The impact of sheep breed on the risk of classical scrapie

2009 ◽  
Vol 138 (3) ◽  
pp. 384-392 ◽  
Author(s):  
K. M. McINTYRE ◽  
H. TREWBY ◽  
S. GUBBINS ◽  
M. BAYLIS

SUMMARYThe risk of classical scrapie in sheep is associated with polymorphisms in the prion protein (PrP) gene. In recent years, large-scale selective breeding programmes for sheep at lower risk of disease have been undertaken across the European Union. We analysed large-scale datasets on scrapie and sheep demography to investigate additional effects of sheep breed on scrapie risk. There was evidence for variation between certain breeds in the scrapie risk of some PrP genotypes, which could be caused by innate breed differences or distinct scrapie strains circulating within them. While the PrP genotypes of cases are generally consistent across breeds, some exceptions provide evidence that scrapie strain may influence affected PrP genotypes to a greater extent than innate breed differences. There was a significant association between the breed-level incidence of scrapie and the frequency of susceptible PrP genotypes in breeds. Our results lend support to selective breeding programmes which aim to reduce the frequency of high-risk PrP genotypes with measures not varying by sheep breed.

2020 ◽  
Vol 6 (3) ◽  
pp. 270-297
Author(s):  
A. I. Pogorletskiy ◽  
◽  
F. Söllner ◽  

In this article, we shall see how pandemics of deadly diseases have changed tax systems over the past two millennia, each time leading to the emergence of new forms of taxation and tax administration. The purpose of the article is to prove that pandemics and the most notable innovations in tax policy are closely interrelated and that the consequences of the largest pandemics in the history of mankind are new approaches to the organization of national tax systems as well as the formation of interstate tax regulation. The lessons from history can be applied to the current corona crisis and may help us devise the appropriate anti-crisis tax policy. The study is based on the historical empirical-inductive method applied to reliable facts of the past related to pandemics and taxation. We trace the evolution of tax policy under the impact of the most significant pandemics and identify patterns of taxation and tax administration that are specific to their eras and are still relevant in the course of the pandemic COVID-19. Our analysis allows us to draw the following conclusions: (1) There is a historical link between pandemics and tax regulation. Many tax innovations originated in response to the consequences of large-scale epidemics of deadly diseases. (2) Many of the tax incentive tools used today in the fight against the corona crisis have already been used during previous pandemics so that we may learn from the experience of earlier times. (3) The COVID-19 pandemic can be expected to have several important consequences for taxation and public finance: innovations in tax administration with an emphasis on remote fiscal audits and digital control; innovations in the taxation of digital companies and their operations at the national and international level; possibly fundamental changes in the tax system of the European Union; and possibly a return of the inflation tax.


2021 ◽  
Vol 15 (3) ◽  
pp. 99-113
Author(s):  
Sławomir Palicki ◽  
Stoyan Stoyanov ◽  
Ivo Kostov ◽  
Tsvetelina Atanasova ◽  
Patrycjusz Ostrowski

The article explores the issue of the function of shopping centres, in particular the analysis of the impact of their presence on society and the local development of cities and regions. Regarding the empirical aspect, the examples of Poznań (Poland) and Varna (Bulgaria) will be presented. As a result of similar socio‑economic conditions and joining the European Union at almost the same moment, all comparative studies reflecting preferences and market reactions seem both viable and interesting. In addition, the two cities chosen for the studies occupy a similar place in the hierarchy of the settlement network in their countries. They are large, well‑developed centres that attract the attention of investors from various segments of the real estate market. The research is part of the modelling of preferences of shopping centre customers areas, which in particular supports the investment decisions of developers operating in the analysed real estate market, and at the same time permits a diagnosis of social satisfaction. A derivative of the research is also the reconstruction of the effects of the functioning of large‑scale shopping malls in two Central‑Eastern European countries.


2021 ◽  
Vol 25 (1) ◽  
pp. 1229-1240
Author(s):  
Liga Rozentale ◽  
Dagnija Blumberga

Abstract In the last decade the European Union (EU) has been steadily increasing its’ ambition regarding the climate policy. Considering the linkage between the climate targets and energy sector’s greenhouse gas emissions, the EU’s member states are respectively adjusting their energy policies. One of the current trends in the EU is to increase the renewable electricity generation by roll-out of onshore and offshore wind parks. This research aims at evaluating the potential of large-scale wind parks in Latvia by using the cost-benefit and multi-criteria analysis from financial, technical, climate and administrative perspectives as well as considering the impact on security of energy supply. The results of the research show a good potential for onshore wind park development in Latvia without any state aid, while offshore wind parks are in a much worse position and would not be beneficial for the project promoters without any kind of EU or state aid.


2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Rahmanta Setiahadi ◽  
S. R. Kartika Sari ◽  
Ahmad Maryudi ◽  
Julia Kalmirah ◽  
Liliana Baskorowati

The Europe Union (E.U.) has agreed to grant the Forest Law Enforcement, Governance and Trade (FLEGT) license to Indonesia as the first country in the world to receive it. FLEGT VPA (Voluntary Partnership Agreement) is a bilateral agreement between the European Union (E.U.) and wood exporting countries, to improve forest governance sector and ensure that timber and wood products imported into the E.U. are produced by the laws and regulation of partner countries. The Indonesian government has obliged to implement Article 12 relating to social safeguards. Indonesia has to periodically monitor to see the extent to which the VPA has an environmental and social impact that affect the lives and welfare of vulnerable and marginalised groups. The purpose of this study is to analyse how the effect of implementation of the Sistem Verifikasi Legalitas Kayu (SVLK) as part of VPA in the small and medium forestry industry sector. Methodology survey with focus group discussions, structured interviews, and semistructured interviews to find out the response and opinion of SME’s owner and employee addressed the effect of SVLK in East Java and Central Java, Indonesia. The theory of change (ToC) was used to consider the implications of SVLK implementation on the sustainable livelihood of small and medium enterprises (SME’s). The results of this study showed that SVLK had a more significant impact on livelihoods, as follows. First, the vulnerable and marginalised groups need to be supported by stakeholders to encourage readiness in faces of SVLK impact. Second, SVLK is susceptible to the effects and at risk of losing livelihoods for women and disabled groups in a short time. This group includes vulnerable groups of aspects of adaptability and sensitivity to the effect. Third, SME’s worker groups who do not have a labour organisation are sensitive to the impact on the workplace company. This group is classified as a group that is quite vulnerable if the effect lasts long enough and on a large scale of impact.


2021 ◽  
Vol 288 (1960) ◽  
Author(s):  
Erinn M. Muller ◽  
Ashley M. Dungan ◽  
Wyatt C. Million ◽  
Katherine R. Eaton ◽  
Chelsea Petrik ◽  
...  

Knowledge of multi-stressor interactions and the potential for tradeoffs among tolerance traits is essential for developing intervention strategies for the conservation and restoration of reef ecosystems in a changing climate. Thermal extremes and acidification are two major co-occurring stresses predicted to limit the recovery of vital Caribbean reef-building corals. Here, we conducted an aquarium-based experiment to quantify the effects of increased water temperatures and p CO 2 individually and in concert on 12 genotypes of the endangered branching coral Acropora cervicornis, currently being reared and outplanted for large-scale coral restoration. Quantification of 12 host, symbiont and holobiont traits throughout the two-month-long experiment showed several synergistic negative effects, where the combined stress treatment often caused a greater reduction in physiological function than the individual stressors alone. However, we found significant genetic variation for most traits and positive trait correlations among treatments indicating an apparent lack of tradeoffs, suggesting that adaptive evolution will not be constrained. Our results suggest that it may be possible to incorporate climate-resistant coral genotypes into restoration and selective breeding programmes, potentially accelerating adaptation.


2007 ◽  
Vol 88 (12) ◽  
pp. 3486-3492 ◽  
Author(s):  
Darren M. Green ◽  
Victor J. del Rio Vilas ◽  
Colin P. D. Birch ◽  
Jethro Johnson ◽  
Istvan Z. Kiss ◽  
...  

Following the bovine spongiform encephalopathy (BSE) crisis, the European Union has introduced policies for eradicating transmissible spongiform encephalopathies (TSEs), including scrapie, from large ruminants. However, recent European Union surveillance has identified a novel prion disease, ‘atypical’ scrapie, substantially different from classical scrapie. It is unknown whether atypical scrapie is naturally transmissible or zoonotic, like BSE. Furthermore, cases have occurred in scrapie-resistant genotypes that are targets for selection in legislated selective breeding programmes. Here, the first epidemiological study of British cases of atypical scrapie is described, focusing on the demographics and trading patterns of farms and using databases of recorded livestock movements. Triplet comparisons found that farms with atypical scrapie stock more sheep than those of the general, non-affected population. They also move larger numbers of animals than control farms, but similar numbers to farms reporting classical scrapie. Whilst there is weak evidence of association through sheep trading of farms reporting classical scrapie, atypical scrapie shows no such evidence, being well-distributed across regions of Great Britain and through the sheep-trading network. Thus, although cases are few in number so far, our study suggests that, should natural transmission of atypical scrapie be occurring at all, it is doing so slowly.


2018 ◽  
Vol 4 (11) ◽  
pp. eaau3523 ◽  
Author(s):  
Emanuele Lugato ◽  
Pete Smith ◽  
Pasquale Borrelli ◽  
Panos Panagos ◽  
Cristiano Ballabio ◽  
...  

Understanding of the processes governing soil organic carbon turnover is confounded by the fact that C feedbacks driven by soil erosion have not yet been fully explored at large scale. However, in a changing climate, variation in rainfall erosivity (and hence soil erosion) may change the amount of C displacement, hence inducing feedbacks onto the land C cycle. Using a consistent biogeochemistry-erosion model framework to quantify the impact of future climate on the C cycle, we show that C input increases were offset by higher heterotrophic respiration under climate change. Taking into account all the additional feedbacks and C fluxes due to displacement by erosion, we estimated a net source of 0.92 to 10.1 Tg C year−1 from agricultural soils in the European Union to the atmosphere over the period 2016–2100. These ranges represented a weaker and stronger C source compared to a simulation without erosion (1.8 Tg C year−1), respectively, and were dependent on the erosion-driven C loss parameterization, which is still very uncertain. However, when setting a baseline with current erosion rates, the accelerated erosion scenario resulted in 35% more eroded C, but its feedback on the C cycle was marginal. Our results challenge the idea that higher erosion driven by climate will lead to a C sink in the near future.


2018 ◽  
pp. 3-10
Author(s):  
S. Kaltyhina ◽  
A. Shanchuk ◽  
Yu. Yesypenko ◽  
O. Pecherytsia

The paper presents an overview of changes and trends in the energy policy of the European Union during the recent years, and shows the impact of the energy security issues on the development of nuclear power industry in Europe. Further development of the nuclear power industry as a low carbon source of energy is considered in the context of a comprehensive approach to the struggle against the climate change. In addition, a short overview of the new energy strategy of Ukraine until 2035 is presented, which defines a complex of large-scale reforms in the energy sector in consideration of the European approaches and the EU energy strategy.


2000 ◽  
Vol 4 (2) ◽  
pp. 222-256 ◽  
Author(s):  
William A. Barnett ◽  
Robert Solow

Franco Modigliani's contributions in economics and finance have transformed both fields. Although many other major contributions in those fields have come and gone, Modigliani's contributions seem to grow in importance with time. His famous 1944 article on liquidity preference has not only remained required reading for generations of Keynesian economists but has become part of the vocabulary of all economists. The implications of the life-cycle hypothesis of consumption and saving provided the primary motivation for the incorporation of finite lifetime models into macroeconomics and had a seminal role in the growth in macroeconomics of the overlapping generations approach to modeling of Allais, Samuelson, and Diamond. Modigliani and Miller's work on the cost of capital transformed corporate finance and deeply influenced subsequent research on investment, capital asset pricing, and recent research on derivatives. Modigliani received the Nobel Memorial Prize for Economics in 1985.In macroeconomic policy, Modigliani has remained influential on two continents. In the United States, he played a central role in the creation of a the Federal Reserve System's large-scale quarterly macroeconometric model, and he frequently participated in the semiannual meetings of academic consultants to the Board of Governors of the Federal Reserve System in Washington, D.C. His visibility in European policy matters is most evident in Italy, where nearly everyone seems to know him as a celebrity, from his frequent appearances in the media. In the rest of Europe, his visibility has been enhanced by his publication, with a group of distinguished European and American economists, of “An Economists' Manifesto on Unemployment in the European Union,” which was signed by a number of famous economists and endorsed by several others.This interview was conducted in two parts on different dates in two different locations, and later unified. The initial interview was conducted by Robert Solow at Modigliani's vacation home in Martha's Vineyard. Following the transcription of the tape from that interview, the rest of the interview was conducted by William Barnett in Modigliani's apartment on the top floor of a high-rise building overlooking the Charles River near Harvard University in Cambridge, Massachusetts. Those concluding parts of the interview in Cambridge continued for the two days of November 5–6, 1999 with breaks for lunch and for the excellent espresso coffee prepared by Modigliani in an elaborate machine that would be owned only by someone who takes fine coffee seriously.Although the impact that Modigliani has had on the economics and finance professions is clear to all members of those professions, only his students can understand the inspiration that he has provided to them. However, that may have been adequately reflected by Robert Shiller at Yale University in correspondence regarding this interview, when he referred to Modigliani as: “my hero.”


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