The effects of a low-sodium base-producing diet including red meat compared with a high-carbohydrate, low-fat diet on bone turnover markers in women aged 45–75 years

A randomised, parallel-design dietary intervention study was conducted in women (aged 45–75 years) with prehypertension or stage 1 hypertension. The aim was to compare the effects on bone turnover of a low-Na base-producing (LNAB) Dietary Approaches to Stop Hypertension (DASH)-type diet (including six serves lean red meat/week) with a high-carbohydrate low-fat (HCLF) diet with a higher acid load (both >800 mg dietary Ca/d). Fasting serum bone markers (baseline and week 14) and 24 h urinary electrolyte excretion (baseline, weeks 4, 8, 12 and 14) were measured. After the intervention period, the LNAB group (n 46) had a fall of 26 (sem 6) % (P < 0·0001) in urinary Na, an increase in K excretion (6·8 (sem 3·6) mmol/d; P = 0·07) and, compared with the HCLF group (n 49), a greater reduction in urinary Ca excretion by 0·7 (sem 0·3) mmol/d. Serum 25-hydroxyvitamin D, intact parathyroid hormone and osteocalcin did not change, and both groups had a similar increase of 23 (sem 5) % (P < 0·0001) in C-terminal telopeptide of type I collagen. The HCLF group had an 11 (sem 4) % increase (P = 0·003) in N-terminal propeptide, type I procollagen, which could indicate an increased rate of bone turnover. The fall in urinary Ca with the lower-Na lower-acid load diet is likely to have long-term beneficial effects on bone. As bone resorption was not different between the two dietary patterns with relatively high Ca intake, the effect on bone health of a dietary pattern with a lower acid load warrants further study on a lower Ca intake.

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SAT-021 Effects of E2/P4 Oral Capsules on Bone Turnover in Women with Vasomotor Symptoms

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.536 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Ginger Constantine ◽

Michael R McClung ◽

Risa Kagan ◽

Shelli Graham ◽

Brian Bernick ◽

...

Keyword(s):

Bone Turnover ◽

Type I Collagen ◽

Osteoporotic Fractures ◽

Vasomotor Symptoms ◽

Type I ◽

Bone Specific Alkaline Phosphatase ◽

Type I Procollagen ◽

Turnover Markers ◽

Mean Differences ◽

Post Hoc

Abstract Menopausal hormone therapy slows bone turnover and reduces the risk of osteoporotic fractures. The objective of this post hoc analysis was to evaluate bone turnover markers (BTM) in the phase 3 REPLENISH trial, which evaluated vasomotor symptoms (VMS) with an oral estradiol/progesterone (E2/P4) in postmenopausal women with a uterus. Eligible women for this analysis had ≥50 moderate to severe VMS/week, <5 years since last menstrual period, and BTM measurements at baseline, and months 6 and 12. Percent changes for 3 BTM (bone specific alkaline phosphatase [BSAP], C-terminal telopeptide of type I collagen [CTX-1], and N-terminal propeptide of type I procollagen [PINP]) assessed by immunoassay methods were evaluated from baseline to months 6 and 12 for the 1/100, 0.5/100 and placebo groups. A total of 157 women (40–61 years, 69% White) were analyzed (56 for each 1/100 and 0.5/100; 45 for placebo). Mean baseline values ranged from 14.0–14.3 U/L for BSAP, 0.34–0.39 ng/mL for CTX-1, and 76.9–79.3 ng/mL for PINP. Mean differences in percent change from baseline versus placebo significantly decreased with both E2/P4 doses for all 3 BTM at months 6 and 12. Mean differences from placebo for E2/P4 at months 6/12 ranged from -8.1% to -17.8% for BSAP (all, P≤0.02), -30% to -41% for CTX-1 (all, P≤0.001), and -14% to -29% for PINP (all, P≤0.007). REPLENISH data provide support for a potential skeletal benefit of E2/P4 when used for the treatment of moderate to severe VMS.

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Oncological validation of bone turnover markers c-terminal telopeptide of type I collagen (1CTP) and peptides n-terminal propeptide of type I procollagen (P1NP) in patients with prostate cancer and bone metastases

Translational Andrology and Urology ◽

10.21037/tau-20-1120 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Stefan Aufderklamm ◽

Jörg Hennenlotter ◽

Steffen Rausch ◽

Cornelia Bock ◽

Eva Erne ◽

...

Keyword(s):

Prostate Cancer ◽

Bone Turnover ◽

Bone Metastases ◽

Bone Turnover Markers ◽

Type I Collagen ◽

Type I ◽

Type I Procollagen ◽

Turnover Markers

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Inhibition of bone turnover by milk intake in postmenopausal women

British Journal Of Nutrition ◽

10.1017/s0007114508937429 ◽

2008 ◽

Vol 100 (4) ◽

pp. 866-874 ◽

Cited By ~ 36

Author(s):

Jean-Philippe Bonjour ◽

Marion Brandolini-Bunlon ◽

Yves Boirie ◽

Françoise Morel-Laporte ◽

Véronique Braesco ◽

...

Keyword(s):

Parathyroid Hormone ◽

Bone Loss ◽

Bone Turnover ◽

Postmenopausal Women ◽

Type I Collagen ◽

Hormone Secretion ◽

Type I ◽

Type I Procollagen ◽

Prevention Of Osteoporosis ◽

Skimmed Milk

Increased postmenopausal bone turnover leads to bone loss and fragility fracture risk. In the absence of osteoporosis, risk preventive measures, particularly those modifying nutritional lifestyle, are appropriate. We tested the hypothesis that milk supplementation affects bone turnover related to biochemical markers in a direction that, in the long term, may be expected to reduce postmenopausal bone loss. Thirty healthy postmenopausal women aged 59·3 (sd3·3) years were enrolled in a prospective crossover trial of 16 weeks. After a 4-week period of adaptation with diet providing 600 mg calcium plus 300 mg ingested as 250 ml semi-skimmed milk, participants were maintained during 6 weeks under the same 600 mg calcium diet and randomized to receive either 500 ml semi-skimmed milk, thus providing a total of 1200 mg calcium, or no milk supplement. In the next 6 weeks they were switched to the alternative regimen. At the end of the each period, i.e. after 4, 10 and 16 weeks, blood and urinary samples were collected. The changes in blood variables between the periods of 6 weeks without and with milk supplementation were: for parathyroid hormone, − 3·2 pg/ml (P = 0·0054); for crosslinked telopeptide of type I collagen, − 624 pg/ml (P < 0·0001); for propeptide of type I procollagen, − 5·5 ng/ml (P = 0·0092); for osteocalcin, − 2·8 ng/ml (P = 0·0014). In conclusion, a 6-week period of milk supplementation induced a decrease in several biochemical variables compatible with diminished bone turnover mediated by reduction in parathyroid hormone secretion. This nutritional approach to postmenopausal alteration in bone metabolism may be a valuable measure in the primary prevention of osteoporosis.

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Levels of bone turnover markers (N-terminal propeptide of type I procollagen and carboxy-terminal telopeptide of type I collagen) in Ukrainian population of different age and gender

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.16.7.2020.219005 ◽

2020 ◽

Vol 16 (7) ◽

pp. 515-525

Author(s):

V.V. Povoroznyuk ◽

I.V. Pankiv ◽

N.V. Zaverukha ◽

T.Yu. Solonenko ◽

A.S. Musiienko

Keyword(s):

Bone Turnover ◽

Bone Turnover Markers ◽

Type I Collagen ◽

Type I ◽

Age And Gender ◽

Type I Procollagen ◽

Turnover Markers ◽

And Gender ◽

Carboxy Terminal

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Low Serum 25-hydroxyvitamin D Level Does Not Adversely Affect Bone Turnover in Prepubertal Children

Nutrients ◽

10.3390/nu13103324 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3324

Author(s):

Wojciech J. Bilinski ◽

Lukasz Szternel ◽

Joanna Siodmiak ◽

Przemyslaw T. Paradowski ◽

Krzysztof Domagalski ◽

...

Keyword(s):

Bone Turnover ◽

Type I Collagen ◽

Type I ◽

Healthy Children ◽

Strong Positive Correlation ◽

Hydroxyvitamin D ◽

Type I Procollagen ◽

25 Hydroxyvitamin D ◽

Turnover Markers ◽

Low Serum

Both vitamin D and insulin-like growth factor 1 (IGF-1) play essential roles in bone metabolism and may interact during prepubertal bone accrual. We investigated the association of low serum 25-hydroxyvitamin D (25(OH)D) (<20 ng/mL) with the circulating bone turnover markers, when compared to their interaction with IGF-1. Subjects and Methods: Serum 25(OH)D, IGF-I, P1NP (N-terminal propeptide of type I procollagen), and CTX-1 (C-terminal telopeptide of type I collagen) were measured, and the bone turnover index (BTI) was calculated in 128 healthy children, aged 9–11 years. Results: Mean 25(OH)D concentration was 21.9 ± 4.9 ng/mL, but in 30.5% of participants it was <20 ng/mL (<50 nmol/L). We observed a trend for higher P1NP (p < 0.05) and IGF-1 (p = 0.08), towards lower 25(OH)D in tertiles. Levels of P1NP in the lowest 25(OH)D tertile (<20 ng/mL) were the highest, while CTX and BTI remained unchanged. Additionally, 25(OH)D negatively correlated with IGF-1, while the correlation with P1NP was not significant. A strong positive correlation of IGF-1 with P1NP and BTI but weak with CTX was observed. Low 25(OH)D (<20 ng/mL) explained 15% of the IGF-1 variance and 6% of the P1NP variance. Conclusions: Low levels of 25(OH)D do not unfavorably alter bone turnover. It seems that serum 25(OH)D level may not be an adequate predictor of bone turnover in children.

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Effects of different vibration frequencies on muscle strength, bone turnover and walking endurance in chronic stroke

Scientific Reports ◽

10.1038/s41598-020-80526-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Zhenhui Yang ◽

Tiev Miller ◽

Zou Xiang ◽

Marco Y. C. Pang

Keyword(s):

Muscle Strength ◽

Bone Turnover ◽

Intervention Program ◽

Type I Collagen ◽

Chronic Stroke ◽

Medium Effect ◽

Whole Body ◽

Type I ◽

Leg Muscle ◽

Walking Endurance

AbstractThis randomized controlled trial aimed to evaluate the effects of different whole body vibration (WBV) frequencies on concentric and eccentric leg muscle strength, bone turnover and walking endurance after stroke. The study involved eighty-four individuals with chronic stroke (mean age = 59.7 years, SD = 6.5) with mild to moderate motor impairment (Fugl-Meyer Assessment lower limb motor score: mean = 24.0, SD = 3.5) randomly assigned to either a 20 Hz or 30 Hz WBV intervention program. Both programs involved 3 training sessions per week for 8 weeks. Isokinetic knee concentric and eccentric extension strength, serum level of cross-linked N-telopeptides of type I collagen (NTx), and walking endurance (6-min walk test; 6MWT) were assessed at baseline and post-intervention. An intention-to-treat analysis revealed a significant time effect for all muscle strength outcomes and NTx, but not for 6MWT. The time-by-group interaction was only significant for the paretic eccentric knee extensor work, with a medium effect size (0.44; 95% CI: 0.01, 0.87). Both WBV protocols were effective in improving leg muscle strength and reducing bone resorption. Comparatively greater improvement in paretic eccentric leg strength was observed for the 30 Hz protocol.

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Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

Journal of the International Society of Sports Nutrition ◽

10.1186/s12970-021-00430-8 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Jan Mieszkowski ◽

Andrzej Kochanowicz ◽

Elżbieta Piskorska ◽

Bartłomiej Niespodziński ◽

Joanna Siódmiak ◽

...

Keyword(s):

Vitamin D ◽

Bone Formation ◽

Bone Turnover ◽

Bone Turnover Markers ◽

Type I Collagen ◽

Serum Levels ◽

Type I ◽

Vitamin D Metabolites ◽

Physically Active ◽

Turnover Markers

Abstract Purpose/introduction To compare serum levels of bone turnover markers in athletes and non-athletes, and to evaluate the relationship between serum levels of vitamin D metabolites and exercise-induced changes in biomarker levels. Methods Sixteen elite male artistic gymnasts (EG; 21.4 ± 0.8 years-old) and 16 physically active men (the control group, PAM; 20.9 ± 1.2 years-old) performed lower and upper body 30-s Wingate anaerobic tests (LBWT and UBWT, respectively). For biomarker analysis, blood samples were collected before, and 5 and 30 min after exercise. Samples for vitamin D levels were collected before exercise. N-terminal propeptide of type I collagen (PINP) was analysed as a marker of bone formation. C-terminal telopeptide of type I collagen (CTX) was analysed as a marker of bone resorption. Results UBWT fitness readings were better in the EG group than in the PAM group, with no difference in LBWT readings between the groups. UBWT mean power was 8.8% higher in subjects with 25(OH)D3 levels over 22.50 ng/ml and in those with 24,25(OH)2D3 levels over 1.27 ng/ml. Serum CTX levels increased after both tests in the PAM group, with no change in the EG group. PINP levels did not change in either group; however, in PAM subjects with 25(OH)D3 levels above the median, they were higher than those in EG subjects. Conclusion Vitamin D metabolites affect the anaerobic performance and bone turnover markers at rest and after exercise. Further, adaptation to physical activity modulates the effect of anaerobic exercise on bone metabolism markers.

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Diurnal Rhythms of Bone Turnover Markers in Three Ethnic Groups

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2016-1183 ◽

2016 ◽

Vol 101 (8) ◽

pp. 3222-3230 ◽

Cited By ~ 25

Author(s):

Jean Redmond ◽

Anthony J. Fulford ◽

Landing Jarjou ◽

Bo Zhou ◽

Ann Prentice ◽

...

Keyword(s):

Bone Turnover ◽

Bone Metabolism ◽

Ethnic Groups ◽

Bone Turnover Markers ◽

Type I Collagen ◽

Diurnal Rhythms ◽

Type I ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

Turnover Markers

Context: Ethnic groups differ in fragility fracture risk and bone metabolism. Differences in diurnal rhythms (DRs) of bone turnover and PTH may play a role. Objective: We investigated the DRs of plasma bone turnover markers (BTMs), PTH, and 1,25(OH)2D in three groups with pronounced differences in bone metabolism and plasma PTH. Participants: Healthy Gambian, Chinese, and white British adults (ages 60–75 years; 30 per country). Interventions: Observational study with sample collection every 4 hours for 24 hours. Main Outcomes: Levels of plasma C-terminal telopeptide of type I collagen, procollagen type-1 N-propeptide, N-mid osteocalcin, bone alkaline phosphatase, PTH, and 1,25-dihydroxyvitamin D were measured. DRs were analyzed with random-effects Fourier regression and cross-correlation and regression analyses to assess associations between DRs and fasting and 24-hour means of BTMs and PTH. Results: Concentrations of BTMs, PTH, and 1,25-dihydroxyvitamin D were higher in Gambians compared to other groups (P < .05). The DRs were significant for all variables and groups (P < .03) and were unimodal, with a nocturnal peak and a daytime nadir for BTMs, whereas PTH had two peaks. The DRs of BTMs and PTH were significantly cross-correlated for all groups (P < .05). There was a significant positive association between C-terminal telopeptide of type I collagen and PTH in the British and Gambian groups (P = .03), but not the Chinese group. Conclusions: Despite ethnic differences in plasma BTMs and PTH, DRs were similar. This indicates that alteration of rhythmicity and loss of coupling of bone resorption and formation associated with an elevated PTH in other studies may not uniformly occur across different populations and needs to be considered in the interpretation of PTH as a risk factor of increased bone loss.

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