scholarly journals Emergence of increasing linezolid-resistance in enterococci in a post-outbreak situation with vancomycin-resistantEnterococcus faecium

2007 ◽  
Vol 136 (8) ◽  
pp. 1131-1133 ◽  
Author(s):  
B. SCHULTE ◽  
A. HEININGER ◽  
I. B. AUTENRIETH ◽  
C. WOLZ
Keyword(s):  
Enterococcus Faecium ◽  
Drug Exposure ◽  
University Hospital ◽  
Linezolid Resistance ◽  
Vancomycin Resistant ◽  
Over Time ◽  
Outbreak Situation ◽  
Southwest Germany

SUMMARYDuring 2004 and at the start of 2005 a university hospital in Southwest Germany was affected by an extensive outbreak of vancomycin-resistantEnterococcus faecium(VRE). Although the outbreak was contained, linezolid-resistant enterococci emerged during and after the outbreak as the usage of linezolid became more common. Linezolid resistance was no longer limited to VRE. Nosocomial spread of linezolid-resistant but vancomycin-susceptibleE. faeciumwas detected and these strains also emerged in patients without prior drug exposure. Linezolid should therefore be used with caution and the susceptibility of isolates monitored over time. Isolation precautions and screening of contacts should be considered to avoid spread of resistant isolates.

Activity of Oritavancin Against Gram-positive Pathogens Causing Bloodstream Infections in the United States Over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010-2019)

2021 ◽  
Author(s):  
Cecilia G. Carvalhaes ◽  
Helio S. Sader ◽  
Jennifer M. Streit ◽  
Mariana Castanheira ◽  
Rodrigo E. Mendes
Keyword(s):  
United States ◽  
Staphylococcus Aureus ◽  
Enterococcus Faecium ◽  
Bloodstream Infections ◽  
The United States ◽  
Drug Resistant ◽  
Gram Positive ◽  
Methicillin Resistant ◽  
Vancomycin Resistant ◽  
Over Time

Oritavancin displayed potent and stable activity (MIC 90 range, 0.06-0.5 mg/L) over time (2010-2019) against Gram-positive pathogens causing bloodstream infections, including methicillin-resistant Staphylococcus aureus and resistant subsets of Enterococcus spp. Daptomycin and linezolid were also active against methicillin-resistant S. aureus and vancomycin-resistant Enterococcus . Only oritavancin and linezolid remained active against Enterococcus faecium isolates displaying an elevated daptomycin MIC (i.e., 2-4 mg/L). Proportions of methicillin-resistant S. aureus and vancomycin-resistant Enterococcus within the respective S. aureus and enterococcal populations decreased over this period.

The Increase of Vancomycin-Resistant Enterococcus Faecium in Urine: A Retrospective Study at University Hospital of Bari

Pharmacophore ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 11-19
Author(s):  
Stolfa Stefania ◽  
Romanelli Federica ◽  
Ronga Luigi ◽  
Del Prete Raffaele ◽  
Mosca Adriana
Keyword(s):  
Retrospective Study ◽  
Enterococcus Faecium ◽  
University Hospital ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant

scholarly journals Population Structure of Enterococcus faecium Causing Bacteremia in a Spanish University Hospital: Setting the Scene for a Future Increase in Vancomycin Resistance?

2005 ◽  
Vol 49 (7) ◽  
pp. 2693-2700 ◽  
Author(s):  
Teresa M. Coque ◽  
Rob J. L. Willems ◽  
Jesús Fortún ◽  
Janetta Top ◽  
Sergio Diz ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Fragment Length Polymorphism ◽  
Hospital Setting ◽  
Clonal Diversity ◽  
Vancomycin Resistance ◽  
University Hospital ◽  
Vancomycin Resistant ◽  
Specific Association ◽  
Great Genetic Diversity ◽  
Very High

ABSTRACT Over an 8-year period (1995 to 2002), 86 Enterococcus faecium blood isolates from 84 patients, of which 54 were ampicillin resistant (AREF) and 32 were ampicillin susceptible (ASEF), were studied in a university hospital (1,200 beds; serving a population of 600,000) in Spain, a country characterized by a near-absence of resistance to vancomycin and very high rates of ampicillin resistance among enterococci. Clonal relatedness by pulsed-field gel electrophoresis (PFGE), antibiotic susceptibility, presence of the virulence/epidemicity genes esp Efm and hyl Efm, and identification of purK alleles were studied. A group of isolates was also analyzed by amplified fragment length polymorphism (AFLP) and multilocus sequence typing. Medical charts (30 variables collected) were reviewed for 60/84 patients. ASEF showed high clonal diversity (32 PFGE types, 11 purK alleles, 4 AFLP genogroups), did not harbor putative virulence genes, and had no specific association with hospital acquisition. AREF isolates belonged to a clonal complex (CC) of genetically related strains (purK-1, AFLP genogroup C), occasionally harboring putative virulence traits, and were from patients with particular risk factors. Within this CC, previously associated with vancomycin-resistant E. faecium isolates causing outbreaks worldwide (W. L. Homan et al., J. Clin. Microbiol. 40:1963-1971, 2002), a great genetic diversity of antibiotic resistance and virulence/epidemicity profiles was found. Associations between esp and a >7-day hospital stay and between purK-1, hospital location, and nosocomial acquisition were noted (P < 0.001). These findings reflect the importance of local environmental differences in the evolution of this CC, suggesting that the emergence of vancomycin resistance among AREF strains in Spain may be a question of time.

scholarly journals Institution-wide and Within-Patient Evolution of Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium Bloodstream Infections

2018 ◽  
Vol 39 (2) ◽  
pp. 226-228 ◽  
Author(s):  
Robert J. Woods ◽  
Twisha S. Patel ◽  
Jerod L. Nagel ◽  
Duane W. Newton ◽  
Andrew F. Read
Keyword(s):  
Enterococcus Faecium ◽  
Bloodstream Infections ◽  
Infect Control Hosp ◽  
Vancomycin Resistant Enterococcus ◽  
Minimum Inhibitory Concentrations ◽  
Vancomycin Resistant ◽  
Over Time

We report daptomycin minimum inhibitory concentrations (MICs) for vancomycin-resistant Enterococcus faecium isolated from bloodstream infections over a 4-year period. The daptomycin MIC increased over time hospital-wide for initial isolates and increased over time within patients, culminating in 40% of patients having daptomycin-nonsusceptible isolates in the final year of the study.Infect Control Hosp Epidemiol 2018;39:226–228

scholarly journals Low Proportion of Linezolid and Daptomycin Resistance Among Bloodborne Vancomycin-Resistant Enterococcus faecium and Methicillin-Resistant Staphylococcus aureus Infections in Europe

2021 ◽  
Vol 12 ◽  
Author(s):  
Robby Markwart ◽  
Niklas Willrich ◽  
Tim Eckmanns ◽  
Guido Werner ◽  
Olaniyi Ayobami
Keyword(s):  
Staphylococcus Aureus ◽  
Enterococcus Faecium ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Temporal Change ◽  
Methicillin Resistant ◽  
Linezolid Resistance ◽  
Multivariable Regression ◽  
Vancomycin Resistant ◽  
Significant Health ◽  
The Eu

Vancomycin-resistant Enterococcus faecium (VREF) and methicillin-resistant Staphylococcus aureus (MRSA) are associated with significant health burden. We investigated linezolid and daptomycin resistance among VREF and MRSA in the EU/EEA between 2014 and 2018. Descriptive statistics and multivariable logistic regression were used to analyze 6,949 VREF and 35,131 MRSA blood isolates from patients with bloodstream infection. The population-weighted mean proportion of linezolid resistance in VREF and MRSA between 2014 and 2018 was 1.6% (95% CI 1.33–2.03%) and 0.28% (95% CI 0.32–0.38%), respectively. Daptomycin resistance in MRSA isolates was similarly low [1.1% (95% CI 0.75–1.6%)]. On the European level, there was no temporal change of daptomycin and linezolid resistance in MRSA and VREF. Multivariable regression analyses showed that there was a higher likelihood of linezolid and daptomycin resistance in MRSA (aOR: 2.74, p &lt; 0.001; aOR: 2.25, p &lt; 0.001) and linezolid in VREF (aOR: 1.99, p &lt; 0.001) compared to their sensitive isolates. The low proportion of linezolid and daptomycin resistance in VREF and MRSA suggests that these last-resort antibiotics remain effective and will continue to play an important role in the clinical management of these infections in Europe. However, regional and national efforts to contain antimicrobial resistance should continue to monitor the trend through strengthened surveillance that includes genomic surveillance for early warning and action.

Outbreak of Colonization and Infection With Vancomycin-ResistantEnterococcus faeciumin a French University Hospital

2006 ◽  
Vol 27 (9) ◽  
pp. 984-986 ◽  
Author(s):  
Olivier Lesens ◽  
L. Mihaila ◽  
F. Robin ◽  
O. Baud ◽  
J. P. Romaszko ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Odds Ratio ◽  
Case Control Study ◽  
Urinary Catheter ◽  
Generation Cephalosporin ◽  
Case Control ◽  
Prior Exposure ◽  
University Hospital ◽  
Vancomycin Resistant ◽  
Control Study

An outbreak of infection with vancomycin-resistantEnterococcus faeciumoccurred at Hôtel-Dieu Hospital (Clermont-Ferrand, France). A case-control study was performed in the infectious diseases and hematology units of the hospital. Urinary catheter use (odds ratio [OR], 12 [95% confidence interval {CI}, 1.5-90];P<.02), prior exposure to a third-generation cephalosporin (OR, 22 [95% CI, 3-152];P= .002), and prior exposure to antianaerobials (OR, 11 [95% CI, 1.5-88];P<.02) were independently predictive of vancomycin-resistantEnterococcus faeciumcarriage.

scholarly journals Linezolid Resistance in Vancomycin-Resistant Enterococcus faecalis and Enterococcus faecium Isolates in a Brazilian Hospital

2014 ◽  
Vol 58 (5) ◽  
pp. 2993-2994 ◽  
Author(s):  
L. M. de Almeida ◽  
M. R. E. de Araujo ◽  
M. F. Iwasaki ◽  
A. G. Sacramento ◽  
D. Rocha ◽  
...  
Keyword(s):  
Enterococcus Faecalis ◽  
Enterococcus Faecium ◽  
Vancomycin Resistant Enterococcus ◽  
Linezolid Resistance ◽  
Vancomycin Resistant
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