Is myocardial performance index useful in differential diagnosis of moderate and severe hypoxic–ischaemic encephalopathy? A serial Doppler echocardiographic evaluation

2012 ◽  
Vol 22 (3) ◽  
pp. 335-340 ◽  
Author(s):  
Sevim Karaarslan ◽  
Hayrullah Alp ◽  
Tamer Baysal ◽  
Derya Çimen ◽  
Rahmi Örs ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Left Ventricle ◽  
Right Ventricle ◽  
Performance Index ◽  
Myocardial Performance Index ◽  
Control Group ◽  
Myocardial Performance ◽  
Performance Indexes ◽  
Left And Right ◽  
The Right

AbstractIntroductionThe aim of this study was to investigate the importance of myocardial performance index as an additive criterion to Sarnat criteria in differential diagnosis of newborn babies with moderate and severe hypoxic–ischaemic encephalopathy.MethodsOur study group included 50 healthy term newborn babies and 20 newborn babies with hypoxic–ischaemic encephalopathy. The 20 newborn babies with hypoxic–ischaemic encephalopathy were scored using Sarnat grades. Left and right ventricular functions were determined on the first day and thereafter in the 1, 3–4, 6–7, and 11–12 months of life by M-Mode and pulsed Doppler.ResultsMyocardial performance indexes of the left ventricle were significantly higher in the severe hypoxic–ischaemic encephalopathy group than in the control group during the first, second, and third analyses (p = 0.01, p = 0.02, p = 0.02, respectively) and only during the first analysis (p = 0.01) in the moderate hypoxic–ischaemic encephalopathy group. In addition, the myocardial performance indexes of the right ventricle were significantly higher during the first, second, and third analyses in both severe and moderate hypoxic–ischaemic encephalopathy groups than in the control group (p = 0.01, all). Hypoxia-induced alterations last longer in the right ventricle than in the left ventricle in the moderate group, as during the second and third analyses myocardial performance index continues to be higher than the control group.ConclusionMyocardial performance indexes for the left and right ventricles were significantly higher in both severe and moderate hypoxic–ischaemic encephalopathy groups than in the control group during the first analysis, and myocardial performance index greater than or equal to 0.5 can be used in order to distinguish moderate and severe hypoxic–ischaemic encephalopathy babies according to Sarnat grades as a discriminative additive criterion.

Feasibility of Measuring Myocardial Performance Index of the Right Ventricle in Anesthetized Patients

2010 ◽  
Vol 24 (2) ◽  
pp. 270-274 ◽  
Author(s):  
Isabelle Michaux ◽  
Manfred Seeberger ◽  
Regina Schuman ◽  
Karl Skarvan ◽  
Miodrag Filipovic
Keyword(s):  
Right Ventricle ◽  
Performance Index ◽  
Myocardial Performance Index ◽  
Myocardial Performance ◽  
The Right

scholarly journals Excessive Treadmill Training Produces different Cardiac-related MicroRNA Profiles in the Left and Right Ventricles in Mice

2021 ◽  
Author(s):  
Jing Yang ◽  
Lin Xu ◽  
Xin Yin ◽  
Yi Li Zheng ◽  
Hai Peng Zhang ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Right Ventricle ◽  
High Volume ◽  
Treadmill Training ◽  
Load Test ◽  
Control Group ◽  
Downhill Running ◽  
Individual Mirnas ◽  
Left And Right ◽  
The Right

AbstractHigh-volume training followed by inadequate recovery may cause overtraining. This process may undermine the protective effect of regular exercise on the cardiovascular system and may increase the risk of pathological cardiac remodelling. We evaluated whether chronic overtraining changes cardiac-related microRNA profiles in the left and right ventricles. C57BL/6 mice were divided into the control, normal training, and overtrained by running without inclination, uphill running or downhill running groups. After an 8-week treadmill training protocol, the incremental load test and training volume results showed that the model had been successfully established. The qRT-PCR results showed increased cardiac miR-1, miR-133a, miR-133b, miR-206, miR-208b and miR-499 levels in the left ventricle of the downhill running group compared with the left ventricle of the control group. Similarly, compared with the control group, the downhill running induced increased expression of miR-21, miR-17–3p, and miR-29b in the left ventricle. Unlike the changes in the left ventricle, no difference in the expression of the tested miRNAs was observed in the right ventricle. Briefly, our results indicated that overtraining generally affects key miRNAs in the left ventricle (rather than the right ventricle) and that changes in individual miRNAs may cause either adaptive or maladaptive remodelling with overtraining.

scholarly journals Early alterations in myocardia and vessels of the diabetic rat heart: an FTIR microspectroscopic study

2006 ◽  
Vol 397 (3) ◽  
pp. 427-436 ◽  
Author(s):  
Neslihan Toyran ◽  
Peter Lasch ◽  
Dieter Naumann ◽  
Belma Turan ◽  
Feride Severcan
Keyword(s):  
Left Ventricle ◽  
Right Ventricle ◽  
Rat Heart ◽  
Molecular Level ◽  
Diabetic Group ◽  
Control Group ◽  
Type I ◽  
Short Term ◽  
The Right ◽  
Left Ventricle Myocardium

Diabetes mellitus is associated with a high incidence and poor prognosis of cardiovascular disease. The aim of the present study was to examine the effect of relatively short-term (5 weeks) Type I diabetes on the left ventricle, the right ventricle and the vessel (vein) on the left ventricle of the myocardium at molecular level by FTIR (Fourier-transform infrared) microspectroscopy. The rats were categorized into two groups: control group (for the left ventricle myocardium, n=8; for the right ventricle myocardium, n=9; for the vein, n=9) and streptozotocin-induced diabetic group (for the left ventricle myocardium, n=7; for the right ventricle myocardium, n=9; for the vein, n=8). Two adjacent cross-sections of 9 μm thickness were taken from the ventricles of the hearts in two groups of rats by using a cryotome. The first sections were used for FTIR microspectroscopy measurements. The second serial sections were stained by haematoxylin/eosin for comparative purposes. Diabetes caused an increase in the content of lipids, an alteration in protein profile with a decrease in α-helix and an increase in β-sheet structure as well as an increase in glycogen and glycolipid contents in both ventricles and the vein. Additionally, the collagen content was found to be increased in the vein of the diabetic group. The present study demonstrated that diabetes-induced alterations in the rat heart can be detected by correlating the IR spectral changes with biochemical profiles in detail. The present study for the first time demonstrated the diabetes-induced alterations at molecular level in both ventricle myocardia and the veins in relatively short-term diabetes.

Third Trimester Myocardial Performance Index in Fetuses from Women with Hyperglycemia in Pregnancy: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Angelo Sirico ◽  
Antonio Raffone ◽  
Giuseppe Maria Maruotti ◽  
Antonio Travaglino ◽  
Carmela Paciullo ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Cardiac Dysfunction ◽  
Performance Index ◽  
Myocardial Performance Index ◽  
Control Group ◽  
Healthy Controls ◽  
Myocardial Performance ◽  
Third Trimester ◽  
Potential Marker ◽  
In Pregnancy

Abstract Introduction The myocardial performance index (MPI) has been proposed to evaluate cardiac dysfunction in newborns from diabetic mothers. Although MPI is routinely assessed in newborns, its role in the evaluation of fetuses from women with hyperglycemia in pregnancy (HIP) is still under evaluation. We aimed to evaluate the differences in third trimester fetal MPI in pregnant women with hyperglycemia compared to healthy controls. Materials and Methods Seven electronic databases were searched for all studies assessing women with HIP who underwent evaluation of fetal left MPI during pregnancy compared to a control group. The summary measures were reported as mean differences (MD) in the mean fetal left MPI between women with HIP and healthy controls, with a 95 % confidence interval (CI). A post hoc subgroup analysis based on the type of HIP – pregestational diabetes, GDM, or gestational impaired glucose tolerance (GIGT) – was performed as an additional analysis. Results 14 studies assessing 1326 fetuses (580 from women with HIP and 746 from controls) were included. Women with HIP had a significantly higher mean left fetal MPI compared to controls (MD 0.08; 95 %CI: 0.05 to 0.11; p < 0.00 001). Subgroup analysis according to the type of HIP concurred with the overall analysis for women with DM (MD 0.07; 95 %CI: 0.01 to 0.13; p = 0.02) and for women with GDM (MD 0.012; 95 %CI: 0.07 to 0.17; p < 0.00 001) but not for women with GIGT (MD –0.01, 95 % CI –0.28 to 0.27; p = 0.96). Conclusion Fetal left MPI is increased in pregnancies with HIP appearing as a potential marker of cardiac dysfunction.

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