Association between selenium intake, diabetes, and mortality in adults: findings from National Health and Nutrition Examination Survey (NHANES) 2003-2014

2021 ◽  
pp. 1-24
Author(s):  
Bushra Hoque ◽  
Zumin Shi
Keyword(s):  
National Health ◽  
Cox Regression ◽  
Inverse Association ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Hazard Ratios ◽  
The Us ◽  
All Cause Mortality ◽  
Cvd Mortality

Abstract Selenium (Se) is a trace mineral that has antioxidant and anti-inflammatory properties. This study aimed to investigate the association between Se intake, diabetes, all-cause and cause-specific mortality in a representative sample of US adults. Data from 18,932 adults who attended the 2003-2014 National Health and Nutrition Examination Survey (NHANES) were analysed. Information on mortality was obtained from the US mortality registry updated to 2015. Multivariable logistic regression and Cox regression were used. Cross-sectionally, Se intake was positively associated with diabetes. Comparing extreme quartiles of Se intake, the odds ratio (OR) for diabetes was 1.44 (95% CI: 1.09–1.89). During a mean of 6.6 years follow-up, there were 1627 death (312 CVD, 386 cancer). High intake of Se was associated with a lower risk of all-cause mortality. When comparing the highest with the lowest quartiles of Se intake, the hazard ratios (HRs) for all-cause, CVD mortality, cancer mortality and other mortality were: 0.77 (95% CI 0.59-1.01), 0.62 (95% CI, 0.35-1.13), 1.42 (95% CI, 0.78-2.58) and 0.60 (95% CI,0.40-0.80), respectively. The inverse association between Se intake and all-cause mortality was only found among white participants. In conclusion, Se intake was positively associated with diabetes but inversely associated with all-cause mortality. There was no interaction between Se intake and diabetes in relation to all-cause mortality.

scholarly journals Association between Caffeine Intake and All-Cause and Cause-Specific Mortality: An Analysis of the National Health and Nutrition Examination Survey (NHANES) 1999–2014 Database

2021 ◽  
Vol 11 (4) ◽  
pp. 901-912
Author(s):  
Juan Feng ◽  
Jing Wang ◽  
Mini Jose ◽  
Yaewon Seo ◽  
Li Feng ◽  
...  
Keyword(s):  
National Health ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Caffeine Intake ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Hazard Ratios ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Cvd Mortality

Sixty-four percent of adults in America drink coffee daily, and caffeine is the main reason people tend to drink coffee habitually. Few studies have examined the association between caffeine and all-cause and cause-specific mortality. The objective of this study was to examine the association between caffeine and all-cause and cause-specific mortality using the National Health and Nutrition Examination Survey (NHANES) 1999–2014 database. The multivariate Cox proportional hazards regression model was used to examine 23,878 individuals 20 years and older. Daily caffeine intake was measured once at baseline. A total of 2206 deaths occurred, including 394 cardiovascular (CVD) deaths and 525 cancer deaths. Compared to those with a caffeine intake of <100 mg/day, the hazard ratios (HRs) for CVD mortality were significantly lower in the participants with a caffeine intake of 100–200 mg/day (HR, 0.63; 95% confidence interval [CI], 0.45–0.88), and those with a caffeine intake of >200 mg/day (HR, 0.67; 95% CI, 0.50–0.88) after adjusting for potential confounders. The HRs for all-cause mortality were significantly lower in the participants with a caffeine intake of 100–200 mg/day (HR, 0.78; 95% CI, 0.67–0.91), and those with a caffeine intake of >200 mg/day (HR, 0.68; 95% CI, 0.60–0.78). Subgroup analyses showed that caffeine may have different effects on all-cause mortality among different age and body mass index (BMI) groups. In conclusion, higher caffeine intake was associated with lower all-cause and CVD mortality.

scholarly journals Diet and sedentary behaviour in relation to mortality in US adults with a cardiovascular condition: results from the National Health and Nutrition Examination Survey linked to the US mortality registry

2020 ◽  
Vol 124 (12) ◽  
pp. 1329-1337
Author(s):  
Cristian Ricci ◽  
Michael F. Leitzmann ◽  
Heinz Freisling ◽  
Aletta E. Schutte ◽  
Rudolph Schutte ◽  
...  
Keyword(s):  
Sedentary Behaviour ◽  
National Health ◽  
Mortality Risk ◽  
Dietary Fibre ◽  
Cox Regression ◽  
Interaction Analysis ◽  
Additive Interaction ◽  
Health And Nutrition ◽  
The Us ◽  
Cvd Mortality

AbstractCVD is the most common chronic condition and the highest cause of mortality in the USA. The aim of the present work was to investigate diet and sedentary behaviour in relation to mortality in US CVD survivors. The National Health and Nutrition Examination Surveys conducted between 1999 and 2014 linked to the US mortality registry updated to 2015 were investigated. Multivariate adjusted Cox regression was used to derive mortality hazards in relation to sedentary behaviour and nutrient intake. A multiplicative and additive interaction analysis was conducted to evaluate how sedentariness and diet influence mortality in US CVD survivors. A sample of 2473 participants followed for a median period of 5·6 years resulted in 761 deaths, and 199 deaths were due to CVD. A monotone increasing relationship between time spent in sedentary activities and mortality risk was observed for all-cause and CVD mortality (hazard ratio (HR) = 1·20, 95 % CI 1·09, 1·31 and HR = 1·19, 95 % CI 1·00, 1·67, respectively). Inverse mortality risks in the range of 22–34 % were observed when comparing the highest with the lowest tertile of dietary fibre, vitamin A, carotene, riboflavin and vitamin C. Sedentariness below 360 min/d and dietary fibre and vitamin intake above the median interact on an additive scale influencing positively all-cause and CVD mortality risk. Reduced sedentariness in combination with a varied diet rich in dietary fibre and vitamins appears to be a useful strategy to reduce all-cause and CVD mortality in US CVD survivors.

scholarly journals Ultra-processed food intake and mortality in the USA: results from the Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994)

2019 ◽  
Vol 22 (10) ◽  
pp. 1777-1785 ◽  
Author(s):  
Hyunju Kim ◽  
Emily A Hu ◽  
Casey M Rebholz
Keyword(s):  
Food Intake ◽  
National Health ◽  
Representative Sample ◽  
Nhanes Iii ◽  
Nutrition Examination Survey ◽  
Processed Food ◽  
The Third ◽  
Health And Nutrition ◽  
All Cause Mortality ◽  
Cvd Mortality

AbstractObjectiveTo evaluate the association between ultra-processed food intake and all-cause mortality and CVD mortality in a nationally representative sample of US adults.DesignProspective analyses of reported frequency of ultra-processed food intake in 1988–1994 and all-cause mortality and CVD mortality through 2011.SettingThe Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994).ParticipantsAdults aged ≥20 years (n11898).ResultsOver a median follow-up of 19 years, individuals in the highest quartile of frequency of ultra-processed food intake (e.g. sugar-sweetened or artificially sweetened beverages, sweetened milk, sausage or other reconstructed meats, sweetened cereals, confectionery, desserts) had a 31% higher risk of all-cause mortality, after adjusting for demographic and socio-economic confounders and health behaviours (adjusted hazard ratio=1·31; 95% CI 1·09, 1·58;P-trend = 0·001). No association with CVD mortality was observed (P-trend=0·86).ConclusionsHigher frequency of ultra-processed food intake was associated with higher risk of all-cause mortality in a representative sample of US adults. More longitudinal studies with dietary data reflecting the modern food supply are needed to confirm our results.

scholarly journals Energy intake, energy required and mortality in an older population

2016 ◽  
Vol 19 (17) ◽  
pp. 3178-3184 ◽  
Author(s):  
Paul H Lee ◽  
Choi-Wan Chan
Keyword(s):  
Older Adults ◽  
Energy Intake ◽  
Cox Regression ◽  
Economic Status ◽  
Dietary Recall ◽  
Hazard Ratios ◽  
Co Morbidity ◽  
All Cause Mortality ◽  
Cvd Mortality

AbstractObjectivesThe present study evaluated the association between energy intake, energy required and mortality in older adults.DesignA cohort study with a mean of 10·67 (sd 4·74) years of follow-up. Participants completed a 24 h dietary recall. Energy required per day was computed by BMR. Deaths through 2006 were identified from the National Death Index. A Cox regression was used to estimate the hazard ratios (HR) of quantiles of energy intake and energy required on all-cause and CVD mortality, adjusting for demographics, socio-economic status and co-morbidity.SettingThe National Health and Nutrition Examination Survey (NHANES) III, 1988–1994.SubjectsA total of 4846 participants aged 60 years or above were analysed.ResultsWithin the follow-up period, there were a total of 2954 deaths (61·0 %), 51·9 % were caused by CVD. Relative to those in quartile 1 of energy intake, only quartile 4 was associated with all-cause mortality and CVD mortality with HR of 0·86 (95 % CI 0·77, 0·96, P=0·006) and 0·76 (95 % CI 0·65, 0·89, P=0·001), respectively. On the other hand, relative to those in quartile 1 of energy required, all quartiles of participants had a lower risk of all-cause mortality and CVD mortality. The interaction effects between energy intake and energy required with all-cause and CVD mortality were insignificant (P=0·70 and 0·61, respectively).ConclusionsIndependent of energy required, higher energy intake was associated with lower HR of both all-cause and CVD mortality in older adults.

scholarly journals Associations between elevated kidney and liver biomarker ratios, metabolic syndrome and all-cause and coronary heart disease (CHD) mortality: analysis of the U.S. National Health and Nutrition Examination Survey (NHANES)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Akinkunle Oye-Somefun ◽  
Jennifer L. Kuk ◽  
Chris I. Ardern
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
National Health ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Increased Risk ◽  
All Cause Mortality ◽  
The U.S

Abstract Background We examined the relationship between ratios of select biomarkers of kidney and liver function on all-cause and coronary heart disease (CHD) mortality, both in isolation, and in combination with metabolic syndrome (MetS), among adults (20 + years, n = 10,604). Methods Data was derived from the U.S. National Health and Nutrition Examination Survey (1999–2016) including public-use linked mortality follow-up files through December 31, 2015. Results Select biomarker ratios of kidney (UACR or albuminuria and BUN-CR) and liver (AST-ALT and GGT-ALP) function in isolation and in combination with MetS were associated with all-cause and CHD mortality. Compared to individuals with neither elevated biomarker ratios nor MetS (HR = 1.00, referent), increased risk of all-cause mortality was observed in the following groups: MetS with elevated UACR (HR, 95% CI = 2.57, 1.99–3.33), MetS with elevated AST-ALT (HR = 2.22, 1.61–3.07), elevated UACR without MetS (HR = 2.12, 1.65–2.72), and elevated AST-ALT without MetS (HR = 1.71, 1.35–2.18); no other biomarker ratios were associated with all-cause mortality. For cause-specific deaths, elevated risk of CHD mortality was associated with MetS with elevated UACR (HR = 1.67, 1.05–2.67), MetS with elevated AST-ALT (HR = 2.80, 1.62–4.86), and elevated BUN-CR without MetS (HR = 2.12, 1.12–4.04); no other biomarker ratios were associated with CHD mortality. Conclusion Future longitudinal studies are necessary to examine the utility of these biomarker ratios in risk stratification for chronic disease management.

scholarly journals Association of serum levels of antioxidant micronutrients with mortality in US adults: National Health and Nutrition Examination Survey 1999–2002

2020 ◽  
pp. 1-10
Author(s):  
Noah C Peeri ◽  
Weiwen Chai ◽  
Robert V Cooney ◽  
Meng-Hua Tao
Keyword(s):  
Vitamin E ◽  
National Health ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Race Ethnicity ◽  
Risk Of Cancer ◽  
Reduced Risk ◽  
Cvd Mortality

Abstract Objective: To examine associations between serum antioxidant levels and mortality (all-cause, cancer and CVD) among US adults. Design: We examined the risk of death from all-cause and cause-specific mortality associated with serum antioxidant (vitamin E and carotenoids) and vitamin A levels using Cox regression models to estimate hazards ratios (HR) and 95 % CI. Setting: The National Health and Nutrition Examination Survey (NHANES) 1999–2002 was followed up through 31 December 2015. Participants: The NHANES 1999–2002 cohort included 8758 participants aged ≥ 20 years. Serum carotenoid levels were only assessed for the 1999–2000 cycle. Therefore, sample size for each assessed antioxidant ranged from 4633 to 8758. Results: Serum vitamin E level was positively associated with all-cause mortality (HR = 1·22, 95 % CI 1·04, 1·43, highest v. lowest quartile). No other antioxidants were associated with mortality in overall analysis. In race/ethnicity-specific analyses, high vitamin E and α-tocopherol levels were associated with increased risk of all-cause mortality among non-Hispanic Whites. Among non-Hispanic Blacks, serum α-tocopherol level was associated with decreased risk of cancer mortality (HR = 0·30, 95 % CI 0·12, 0·75, third v. first quartile) and total carotenoid levels with reduced risk of CVD mortality (HR = 0·26; 95 % CI 0·07, 0·97, second v. lowest quartile). Hispanics with high β-carotene levels had reduced risk of CVD mortality. Conclusions: Serum antioxidant levels may be related to mortality; these associations may differ by race/ethnicity and appeared to be non-linear for all-cause and cause-specific mortality. Further studies are needed to confirm our results.

scholarly journals Hypotension and survival: diagnostic criteria in Russian and United States population

2021 ◽  
Vol 26 (5) ◽  
pp. 4365
Author(s):  
V. G. Vilkov ◽  
Yu. A. Balanova ◽  
A. V. Kapustina ◽  
G. A. Muromtseva ◽  
S. A. Shalnova
Keyword(s):  
United States ◽  
Risk Factors ◽  
National Health ◽  
Population Studies ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
United States Population ◽  
Severe Hypotension ◽  
All Cause Mortality

Aim. Based on Russian and United States population studies, to determine the criterion for distinguishing between normal and low blood pressure (BP), which is the most significant for predicting all-cause mortality.Material and methods. We used data from prospective Russian studies of 14730 men aged 19-82 years (9307 deaths per 342309 person-years of followup) and 6141 women aged 18-72 years (2101 deaths per 158727 person-years of follow-up), and two United States population studies: the First National Health and Nutrition Examination Survey (NHANES I) in conjunction with the NHANES I Epidemiologic Followup Study, and the Second National Health and Nutrition Examination Survey (NHANES II) in conjunction with the NHANES II Mortality Study. The total American cohort included only white subjects: 8618 men aged 25-75 years (3130 deaths per 121794 person-years of follow-up) and 11135 women 25-75 years (2465 deaths per 176676 person-years of follow-up). Primary examinations were carried out in 1971-1982, while the latest information on the subjects’ survival status was obtained in 2017 (Russia) and 1992 (USA). KaplanMeier curves and Cox proportional hazards models were created; all-cause death was taken into account as an outcome.Results. Survival analysis using Cox models, in which, in addition to BP levels, sex, age and risk factors were taken into account, showed that in persons with a pronounced BP decrease, survival is worse in comparison with those with normal BP. Mean dynamic BP, unfavorable for all-cause mortality, was below 70 and 68 mm Hg and 76 and 72 mm Hg in men and women in the Russian and US cohorts, respectively.Conclusion. Not only hypertension, but also severe hypotension is associated with increased all-cause mortality compared to normal BP. Survival decrease is manifested in severe hypotension, subject to sex and adjustment for age and risk factors.

scholarly journals The association of calf circumference and all-cause, cardiovascular and cerebrovascular mortality: Results from the National Health and Nutrition Examination Surveys

2021 ◽  
Author(s):  
Jiayi Huang ◽  
Lin Liu ◽  
Kenneth Lo ◽  
Yuling Yu ◽  
chao-lei CHEN ◽  
...  
Keyword(s):  
National Health ◽  
Cardiovascular Mortality ◽  
Lower Risk ◽  
Regression Models ◽  
Cox Regression ◽  
Inverse Association ◽  
Calf Circumference ◽  
Health And Nutrition ◽  
All Cause Mortality ◽  
Adjusted Model

IntroductionStudies on the association between calf circumference (CC) and mortality has been limited. Therefore, we examined the association between CC and all-cause, cardiovascular and cerebrovascular mortality in the present study.Material and methodsThe data was retrieved from the 1999-2006 National Health and Nutritional Examination Surveys (NHANES), composing of 20, 214 individuals aged ≥ 18 years with CC being measured. We performed multivariate Cox regression models to examine the associations, then stratified the regression models into subgroups to test for interactions.ResultsAmong 20, 214 participants, 47.25% were men and the mean age was 45.8 years. In the fully adjusted model, each 1 cm increment in CC was inversely associated with the risk of all-cause mortality (HR = 0.92, 95%CI = 0.90-0.94, P < 0.0001) and cardiovascular mortality (HR = 0.90, 95%CI = 0.84-0.97, P = 0.0056). Meanwhile, the highest quartile of CC had 50% (HR = 0.50, 95%CI = 0.40-0.64, P trend < 0.001) lower risk of all-cause mortality and 57% (HR = 0.43, 95%CI = 0.21-0.88, P trend = 0.045) lower risk of cardiovascular mortality, compared to the lowest quartile of CC. For cerebrovascular mortality, CC did not have significant associations with mortality.ConclusionsOur results suggested an independently inverse association between CC and all-cause and cardiovascular mortality.

scholarly journals Serum Antioxidant Status and Cause-Specific Mortality in US Adults: Results from the National Health and Nutrition Examination Survey (NHANES) 1999–2002

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1475-1475
Author(s):  
Noah Peeri ◽  
Meng-Hua Tao ◽  
Weiwen Chai
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Risk Of Cancer ◽  
Β Carotene ◽  
Cvd Mortality

Abstract Objectives Oxidative stress is one of the most important risk factors of non-communicable diseases. Studies on the association of serum antioxidants with mortality in a representative sample of US adults are still limited with inconsistent results. The objective of this study was to examine associations between serum concentrations of antioxidants (vitamins A and E, γ-tocopherol, total carotenoids, and β-carotene) and mortality among US adults. Methods The study cohort included adults aged ≥20 years who participated in the National Health and Nutrition Examination Survey (NHANES) 1999–2002, with measured serum antioxidants and mortality follow-up through December 31st, 2015 (N = 10,291). Outcomes were all-cause, cancer, and cardiovascular (CVD) mortality. Cox Proportional Hazards modelling was used to estimate adjusted hazards ratios (aHR) and 95% confidence intervals (CIs) for associations between serum antioxidant levels and mortality. Results Median follow-up was 14.2 years, with 2708 deaths, 556 from CVD, and 471 from cancer. Overall, a high level of vitamin E (&gt;1529.5 ug/dL) was associated with increased risk of all-cause mortality (aHR: 1.3; 95% CI: 1.10, 1.54), while a low carotenoid level (&lt;46.73 ug/dL) was associated with increased risk of all-cause mortality (aHR: 1.25; 95% CI: 0.88, 1.43). Vitamin A, γ-tocopherol, and β-carotene were not associated with mortality. The positive association between vitamin E and all-cause mortality was stronger among non-Hispanic whites (aHR: 1.37; 95% CI: 1.15, 1.65). Among Hispanics, compared to participants with vitamin A levels between 48.41–58.93 (ug/dL), participants in the highest vitamin A quartile (&gt;70.54 ug/dL) had increased risk of all-cause and CVD mortality, while the third quartile (58.94–70.54 ug/dL) had reduced risk of cancer mortality. Among non-Hispanic blacks, total carotenoid levels between 63.60–87.24 (ug/dL) were negatively associated with all-cause mortality and vitamin E levels between 1154.57–1529.54 (ug/dL) were associated with decreased risk of cancer mortality, while high vitamin A levels were associated with increased CVD mortality. Conclusions Findings suggest that optimal levels of serum antioxidants may protect against mortality, with differences between race/ethnicity. Further studies in minority populations are warranted to confirm the findings. Funding Sources N/A.

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