scholarly journals Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial

2013 ◽  
Vol 111 (7) ◽  
pp. 1263-1271 ◽  
Author(s):  
Juan Mielgo-Ayuso ◽  
Lurdes Barrenechea ◽  
Pilar Alcorta ◽  
Eider Larrarte ◽  
Javier Margareto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Function ◽  
Cardiometabolic Risk ◽  
Ldl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
Obese Women ◽  
Restricted Diet ◽  
Control Groups ◽  
Double Blind ◽  
And Control

The aim of the present study was to examine the effects of green tea epigallocatechin-3-gallate (EGCG) on changes in body composition, energy and substrate metabolism, cardiometabolic risk factors and liver function enzymes after an energy-restricted diet intervention in obese women. In the present randomised, double-blind, placebo-controlled study, eighty-three obese (30 kg/m2>BMI < 40 kg/m2) pre-menopausal women consumed 300 mg/d of EGCG or placebo (lactose). We measured body weight and adiposity (dual-energy X-ray absorptiometry), energy expenditure and fat oxidation rates (indirect calorimetry), blood lipid levels (TAG, total cholesterol, LDL-cholesterol and HDL-cholesterol), insulin resistance, C-reactive protein and liver function markers (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, γ-glutamyltransferase, urea, bilirubin and 2-keto[1-13C]isocaproate oxidation) before and after the intervention in the EGCG and control groups. We did not find any significant difference in the changes in body weight ( − 0·3 kg, 95 % CI − 5·0, 4·3), fat mass ( − 0·7 kg, 95 % CI − 3·5, 2·1), energy (0·3 kJ/kg per d, 95 % CI − 3·1, 2·7) and fat ( − 0·1 g/min, 95 % CI − 0·03, 0·01) metabolism, homeostasis assessment model for insulin resistance (0·2, 95 % CI − 0·2, 0·7), total cholesterol ( − 0·21 mmol/l, 95 % CI − 0·55, 0·13), LDL-cholesterol ( − 0·15 mmol/l, 95 % CI − 0·50, 0·20), TAG ( − 0·14 mmol/l, 95 % CI − 0·56, 0·29) and liver function markers between the EGCG and control groups. In conclusion, the present results suggest that dietary supplementation with 300 mg/d of EGCG for 12 weeks did not enhance energy-restricted diet-induced adiposity reductions, and did not improve weight-loss-induced changes in cardiometabolic risk factors in obese Caucasian women. The intake of 300 mg/d of EGCG for 12 weeks did not cause any adverse effect on liver function biomarkers.

scholarly journals Association of Blood Cadmium Level with Cardiometabolic Risk Factors and Liver Enzymes in a Nationally Representative Sample of Adolescents: The CASPIAN-III Study

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Roya Kelishadi ◽  
Ahmadreza Askarieh ◽  
Mohammaad Esmaeil Motlagh ◽  
Mohammadhasan Tajadini ◽  
Ramin Heshmat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Liver Enzymes ◽  
Cardiometabolic Risk Factors ◽  
World Health ◽  
Cadmium Level ◽  
Control Groups ◽  
Blood Cadmium ◽  
The Mean ◽  
And Control

Introduction. This study aimed to determine the association of blood cadmium level with cardiometabolic risk factors and liver enzymes in adolescents.Methods. This case control study comprised 320 Iranian adolescents, 160 with metabolic syndrome and an equal number of controls. They were selected from participants of a nationwide survey entitled the CASPIAN-III study. Cadmium was measured by atomic absorption method.Results. The mean age of the case and control groups was not significantly different (15.3±2.6versus14.63±2.5years, resp.,P>0.05). The mean cadmium level was near double-fold higher than the standards of the World Health Organization, without significant difference between the MetS and control groups (10.09±2.21,9.97±2.38 μg/L, resp.,P>0.05). Cadmium level had positive but nonsignificant correlations with diastolic blood pressure, serum triglycerides, fasting blood glucose, LDL-C, and liver enzymes.Conclusion. Cadmium level had positive but nonsignificant association with some cardiometabolic risk factors and liver enzymes. The associations did not reach statistical significant level, and this may be because of the high levels of cadmium in both groups studied or because of the young age group of participants. Controlling environmental pollutants shall be a priority for the prevention of chronic diseases.

scholarly journals Effects of Nine-Month Lifestyle Intervention on Cardiometabolic Risk Factors: Sex Differences in Obese Individuals

Obesities ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 29-35
Author(s):  
Florent Besnier ◽  
Anil Nigam ◽  
Martin Juneau ◽  
Valérie Guilbeault ◽  
Elise Latour ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Composition ◽  
Sex Differences ◽  
Body Mass ◽  
Cardiometabolic Risk ◽  
Interval Training ◽  
Cardiometabolic Risk Factors ◽  
Obese Women ◽  
Baseline Values ◽  
High Intensity Interval

Limited data is available on the sex differences and individual responses of cardiometabolic parameters adjusted with potential confounders (i.e. sex, age, baseline values) after a longer term Mediterranean diet (MedD) and high intensity interval training (HIIT) in obese subjects. The objective of this study was to compare the effects of nine-month MedD counseling and supervised HIIT on cardiometabolic risk factors and individual responses in obese women (n = 99) and obese men (n = 35). Body composition (body mass, fat mass, lean body mass, waist circumference), cardiorespiratory fitness (METs), and cardiometabolic risk factors (blood pressure, blood sample variables) were measured at baseline and after nine months of a program combining MedD and HIIT two to three times a week. When adjusted with sex, age, and baseline values, obese women similarly improved their body composition, METs, and cardiometabolic risk factors vs. obese men. The proportion of responders according to clinical cutoff levels were the same in obese women and men. A longer MedD and HIIT intervention similarly improves body composition, cardiometabolic risk factors, and individual responses in obese women and men, even after adjustment of confounders (sex, age, baseline value).

scholarly journals The Effects of Aerobic-Resistance Training and Broccoli Supplementation on Plasma Dectin-1 and Insulin Resistance in Males with Type 2 Diabetes

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3144
Author(s):  
Ayoub Saeidi ◽  
Mohammad Soltani ◽  
Ali Daraei ◽  
Hanieh Nohbaradar ◽  
Marjan Mosalman Haghighi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Resistance Training ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
And Control

Background: This study aimed to evaluate the effects of a combination of aerobic-resistance training (CARET) and broccoli supplementation on dectin-1 levels and insulin resistance in men with type 2 diabetes mellitus (T2D). Methods: Forty-four males with T2D were randomly allocated to four groups (n = 11 each group): CARET + broccoli supplement (TS), CARET + placebo (TP), control + broccoli supplement (S), and control + placebo (CP). CARET was performed three days per week for 12 weeks. TS and S groups received 10 g of broccoli supplement per day for 12 weeks. All variables were assessed at baseline and 12 weeks. Results: Plasma dectin-1 levels were decreased in TS and TP groups compared with the CP group (p < 0.05). Cardiometabolic risk factors showed significant reductions in TP and TS groups compared to S and CP groups (p < 0.05). Conclusion: The combination of CARET and broccoli supplementation produced the largest improvements in insulin resistance and dectin-1 and other complications of T2D.

scholarly journals Adherence to a Plant-Based Diet and Consumption of Specific Plant Foods—Associations with 3-Year Weight-Loss Maintenance and Cardiometabolic Risk Factors: A Secondary Analysis of the PREVIEW Intervention Study

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3916
Author(s):  
Ruixin Zhu ◽  
Mikael Fogelholm ◽  
Sally D. Poppitt ◽  
Marta P. Silvestre ◽  
Grith Møller ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Weight Loss ◽  
Weight Management ◽  
Cardiometabolic Risk ◽  
Ldl Cholesterol ◽  
Secondary Analysis ◽  
Weight Loss Maintenance ◽  
Cardiometabolic Risk Factors ◽  
Plant Foods

Plant-based diets are recommended by dietary guidelines. This secondary analysis aimed to assess longitudinal associations of an overall plant-based diet and specific plant foods with weight-loss maintenance and cardiometabolic risk factors. Longitudinal data on 710 participants (aged 26–70 years) with overweight or obesity and pre-diabetes from the 3-year weight-loss maintenance phase of the PREVIEW intervention were analyzed. Adherence to an overall plant-based diet was evaluated using a novel plant-based diet index, where all plant-based foods received positive scores and all animal-based foods received negative scores. After adjustment for potential confounders, linear mixed models with repeated measures showed that the plant-based diet index was inversely associated with weight regain, but not with cardiometabolic risk factors. Nut intake was inversely associated with regain of weight and fat mass and increments in total cholesterol and LDL cholesterol. Fruit intake was inversely associated with increments in diastolic blood pressure, total cholesterol, and LDL cholesterol. Vegetable intake was inversely associated with an increment in diastolic blood pressure and triglycerides and was positively associated with an increase in HDL cholesterol. All reported associations with cardiometabolic risk factors were independent of weight change. Long-term consumption of nuts, fruits, and vegetables may be beneficial for weight management and cardiometabolic health, whereas an overall plant-based diet may improve weight management only.

scholarly journals Body fat distribution, in particular visceral fat, is associated with cardiometabolic risk factors in obese women

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0185403 ◽  
Author(s):  
Theodora W. Elffers ◽  
Renée de Mutsert ◽  
Hildo J. Lamb ◽  
Albert de Roos ◽  
Ko Willems van Dijk ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Fat ◽  
Visceral Fat ◽  
Cardiometabolic Risk ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Cardiometabolic Risk Factors ◽  
Obese Women

scholarly journals Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions

2019 ◽  
Author(s):  
Lukas Schwingshackl ◽  
Manuela Neuenschwander ◽  
Georg Hoffmann ◽  
Anette E Buyken ◽  
Sabrina Schlesinger
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Uric Acid ◽  
Cardiometabolic Risk ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Cardiometabolic Risk Factors ◽  
Cardiometabolic Health ◽  
Dietary Sugar ◽  
Dietary Sugars

ABSTRACT Background There is controversy on the relevance of dietary sugar intake for cardiometabolic health. Objective The aim of this network meta-analysis (NMA) was to assess how isocaloric substitutions of dietary sugar with other carbohydrates affect cardiometabolic risk factors, comparing different intervention studies. Methods We included randomized controlled trials (RCTs) investigating the isocaloric effect of substituting dietary sugars (fructose, glucose, sucrose) with other sugars or starch on cardiometabolic risk markers, including LDL cholesterol, triacylglycerol (TG), fasting glucose (FG), glycated hemoglobin (HbA1c), insulin resistance (HOMA-IR), uric acid, C-reactive protein (CRP), alanine transaminase (ALT), aspartate transaminase (AST), and liver fat content. To identify the most beneficial intervention for each outcome, random-effects NMA was conducted by calculating pooled mean differences (MDs) with 95% CIs, and by ranking the surface under the cumulative ranking curves (SUCRAs). The certainty of evidence was evaluated using the Confidence In Network Meta-Analysis tool. Results Thirty-eight RCTs, including 1383 participants, were identified. A reduction in LDL-cholesterol concentrations was shown for the exchange of sucrose with starch (MD: −0.23 mmol/L; 95% CI: −0.38, −0.07 mmol/L) or fructose with starch (MD: −0.22 mmol/L; 95% CI: −0.39, −0.05 mmol/L; SUCRAstarch: 98%). FG concentrations were also lower for the exchange of sucrose with starch (MD: −0.14 mmol/L; 95% CI: −0.29, 0.01 mmol/L; SUCRAstarch: 91%). Replacing fructose with an equivalent energy amount of glucose reduced HOMA-IR (MD: −0.36; 95% CI: −0.71, −0.02; SUCRAglucose: 74%) and uric acid (MD: −23.77 µmol/L; 95% CI: −44.21, −3.32 µmol/L; SUCRAglucose: 93%). The certainty of evidence was rated very low to moderate. No significant effects were observed for TG, HbA1c, CRP, ALT, and AST. Conclusions Our findings indicate that substitution of sucrose and fructose with starch yielded lower LDL cholesterol. Insulin resistance and uric acid concentrations were beneficially affected by replacement of fructose with glucose. Our findings are limited by the very low to moderate certainty of evidence. This review was registered at www.crd.york.ac.uk/prospero as CRD42018080297.

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