scholarly journals A genetic variant brain-derived neurotrophic factor (BDNF) polymorphism interacts with hostile parenting to predict error-related brain activity and thereby risk for internalizing disorders in children

2017 ◽  
Vol 30 (1) ◽  
pp. 125-141 ◽  
Author(s):  
Alexandria Meyer ◽  
Greg Hajcak ◽  
Elizabeth Hayden ◽  
Haroon I. Sheikh ◽  
Shiva M. Singh ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Activity ◽  
Brain Derived Neurotrophic Factor ◽  
Internalizing Disorders ◽  
Externalizing Disorders ◽  
Event Related Potential ◽  
Harsh Parenting ◽  
Early Life Adversity ◽  
Parents And Children ◽  
The Impact

AbstractThe error-related negativity (ERN) is a negative deflection in the event-related potential occurring when individuals make mistakes, and is increased in children with internalizing psychopathology. We recently found that harsh parenting predicts a larger ERN in children, and recent work has suggested that variation in the brain-derived neurotrophic factor (BDNF) gene may moderate the impact of early life adversity. Parents and children completed measures of parenting when children were 3 years old (N = 201); 3 years later, the ERN was measured and diagnostic interviews as well as dimensional symptom measures were completed. We found that harsh parenting predicted an increased ERN only among children with a methionine allele of the BDNF genotype, and evidence of moderated mediation: the ERN mediated the relationship between parenting and internalizing diagnoses and dimensional symptoms only if children had a methionine allele. We tested this model with externalizing disorders, and found that harsh parenting predicted externalizing outcomes, but the ERN did not mediate this association. These findings suggest that harsh parenting predicts both externalizing and internalizing outcomes in children; however, this occurs through different pathways that uniquely implicate error-related brain activity in the development of internalizing disorders.

Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age

2014 ◽  
Vol 26 (4pt2) ◽  
pp. 1255-1266 ◽  
Author(s):  
Kieran J. O'Donnell ◽  
Vivette Glover ◽  
Joanna D. Holbrook ◽  
Thomas G. O'Connor
Keyword(s):  
Neurotrophic Factor ◽  
Internalizing Symptoms ◽  
Brain Derived Neurotrophic Factor ◽  
Maternal Anxiety ◽  
Individual Vulnerability ◽  
Prenatal Anxiety ◽  
Parents And Children ◽  
Gene Environment ◽  
Strengths And Difficulties ◽  
Anxiety Depression

AbstractMultiple behavioral and health outcomes, including internalizing symptoms, may be predicted from prenatal maternal anxiety, depression, or stress. However, not all children are affected, and those that are can be affected in different ways. Here we test the hypothesis that the effects of prenatal anxiety are moderated by genetic variation in the child's brain-derived neurotrophic factor (BDNF) gene, using the Avon Longitudinal Study of Parents and Children population cohort. Internalizing symptoms were assessed from 4 to 13 years of age using the Strengths and Difficulties Questionnaire (n = 8,584); a clinical interview with the adolescents was conducted at age 15 years (n = 4,704). Obstetric and psychosocial risk and postnatal maternal symptoms were included as covariates. Results show that prenatal maternal anxiety predicted internalizing symptoms, including with the diagnostic assessment at 15 years. There was a main effect of two BDNF polymorphisms (rs6265 [val66met] and rs11030104) on internalizing symptoms up to age 13. There was also genetic moderation of the prenatal anxiety effect by different BDNF polymorphisms (rs11030121 and rs7124442), although significant effects were limited to preadolescence. The findings suggest a role for BDNF gene–environment interactions in individual vulnerability to the effects of prenatal anxiety on child internalizing symptoms.

scholarly journals Developmental cascade effects of the New Beginnings Program on adolescent adaptation outcomes

2010 ◽  
Vol 22 (4) ◽  
pp. 771-784 ◽  
Author(s):  
Darya Bonds McClain ◽  
Sharlene A. Wolchik ◽  
Emily Winslow ◽  
Jenn-Yun Tein ◽  
Irwin N. Sandler ◽  
...  
Keyword(s):  
Substance Use ◽  
Academic Performance ◽  
Risky Sexual Behavior ◽  
Preventive Intervention ◽  
Self Esteem ◽  
Internalizing Disorders ◽  
Externalizing Disorders ◽  
Baseline Risk ◽  
Cascade Effects ◽  
The Impact

AbstractUsing data from a 6-year longitudinal follow-up sample of 240 youth who participated in a randomized experimental trial of a preventive intervention for divorced families with children ages 9–12, the current study tested alternative cascading pathways by which the intervention decreased symptoms of internalizing disorders, symptoms of externalizing disorders, substance use, and risky sexual behavior and increased self-esteem and academic performance in mid- to late adolescence (15–19 years old). It was hypothesized that the impact of the program on adolescent adaptation outcomes would be explained by progressive associations between program-induced changes in parenting and youth adaptation outcomes. The results supported a cascading model of program effects in which the program was related to increased mother–child relationship quality that was related to subsequent decreases in child internalizing problems, which then was related to subsequent increases in self-esteem and decreases in symptoms of internalizing disorders in adolescence. The results were also consistent with a model in which the program increased maternal effective discipline that was related to decreased child externalizing problems, which was related to subsequent decreases in symptoms of externalizing disorders, less substance use, and better academic performance in adolescence. There were no significant differences in the model based on level of baseline risk or adolescent gender. These results provide support for a cascading pathways model of child and adolescent development.

scholarly journals The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met

2010 ◽  
Vol 214 (1) ◽  
pp. 319-328 ◽  
Author(s):  
Bernet M. Elzinga ◽  
Marc L. Molendijk ◽  
Richard C. Oude Voshaar ◽  
Boudewijn A. A. Bus ◽  
Jos Prickaerts ◽  
...  
Keyword(s):  
Childhood Abuse ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
The Impact ◽  
Moderating Role

scholarly journals The impact of dietary tarragon (Artemisia dracunculus) on serum apelin, brain-derived neurotrophic factor, cardiac troponin concentrations and histopathology of liver tissue in laying hens housed at different stocking densities

2020 ◽  
Vol 65 (No. 6) ◽  
pp. 269-279
Author(s):  
B Bayraktar ◽  
E Tekce ◽  
H Kaya ◽  
M Karaalp ◽  
E Turunc
Keyword(s):  
Blood Vessels ◽  
Neurotrophic Factor ◽  
Cardiac Troponin ◽  
Stocking Density ◽  
Brain Derived Neurotrophic Factor ◽  
Egg Laying ◽  
Stress Factors ◽  
Negative Consequences ◽  
Artemisia Dracunculus ◽  
The Impact

Due to its association with several other stress factors (poultry house gases, inadequate ventilation, heat, cold and poor hygiene), the high stocking density is a major stress factor that adversely affects the health and performance of poultry and the quality of the poultry products. Therefore, this experimental study was aimed at analysing the impact of different doses of dietary tarragon (Artemisia dracunculus) on the serum apelin, plasma brain-derived neurotrophic factor (p-BDNF), and cardiac troponin I (cTnI) concentrations, and the correlation between these indicators in laying hens housed at different stocking densities. The aim of this study is to investigate the effects of adding tarragon in different ratios to laying hen rations in the 2<sup>nd</sup> ovulation period on the cTnI, apelin, and BDNF hormone concentrations and the liver histopathology. The experiment was carried out over a period of eight weeks, with 192 Lohman Brown commercial hybrids at 50 weeks of age. Eight groups (four replicates each), composed of laying hens of equal body weight, which were housed at stocking densities of 580 cm<sup>2</sup>/hen and 810 cm<sup>2</sup>/hen and received 0, 1, 5 and 10 mmol/kg of tarragon (Artemisia dracunculus) in the feed, were established. At the end of the trial, 96 of the housed egg-laying hens (3 birds in each subgroup, a total of 12 birds in each group) were randomly selected and blood samples were taken from the vena subcutanea ulnaris. The samples collected were analysed for the apelin, p-BDNF, and cTnI contents. The analysis results demonstrated that tarragon supplementation had no effect on the serum apelin, p-BDNF and cTnI concentrations (P &gt; 0.05). The Sub-Groups ST1, ST1.2, and ST6 presented with severe hyperaemia of the sinusoidal, portal and acinar blood vessels, whilst the hyperaemia of these blood vessels was moderate in Sub-Group ST12. Apelin, BDNF, and cTnI can act as protective factors against negative consequences of stress (e.g., stocking density or heat stress).

scholarly journals Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress

2019 ◽  
Vol 148 ◽  
pp. 40-49 ◽  
Author(s):  
Anna M. Rosenhauer ◽  
Linda Q. Beach ◽  
Elizabeth C. Jeffress ◽  
Brittany M. Thompson ◽  
Katharine E. McCann ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Social Stress ◽  
Brain Derived Neurotrophic Factor ◽  
Neurotrophic Factor Signaling ◽  
The Impact

scholarly journals Promoting Neuroplasticity for Motor Rehabilitation After Stroke: Considering the Effects of Aerobic Exercise and Genetic Variation on Brain-Derived Neurotrophic Factor

2013 ◽  
Vol 93 (12) ◽  
pp. 1707-1716 ◽  
Author(s):  
Cameron S. Mang ◽  
Kristin L. Campbell ◽  
Colin J.D. Ross ◽  
Lara A. Boyd
Keyword(s):  
Motor Learning ◽  
Aerobic Exercise ◽  
Motor Function ◽  
Motor Skills ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Motor Rehabilitation ◽  
Bdnf Gene ◽  
The Impact ◽  
Rehabilitation Strategies

Recovery of motor function after stroke involves relearning motor skills and is mediated by neuroplasticity. Recent research has focused on developing rehabilitation strategies that facilitate such neuroplasticity to maximize functional outcome poststroke. Although many molecular signaling pathways are involved, brain-derived neurotrophic factor (BDNF) has emerged as a key facilitator of neuroplasticity involved in motor learning and rehabilitation after stroke. Thus, rehabilitation strategies that optimize BDNF effects on neuroplasticity may be especially effective for improving motor function poststroke. Two potential poststroke rehabilitation strategies that consider the importance of BDNF are the use of aerobic exercise to enhance brain function and the incorporation of genetic information to individualize therapy. Converging evidence demonstrates that aerobic exercise increases BDNF production and consequently enhances learning and memory processes. Nevertheless, a common genetic variant reduces activity-dependent secretion of the BDNF protein. Thus, BDNF gene variation may affect response to motor rehabilitation training and potentially modulate the effects of aerobic exercise on neuroplasticity. This perspective article discusses evidence that aerobic exercise promotes neuroplasticity by increasing BDNF production and considers how aerobic exercise may facilitate the acquisition and retention of motor skills for poststroke rehabilitation. Next, the impact of the BDNF gene val66met polymorphism on motor learning and response to rehabilitation is explored. It is concluded that the effects of aerobic exercise on BDNF and motor learning may be better exploited if aerobic exercise is paired more closely in time with motor training. Additionally, information about BDNF genotype could provide insight into the type and magnitude of effects that aerobic exercise may have across individuals and potentially help guide an individualized prescription of aerobic exercise to enhance motor rehabilitation poststroke.

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