scholarly journals Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats

2011 ◽  
Vol 108 (4) ◽  
pp. 603-610 ◽  
Author(s):  
Shali Xie ◽  
Jundong Zhu ◽  
Yanqi Zhang ◽  
Kai Shi ◽  
Yuangang Shi ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Cholesterol Concentration ◽  
Lipid Levels ◽  
Sprague Dawley ◽  
Vasoactive Substances ◽  
Sprague Dawley Rats ◽  
Diet Control ◽  
Blood Lipid Levels

In the present study, we aimed to examine the effects of soya oligosaccharides (SOS) and soya oligopeptides (SOP) on blood lipid levels, release of vasoactive substances, antioxidant activity and faecal bile acid (FBA) excretion in rats fed a high-fat diet (HFD). Male Sprague–Dawley rats were evenly divided into five groups according to diets as follows: regular diet (control), HFD, HFD enriched with 2 % of SOS (SOS), HFD enriched with 3 % of SOP (SOP) and HFD enriched with 2 % SOS and 3 % SOP (SOSP). The results showed that SOS and SOP significantly reduced plasma total cholesterol, LDL-cholesterol and TAG, whereas HDL-cholesterol concentration was significantly increased. Furthermore, SOS and SOP reduced plasma apoB, apoE and the apoB:apoAI ratio, whereas apoAI was significantly increased. Moreover, SOS and SOP also reduced plasma thromboxane A2(TXA2) and the TXA2:prostacyclin (PGI2) ratio, whereas plasma PGI2and nitric oxide were significantly increased. In addition, SOS and SOP significantly reduced serum and liver malondialdehyde concentrations and increased FBA excretion. However, we did not observe obvious influences of SOS and SOP on superoxide dismutase activities in the liver of HFD-fed rats. The combination of 2 % SOS and 3 % SOP showed a more marked effect than SOS or SOP alone in improving the lipid profile, release of vasoactive substances and increasing FBA excretion (P < 0·05). In summary, SOS and SOP might help prevent atherosclerosis through improving abnormal blood lipid levels, regulating vasoactive substances and protecting against oxidative stress.

scholarly journals Effect of Yogurt Fermented by Lactobacillus Fermentum TSI and L. Fermentum S2 Derived from a Mongolian Traditional Dairy Product on Rats with High-Fat-Diet-Induced Obesity

Foods ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 594
Author(s):  
Won-Young Cho ◽  
Go-Eun Hong ◽  
Ha-Jung Lee ◽  
Su-Jung Yeon ◽  
Hyun-Dong Paik ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Dairy Product ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Normal Diet ◽  
Lactobacillus Fermentum ◽  
Sprague Dawley ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Saline Administration

This study aimed to investigate the metabolic effect of yogurt fermented by Lactobacillus fermentum TSI and S2 isolated from a Mongolian traditional dairy product on rats with high-fat-diet-induced obesity. Quality characteristics of yogurt fermented by commercial starter (CON), L. fermentum TSI2 (TSI2 group), L. fermentum S2 (S2 group), and mixed TSI2 and S2 strains at 1:1 (MIX group), were verified. Six-week-old male Sprague-Dawley rats were divided into five groups and administered the following diets: group NOR, normal diet with oral saline administration; group HF, high-fat diet (HD) with oral saline administration; group TSI, HD and L. fermentum TSI-fermented yogurt; group S2, HD and L. fermentum S2-fermented yogurt; and group MIX, HD and MIX-fermented yogurt. After eight weeks, the HD groups displayed significantly increased body weight and fat, serum cholesterol, and abdominal adipose tissue levels. However, serum HDL cholesterol levels were higher, triglyceride levels were lower, and abdominal adipocytes were smaller in the TSI and S2 groups than in the HF group. These results indicate that L. fermentum TSI reduces abdominal fat and improves blood lipid metabolism in HD-induced obese rats.

scholarly journals PENGARUH PEMBERIAN SARI DAUN CINCAU HIJAU (PREMNA OBLONGIFOLIA MERR) TERHADAP KADAR KOLESTEROL HDL DAN KOLESTEROL LDL TIKUS SPRAGUE DAWLEY DISLIPIDEMIA

2012 ◽  
Vol 1 (1) ◽  
pp. 265-272
Author(s):  
Ananda Eka Astirani ◽  
Hesti Murwani Rahayuningsih
Keyword(s):  
Fruits And Vegetables ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Cholesterol Concentration ◽  
Sprague Dawley ◽  
Fat Consumption ◽  
Sprague Dawley Rats ◽  
Post Test ◽  
Experimental Laboratory ◽  
Randomized Control

Background : Dyslipidemia is an increase in total cholesterol, LDL-cholesterol and triglycerides and also decrease HDL-cholesterol concentration from normal range. Restricting fat consumption, increasing intake of fruits and vegetables rich in fiber and antioxidant can help manage dyslipidemia. Green grass jelly (Premna oblongifolia Merr) rich in fiber and chlorophyll which can increase HDL-cholesterol and decrease LDL cholesterol. Objective : to analyze the effect of green grass jelly extract on HDL-cholesterol and LDL-cholesterol alteration. Methods : This research was experimental laboratory using pre-post test with randomized control groups design. Sample were male Sprague Dawley rats, 7-8 weeks old, inducted dyslipidemia, given green grass jelly diet using 2,7 ml and 5,4 ml dosage for 28 days. HDL-cholesterol and LDL-cholesterol were measured by CHOD-PAP and diasis reagent. Normality data were tested by Saphiro Wilk test. Data were analyzed by paired t test/wilcoxon and Anova/ Kruskal wallis. Result : Green grass jelly (Premna oblongifolia Merr) extract 5,4 ml/day can significantly increase HDL-cholesterol in Sprague dawley dyslipidemia rats from 22,29±4,82 mg/dl to 27,29±3,82 mg/dl (p<0,05) but have no effect for decreasing LDL-cholesterol serum. Conclusion : Green grass jelly (Premna oblongifolia Merr) extract 5,4 ml/day can significantly increase HDL-cholesterol in Sprague dawley dyslipidemia rats for about 22%.

SNPs in Apolipoproteins Contribute to Sex-Dependent Differences in Blood Lipids Before and After A Dietary Challenge in Healthy U.S. Adults

2020 ◽  
Author(s):  
Yining E. Wang ◽  
Catherine P. Kirschke ◽  
Leslie R. Woodhouse ◽  
Ellen L. Bonnel ◽  
Charles B. Stephensen ◽  
...  
Keyword(s):  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Healthy Adults ◽  
Dependent Manner ◽  
Lipid Levels ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Postprandial Triglyceride ◽  
Before And After ◽  
Blood Lipid Levels

Abstract Background The effect of genetic polymorphisms on fasting blood lipid levels have been widely studied but the effects of these within the context of a meal challenge remain less characterized. The current study aimed to investigate the association of SNPs in lipoprotein-related genes with blood lipid levels in healthy adults in the U.S. Methods Men and women (n = 393) between 18-66 years of age with BMIs ranging from 18.5-45 kg/m 2 completed the cross-sectional Nutritional Phenotyping Study. Among them, 349 subjects (men = 167, 48%; women = 182, 52%) gave consent for genotyping. SNPs in APOA5 , APOB , APOC3 , APOE , and LDLR were assessed. Results Reduced blood HDL-cholesterol levels were associated with the C allele of the APOA5 SNP (rs3135506) in women and the C allele of the APOE SNP (rs429358) in men in both fasting and postprandial states. The C allele of the APOE SNP was also correlated with increased LDL-C levels. The APOC3 rs2854116 TT genotype was associated with elevated total cholesterol in both sexes. Nevertheless, these SNPs had little impact on the postprandial triglyceride responses to the high-fat challenge meal. Additionally, no significant effects of SNPs in APOB (rs1042034) and LDLR (rs2228671) on triglycerides, cholesterol, or non-esterified free fatty acids levels were found. Conclusions Cholesterol levels are strongly correlated with genotypes of the tested SNPs in APOA5 and APOE in a sex-dependent manner during fasting and postprandial states of healthy adults. Trial registration: ClinicalTrials.gov, NCT02367287. Registered February 20, 2015, https://clinicaltrials.gov/ct2/show/NCT02367287.

Effect of Armillaria mellea on Blood Lipid Levels and Antioxidant Enzymes Activity in High Fat Mice

2014 ◽  
Vol 884-885 ◽  
pp. 423-428
Author(s):  
Yan Hui Yang ◽  
Guo Qiang Zheng ◽  
Juan Tang ◽  
Yue Meng Wang ◽  
Chuan Wang Zhu ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
High Fat Diet ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Model Group ◽  
High Fat ◽  
Treatment Groups ◽  
Armillaria Mellea ◽  
And Oxidative Stress ◽  
Blood Lipid Levels

The effect of Armillaria mellea on blood lipid levels and oxidative stress in mice fed on high-fat diet was investigated. Animals were allocated to the Armillaria mellea polysaccharides-treatment groups (I, II) and Armillaria mellea oligosaccharides-treatment groups (I, II). All mice were fed with high-fat diet for 40 days but control mice with basic diet. TC, TG, HDL-c, LDL-c were measured by enzymatic and colorimetric methods. The same, MDA,SOD, GSH-PX were measured. Results showed that administration of Armillaria mellea polysaccharides and oligosaccharides significantly increased antioxidant enzymes GSH-Px activities and decreased TC, TG, LDL-c, MDA level in mice (P < 0.05) compared with model group. In conclusion Armillaria mellea polysaccharides and oligosaccharides were able to protect mices antioxidative and improve abnormal blood lipid levels.

Blood Lipid Levels in a Rural Male Population

2001 ◽  
Vol 8 (3) ◽  
pp. 165-174 ◽  
Author(s):  
A. Thelin ◽  
E.-L. Stiernstrom ◽  
S. Holmberg
Keyword(s):  
Blood Lipid ◽  
Lipid Levels ◽  
Male Population ◽  
Blood Lipid Levels
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