Mesenchymal cell atypicality in inflammatory polyps

1977 ◽  
Vol 91 (9) ◽  
pp. 751-756 ◽  
Author(s):  
Bruce H. Klenoff ◽  
Max L. Goodman
Keyword(s):  
Medical Therapy ◽  
Nasal Polyps ◽  
Mesenchymal Cell ◽  
Surgical Excision ◽  
Histological Changes ◽  
Nasal Symptoms ◽  
Neoplastic Lesions ◽  
The Subject ◽  
Mesenchymal Stroma Cells ◽  
Rule Out

Excised nasal polyps should be examined histologically for classification as to aetiological process. Recently a ‘pseudosarcomatous’ change was reported in nasal polyps. We reviewed one hundred excised polyps for mesenchymal atypicality and found a wide degree of mesenchymal atypicality in the majority of nasal polyps.Nasal and choanal inflammatory polyps are the most frequent nasal masses which the otolaryngologist has to treat. Surgical excision is frequently required to alleviate the nasal symptoms of polyps unresponsive to medical therapy. Excised nasal polyps should be examined histologically for classification as to possible aetiological mechanisms and to rule out neoplastic lesions (Shea, 1947).Smith, Echevarria, and McLelland (Smith, 1974) recently described ‘pseudosarcomatous changes’ in nasal polyps. This stimulated us to investigate our inflammatoru nasal polyps for these histological changes. Casual observations demonstrated an impressive number of inflammatory polyps with varying amounts of atypical mesenchymal stroma cells. To quantitate these alterations, we reviewed the histological slides from one hundred patients with excised inflammatory polyps and the results are the subject of this report.

scholarly journals Nasal Epithelial Myoepithelial Carcinoma: An Unusual Cause of Epiphora, a Case Report and Review of the Literature

2015 ◽  
Vol 6 (2) ◽  
pp. ar.2015.6.0127 ◽  
Author(s):  
Juliette O. Flam ◽  
Christopher D. Brook ◽  
Rachel Sobel ◽  
John C. Lee ◽  
Michael P. Platt
Keyword(s):  
Case Report ◽  
Physical Examination ◽  
Nasal Cavity ◽  
Surgical Excision ◽  
Myoepithelial Carcinoma ◽  
Review Of The Literature ◽  
Nasal Symptoms ◽  
First Case ◽  
Nasal Tumor ◽  
Epithelial Myoepithelial Carcinoma

Introduction Epithelial myoepithelial carcinoma (EMC) of the nasal cavity is a rare tumor, and here we describe the first case of EMC of the nasal cavity presenting with epiphora. A case presentation and review of the literature is provided. Methods A case report is described of a 63-year-old man who presented with unilateral epiphora and was found via a thorough history and physical examination to have a nasal tumor. The physical examination consisted of an ocular examination, including probing and irrigation, and a detailed nasal examination (anterior rhinoscopy, nasal endoscopy). The nasal examination was prompted by the patient's report of concurrent nasal symptoms during history taking. Immunohistochemistry subsequently identified the nasal tumor as EMC. A literature search was performed to gain insights into similar malignancies of the nasal cavity. Results Eight cases of EMC of the nasal cavity were identified in the literature, none of the patients presented with epiphora. The case presented here resulted in resolution of the patient's symptoms and no evidence of disease after surgical excision. Conclusion Epithelial myoepithelial is a rare salivary gland malignancy that can arise in the nasal cavity. Unilateral epiphora with concurrent nasal symptoms should prompt nasal cavity examination for the possibility of an obstructive tumor.

scholarly journals The Subject of Critique: Ricoeur in Dialogue with Feminist Philosophers

2013 ◽  
Vol 4 (1) ◽  
pp. 21-39
Author(s):  
Annemie Halsema
Keyword(s):  
Feminist Theory ◽  
Thought Experiments ◽  
The Self ◽  
Major Point ◽  
The Subject ◽  
Rule Out

This paper aims to show the relevance of Ricœur’s notion of the self for postmodern feminist theory, but also to critically assess it. By bringing Ricœur’s “self” into dialogue with Braidotti’s, Irigaray’s and Butler’s conceptions of the subject, it shows that it is close to the feminist self in that it is articulated into language, is embodied and not fully conscious of itself. In the course of the argument, the major point of divergence also comes to light, namely, that the former considers discourse to be a laboratory for thought experiments, while the latter consider discourse to be normative, restrictive and exclusive. In the second part, the possibility of critique and change are further developed. Ricœur does not rule out critique, rather interpretation includes distanciation and critique. Finally, his notion of productive imagination explains how new identifications become possible. 

scholarly journals A rare clinical case: schwannoma of tongue

2019 ◽  
Vol 5 (3) ◽  
pp. 789
Author(s):  
Chandra Veer Singh ◽  
Sheetal Radia ◽  
Saalim Sheikh ◽  
Vijay Haribhakti
Keyword(s):  
Head And Neck ◽  
Rare Case ◽  
Neck Region ◽  
Surgical Excision ◽  
Imaging Studies ◽  
Head And Neck Tumours ◽  
Head And Neck Region ◽  
Complete Surgical Excision ◽  
Slow Growing ◽  
Rule Out

<p class="abstract">Schwannoma are slow growing tumours, which can arise from any peripheral nerve. 10% of schwannomas that occur in the head and neck region mostly originate from the vagus or sympathetic nervous system. Extracranial schwannomas in the head and neck region are rare neoplasm. Intraoral schwannoma are only 1% of the all head and neck tumours. Diagnosis is established by imaging studies such as magnetic resonance imaging or computed tomography, while FNAC is used to rule out other conditions. We report a rare case of lingual schwannomas generally present as a painless lump schwannoma of the tongue in a 27-year-old male complaining of asymptomatic swelling over a posterolateral surface of the tongue, treated by complete surgical excision. The diagnosis was established on the basis of clinical, histopathological, and immunohistochemical examination. We report a rare case of schwannoma over the posterolateral surface of tongue. Prognosis is good for the patient when this condition is correctly diagnosed as the condition rarely recurs after complete resection.</p>

Efficacy of an Aqueous and a Powder Formulation of Nasal Budesonide Compared in Patients with Nasal Polyps

1998 ◽  
Vol 12 (3) ◽  
pp. 183-190 ◽  
Author(s):  
Mirko Tos ◽  
Frank Svendstrup ◽  
Helge Arndal ◽  
Steffen Ørntoft ◽  
John Jakobsen ◽  
...  
Keyword(s):  
Nasal Polyps ◽  
Treated Group ◽  
Nasal Symptom ◽  
Primary Efficacy Variable ◽  
Treatment Alternative ◽  
Polyp Size ◽  
Sense Of Smell ◽  
Nasal Symptoms ◽  
Symptom Scores ◽  
Overall Evaluation

Nasal polyps are commonly treated surgically. Intranasal administration of topical corticosteroids has gained increased acceptance as a treatment alternative. The aim of our study was to compare the efficacy of treatment of two formulations of budesonide with placebo on nasal polyps. At four Danish clinics 138 patients suffering from moderate or severe nasal polyps were randomized to a twice daily treatment with Rhinocort® Aqua 128 μg, Rhinocort Turbuhaler® 140 μg or placebo (Astra Draco, Sweden) for 6 weeks. Polyp size (primary efficacy variable), nasal symptoms, sense of smell, and patients’ overall evaluation of treatment of efficacy were assessed by scores. Polyp size was reduced significantly in both budesonide treated groups compared with placebo, but there was no statistical difference between the two actively treated groups. Patients’ nasal symptom scores was significantly more reduced in the Aqua compared to the Turbuhaler treated group, and both reduced symptom scores were significantly better compared to placebo. Sense of smell was significantly improved in the actively treated groups compared to placebo. The proportion of patients rating substantial or total control over symptoms after 6 weeks treatment was 60.9% and 48.2% in the Aqua and Turbuhaler-treated groups, respectively, which was significantly better compared with 29.8% in the placebo-treated group. Rhinocort Aqua and Rhinocort Turbuhaler were equally well tolerated.

scholarly journals Alternative Therapeutic Approach in the Treatment of Oral Pyogenic Granuloma

2015 ◽  
Vol 8 (3) ◽  
pp. 493-497 ◽  
Author(s):  
Amr Bugshan ◽  
Harsh Patel ◽  
Karen Garber ◽  
Timothy F. Meiller
Keyword(s):  
Oral Cavity ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Pyogenic Granuloma ◽  
Hormonal Imbalance ◽  
Choice Of Treatment ◽  
Chronic Irritation ◽  
Multiple Recurrences ◽  
And Behavior ◽  
Rule Out

Pyogenic granulomas (PGs) in the oral cavity present as an inflammatory hyperplasia usually caused by trauma, hormonal imbalance, chronic irritation, or as the response to a wide variety of drugs. PGs with atypical presentation and behavior may clinically mimic malignant tumors. Thus, histological examination is required to rule out cancer development. Lesions in the oral cavity have been described to be either an isolated entity or present in multiple forms and with multiple recurrences. Conservative surgical excision is the standard choice of treatment in almost every scenario. However, the severity of the lesions and the affected sites often challenge surgical treatment. In this report, we describe the clinical scenario of a recurrent PG, where surgical excision of the lesion was questioned. As an alternative, we describe a noninvasive approach with lesional steroid injections.

A Rare Case of Nasopharyngeal Glial Heterotopia in a Neonate

2021 ◽  
pp. 097321792110425
Author(s):  
Viveka Singh ◽  
Neha Nabar ◽  
Sanjiv Badhwar ◽  
Preetha Joshi
Keyword(s):  
Gold Standard ◽  
Rare Case ◽  
Neural Tissue ◽  
Surgical Excision ◽  
Intracranial Extension ◽  
Resonance Imaging ◽  
Radiological Studies ◽  
Rule Out ◽  
Glial Heterotopia

Nasopharyngeal glial heterotopias is an extremely rare, nonhereditary, developmental malformation manifesting as a mass composed of mature neural tissue with no intracranial continuity. Glial heterotopia is a rare, non-neoplastic, extracranial midline malformation. Nasal glioma is the most frequently encountered entity among congenital nasal masses. Cases which are associated with intracranial extension are termed as encephalocele. It must be considered in the differential diagnosis of airway obstruction in neonates. Magnetic resonance imaging is mandatory to rule out intracranial extension. We report a rare case of heterotopic brain tissue in nasopharynx with no intracranial extension to attract attention to the diagnostic workup of nasopharyngeal obstruction in a neonate with respiratory distress. Clinical examination and radiological studies are diagnostic while early surgical excision and histopathological confirmation is the gold standard. This baby underwent complete intranasal endoscopic excision of mass on day 20 of life. The postoperative course was uneventful and the baby is growing well on follow-up. This case would be one of the few cases reported from India.

scholarly journals Association of chronic rhinosinusitis with nasal polyps and asthma: Clinical and radiological features, allergy and inflammation markers

Medicina ◽  
2008 ◽  
Vol 44 (4) ◽  
pp. 257 ◽  
Author(s):  
Jūratė Staikūnienė ◽  
Saulius Vaitkus ◽  
Lidija Japertienė ◽  
Silvija Ryškienė
Keyword(s):  
Allergic Rhinitis ◽  
Pulmonary Function ◽  
Chronic Rhinosinusitis ◽  
Systemic Inflammation ◽  
Eosinophil Count ◽  
Nasal Polyps ◽  
Older Age ◽  
Bronchial Obstruction ◽  
Inflammation Markers ◽  
Nasal Symptoms

Chronic rhinosinusitis (CRS) with and without nasal polyps represent different stages of one chronic inflammatory disease of the mucosa of the nasal cavity and paranasal sinuses. Coexistence of chronic rhinosinusitis with nasal polyps and asthma and rather similar characteristics of inflammation support assumption that chronic rhinosinusitis and nasal polyps and asthma may be, at least in part, the same disease process. We therefore aimed to evaluate the differences of sinus radiologic findings, systemic inflammation and allergy markers, pulmonary function of chronic rhinosinusitis associated with nasal polyps and asthma. A total of 121 patients with chronic rhinosinusitis referred to tertiary center were evaluated; 23 healthy persons served as controls. Sinus CT scans and nasal endoscopy were performed. Allergic rhinitis was diagnosed according to history and positive skin prick tests to common inhalant allergens. Asthma was diagnosed according to GINA by history and pulmonary function tests. Aspirin intolerance was assessed by history. Total IgE, Aspergillus fumigatus-specific IgE levels, leukocyte and eosinophil count in the peripheral blood were measured. Nasal polyps were detected in 84 patients (69.4%), asthma diagnosed in 48 patients (39.6%), associated with nasal polyps (91.7%) and allergic rhinitis in 45.5% of patients. Forty-four patients with chronic rhinosinusitis and having nasal polyps and asthma were characterized by older age (P<0.01), greater duration of nasal symptoms (P<0.001), higher number previous surgeries (P<0.01), more severe sinus disease on CT scan (P<0.001), greater blood leukocyte and eosinophil count, total IgE level (P<0.01), bronchial obstruction (P<0.05), incidence of allergic rhinitis (P<0.01), and sensitivity to house dust mite D. pteronyssinus (47.7%, P<0.01) and mold allergens (29.5%, P<0.01) comparing to the patients with isolated chronic rhinosinusitis. The extent of sinus CT changes was greater in asthmatics and correlated with greater duration of asthma (P<0.0001), higher number of previous surgeries (P=0.001), leukocyte count in blood (P=0.025), and age (P=0.039). Conclusion. Our data indicate that patients with chronic rhinosinusitis compose clinically heterogeneous group and when associated with nasal polyps and asthma constitutes the most severe form of unified respiratory tract disease, which is characterized by older age of the patients, greater duration of nasal symptoms, extent of sinus radiological changes, more prominent systemic inflammation markers, greater bronchial obstruction, incidence of perennial allergic rhinitis

scholarly journals ZAKAZ WYROKOWANIA PONAD ŻĄDANIE STRONY (‘NE EAT IUDEX ULTRA PETITA PARTIUM’) – RZYMSKIE TRADYCJE I WSPÓŁCZESNE REGULACJE POLSKIEGO PROCESOWEGO PRAWA CYWILNEGO

2016 ◽  
Vol 12 (4) ◽  
pp. 41
Author(s):  
Joanna Misztal-Konecka
Keyword(s):  
Supreme Court ◽  
Civil Law ◽  
Roman Law ◽  
Political Transformation ◽  
Original Formulation ◽  
Current Formulation ◽  
The Social ◽  
The Subject ◽  
Polish Code ◽  
Rule Out

‘NE EAT IUDEX ULTRA PETITA PARTIUM’: THE PROHIBITION ON JUDGEMENTS OVER AND ABOVE THE CLAIM A PARTY HAS LODGED. ROMAN TRADITIONS AND CONTEMPORARY REGULATIONS IN POLISH CIVIL LAW PROCEEDINGS Summary One of the testimonials to the vast influence of Roman law on contemporary civil law, including proceedings, are the Latin legal maxims which have been used for centuries not only by theorists of the law but also by its practitioners. Following the social and political transformation, one of the maxims very often resorted to in Poland is ne eat iudex ultra petita partium. Its importance is confirmed by the fact that it is among the 86 inscriptions decorating the columns in the building of the Polish Supreme Court. This legal maxim is an excerpt from the Roman jurist Iavolenus (D. 10,3,18), who used this expression to rule out the possibility of one of the beneficiaries in an inheritance case obtaining an easement on the testator’s estate for use on his own property which was not part of the estate devised. Clearly the original formulation applied to a different issue than the sense in which it is used nowadays: as a reference to the limitation on a judge’s powers to the subject of the proceedings he is hearing. In the light of the current formulation of Art. 321 of the Polish Code of Civil Procedure a court cannot or rule over and above the claim, or issue a verdict not relating to the claim. This prohibition means that the court cannot issue a verdict other than (aliud) or over and above (super) what the plaintiff or claimant petitioned for. Neither can it rule on any other grounds than those petitioned for by the plaintiff or claimant. The prohibition on judgements over and above the petition applies both to the object of the petition or claim (petitum) as well as to the grounds thereof (causa petendi).

scholarly journals Liposarcoma of mesorectum presenting as chronic intestinal obstruction: a rare case

2018 ◽  
Vol 5 (10) ◽  
pp. 3437 ◽  
Author(s):  
Rajesh Goud E. ◽  
Muvva Sri Harsha ◽  
Jakkula Srikanth ◽  
Kanmathareddy Amulya
Keyword(s):  
Soft Tissue ◽  
Local Recurrence ◽  
Rare Case ◽  
Spindle Cell ◽  
Surgical Excision ◽  
Clear Cut ◽  
Complete Surgical Excision ◽  
Neoplastic Lesions ◽  
Cell Variant ◽  
Well Differentiated

The term ‘liposarcoma’ refers to a spectrum of neoplastic lesions that can be benign to malignant and likely to recur or metastasize. Liposarcoma is a common soft tissue sarcoma found in adults and occurs mostly in extremities especially thigh followed by retroperitoneum. Here we present a case of spindle cell variant of well differentiated liposarcoma of mesorectum and underwent Anterior resection for the same. The treatment of choice for liposarcomas of retroperitoneum remains debatable and there are no clear-cut guidelines available regarding the same. However, considering the higher rates of local recurrence we advise a complete surgical excision following anatomical principles.

scholarly journals Tax control and inspection supervision in the Republic of Serbia: Characteristics of the legal framework and the need for coordination

Ekonomika ◽  
2021 ◽  
Vol 67 (4) ◽  
pp. 75-90
Author(s):  
Milan Rapajić ◽  
Milivoje Lapčević ◽  
Violeta Miladinović
Keyword(s):  
Tax Evasion ◽  
Legal Framework ◽  
General Law ◽  
Official Control ◽  
Tax Laws ◽  
The Subject ◽  
Comprehensive Reform ◽  
The Law ◽  
The Republic ◽  
Rule Out

Today, the success of entire tax system is viewed through the effectiveness of tax control. Tax control activities are performed by tax inspectors with special authorities, duties and responsibilities, and its purpose is to control whether taxpayers activities comply with tax laws and regulations. With the adoption of the Law on inspection supervision, the Republic of Serbia has implemented a crucial, comprehensive reform of inspection bodies and the process of inspection supervision which has been of great significance for public administration, economy and citizens. The provisions of this law are applied to tax procedures based on the principle of subsidiarity, while the activities of tax inspection are mostly based on the provisions of the Law on tax procedure and tax administration. In tax procedures, the issues which are not regulated by the general Law on inspection supervision, are the subject of another specific law-however, the direct application of the specific law cannot rule out or restrict the application of the law which governs the issues of inspection supervision and official control which are not regulated by the specific law. In this paper, the author discusses the similarities and differences between two laws and solutions for their harmonization underlining their advantages and weaknesses aimed at ensuring the maximum compliance with tax laws and reduction of tax evasion and shadow economy.

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