EARLY AWARENESS AND ALERT SYSTEMS FOR MEDICAL TECHNOLOGIES IN ISRAEL

2012 ◽  
Vol 28 (3) ◽  
pp. 333-338 ◽  
Author(s):  
Orna Tal ◽  
Nina Hakak
Keyword(s):  
Technology Implementation ◽  
Medical Technology ◽  
Decision Makers ◽  
Short Term ◽  
Future Health ◽  
Complex Situation ◽  
The Matrix ◽  
Future Health Care ◽  
Insight Into

Background: Throughout the world, decision makers face the need to plan on the basis of uncertainty. Prospective updates on future trends of medical technology usage are tools to improve national health status. In Israel, this challenge is met by several steps taken to promote insight into the realm of emerging technologies. Israel's unique horizon strategy refers to three time spans: the immediate to short-term (for the coming year) updating the National List of Health Services (NLHS) and quarterly scanning; the medium-term (3 years to a decade) revitalizing hospital devices and infrastructure; and long-term planning (over a decade), such as the “Health Israel 2020 Project”.Methods: A description of the Israeli setup of different time spans and tiers.Results: The matrix of players, loci, interests, population groups, and incentives creates a complex situation and the Ministry of Health has to regulate the different suppliers and tiers of insurance (obligatory, supplementary, and private), balancing need, equity, and cost containment in preparing for future health care. However, preparedness is not a sterile laboratory and is pervaded by numerous dilemmas and the search for adequate evidence for new less mature technologies is an on-going challenge.Conclusion: Bridging the forecasting chasm for the future requires analyzing needs, reinforcing evidence and seeing “around the corner” when synergizing between all the “actors” in the national arena. Expert consultation and international cooperation with similar horizon organizations can assist in paving the way for more successful planning efforts for future medical technology implementation.

Athletes Play Through Pain—What Does That Mean for Rehabilitation Specialists?

2020 ◽  
Vol 29 (5) ◽  
pp. 640-649 ◽  
Author(s):  
Amy Barrette ◽  
Katherine Harman
Keyword(s):  
Well Being ◽  
Short Term ◽  
Semistructured Interviews ◽  
Sport Organization ◽  
The University ◽  
E Mail ◽  
Competitive Nature ◽  
And Training ◽  
Insight Into

Context: Pain in sport has been normalized to the point where athletes are expected to ignore pain and remain in the game despite the possible detrimental consequences associated with playing through pain. While rehabilitation specialists may not have an influence on an athlete’s competitive nature or the culture of risk they operate in, understanding the consequences of those factors on an athlete’s physical well-being is definitely in their area of responsibility. Objective: To explore the factors associated with the experiences of subelite athletes who play through pain in gymnastics, rowing, and speed skating. Design: The authors conducted semistructured interviews with subelite athletes, coaches, and rehabilitation specialists. They recruited coach participants through their provincial sport organization. Athletes of the recruited coaches who were recovering from a musculoskeletal injury and training for a major competition were then recruited. They also recruited rehabilitation specialists who were known to treat subelite athletes independently by e-mail. Setting: An observation session was conducted at the athlete’s training facility. Interviews were then conducted either in a room at the university or at a preferred sound-attenuated location suggested by the participant. Participants: The authors studied 5 coaches, 4 subelite athletes, and 3 rehabilitation specialists. Interventions: The authors photographed athletes during a practice shortly before an important competition, and we interviewed all the participants after that competition. Our photographs were used during the interview to stimulate discussion. Results: The participant interviews revealed 3 main themes related to playing through pain. They are: Listening to your body, Decision making, and Who decides. Conclusion: When subelite athletes, striving to be the best in their sport continue to train with the pain of an injury, performance is affected in the short-term and long-term consequences are also possible. Our study provides some insight into the contrasting forces that athletes balance as they decide to continue or to stop.

scholarly journals Effectiveness of COVID-19 Vaccines against Delta (B.1.617.2) Variant: A Systematic Review and Meta-Analysis of Clinical Studies

Vaccines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 23
Author(s):  
Ali Pormohammad ◽  
Mohammad Zarei ◽  
Saied Ghorbani ◽  
Mehdi Mohammadi ◽  
Saeideh Aghayari Sheikh Neshin ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Severe Infection ◽  
Vaccination Rate ◽  
Decision Makers ◽  
Morbidity Rate ◽  
Short Term ◽  
Mortality And Morbidity ◽  
Public Health Decision ◽  
Health Decision

The high transmissibility, mortality, and morbidity rate of the SARS-CoV-2 Delta (B.1.617.2) variant have raised concerns regarding vaccine effectiveness (VE). To address this issue, all publications relevant to the effectiveness of vaccines against the Delta variant were searched in the Web of Science, Scopus, EMBASE, and Medline (via PubMed) databases up to 15 October 2021. A total of 15 studies (36 datasets) were included in the meta-analysis. After the first dose, the VE against the Delta variant for each vaccine was 0.567 (95% CI 0.520–0.613) for Pfizer-BioNTech, 0.72 (95% CI 0.589–0.822) for Moderna, 0.44 (95% CI 0.301–0.588) for AstraZeneca, and 0.138 (95% CI 0.076–0.237) for CoronaVac. Meta-analysis of 2,375,957 vaccinated cases showed that the Pfizer-BioNTech vaccine had the highest VE against the infection after the second dose, at 0.837 (95% CI 0.672–0.928), and third dose, at 0.972 (95% CI 0.96–0.978), as well as the highest VE for the prevention of severe infection or death, at 0.985 (95% CI 0.95–0.99), amongst all COVID-19 vaccines. The short-term effectiveness of vaccines, especially mRNA-based vaccines, for the prevention of the Delta variant infection, hospitalization, severe infection, and death is supported by this study. Limitations include a lack of long-term efficacy data, and under-reporting of COVID-19 infection cases in observational studies, which has the potential to falsely skew VE rates. Overall, this study supports the decisions by public health decision makers to promote the population vaccination rate to control the Delta variant infection and the emergence of further variants.

scholarly journals Az etopozid szervezeten belüli eloszlásában és metabolizmusában szerepet játszó epigenetikai hatások

2018 ◽  
Vol 159 (32) ◽  
pp. 1295-1302
Author(s):  
Erika Rozália Kovács ◽  
Sára Tóth ◽  
Dániel János Erdélyi
Keyword(s):  
Topoisomerase Ii ◽  
Therapeutic Index ◽  
Antitumor Agent ◽  
Hematologic Malignancies ◽  
Short Term ◽  
Drug Dosing ◽  
And Personalized Medicine ◽  
Insight Into ◽  
Pharmacogenomic Studies

Abstract: Etoposide is a topoisomerase II inhibitor antitumor agent which is widely used in the treatment of several hematologic malignancies and solid tumors. The therapeutic index of etoposide is quite high, thus its application causes several short-term and long-term side effects which can decrease the chance to cure patients. Drug dosing is based on body surface area calculation; recommendations for individual dosing do not exist yet. The biotransformation and transportation of etoposide are carried out by enzymes and transporters as reported in pharmacogenomic studies published in this area. Nowadays pharmacoepigenetics research has come to the fore. The authors wish to give an insight into the research of the epigenetical changes of the etoposide pathways, especially focusing on published findings on enzymes and transporters with pharmacokinetic relevance. In the future, epigenetical changes of the etoposide pathway might have a great role in diagnostics, prognostics and personalized medicine. Orv Hetil. 2018; 159(32): 1295–1302.

Intra-arterial chemotherapy for retinoblastoma: an updated systematic review and meta-analysis

2019 ◽  
Vol 11 (12) ◽  
pp. 1266-1272 ◽  
Author(s):  
Krishnan Ravindran ◽  
Lauren A Dalvin ◽  
Jose S Pulido ◽  
Waleed Brinjikji
Keyword(s):  
Metastatic Disease ◽  
Meta Analysis ◽  
Inclusion Criteria ◽  
First Line ◽  
Short Term ◽  
Systemic Complications ◽  
Substantial Heterogeneity ◽  
Insight Into

Background and purposeIntra-arterial chemotherapy for retinoblastoma has been adopted as a first-line treatment option by numerous tertiary centers. The effect of intra-arterial chemotherapy on future rates of metastatic disease as well as on globe salvage in advanced eyes remains relatively unknown.MethodsA search of PubMED, MEDLINE, EMBASE, and Web of Science electronic databases was conducted from inception until January 2019 for studies with a minimum of 10 patients reporting outcomes and complications following intra-arterial chemotherapy for retinoblastoma.ResultsA total of 20 studies met the inclusion criteria for analysis, comprising 873 patients and 1467 eyes. Only one study was comparative; there was substantial heterogeneity in reported outcomes and several overlapping patient cohorts that were published. Across all studies, 174 of 1467 eyes were enucleated (11.8%). Metastatic disease occurred in 8 of 513 patients (1.6%). Globe salvage was achieved in 318 of 906 (35.6%) cases of advanced retinoblastoma. The most common ocular complication was retinal detachment, occurring in 23% of eyes, and the most common systemic complications were transient fever and nausea/vomiting.ConclusionsThere is a paucity of higher-level evidence with adequate follow-up surrounding the long-term safety of intra-arterial chemotherapy and effect on metastasis in retinoblastoma. Studies to date have been limited by short-term follow-up. Longitudinal prospective studies could provide greater insight into the ability of intra-arterial chemotherapy to reduce the risk of retinoblastoma metastasis.

scholarly journals Alternatives to groundwater abstraction as a measure to stop land subsidence: a case study of Semarang, Indonesia

2019 ◽  
Vol 125 ◽  
pp. 01003 ◽  
Author(s):  
Wesley Beek ◽  
Bart Letitre ◽  
H. Hadiyanto ◽  
S. Sudarno
Keyword(s):  
Cost Benefit Analysis ◽  
Cost Benefit ◽  
Drinking Water Treatment ◽  
Decision Makers ◽  
Groundwater Abstraction ◽  
Short Term ◽  
Treatment Services

The Water as Leverage project aims to lay a blueprint for urban coastal areas around the world that are facing a variety of water-related issues. The blueprint is based upon three real case studies in Bangladesh, India and Indonesia. The case of Indonesia focuses on Semarang, a city that faces issues like flooding, increased water demand, and a lack of wastewater treatment. In this report I summarise the different techniques available to tackling these issues. Along with this I provide a cost-benefit analysis to support decision makers. For a short term it is recommended to produce industrial water from (polluted) surface water as a means to offer an alternative to groundwater abstraction. On a long term it is recommended to install additional wastewater and drinking water treatment services to facilitate better hygiene and a higher quality of life.

scholarly journals The use of borehole inclinometry in determining basal sliding and internal deformation at Haut Glacier d’Arolla, Switzerland

1997 ◽  
Vol 24 ◽  
pp. 331-337 ◽  
Author(s):  
Luke Copland ◽  
Jon Harbor ◽  
Marie Minner ◽  
Martin Sharp
Keyword(s):  
Hot Water ◽  
Short Term ◽  
Digital Inclinometer ◽  
Basal Sliding ◽  
Internal Deformation ◽  
One Year ◽  
Annual Scale ◽  
Insight Into ◽  
Displacement Measurements

A series of boreholes were drilled with high-pressure hot water across a section of Haut Glacier d’Arolla, Switzerland, in summer 1995. Twenty-three of the boreholes were profiled with a digital inclinometer soon aller drilling, and 14 were re-profiled up to 6 weeks later to determine changes in the longitudinal shape of boreholes with time. In addition to the main surveys, three boreholes were surveyed 14 times each to assess the accuracy and reproducibility of inclinometry measurements. These repeat surveys suggest that caution is needed in the interpretation of short-term borehole displacement measurements, and that the reoccupation of boreholes from one year to the next may be a better way to determine patterns of internal deformation and basal sliding. The annual scale may also have advantages in providing more long-term insight into glaciological processes than short term (single season) measurements.

The Shift towards Smart, Green and Integrated Raw Materials Efficiency

2014 ◽  
Vol 718 ◽  
pp. 105-109
Author(s):  
Eva Oravcová ◽  
Miroslav Zelko
Keyword(s):  
Decision Support ◽  
Raw Materials ◽  
Decision Makers ◽  
Short Term ◽  
Supervision System ◽  
Requirements Development ◽  
And Control ◽  
Term Data

Comprehensive environmental observation, eco-innovation and smartization are essential to ensure the delivery of the long-term data and information required to address the shift towards smart, green and integrated raw materials efficiency. For this reason we need the mine-wide digitalization and informatization base model, an advanced mine-wide decision support system and a smart supervision system to supervise and control the production, back to predefined short-term production targets with most likelihood and optimal approaches. There are three main steps to be taken: analysis, evaluation and determination of the shift requirements, development of the models as well as modeling of the scenarios and connection to the smart platform for the support of the decision makers. The paper aims to consider what would be required for a raw materials area to operate as a modern smart technology-supported business. It attempts to provide a vision of some future smart architectures scenarios.

scholarly journals Characterizing agile supply partnerships in the fashion industry

2016 ◽  
Vol 36 (8) ◽  
pp. 923-947 ◽  
Author(s):  
Corrado Cerruti ◽  
Carlos Mena ◽  
Heather Skipworth ◽  
Ernesto Tavoletti
Keyword(s):  
Decision Makers ◽  
Exploratory Research ◽  
Fashion Industry ◽  
Strategic Partnerships ◽  
Short Term ◽  
Organizational Relationships ◽  
Apparent Paradox ◽  
Content Type ◽  
High Turbulence

Purpose – The purpose of this paper is to investigate high-involvement and short-term supply relationships, known as agile supply partnerships (ASPs), and explores the conditions that support the development of such inter-organizational relationships. Design/methodology/approach – A qualitative exploratory research design was followed, based on in-depth case studies of Italian fashion footwear manufacturers and their relationships with key suppliers. Findings – ASPs appear to be most relevant in supply material categories which have a high impact on the appearance or functionality of the product. Conversely, in supply categories with a low impact, long-term partnerships are preferred. Four main characteristics of ASPs are identified: they are part of a portfolio of relationships to balance the rigidities of long-term strategic partnerships; they have project-like features; they are developed from a network of pre-qualified suppliers; they are recurring and intermittent rather than continuous or isolated one-off short-term partnerships. Research limitations/implications – The research has been carried out in the context of an Italian footwear district. Further research is required to evaluate the validity of the propositions in other sectors and geographies. Practical implications – The research can help decision makers in the fashion industry, and potentially other sectors affected by high turbulence, to identify when ASPs are most appropriate and what characteristics they should have. Originality/value – This research contributes to the literature on agility by empirically evaluating the apparent paradox related to the specific characteristics of supply relationships required to foster an agile strategy and by clarifying the conditions under which fashion companies develop ASPs.

scholarly journals The financial and structural capabilities of key infrastructure sectors in Serbia

2012 ◽  
Vol 57 (195) ◽  
pp. 7-42 ◽  
Author(s):  
Dejan Malinic ◽  
Vlade Milicevic
Keyword(s):  
Sustainable Growth ◽  
Economic Prosperity ◽  
Strategic Decisions ◽  
Short Term ◽  
Economic Sectors ◽  
Financial Strength ◽  
Energy Transportation ◽  
Economic Growth Rates ◽  
Insight Into

Experts and economic policy creators debate various economic growth rates without a direct insight into the capabilities of the different economic sectors motivated us to devote this paper to the research of key infrastructure sector capabilities, both in terms of the economic prosperity of the Serbian national economy and as a support for the development of other sectors. This paper examines the energy, transportation, and telecommunications sectors? exposure to short-term and long-term risks, and assesses their financial strength, investment possibilities, and long-term profitability. We believe that the following results will be a valuable information input for making better strategic decisions and more expedient planning of economic sustainable growth.

Adaptive Motor Control During Experiments With Brain Machine Interfaces

2008 ◽  
Author(s):  
Koren Beiser ◽  
Miriam Zacksenhouse
Keyword(s):  
Motor Control ◽  
Task Performance ◽  
Internal Representation ◽  
Dimensional Model ◽  
Further Training ◽  
Short Term ◽  
Brain Machine Interfaces ◽  
Neural Modulation ◽  
Insight Into

Recent experiments with Brain Machine Interfaces indicate that the extent of neural modulations increases abruptly upon starting to operate the interface. In contrast, neural modulations due to the trajectory profile remain relatively unchanged. Furthermore, the enhanced modulations subside with further training, mirroring the trend in task performance, which degraded upon starting to operate the interface and improved gradually with training. Here we investigate the hypothesis that the enhanced modulations reflect internal representation of trajectory errors, which results in corrective commands in the short term and adaptive modifications of internal models in the long term. A simplified uni-dimensional model is analyzed to demonstrate the observed transient enhancement in neural modulations during the operation of Brain machine Interfaces. Identifying the source of the transient enhancement in neural modulation would provide insight into adaptive motor control and facilitate the improvement of future Brain Machine Interfaces.

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