scholarly journals Contribution of dietary advanced glycation end products (AGE) to circulating AGE: role of dietary fat

2015 ◽  
Vol 114 (11) ◽  
pp. 1797-1806 ◽  
Author(s):  
Kathleen E. Davis ◽  
Chandan Prasad ◽  
Parakat Vijayagopal ◽  
Shanil Juma ◽  
Beverley Adams-Huet ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Test Meal ◽  
Dietary Factors ◽  
High Fat ◽  
Advanced Glycation ◽  
Low Fat ◽  
High Molecular Weight Adiponectin ◽  
Glycation End Products ◽  
End Products ◽  
High Age

AbstractThe purpose of this pilot study was to determine whether macronutrient content (low-fat v. high-fat diet) influences an indicator of advanced glycation end products (AGE), Nε carboxymethyl-lysine (CML), in the context of a 1-d, high-AGE diet. The effect of the diets on inflammatory markers was also assessed. A total of nineteen overweight and obese adults (nine men and ten women) without known disease were recruited to participate in a crossover challenge of a high-fat, high-AGE (HFHA) and low-fat, high-AGE (LFHA) diet. In each phase patients had fasting blood drawn, followed by consumption of a high-fat or low-fat breakfast test meal, then three postprandial blood draws at 1, 2 and 3 h after consuming the test meal. After consuming high-AGE meals for the remainder of the day, participants returned the next day for a follow-up analysis. A different pattern in the 3-h post-meal CML and soluble receptor for AGE response to the two diets was observed (P=0·01 and 0·05, respectively). No change in serum CML was observed following consumption of a LFHA breakfast (535 (25th–75th percentile 451–790) to 495 (25th–75th percentile 391–682) ng/ml; P=0·36), whereas a rise in CML occurred after the HFHA breakfast (463 (25th–75th percentile 428–664) to 578 (25th–75th percentile 474–865) ng/ml; P=0·05). High sensitivity C-reactive protein and high molecular weight adiponectin were not affected by either diet. These findings suggest that dietary CML may not be as important in influencing serum CML as other dietary factors. In addition, acute exposure to dietary CML may not influence inflammation in adults without diabetes or kidney disease. This is contrary to previous findings.

scholarly journals Impact of Androgen and Dietary Advanced Glycation End Products on Female Rat Liver

2015 ◽  
Vol 37 (3) ◽  
pp. 1134-1146 ◽  
Author(s):  
Eleni Palioura ◽  
Sotiria Palimeri ◽  
Christina Piperi ◽  
Stratigoula Sakellariou ◽  
Eleni Kandaraki ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Polycystic Ovary ◽  
Gamma Glutamyl Transferase ◽  
Female Rat ◽  
Advanced Glycation ◽  
Wide Range ◽  
Glycation End Products ◽  
End Products ◽  
High Age ◽  
Glutamyl Transferase

Background/Aims: Advanced glycation end products (AGEs) have been related to a wide range of liver disorders including hyperandrogenic states such as the Polycystic Ovary Syndrome (PCOS). The aim of the present study is to evaluate the potential impact of dietary glycotoxins exposure and androgen excess on hepatic histology and biochemistry in an androgenized female rat model. Methods: The study population consisted of 80 female Wistar rats, divided in 3 groups, a group of prepubertal (Group A, n=30) and adult rats (Group B, n=20) that were androgenized via subcutaneous implantation of dihydrotestosterone-containing pellets as well as a group of adult non-androgenized rodents (Group C, n=30). All groups were randomly assigned either to a high-AGE or low-AGE diet for 3 months. Results: Rats fed with a high-AGE diet exhibited significantly elevated levels of gamma-glutamyl transferase (γGT) (p≤0.0002) and indices of AGE immunostaining in liver tissue (p<0.01) when compared to the respective low-AGE group, while aspartate aminotransferase (AST) levels were affected only in non-androgenized animals (p=0.0002). Androgenization per se constitutes an aggravating factor as demonstrated by the elevated γGT levels in adult androgenized animals compared to non-androgenized, independent of diet content (p=0.0002) and by the elevated AST and alanine aminotransferase (ALT) levels in low-AGE subgroups (adult androgenized vs. non-androgenized, p=0.0002) followed by increased immunohistochemical AGE deposition in hepatocytes of the latter categories (p=0.0007). Conclusion: The present study suggests that androgens and glycotoxins may contribute synergistically to distort hepatic physiology and function as observed in hyperandrogenic conditions.

Mangiferin suppressed advanced glycation end products (AGEs) through NF-κB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats

2016 ◽  
Vol 94 (3) ◽  
pp. 332-340 ◽  
Author(s):  
Jun Hou ◽  
Dezhi Zheng ◽  
Gabriel Fung ◽  
Haoyu Deng ◽  
Lin Chen ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Diabetic Cardiomyopathy ◽  
Advanced Glycation End Products ◽  
High Fat Diet ◽  
Nuclear Translocation ◽  
High Fat ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Mrna And Protein Expression

Given the importance of the aggregation of advanced glycation end products (AGEs) and cardiac inflammation in the onset and progression of diabetic cardiomyopathy (DCM), our objective in this study was to demonstrate the cardioprotective effect of mangiferin, an antidiabetic and anti-inflammatory agent, on diabetic rat model. The DCM model was established by a high-fat diet and a low dose of streptozotocin. DCM rats were treated orally with mangiferin (20 mg/kg) for 16 weeks. Serum and left ventricular myocardium were collected for determination of inflammatory cytokines. AGEs mRNA and protein expression of nuclear factor kappa B (NF-κB) and receptor for AGEs (RAGE) in myocardium were assayed by real-time PCR and Western blot. ROS levels were measured by dihydroethidium fluorescence staining. NF-κB binding activity was assayed by TransAM NF-κB p65 ELISA kit. Chronic treatment with mangiferin decreased the levels of myocardial enzymes (CK-MB, LDH) and inflammatory mediators (TNF-α, IL-1β). Meanwhile, NF-κB is inhibited by the reduction of nuclear translocation of p65 subunit, and mangiferin reduced AGE production and decreased the mRNA and protein expression of RAGE in DCM rats. Our data indicated that mangiferin could significantly ameliorate DCM by preventing the release of inflammatory cytokines, and inhibiting ROS accumulation, AGE/RAGE production, and NF-κB nuclear translocation, suggesting that mangiferin treatment might be beneficial in DCM.

scholarly journals The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mohammad Hassan Sohouli ◽  
Elham Sharifi-Zahabi ◽  
Abolfazl Lari ◽  
Somaye Fatahi ◽  
Farzad Shidfar
Keyword(s):  
Systematic Review ◽  
Systematic Reviews ◽  
Advanced Glycation End Products ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
High Age ◽  
The Impact

AbstractSeveral randomized clinical trials (RCTs) have investigated the effect of dietary advanced glycation end products (AGE) on obesity factors and related hormones in adults; results were conflicting. Therefore, a study was performed to assess the effect of low advanced glycation end products diet on obesity and related hormones. A comprehensive literature search without any limitation on language was conducted using the following bibliographical databases: Web of Science, Scopus, Ovid MEDLINE, Cochrane, and Embase up to October, 2019. From the eligible trials, 13 articles were selected for the systematic review and meta-analysis. Our systematic reviews and meta-analyses have shown a significant decrease in BMI (WMD: − 0.3 kg/m2; 95% CI: − 0.52, − 0.09, p = 0.005; I2 = 55.8%), weight (WMD: − 0.83 kg; 95% CI: − 1.55, − 0.10, p = 0.026; I2 = 67.0%), and leptin (WMD: − 19.85 ng/ml; 95% CI: − 29.88, − 9.82, p < 0.001; I2 = 81.8%) and an increase in adiponectin (WMD: 5.50 µg/ml; 95% CI: 1.33, 9.67, p = 0.010; I2 = 90.6%) levels after consumption of the low AGE diets compared to the high AGE diets. Also, the effect of intake of low AGE compared to high AGE diets was more pronounced in subgroup with duration > 8 weeks for the BMI and weight. Overall, according to our results, although low AGE diets appeared to be statistically significant in reducing the prevalence of obesity and chronic diseases compared to high consumption of dietary AGEs. But, no clinical significance was observed. Therefore, to confirm these results clinically, further prospective studies should be conducted in this regard. The study protocol was registered in the in International prospective register of systematic reviews (PROSPERO) database as CRD42020203734.

Advanced glycation end-products (AGEs) and associations with cardio-metabolic, lifestyle, and dietary factors in a general population: the NQplus study

2017 ◽  
Vol 33 (5) ◽  
pp. e2892 ◽  
Author(s):  
Nadia Botros ◽  
Diewertje Sluik ◽  
Robert P. van Waateringe ◽  
Jeanne H.M. de Vries ◽  
Anouk Geelen ◽  
...  
Keyword(s):  
General Population ◽  
Advanced Glycation End Products ◽  
Dietary Factors ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products
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