Trends in paediatric, neonatal, and adult cardiology publications over the past 10 years

2013 ◽  
Vol 24 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Samuel Menahem ◽  
Daniel Fink ◽  
Francis B. Mimouni
Keyword(s):  
Clinical Trials ◽  
Practice Guidelines ◽  
Case Reports ◽  
Linear Increase ◽  
Publication Type ◽  
The Past ◽  
Rate Of Increase ◽  
Randomised Control Trials ◽  
Number Of Publications ◽  
Meta Analyses

AbstractObjective:Medline classifies publications as clinical trials, randomised control trials, meta-analyses, practice guidelines, reviews, case reports, editorials, and letters. We tested the hypothesis that cardiology-related publications have increased with a shift in the type of publications over the past 10 years by age category.Methods:To retrieve from Medline the cardiology articles, we used the keyword “heart disease”, but limited the search to articles in English from 2000 to 2009. We repeated the search using one limit according to the publication type and using age tags. We used regression analysis to determine the effect of the year of publication on the number of publications of each type.Results:During the 10-year period, Medline registered 152,849 cardiology articles, doubling from 10,452 in 2000 to 20,841 in 2009, of which 8.5% were tagged as both paediatric and adult. There was a linear increase in the number over the study period in the total number of publications and in all categories, except for practice guidelines. There was almost a twofold increase in adult and neonatal articles, but ∼70% in paediatric articles. The rate of increase was 66% for randomised control trials, 73% for clinical trials, 124% for meta-analyses, 117% for editorials, 36% for reviews, and 103% for case reports. Practice guidelines remained very low, increasing significantly for paediatric and neonatal articles.Conclusions:There was a substantial increase in cardiology articles over the past 10 years, being greater for adult and neonatal articles compared with paediatric articles. The increase varied according to the type of article.

Trends in Health Quality-related Publications over the past three decades. (Preprint)

2021 ◽  
Author(s):  
Joseph Mendlovic ◽  
Francis B Mimouni ◽  
Iris Arad ◽  
Eyal Heiman
Keyword(s):  
Health Care ◽  
Health Care Quality ◽  
Case Reports ◽  
Quality Care ◽  
Care Quality ◽  
Publication Type ◽  
The Past ◽  
Management Quality ◽  
Rate Of Increase ◽  
Number Of Publications

BACKGROUND Quality assessment in health care is a process of planned activities whose ultimate goal is to achieve a continuous improvement of medical care through the evaluation of structure, process, and outcome measures. Physicians and health care specialists involved with quality issues are faced with an enormous and nearly always increasing amount of literature to read and integrate OBJECTIVE To test the hypothesis that the number of publications in the field of health care quality increases over time, and particularly the number of high-evidence journal articles such as randomized control trials, systematic reviews, and ultimately, practice guidelines. METHODS We used MEDLINE database to retrieve relevant articles published between during the 29 year-period between 1/1/1989 and 12/31/2018. The search was conducted in March 2021. Publications from 2019 and 2020 were excluded because of incomplete data. We used the keywords "quality care", "quality management", "quality indicators" and "quality improvement” and limited the search fields to title and abstract. RESULTS During the 29-year evaluation period there was a significant cubic increase in the number of publications both in total number of publications and in the variety of publication types studied The rate of increase varied for different types of publications, with the largest increase in reviews, and the smallest increase in case reports. There was a systematic stagnation or even decrease in the number of publications starting in 2015 regardless of publication type. CONCLUSIONS Over the past 29 years the field of quality in health care has seen a significant yearly increase of published original studies with a relative stagnation since 2015. We suggest that contributors to this dynamic field of research should focus on producing more evidence based publications and guidelines

scholarly journals Review of research output of Australian and New Zealand colorectal surgeons over the past 20 years

2020 ◽  
Vol 8 ◽  
pp. 205031212097711
Author(s):  
Jessica Rahme ◽  
Adele Lee ◽  
Mat (Matija) Radojcic ◽  
Pith Beh Soh ◽  
Satish Warrier ◽  
...  
Keyword(s):  
New Zealand ◽  
Research Output ◽  
Case Series ◽  
Medical Decision ◽  
High Quality Research ◽  
The Past ◽  
Randomised Control Trials ◽  
Colorectal Surgeons ◽  
Number Of Publications ◽  
Meta Analyses

Objectives: High-quality research has a tangible impact on patient care and should inform all medical decision-makings. Appraising and benchmarking of research is necessary in evidence-based medicine and allocation of funding. The aim of this review is to demonstrate how evidence may be gathered by quantifying the amount and type of research by a group of surgeons over a 20-year period. Methods: Members of the Colorectal Surgical Society of Australia and New Zealand were identified in April 2020. A search of the Scopus database was conducted to quantify each surgeon’s research output from 1999 to 2020. Authorship details such as the Hirsch index and number of papers published were recorded, as were publication-related details. Results: 226 colorectal surgeons were included for analysis, producing a total of 5053 publications. The most frequent colorectal topics were colorectal cancer (32%, n = 1617 of all publications), followed by pelvic floor disorders (4.3%, n = 217) and inflammatory bowel disease (3.5%, n = 177). 56% ( n = 2830) of all publications were case series audits (21%, n = 1061), expert opinion pieces (20%, n = 1011) and cohort studies (15%, n = 758). 7% ( n = 354) were randomised control or non-randomised control trials, 3% ( n = 152) were systematic reviews and 1% ( n = 50) were meta-analyses. The top 10% ( n = 23) of authors accounted for more than half (54%, n = 2729) of manuscripts published. Conclusion: Australasian colorectal surgeons made a significant contribution to the medical literature over the past 20 years and the number of publications is increasing over time. A greater output of higher-level evidence research is needed. This information may be used to better allocate researcher funding and grants for future projects.

scholarly journals Profile of Scientific Production on Ankyloglossia

2020 ◽  
pp. 1-13
Author(s):  
Roberta Lopes de Castro Martinelli ◽  
Reinaldo Jordão Gusmão ◽  
María Paz Moya Daza ◽  
Irene Queiroz Marchesan ◽  
Giédre Berretin-Felix
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Case Reports ◽  
Case Series ◽  
Scientific Production ◽  
Publication Type ◽  
Level Of Evidence ◽  
First Results ◽  
Bibliometric Review

This work aims to describe the profile of scientific production referring to ankyloglossia. For this an investigation was carried out by searching for scientific articles indexed in the electronic databases LILACS and PUBMED. For the bibliometric review, the data referring to the year of publication, type of study and level of evidence were examined and tabulated. The data were discussed on the quantitative and representative values optics. The first results allowed to analyzic 651 published studies were analyzed. Most of the research on tongue tie found correspond to descriptive studies and case series (49.31%), followed by case reports, in vitro research, in animals and literature review (24.27%), cohort and cases and controls (11.98%), specialist opinion (11.68%), randomized clinical trials (1.54%) and systematic reviews (1.22%). Few studies addressed complications during or after lingual frenulum release surgery. In conclusion Scientific production on ankyloglossia has shown an increasing increase in the last 28 years, with studies with evidence levels 1, 2 and 3 being published, whose main focus was the performance of surgery to release the lingual frenulum.

scholarly journals Analysis of the Type and Study Design of Publications in the Journal of Indian Orthodontic Society and the Changes in Trends Over 2 Decades

2021 ◽  
pp. 030157422098458
Author(s):  
Shivangi Ramteke ◽  
Balasubramanian Madhan
Keyword(s):  
Study Design ◽  
Systematic Reviews ◽  
Case Reports ◽  
Chi Square ◽  
Cross Sectional ◽  
Randomized Controlled ◽  
The Past ◽  
Hierarchy Of Evidence ◽  
Number Of Publications ◽  
Study Designs

Background: The aim of the study was to analyze the type and study design of publications in the Journal of Indian Orthodontic Society (JIOS) and the changes in their trends from 2001 to 2020. Materials and Methods: All the online publications in JIOS were classified as background resource, original articles, and case reports. The original articles were further divided into 7 types based on study design. The annual and overall data were compiled. To evaluate the change in trends, the study period was divided into 2 block years: 2001 to 2010 and 2011 to 2020. The differences in the total number of articles and distribution of articles by type and study design were analyzed using Mann–Whitney and chi-square/Fisher’s exact tests, respectively. Results: Background resource, original articles, and case reports comprised 38.7%, 43.9%, and 17.4% of the total articles (n = 845), respectively. Non-clinical (34.5%) and cross-sectional (32.35%) studies formed the bulk of original articles. There were 17 randomized controlled trials (RCTs) (4.58%) and 5 systematic reviews (1.35%) among the original articles. The total number of publications were higher for years in the second block compared to those in the first (Mdn of 63.5 vs 14.5, P < .001). The differences in the distribution according to type were not statistically significant [ X2(2) = 2.052, P = .35]. A reduction in the share of cohort studies and increase in RCTs were found in the second block (F = 19.174, P = .002). Conclusions: The higher proportion of background resource publications and those with study designs lower in the hierarchy of evidence is a matter of concern. Though slow paced, the increase in the number of RCTs and systematic reviews over the past few years is encouraging.

scholarly journals The Value of Systematic Reviews and Meta-Analyses in Surgery

2021 ◽  
pp. 1-8
Author(s):  
Simon R. Knight
Keyword(s):  
Clinical Trials ◽  
Systematic Reviews ◽  
Practice Guidelines ◽  
Statistical Power ◽  
Clinical Decision Making ◽  
Learning Curves ◽  
Current Evidence ◽  
Level Of Evidence ◽  
Surgical Interventions ◽  
Meta Analyses

<b><i>Background:</i></b> Systematic reviews and meta-analyses are generally regarded as sitting atop the hierarchy of clinical evidence. The unbiased summary of current evidence that a systematic review provides, along with the increased statistical power from larger numbers of patients, is invaluable in guiding clinical decision-making and development of practice guidelines. Surgical specialties have historically lagged behind other areas of medicine in the application of evidence-based medicine, perhaps due to the unique challenges faced in the conduct of surgical clinical trials. These challenges extend to the conduct of systematic reviews, due to issues with the quality and heterogeneity of the underlying literature. <b><i>Summary:</i></b> Recent years have seen an improvement in the quality of randomized controlled trials in surgical topics and an explosion in the publication of systematic reviews. This review explores recent trends in systematic reviews in surgery and discussed some of the aspects in conducting and interpreting reviews that are unique to surgical topics, including blinding, surgical heterogeneity and learning curves, patient and clinician preference, and industry involvement. <b><i>Key Messages:</i></b> Clinical trials, and therefore systematic reviews, of surgical interventions pose unique challenges which are important to consider when conducting them or applying the findings to clinical practice. Despite the challenges, systematic reviews still represent the best level of evidence for development of surgical practice guidelines.

scholarly journals Gender disparity in cases enrolled in clinical trials of visceral leishmaniasis: A systematic review and meta-analysis

2021 ◽  
Vol 15 (3) ◽  
pp. e0009204
Author(s):  
Prabin Dahal ◽  
Sauman Singh-Phulgenda ◽  
Piero L. Olliaro ◽  
Philippe J. Guerin
Keyword(s):  
Clinical Trials ◽  
Visceral Leishmaniasis ◽  
Treatment Guidelines ◽  
Meta Analysis ◽  
Gender Disparity ◽  
Eastern Africa ◽  
Adult Males ◽  
Community Based ◽  
The Past ◽  
Meta Analyses

Background A higher caseload of visceral leishmaniasis (VL) has been observed among males in community-based surveys. We carried out this review to investigate how the observed disparity in gender distribution is reflected in clinical trials of antileishmanial therapies. Methods We identified relevant studies by searching a database of all published clinical trials in VL from 1980 through 2019 indexed in the Infectious Diseases Data Observatory (IDDO) VL clinical trials library. The proportion of male participants enrolled in studies eligible for inclusion in this review were extracted and combined using random effects meta-analysis of proportion. Results were expressed as percentages and presented with respective 95% confidence intervals (95% CIs). Heterogeneity was quantified using I2 statistics and sub-group meta-analyses were carried out to explore the sources of heterogeneity. Results We identified 135 published studies (1980–2019; 32,177 patients) with 68.0% [95% CI: 65.9%–70.0%; I2 = 92.6%] of the enrolled participants being males. The corresponding estimates were 67.6% [95% CI: 65.5%–69.7%; n = 91 trials; I2 = 90.5%; 24,218 patients] in studies conducted in the Indian sub-continent and 74.1% [95% CI: 68.4%–79.1%; n = 24 trials; I2 = 94.4%; 6,716 patients] in studies from Eastern Africa. The proportion of male participants was 57.9% [95% CI: 54.2%–61.5%] in studies enrolling children aged <15 years, 78.2% [95% CI: 66.0%–86.9%] in studies that enrolled adults (≥15 years), and 68.1% [95% CI: 65.9%–70.0%] in studies that enrolled patients of all ages. There was a trend for decreased proportions of males enrolled over time: 77.1% [95% CI: 70.2%–82.8%; 1356 patients] in studies published prior to the 1990s whereas 64.3% [95% CI: 60.3%–68.2%; 15,611 patients] in studies published on or after 2010. In studies that allowed the inclusion of patients with HIV co-infections, 76.5% [95% CI: 63.8%–85.9%; 5,123 patients] were males and the corresponding estimate was 64.0% [95% CI: 61.4%–66.5% 17,500 patients] in studies which excluded patients with HIV co-infections. Conclusions Two-thirds of the participants enrolled in clinical studies in VL conducted in the past 40 years were males, though the imbalance was less in children and in more recent trials. VL treatment guidelines are informed by the knowledge of treatment outcomes from a population that is heavily skewed towards adult males. Investigators planning future studies should consider this fact and ensure approaches for more gender-balanced inclusion.

Ushering in the next generation of precision trials for pediatric cancer

Science ◽  
2019 ◽  
Vol 363 (6432) ◽  
pp. 1175-1181 ◽  
Author(s):  
Steven G. DuBois ◽  
Laura B. Corson ◽  
Kimberly Stegmaier ◽  
Katherine A. Janeway
Keyword(s):  
Clinical Trials ◽  
Drug Development ◽  
Pediatric Cancer ◽  
Case Reports ◽  
Precision Oncology ◽  
Genomic Profile ◽  
Key Factors ◽  
Pediatric Drug ◽  
The Past ◽  
Pediatric Cancers

Cancer treatment decisions are increasingly based on the genomic profile of the patient’s tumor, a strategy called “precision oncology.” Over the past few years, a growing number of clinical trials and case reports have provided evidence that precision oncology is an effective approach for at least some children with cancer. Here, we review key factors influencing pediatric drug development in the era of precision oncology. We describe an emerging regulatory framework that is accelerating the pace of clinical trials in children as well as design challenges that are specific to trials that involve young cancer patients. Last, we discuss new drug development approaches for pediatric cancers whose growth relies on proteins that are difficult to target therapeutically, such as transcription factors.

scholarly journals Quality of reporting acupuncture interventions for chronic obstructive pulmonary disease: Review of adherence to the STRICTA statement

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 226
Author(s):  
Carles Fernández-Jané ◽  
Mireia Solà-Madurell ◽  
Mingkun Yu ◽  
Changhao Liang ◽  
Yutong Fei ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Clinical Trials ◽  
Pulmonary Disease ◽  
Neurological Diseases ◽  
Chronic Obstructive ◽  
Quality Of Reporting ◽  
Obstructive Pulmonary Disease ◽  
The Past ◽  
Randomised Control Trials

Background: The quality of reporting of acupuncture interventions is critical to ensure the applicability and reproducibility of acupuncture clinical trials. In the past, different publications have evaluated the quality of reporting of acupuncture interventions for different clinical situations, such as knee osteoarthritis, neurological diseases or cancer. However, this has not been done for acupuncture trials for chronic obstructive pulmonary disease (COPD). Objective: To assess the quality of reporting of acupuncture interventions in trials for COPD. Methods: A total of 11 English and Chinese databases were screened up until May 2019 for randomised or quasi-randomised control trials of acupuncture for COPD. The STRICTA checklist was used to determine the quality of the reporting of acupuncture interventions. Results: A total of 28 trials were included in our review. Out of the 16 STRICTA checklist subitems analysed, only 3 were considered appropriately reported in more than 70% of the trials, while 7 were correctly reported in less than 40%. Conclusion: The adherence to STRICTA guidelines of acupuncture trials for COPD is suboptimal, and future efforts need to be addressed to improve the quality of reporting.

scholarly journals Completeness of reporting acupuncture interventions for chronic obstructive pulmonary disease: Review of adherence to the STRICTA statement

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 226
Author(s):  
Carles Fernández-Jané ◽  
Mireia Solà-Madurell ◽  
Mingkun Yu ◽  
Changhao Liang ◽  
Yutong Fei ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Clinical Trials ◽  
Pulmonary Disease ◽  
Neurological Diseases ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The Past ◽  
Randomised Control Trials ◽  
Completeness Of Reporting

Background: The completeness of reporting  of acupuncture interventions is critical to ensure the applicability and reproducibility of acupuncture clinical trials. In the past, different publications have evaluated the completeness of reporting of acupuncture interventions for different clinical situations, such as knee osteoarthritis, neurological diseases or cancer. However, this has not been done for acupuncture trials for chronic obstructive pulmonary disease (COPD). Objective: To assess the completeness of reporting of acupuncture interventions in trials for COPD. Methods: A total of 11 English and Chinese databases were screened up until May 2019 for randomised or quasi-randomised control trials of acupuncture for COPD. The STRICTA checklist was used to determine the quality of the reporting of acupuncture interventions. Results: A total of 28 trials were included in our review. Out of the 16 STRICTA checklist subitems analysed, only 4 were considered appropriately reported in more than 70% of the trials, while 7 were correctly reported in less than 30%. Conclusion: The adherence to STRICTA guidelines of acupuncture trials for COPD is suboptimal, and future efforts need to be addressed to improve the completeness of reporting.

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