deficiency may improve the therapeutic outcome.

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Comparison of the effect of three intramuscular sedation protocols on packed cell volume and total protein in cats

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x211064702 ◽

2021 ◽

pp. 1098612X2110647

Author(s):

Alicia M Skelding ◽

Alexander Valverde

Keyword(s):

Clinical Study ◽

Blood Sample ◽

Cell Volume ◽

Total Protein ◽

Packed Cell Volume ◽

Venous Blood ◽

Blood Sampling ◽

Venous Blood Sample ◽

To Receive ◽

Venous Blood Sampling

Objectives The aim of this study was to evaluate the change in packed cell volume (PCV) and total protein following intramuscular preanesthetic sedation with one of three drug combinations in cats. Methods Thirty client-owned cats were enrolled in this prospective, randomized, blinded, clinical study. A venous blood sample was obtained prior to administration of any sedation and PCV, total protein, electrolytes (Na+, K+, Cl–, iCa2+), glucose and lactate were measured. Cats were randomly assigned to receive one of three intramuscular sedation protocols (n = 10 cats/protocol): methadone 0.2 mg/kg + acepromazine 0.02 mg/kg (MA), methadone 0.2 mg/kg + dexmedetomidine 5 µg/kg (MD) or methadone 0.2 mg/kg + midazolam 0.2 mg/kg + alfaxalone 2 mg/kg (MMA). Twenty-five minutes later, cats were assessed for level of sedation followed by another venous blood sampling to evaluate the same variables as above. Results There were no significant differences in demographics (age, weight, sex) between groups. Level of sedation was significantly higher in MMA cats. Within groups, after premedication, PCV and hemoglobin significantly decreased in all groups, total protein significantly decreased in the MA and MMA groups and glucose significantly increased in the MD group. For electrolytes, statistical changes were not clinically relevant; Cl– mean difference was significantly different between MA and MD; in the MD group Na+ and Cl– significantly decreased and in the MMA group Cl– significantly increased. Conclusions and relevance All three sedation protocols caused significant decreases in PCV and hemoglobin in healthy cats.

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Efficacy and safety of a single monthly dose of cholecalciferol in healthy school children

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2015-0187 ◽

2016 ◽

Vol 29 (4) ◽

Cited By ~ 6

Author(s):

Mohammad Shafi Kuchay ◽

Ganesh Sudhakar Jevalikar ◽

Ambrish Mithal ◽

Sunil Kumar Mishra ◽

Navin Dang

Keyword(s):

Vitamin D ◽

School Children ◽

Cost Effective ◽

Vitamin D Supplementation ◽

Efficacy And Safety ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

The Mean ◽

To Receive ◽

Monthly Dose

AbstractThis study aimed to evaluate the efficacy and safety of a single monthly dose of cholecalciferol in healthy school children.A total of 118 children of class VI of a residential school were selected to receive vitamin D supplementation in the form of oral cholecalciferol 60,000 IU monthly. Serum calcium and 25-hydroxyvitamin D (25OHD) levels were estimated at 0 and 12 months. The proportion of subjects achieving vitamin D sufficiency was assessed.The mean 25OHD levels increased significantly from 12.04±5.27 ng/mL at baseline to 32.6±7.05 ng/mL after 12 months of supplementation (p<0.001). None developed hypercalcemia.Vitamin D supplementation in the doses of 60,000 IU monthly is a reasonable, safe and cost-effective regimen for children to attain and maintain vitamin D sufficiency.

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Effect of High- versus Low-Fat Meal on Serum 25-Hydroxyvitamin D Levels after a Single Oral Dose of Vitamin D: A Single-Blind, Parallel, Randomized Trial

International Journal of Endocrinology ◽

10.1155/2011/809069 ◽

2011 ◽

Vol 2011 ◽

pp. 1-5 ◽

Cited By ~ 17

Author(s):

Fabiana Viegas Raimundo ◽

Gustavo Adolpho Moreira Faulhaber ◽

Paula Kalinka Menegatti ◽

Leonardo da Silva Marques ◽

Tania Weber Furlanetto

Keyword(s):

Vitamin D ◽

Oral Absorption ◽

Oral Intake ◽

Food Group ◽

Low Fat ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

L 14 ◽

Single Blind ◽

Fat Meal

Background/Aims. Vitamin D3is liposoluble, so dietary fat could increase its oral absorption. Our aim was to compare serum 25-hydroxyvitamin D [25(OH)D] after the oral intake of cholecalciferol with a high- or low-fat meal.Methods. In a single-blind, parallel clinical trial, 32 healthy physicians were divided into two groups. In the same day, they ingested 50,000 IU (1.25 mg) of vitamin D3with food: group 1 (G1): lipids: 25.6 g and group 2 (G2) lipids: 1.7 g. Serum 25(OH)D (0, 7, and 14 days), and parathyroid hormone (PTH), and calcium (0 and 14 days) were measured.Results. Baseline mean serum 25(OH)D levels were42.7±19.0 nmol/L in G1 and36.4±19.0 nmol/L in G2 (P=0.38). After cholecalciferol, mean serum 25(OH)D was higher in G1 (P<0.001): 7 days: G1 = 46.2 (38.4–53.9) nmol/L and G2 = 33.7 (25.4–40.1) nmol/L; 14 days: G1 = 53.7 (45.2–62.1) nmol/L and G2 = 33.7 (25.2–42.2) nmol/L. Serum PTH and 25(OH)D were negatively correlated before and after the intake of vitamin D3, respectively,r=-0.42(P=0.02) andr=-0.52(P=0.003).Conclusions. A high-fat meal increased the absorption of vitamin D3, as measured by serum 25(OH)D.

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Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Nutrients ◽

10.3390/nu13103442 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3442

Author(s):

Alicja Kołodziejczyk-Nowotarska ◽

Renata Bokiniec ◽

Joanna Seliga-Siwecka

Keyword(s):

Vitamin D ◽

Preterm Infants ◽

Controlled Trial ◽

Vitamin D Supplementation ◽

Control Group ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Ultrasound Findings ◽

25 Hydroxyvitamin D ◽

To Receive

Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy (n = 55; approximately 800–1000 IU from combined sources) or monitored therapy (n = 54; with an option of dose modification). 25-hydroxyvitamin D [25(OH)D] concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52 ± 2 weeks of post-conceptional age (PCA). Vitamin D supplementation was discontinued in 23% of infants subjected to standard treatment due to increased potentially toxic 25(OH)D concentrations (>90 ng/mL) at 40 weeks of PCA. A significantly higher infants’ percentage in the monitored group had safe vitamin D levels (20−80 ng/mL) at 52 weeks of PCA (p = 0.017). We observed increased vitamin D levels and abnormal ultrasound findings in five infants. Biochemical markers of vitamin D toxicity were observed in two patients at 52 weeks of PCA in the control group. Inadequate and excessive amounts of vitamin D can lead to serious health problems. Supplementation with 800–1000 IU of vitamin D prevents deficiency and should be monitored to avoid overdose.

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Modelling vitamin D status due to oral intake and sun exposure in an adult British population

British Journal Of Nutrition ◽

10.1017/s0007114512005466 ◽

2013 ◽

Vol 110 (3) ◽

pp. 569-577 ◽

Cited By ~ 10

Author(s):

Brian L. Diffey

Keyword(s):

Vitamin D ◽

Observational Studies ◽

Oral Intake ◽

Sun Exposure ◽

Oral Vitamin ◽

Hydroxyvitamin D ◽

Geographical Patterns ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Uk

A mathematical model is described for estimating changes in plasma 25-hydroxyvitamin D (25(OH)D) levels throughout the year as a consequence of varying the oral intake of vitamin D and the behaviour outdoors of white British adults resident in different regions of the UK. The model yields seasonal and geographical patterns of 25(OH)D concentrations that agree closely with observational studies. Use of the model allows estimates to be easily made of the sun exposure and oral intake necessary to avoid vitamin D deficiency in defined proportions of the population, as well as strategies that would lead to vitamin D sufficiency throughout the year. The analysis demonstrates that addressing concerns about insufficient vitamin D levels, especially during the winter, may be achieved by modifying oral vitamin D intake over the winter, increasing summer sun exposure or a combination of both.

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