scholarly journals A reference base for age-related decrease in lean tissue mass: whole body and segmental lean tissue mass in healthy young Irish men and women

2011 ◽  
Vol 70 (OCE3) ◽  
Author(s):  
S. Leahya ◽  
C. O'Neill ◽  
R. Sohun ◽  
P. Jakeman
Keyword(s):  
Whole Body ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Men And Women ◽  
Lean Tissue Mass ◽  
Reference Base ◽  
Age Related

scholarly journals Skeletal Muscle Mass in Acromegaly Assessed by Magnetic Resonance Imaging and Dual-Photon X-Ray Absorptiometry

2009 ◽  
Vol 94 (8) ◽  
pp. 2880-2886 ◽  
Author(s):  
Pamela U. Freda ◽  
Wei Shen ◽  
Carlos M. Reyes-Vidal ◽  
Eliza B. Geer ◽  
Fernando Arias-Mendoza ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Skeletal Muscle ◽  
Whole Body ◽  
Resonance Imaging ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Lean Tissue Mass ◽  
X Ray ◽  
Igf I ◽  
Active Acromegaly

Context: GH and IGF-I are nitrogen retaining and anabolic, but the impact of long-term exposure to supraphysiological GH and IGF-I, either from endogenous overproduction in acromegaly or exogenous sources, on skeletal muscle (SM) mass is not clear. Objectives: The objectives of the study were to assess SM mass by whole-body magnetic resonance imaging (MRI) in acromegaly and test the hypothesis that dual-energy x-ray absorptiometry (DXA) lean tissue mass-derived estimates of SM accurately estimate true SM mass. Design, Setting, and Patients: The design was a cross-sectional study in 27 acromegaly patients compared with predicted models developed in 315 nonacromegaly subjects and to matched controls. Outcome Measures: Mass of SM from whole-body MRI and lean tissue from DXA were measured. Results: SM mass did not differ from predicted or control values in active acromegaly: 31.75 ± 8.6 kg (acromegaly) vs. 33.06 ± 8.9 kg (predicted); SM was 95.6 ± 12.8% of predicted (range 66.7–122%) (P = 0.088). Lean tissue mass (DXA) was higher in acromegaly than controls: 65.91 ± 15.2 vs. 58.73 ± 13.5 kg (P < 0.0001). The difference between lean tissue mass (DXA) and SM in acromegaly patients was higher than that in controls (P < 0.0001) consistent with an enlarged non-SM lean compartment in acromegaly. SM mass predicted by DXA correlated highly with SM mass by MRI (r = 0.97, P < 0.0001). SM (MRI) to SM (DXA predicted) ratio was 1.018 (range 0.896–1.159), indicating high agreement of these measures of SM. Conclusions: SM mass in active acromegaly patients did not differ from predicted values. SM mass estimated from DXA agreed highly with SM by MRI, supporting the validity of the DXA model in assessing SM in acromegaly and other disorders of GH/IGF-I secretion.

Is there evidence for an age-related reduction in metabolic rate?

1998 ◽  
Vol 85 (6) ◽  
pp. 2196-2204 ◽  
Author(s):  
Leonard S. Piers ◽  
Mario J. Soares ◽  
Leanne M. McCormack ◽  
Kerin O’Dea
Keyword(s):  
Metabolic Rate ◽  
Qualitative Change ◽  
Cross Sectional Study ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Cross Sectional ◽  
Lean Tissue Mass ◽  
Age Related ◽  
Older Subjects ◽  
Young Subjects

To determine whether the age-related reduction in basal metabolic rate (BMR) is explained by a quantitative and/or qualitative change in the components of lean tissue, we conducted a cross-sectional study in groups of young ( n = 38, 18–35 yr) and older ( n = 24, 50–77 yr) healthy individuals. BMR was measured by indirect calorimetry. Body composition was obtained by using dual-energy X-ray absorptiometry (DEXA), which permitted four compartments to be quantified [bone mineral mass, fat mass (FM), appendicular lean tissue mass (ALTM), and nonappendicular lean tissue mass (NALTM)]. Absolute BMR and ALTM were lower, whereas FM was significantly higher in the older, compared with young, subjects. BMR, adjusted for differences in FM, ALTM, and NALTM, was significantly lower in the older subjects by 644 kJ/day. In separate regression analyses of BMR on body compartments, older subjects had significantly lower regression coefficients for ALTMand NALTM, compared with young subjects. Hence, the age-related decline in BMR is partly explained by a reduction in the quantity, as well as the metabolic activity, of DEXA-derived lean tissue components.

Comparison of Whole and Split Weight Training Routines in Young Women

1994 ◽  
Vol 19 (2) ◽  
pp. 185-199 ◽  
Author(s):  
Aaron W. Calder ◽  
Phil D. Chilibeck ◽  
Colin E. Webber ◽  
Digby G. Sale
Keyword(s):  
Young Women ◽  
Weight Training ◽  
Upper Body ◽  
Whole Body ◽  
Lower Body ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Lean Tissue Mass ◽  
Key Words Resistance Training ◽  
And Control

Thirty young women comprised three groups (n = 10 in each): whole routine (W) training, split routine training (S), and control. The W group did four upper (five sets, 6-10 RM) and three lower body (five sets, 10-12 RM) weight training exercises together in single sessions twice a week for 20 weeks. The S group did the upper body exercises 2 days a week and the lower body exercises on 2 other days of the week. The single maximal weight lift (1-RM) increased (p < 0.05) (W/S) 54/69%, 33/32%, and 21/22% in arm curl, bench press, and leg press exercises, as did arm (10/9%), and trunk (3.4/2.7%) lean tissue mass, as measured by dual energy x-ray absorptiometry. Leg lean mass increased significantly only in W (4.9% vs. 1.7% in S). Whole-body lean tissue mass increased (4.1/2.6%), and whole body % fat (−1.1/−1.3%) decreased with training. It is concluded that in healthy young women, whole and split weight training routines produce similar results over the first 5 months of training. Key words: resistance training, strength, muscle mass, body composition

scholarly journals Protein Supplementation at Breakfast and Lunch for 24 Weeks beyond Habitual Intakes Increases Whole-Body Lean Tissue Mass in Healthy Older Adults

2015 ◽  
Vol 146 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Catherine Norton ◽  
Clodagh Toomey ◽  
William G McCormack ◽  
Peter Francis ◽  
Jean Saunders ◽  
...  
Keyword(s):  
Older Adults ◽  
Protein Supplementation ◽  
Whole Body ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Lean Tissue Mass ◽  
Healthy Older Adults

Age- and sex-related bone uptake of Tc-99m-HDP measured by whole-body bone scanning

2000 ◽  
Vol 39 (05) ◽  
pp. 127-132 ◽  
Author(s):  
Nicole Sieweke ◽  
K. H. Bohuslavizki ◽  
W. U. Kampen ◽  
M. Zuhayra ◽  
M. Clausen ◽  
...  
Keyword(s):  
Whole Body ◽  
Bone Lesions ◽  
Men And Women ◽  
Bone Uptake ◽  
Normal Bone ◽  
Age Related ◽  
Number Of Patients ◽  
Wide Range ◽  
Bone Scans ◽  
Body Bone

Summary Aim of this study was to validate a recently introduced new and easy-to-perform method for quantifying bone uptake of Tc-99m-labelled diphosphonate in a routine clinical setting and to establish a normal data base for bone uptake depending on age and gender. Methods: In 49 women (14-79 years) and 47 men (6-89 years) with normal bone scans as well as in 49 women (33-81 years) and 37 men (27-88 years) with metastatic bone disease whole-body bone scans were acquired at 3 min and 3-4 hours p.i. to calculate bone uptake after correction for both urinary excretion and soft tissue retention. Results: Bone uptake values of various age-related subgroups showed no significant differences between men and women (p >0.05 ). Furthermore, no differences could be proven between age-matched subgroups of normals and patients with less than 10 metastatic bone lesions, while patients with wide-spread bone metastases revealed significantly increased uptake values. In both men and women highest bone uptake was obtained (p <0.05 ) in subjects younger than 20 years with active epiphyseal growth plates. In men, bone uptake slowly decreased with age up to 60 years and then showed a tendency towards increasing uptake values. In women, the mean uptake reached a minimun in the decade 20-29 years and then slowly increased with a positive linear correlation of age and uptake in subjects older than 55 years (r = 0.57). Conclusion: Since the results proposed in this study are in good agreement with data from literature, the new method used for quantification could be validated in a large number of patients. Furthermore, age- and sexrelated normal bone uptake values of Tc-99m-HDP covering a wide range of age could be presented for this method as a basis for further studies on bone uptake.

scholarly journals Meta-Analysis Examining the Importance of Creatine Ingestion Strategies on Lean Tissue Mass and Strength in Older Adults

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1912
Author(s):  
Scott C. Forbes ◽  
Darren G. Candow ◽  
Sergej M. Ostojic ◽  
Michael D. Roberts ◽  
Philip D. Chilibeck
Keyword(s):  
Resistance Training ◽  
Meta Analysis ◽  
Creatine Supplementation ◽  
Strength Increase ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Resistance Training Program ◽  
Lean Tissue Mass ◽  
Leg Press ◽  
Meta Analyses

Creatine supplementation in conjunction with resistance training (RT) augments gains in lean tissue mass and strength in aging adults; however, there is a large amount of heterogeneity between individual studies that may be related to creatine ingestion strategies. Therefore, the purpose of this review was to (1) perform updated meta-analyses comparing creatine vs. placebo (independent of dosage and frequency of ingestion) during a resistance training program on measures of lean tissue mass and strength, (2) perform meta-analyses examining the effects of different creatine dosing strategies (lower: ≤5 g/day and higher: >5 g/day), with and without a creatine-loading phase (≥20 g/day for 5–7 days), and (3) perform meta-analyses determining whether creatine supplementation only on resistance training days influences measures of lean tissue mass and strength. Overall, creatine (independent of dosing strategy) augments lean tissue mass and strength increase from RT vs. placebo. Subanalyses showed that creatine-loading followed by lower-dose creatine (≤5 g/day) increased chest press strength vs. placebo. Higher-dose creatine (>5 g/day), with and without a creatine-loading phase, produced significant gains in leg press strength vs. placebo. However, when studies involving a creatine-loading phase were excluded from the analyses, creatine had no greater effect on chest press or leg press strength vs. placebo. Finally, creatine supplementation only on resistance training days significantly increased measures of lean tissue mass and strength vs. placebo.

Abstract P330: Growth Differentiation Factor 15 Causes Cardiac Cachexia In Heart Failure

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Da Young Lee ◽  
Zhe Jiao ◽  
Andrew Antolic ◽  
Daiana Weiss ◽  
M. Neale Weitzmann ◽  
...  
Keyword(s):  
Heart Failure ◽  
Food Intake ◽  
Cardiac Fibrosis ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Lean Tissue Mass ◽  
Growth Differentiation Factor 15 ◽  
Tissue Weight ◽  
Reduced Fat ◽  
Differentiation Factor

Background: Cachexia is wasting of normal body tissue and occurs in chronic medical diseases. It is a common complication of heart failure (HF) that is associated with very high mortality. Growth differentiation factor 15 (GDF15) regulates food intake and can cause cancer cachexia. GDF15 is a sensitive biomarker in humans, though its biologic function in HF is unknown. This study investigated the role of GDF15 in HF. Methods: We utilized a genetic mouse model of dilated cardiomyopathy (DCM) caused by a mutation in the phospholamban gene (PLN R9C ). PLN R9C mice have dysregulated cardiac calcium handling (a common feature of nearly all forms of HF) and develop progressive DCM that leads to HF and premature death. Q-PCR and ELISA were performed to assess expression, tissue distribution and circulating levels of GDF15 in PLN R9C and age-matched wild type (WT) mice. A double transgenic mouse was created by crossing our DCM model with a constitutive Gdf15 knock-out (KO). Using this novel model, we quantified food intake, and assessed fat and lean tissue mass by tissue weight at necropsy and by dual-energy X-ray absorptiometry (DXA). Cardiac function was assessed using echocardiography, and histochemistry performed to quantify cardiac fibrosis. Survival was assessed by Kaplan-Meier. Results: GDF15 mRNA (43-fold; p<0.01) and protein (54-fold; p<0.01) were increased in LV tissue, and circulating GDF15 was elevated (8.3-fold; p=0.03) in PLN R9C mice. Gdf15 was expressed at low levels and was not increased in other organs in PLN R9C mice. PLN R9C mice developed cachexia (reduced fat and lean mass by tissue weight, reduced fat mass by DXA vs. WT; p<0.01 for all) and consumed less food (p<0.01 vs. WT). Gdf15 KO in PLN R9C preserved fat and lean tissue mass and resulted in higher food intake (p≤0.01 for all). Gdf15 KO had no effect on cardiac structure or function by echocardiography and PLN R9C / Gdf15 KO mice displayed only a small reduction in cardiac fibrosis relative to PLN R9C mice (3%; p<0.01). Despite this, Gdf15 KO prolonged survival in PLN R9C (29±3 vs. 25±3 weeks; p<0.01). Conclusions: GDF15 is a novel cardiac hormone produced in HF that triggers anorexia and cachexia in HF by an extra-cardiac mechanism.

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