The association of maternal dietary folate intake and folic acid supplementation with small-for-gestational-age births: a cross-sectional study in Northwest China

AbstractThe effect of maternal folate intake on small-for-gestational-age (SGA) births remains inconclusive. The present study aimed to investigate the associations of maternal folate intake from diet and supplements with the risk of SGA births using data from a cross-sectional study in Shaanxi Province of Northwest China. A total of 7307 women who were within 12 months (median 3; 10th–90th percentile 0–7) after delivery were included. Two-level models were adopted to examine the associations of folate (dietary folate, supplemental folic acid and total folate) intake with the risk of SGA births and birth weight Z score, controlling for a minimum set of confounders that were identified in a directed acyclic graph. Results showed that a higher supplemental folic acid intake during the first trimester was negatively associated with the risk of SGA births (≤60 d v. non-use: OR 0·80; 95 % CI 0·66, 0·96; >60 d v. non-use: OR 0·78; 95 % CI 0·65, 0·94; Ptrend = 0·010; per 10-d increase: OR 0·97; 95 % CI 0·95, 0·99). A higher total folate intake during pregnancy was associated with a reduced risk of SGA births (highest tertile v. lowest tertile: OR 0·77; 95 % CI 0·64, 0·94; Ptrend = 0·010; per one-unit increase in the log-transformed value: OR 0·81; 95 % CI 0·69, 0·95). A similar pattern was observed for the birth weight Z score. Our study suggested that folic acid supplementation during the first trimester and a higher total folate intake during pregnancy were associated with a reduced risk of SGA births.

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An Evaluation of Awareness, Knowledge, and Use of Folic Acid and Dietary Folate Intake among Non-Pregnant Women of Childbearing Age and Pregnant Women: A Cross-Sectional Study from Turkey

Ecology of Food and Nutrition ◽

10.1080/03670244.2020.1807344 ◽

2020 ◽

pp. 1-15

Author(s):

Merve Şeyda Karaçil Ermumcu ◽

Özge Mengi Çelik ◽

Nilüfer Acar Tek

Keyword(s):

Folic Acid ◽

Pregnant Women ◽

Cross Sectional Study ◽

Folate Intake ◽

Women Of Childbearing Age ◽

Sectional Study ◽

Childbearing Age ◽

Cross Sectional ◽

Dietary Folate ◽

Dietary Folate Intake

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Folic acid supplementation in Italian women during pregnancy: A cross-sectional study conducted in general practice

Nutrition ◽

10.1016/j.nut.2020.110886 ◽

2020 ◽

Vol 79-80 ◽

pp. 110886 ◽

Cited By ~ 1

Author(s):

Roberta Gazzino ◽

Walter Marrocco ◽

Antonio Pio D'Ingianna ◽

Eleonora Poggiogalle ◽

Anna Maria Giusti ◽

...

Keyword(s):

General Practice ◽

Folic Acid ◽

Folic Acid Supplementation ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Acid Supplementation ◽

Italian Women

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Folic acid supplementation, dietary folate intake and risk of small for gestational age in China

Public Health Nutrition ◽

10.1017/s1368980019003331 ◽

2019 ◽

Vol 23 (11) ◽

pp. 1965-1973

Author(s):

Huaqi Guo ◽

Baohong Mao ◽

Meng Wang ◽

Qing Liu ◽

Liping Yang ◽

...

Keyword(s):

Folic Acid ◽

Gestational Age ◽

Small For Gestational Age ◽

Folic Acid Supplementation ◽

Folate Intake ◽

Care Hospital ◽

Dietary Folate ◽

Acid Supplementation ◽

Dietary Folate Intake ◽

Reduced Risk

AbstractObjective:To investigate the hypothesis that folic acid supplementation and dietary folate intake before conception and during pregnancy reduce the risk of small for gestational age (SGA) and to examine the joint effect of folic acid supplementation and dietary folate intake on the risk of SGA.Design:Participants were interviewed by trained study interviewers using a standardized and structured questionnaire. Information on birth outcomes and maternal complications was abstracted from medical records and dietary information was collected via a semi-quantitative FFQ before conception and during pregnancy.Setting:A birth cohort data analysis using the 2010–2012 Gansu Provincial Maternity and Child Care Hospital.Participants:Women (n 8758) and their children enrolled in the study.Results:Folic acid supplementation was associated with a reduced risk of SGA (OR = 0·72, 95 % CI 0·60, 0·86), with the reduced risk seen mainly for SGA at ≥37 weeks of gestational age (OR = 0·70, 95 % CI 0·58, 0·85) and nulliparous SGA (OR = 0·67, 95 % CI 0·54, 0·84). There was no significant association between dietary folate intake and SGA risk.Conclusions:Our study suggested that folic acid supplementation was associated with a reduced risk of SGA and the risk varied by preterm status and parity.

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Knowledge on preconceptional folic acid supplementation and intention to seek for preconception care among men and women in an urban city: a population-based cross-sectional study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-015-0774-y ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 19

Author(s):

Sevilay Temel ◽

Özcan Erdem ◽

Toon A. J. J. Voorham ◽

Gouke J. Bonsel ◽

Eric A. P. Steegers ◽

...

Keyword(s):

Folic Acid ◽

Preconception Care ◽

Population Based ◽

Folic Acid Supplementation ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Men And Women ◽

Acid Supplementation ◽

Urban City

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Maternal Folic Acid Supplementation, Dietary Folate Intake and Low Birth Weight: A Birth Cohort Study

10.21203/rs.3.rs-163378/v1 ◽

2021 ◽

Author(s):

LiPing Yang ◽

Wenjuan Wang ◽

Baohong Mao ◽

Jie Qiu ◽

Huaqi Guo ◽

...

Keyword(s):

Folic Acid ◽

Folic Acid Supplementation ◽

Folate Intake ◽

Care Hospital ◽

Folic Acid Supplement ◽

Dietary Folate ◽

Acid Supplementation ◽

Dietary Folate Intake ◽

Reduced Risk ◽

Joint Associations

Abstract ObjectivesTo investigate the independent and collective effects of maternal folic acid supplementation or dietary folate intake upon the risk of low birth weight (LBW), and to further comprehensively examine the joint associations of folic acid supplementation and dietary folate intake with LBW by various clinical subtypes.DesignParticipants were recruited in Gansu Provincial Maternity and Child Care Hospital. A standardized and structured questionnaire was distributed to collect demographic factors, reproductive and medical history, occupational and residential history, physical activity and diet. Data on pregnancy-related complications and birth outcomes were extracted from medical records. Unconditional logistic regression models were used to estimate odds ratio (OR) and 95% confidence interval (95%CI) for single and joint associations of folic acid supplementation and dietary folate intake with LBW. SettingA birth cohort data analysis using the 2010–2012 Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China.Participants9231 pregnant women and their children were enrolled in the study. ResultsCompared to non-users, folic acid supplementation was associated with a reduced risk of LBW (OR: 0.80, 95%CI: 0.66-0.97), and the reduced risk was mainly seen for term-LBW (OR: 0.59, 95%CI: 0.41-0.85), and multiparous-LBW (OR: 0.72, 95%CI: 0.54-0.94). For dietary folate intake, there were no significant associations with LBW, and there was no interaction of folic acid supplement and dietary folate intake on LBW.ConclusionsOur study results indicated that folic acid supplementation was associated with a reduced risk of LBW, and there was not interaction of folic acid supplement and dietary folate intake on LBW.

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Adherence to weekly iron and folic acid supplementation among the school students of Thrissur corporation – a cross sectional study

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20171785 ◽

2017 ◽

Vol 4 (5) ◽

pp. 1689 ◽

Cited By ~ 1

Author(s):

Sajna M. V. ◽

Shefaly Ann Jacob

Keyword(s):

Growth Rate ◽

Folic Acid ◽

Pilot Study ◽

Folic Acid Supplementation ◽

Cross Sectional Study ◽

Cluster Sampling ◽

Sectional Study ◽

School Students ◽

Cross Sectional ◽

Iron And Folic Acid

Background: Anemia is one of the major problems among adolescents in India. As daily and once weekly supplementation of iron and folic acid show same effects in terms of growth rate, it has been decided that weekly supply is an effective method to tackle anaemia. The adherence to these tablets is an important factor to monitor the programme. Methods: A cross sectional study was conducted among the school students of 6-10th classes in Thrissur corporation area for a period of 6 months regarding the adherence to weekly iron and folic acid tablets. Sample size was calculated based on a pilot study and for a cluster sampling technology. After getting consent, data were collected, coded and analysed using SPSS17. Results: 380 students participated in the study. Mean age of the population was 13.01+ 1.3 years (with a range of 10 – 16 years). Only 139 (36.6%) students took tablets initially for a period of 1-2 months. Among the total girls, 124 (34.6%) took tablets initially. Of the students who took initially, 57 were continuing intake of iron tablets. The adherence to weekly iron and folic acid tablets for at in this study was 15% (n=57). Among the students who initially consumed tablets 36.6% reported stomach ache. Nausea (13.6%), vomiting (10.7%), black stool (9.3%), diarrhoea (5%) were other reported side effects of the drugs. Conclusions: The adherence to weekly iron and folic to this study was less. This can be effectively improved with continued health education sessions using different methods including the parents.

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Counselling and knowledge on iron and folic acid supplementation (IFAS) among pregnant women in Kiambu County, Kenya: a cross-sectional study

AAS Open Research ◽

10.12688/aasopenres.12891.2 ◽

2019 ◽

Vol 1 ◽

pp. 21

Author(s):

Mary Kamau ◽

Samuel Kimani ◽

Waithira Mirie

Keyword(s):

Folic Acid ◽

Pregnant Women ◽

Community Education ◽

Folic Acid Supplementation ◽

Cross Sectional Study ◽

Health Facilities ◽

Sectional Study ◽

Cross Sectional ◽

Acid Supplementation ◽

Iron And Folic Acid

Background: The increased demand for iron and folic acid during pregnancy is not met through diet due to insufficiency or reduced bioavailability of nutrients among women from low income countries. Thus, iron and folic acid supplementation (IFAS) is a promising interventional strategy for control of anaemia during pregnancy. Kenya adopted the global IFAS intervention with a target of 80% coverage by 2017, however, the compliance remains low. Increasing awareness, counselling, communication and community education on IFAS have improved compliance among pregnant women. Thus, we aimed to determine: IFAS knowledge, availability, practices, and content of IFAS counselling among pregnant women attending health facilities in Kiambu County, Kenya. Methods: A cross-sectional study involving 364 pregnant women aged 15-49 years. A two stage cluster sampling, including one sub-county and five public health facilities were used. A pre-tested structured questionnaire consisting of socio-demographic data, maternal knowledge and counselling on IFAS was used. An observation checklist was used to observe practices and content of antenatal counselling session in each facility. Data was analysed using STATA in which descriptive and inferential statistics were computed. Results: Of 364 respondents, less than half (40.9%) scored high on knowledge on IFAS. Women who were counselled on duration of IFAS intake, side effects, and their mitigation were more likely (p <0.005) to have high IFAS knowledge. Although all the health facilities had varied IFAS posters displayed, none had key IFAS counselling documents. Conclusion: Less than half of the pregnant women had high IFAS knowledge, IFAS documents were scarce in health facilities, IFAS counselling information in different health facilities was limited and varied and content of counselling was associated with levels of knowledge on IFAS. This underscores the need to strengthen focused and targeted IFAS counselling for pregnant women and standardization of counselling messages to improve compliance and pregnancy outcomes.

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