scholarly journals Analysis of the Type and Study Design of Publications in the Journal of Indian Orthodontic Society and the Changes in Trends Over 2 Decades

2021 ◽  
pp. 030157422098458
Author(s):  
Shivangi Ramteke ◽  
Balasubramanian Madhan
Keyword(s):  
Study Design ◽  
Systematic Reviews ◽  
Case Reports ◽  
Chi Square ◽  
Cross Sectional ◽  
Randomized Controlled ◽  
The Past ◽  
Hierarchy Of Evidence ◽  
Number Of Publications ◽  
Study Designs

Background: The aim of the study was to analyze the type and study design of publications in the Journal of Indian Orthodontic Society (JIOS) and the changes in their trends from 2001 to 2020. Materials and Methods: All the online publications in JIOS were classified as background resource, original articles, and case reports. The original articles were further divided into 7 types based on study design. The annual and overall data were compiled. To evaluate the change in trends, the study period was divided into 2 block years: 2001 to 2010 and 2011 to 2020. The differences in the total number of articles and distribution of articles by type and study design were analyzed using Mann–Whitney and chi-square/Fisher’s exact tests, respectively. Results: Background resource, original articles, and case reports comprised 38.7%, 43.9%, and 17.4% of the total articles (n = 845), respectively. Non-clinical (34.5%) and cross-sectional (32.35%) studies formed the bulk of original articles. There were 17 randomized controlled trials (RCTs) (4.58%) and 5 systematic reviews (1.35%) among the original articles. The total number of publications were higher for years in the second block compared to those in the first (Mdn of 63.5 vs 14.5, P < .001). The differences in the distribution according to type were not statistically significant [ X2(2) = 2.052, P = .35]. A reduction in the share of cohort studies and increase in RCTs were found in the second block (F = 19.174, P = .002). Conclusions: The higher proportion of background resource publications and those with study designs lower in the hierarchy of evidence is a matter of concern. Though slow paced, the increase in the number of RCTs and systematic reviews over the past few years is encouraging.

Conducting epidemiological studies in health protection

2016 ◽  
Author(s):  
Sam Ghebrehewet ◽  
Paul Cleary ◽  
Merav Kliner ◽  
Ewan Wilkinson
Keyword(s):  
Case Reports ◽  
Real Life ◽  
Case Series ◽  
Epidemiological Studies ◽  
Health Protection ◽  
Sample Size Determination ◽  
Cross Sectional ◽  
Randomized Controlled ◽  
Different Types ◽  
Study Designs

This chapter describes the different types of epidemiological studies that are used in health protection investigations. These include descriptive studies such as case reports, case series, cross-sectional studies, and analytical studies, particularly case-control and cohort studies. It provides a number of real-life examples illustrating these different types of investigation and their application in health protection practice. It also gives guidance on the type of study to use in different incidents or outbreaks, and on sample size determination. The limitations of the different study designs are described. The particular requirements of randomized controlled trials and systematic reviews, and their role in health protection are described. The roles of qualitative and operational studies are also outlined.

scholarly journals Systematic Differences in Effect Estimates Between Observational Studies and Randomized Control Trials in Meta-Analyses Combining Both Study Designs in Nephrology

2020 ◽  
Author(s):  
Miho Kimachi ◽  
Akira Onishi ◽  
Aran Tajika ◽  
Kimihiko Kimachi ◽  
Toshi Furukawa
Keyword(s):  
Systematic Reviews ◽  
Observational Studies ◽  
Statistical Significance ◽  
Randomized Control Trials ◽  
Causal Inferences ◽  
Randomized Controlled ◽  
The Past ◽  
Randomized Control ◽  
Meta Analyses ◽  
Study Designs

Abstract The limited availability of randomized controlled trials (RCTs) in nephrology undermines causal inferences in meta-analyses. Systematic reviews of observational studies have grown more common under such circumstances. We conducted systematic reviews of all comparative observational studies in nephrology from 2006 to 2016 to assess the trends in the past decade. We then focused on the meta-analyses combining observational studies and RCTs to evaluate the systematic differences in effect estimates between study designs using two statistical methods: by estimating the ratio of odds ratios (ROR) of the pooled OR obtained from observational studies versus those from RCTs and by examining the discrepancies in their statistical significance. The number of systematic reviews of observational studies in nephrology had grown by 11.7-fold in the past decade. Among 56 records combining observational studies and RCTs, ROR suggested that the estimates between study designs agreed well (ROR: 1.05, 95% confidence interval: 0.90-1.23). However, almost half of the reviews led to discrepant interpretations in terms of statistical significance. In conclusion, the findings based on ROR might encourage researchers to justify the inclusion of observational studies in meta-analyses. However, caution is needed as the interpretations based on statistical significance were less concordant than those based on ROR.

scholarly journals Quality of early evidence on the pathogenesis, diagnosis, prognosis and treatment of COVID-19

2020 ◽  
pp. bmjebm-2020-111499
Author(s):  
Sarah Yang ◽  
Allen Li ◽  
Ali Eshaghpour ◽  
Sofia Ivanisevic ◽  
Adrian Salopek ◽  
...  
Keyword(s):  
Study Design ◽  
Systematic Reviews ◽  
Case Reports ◽  
Case Series ◽  
Included Study ◽  
Expert Opinions ◽  
Newcastle Ottawa Scale ◽  
Initial Description ◽  
Number Of Publications

Since the initial description of the SARS-CoV-2 outbreak and its declaration as a worldwide pandemic, the number of publications on the novel virus has increased rapidly. We studied the trends and quality of evidence in early SARS-CoV-2 publications. A comprehensive search of MEDLINE and EMBASE was performed for papers published between 1 January 2020 and 21 April 2020. Two reviewers independently screened titles and abstracts and subsequently full texts for eligibility in this systematic review. The search yielded 2504 citations published between January and February 2020 or an unspecified date, 109 of which remained for extraction after screening. Data extracted included study design, year of publication, country of basis, journal of publication, impact factor of publishing journal, study sample size, number of citations and topic of investigation. Study design-specific critical appraisal tools were used to evaluate the scientific rigour of all included papers: the Joanna Briggs Institute checklist was used for case series, Scale for the Assessment of Narrative Review Articles scale for narrative reviews, Newcastle-Ottawa scale for cohort studies and AMSTAR 2 for systematic reviews. The overall quality of the literature was low-moderate. Of 541 papers that reported clinical characteristics, 295 were commentaries/expert opinions and 36 were case reports. There were no randomised clinical trials, 45 case series studies, 58 narrative reviews, 1 cohort study and 5 systematic reviews. We encourage clinicians to be attentive to these findings when utilising early SARS-CoV-2 evidence in their practices.

scholarly journals Systematic differences in effect estimates between observational studies and randomized control trials in meta-analyses in nephrology

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Miho Kimachi ◽  
Akira Onishi ◽  
Aran Tajika ◽  
Kimihiko Kimachi ◽  
Toshi A. Furukawa
Keyword(s):  
Systematic Reviews ◽  
Observational Studies ◽  
Statistical Significance ◽  
Randomized Control Trials ◽  
Causal Inferences ◽  
Randomized Controlled ◽  
The Past ◽  
Randomized Control ◽  
Meta Analyses ◽  
Study Designs

AbstractThe limited availability of randomized controlled trials (RCTs) in nephrology undermines causal inferences in meta-analyses. Systematic reviews of observational studies have grown more common under such circumstances. We conducted systematic reviews of all comparative observational studies in nephrology from 2006 to 2016 to assess the trends in the past decade. We then focused on the meta-analyses combining observational studies and RCTs to evaluate the systematic differences in effect estimates between study designs using two statistical methods: by estimating the ratio of odds ratios (ROR) of the pooled OR obtained from observational studies versus those from RCTs and by examining the discrepancies in their statistical significance. The number of systematic reviews of observational studies in nephrology had grown by 11.7-fold in the past decade. Among 56 records combining observational studies and RCTs, ROR suggested that the estimates between study designs agreed well (ROR 1.05, 95% confidence interval 0.90–1.23). However, almost half of the reviews led to discrepant interpretations in terms of statistical significance. In conclusion, the findings based on ROR might encourage researchers to justify the inclusion of observational studies in meta-analyses. However, caution is needed, as the interpretations based on statistical significance were less concordant than those based on ROR.

scholarly journals Conceptualising natural and quasi experiments in public health

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Frank de Vocht ◽  
Srinivasa Vittal Katikireddi ◽  
Cheryl McQuire ◽  
Kate Tilling ◽  
Matthew Hickman ◽  
...  
Keyword(s):  
Public Health ◽  
Study Design ◽  
Grey Literature ◽  
Public Health Research ◽  
Natural Experiments ◽  
Target Trial ◽  
Design Elements ◽  
Randomized Controlled ◽  
Study Designs ◽  
The Impact

Abstract Background Natural or quasi experiments are appealing for public health research because they enable the evaluation of events or interventions that are difficult or impossible to manipulate experimentally, such as many policy and health system reforms. However, there remains ambiguity in the literature about their definition and how they differ from randomized controlled experiments and from other observational designs. We conceptualise natural experiments in the context of public health evaluations and align the study design to the Target Trial Framework. Methods A literature search was conducted, and key methodological papers were used to develop this work. Peer-reviewed papers were supplemented by grey literature. Results Natural experiment studies (NES) combine features of experiments and non-experiments. They differ from planned experiments, such as randomized controlled trials, in that exposure allocation is not controlled by researchers. They differ from other observational designs in that they evaluate the impact of events or process that leads to differences in exposure. As a result they are, in theory, less susceptible to bias than other observational study designs. Importantly, causal inference relies heavily on the assumption that exposure allocation can be considered ‘as-if randomized’. The target trial framework provides a systematic basis for evaluating this assumption and the other design elements that underpin the causal claims that can be made from NES. Conclusions NES should be considered a type of study design rather than a set of tools for analyses of non-randomized interventions. Alignment of NES to the Target Trial framework will clarify the strength of evidence underpinning claims about the effectiveness of public health interventions.

scholarly journals The Perceived Demands of Ice Hockey Goaltending Movements on the Hip and Groin Region: An Elite Coach and Player Perspective

2021 ◽  
Vol 9 (11) ◽  
pp. 232596712110556
Author(s):  
Tobias Wörner ◽  
Ryan J. Frayne ◽  
Thomas Magnusson ◽  
Frida Eek
Keyword(s):  
Injury Prevention ◽  
Study Design ◽  
Online Survey ◽  
Likert Scale ◽  
Ice Hockey ◽  
Cross Sectional Survey ◽  
Hip Joints ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

Background: Many ice hockey goaltending techniques force hip joints and groin muscles into extreme ranges of motion, which may increase the risk of hip and groin problems. Purpose: To explore how elite goaltenders and goaltending coaches perceive the demands of common goaltending techniques on the hip and groin region. We further explored differences in perception between goaltenders and their coaches as well as between junior (age <20 years) and senior (age ≥20 years) goaltenders. Study Design: Cross-sectional survey. Methods: We developed a model to categorize common ice hockey goaltending techniques into quantifiable units and invited elite goaltenders and coaches in Sweden to complete an online survey. Participants were asked to rate the perceived demands of each technique on the hip and groin using a Likert scale (not at all, slightly, somewhat, very, or extremely demanding). Using the chi-square test, the proportion of participants perceiving each technique as very or extremely demanding were compared between goaltenders and coaches as well as between senior and junior goaltenders. Results: We received responses from 132 goaltenders and 43 coaches. The stances most frequently perceived as very or extremely demanding were the reverse vertical horizontal post-play (40%) and the butterfly save (25%). Among transitions, movements into the post were most frequently rated as very or extremely demanding (11%–40%). Several techniques were perceived as demanding by a larger share of coaches than goaltenders (difference, 13%–46%; P < .001–.028) and a larger share of senior versus junior goaltenders (difference, 12%–20%; P = .13–.18). Conclusion: The post-play and the butterfly were the goaltending techniques most frequently perceived as demanding, and more coaches than goaltenders percieved these techniques demanding. The results of this study may inform injury prevention efforts for ice hockey goaltending.

scholarly journals A Retrospective study on the dynamics of the clinical and Demographical evolution of Cutaneous Leishmaniasis in the Yazd province, Iran

2020 ◽  
Vol 3 (3) ◽  
pp. 80-83
Author(s):  
Ali Fattahi Bafghi ◽  
◽  
Elham Rezaee ◽  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Epidemiological Study ◽  
Age Groups ◽  
Epidemiological Data ◽  
Educational Status ◽  
Cross Sectional Study ◽  
Personal Hygiene ◽  
Chi Square ◽  
Cross Sectional ◽  
The Past

Leishmaniasis is considered as an important health problem in the world. Cutaneous Leishmaniasis is epidemic in all of places of Iran, this disease begins as small swells and then they gradually grow and turn into wounds. Since the epidemiological study of this problem is effective in preventing and controlling it. The current research was conducted to study the epidemiological study of Cutaneous Leishmaniasis in Yazd province during the past 5(2014-2018) years. This cross-sectional study has been conducted on registered information and documents of the patients having problem in Yazd province remedial and health care centers over the past 5 years. First, the registered demographic and epidemiological data of the patients were extracted and then they were analyzed by using SPSS 18 software with chi-square test and descriptive statistics.897 patients included 457 males (51.06%) and 439 females (48.94%). The majority of the patients were between nine 20-29 years old and the minority of them were over the range of 5-9 years old. Most lesions were on the hand and leg of the patients. It was also found that there was a significant relationship between age groups and types of Leishmaniasis (P<0.05) as well as gender and type Leishmaniasis (P<0.05). According to our study, there has been an ascending trend in disease frequency in Yazd province from 2014 to 2018. This increase in diseases due to lack of health and educational status of the people-is also a lack of personal hygiene.

scholarly journals HUBUNGAN PERSEPSI IBU BALITA TENTANG POSYANDU DENGAN PEMANFAATAN POSYANDU MAWAR 2 RW 06 KEBAGUSAN JAKARTA SELATAN TAHUN 2015

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Alifa Dinda Septifani ◽  
Apriningsih Apriningsih
Keyword(s):  
Data Collection ◽  
Study Design ◽  
Significant Relationship ◽  
Health Workers ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Community Based ◽  
Chi Square ◽  
Cross Sectional

Posyandu was one manifestation of Health Efforts on Community Based (UKBM). Based on data Posyandu Mawar 2 in February 2015 there were a decreased number of mothers’s visit from 81.25% to 62.5%, so the researchers wanted to know about association of the mother’s perception with the utilization of The Posyandu. This research used cross sectional study design using total sampling (80 mothers). Data collection was done by direct interviews based on the questionnaire and analyzed using Chi Square. The result there’s a significant association between mother’ss perception of the distance to the utilization of Posyandu RW 06 Posyandu Mawar 2 Kebagusan South Jakarta and there’s no significant relationship between education, employment and the knowledge and mothers’perceptions about the completeness of facilities, the attitude of cadres and the presence of health workers. Suggestions for Posyandu is to increase  of  mother’confident to visit Posyandu

scholarly journals Diabetes and Pancreatic Anastomosis: Friend or Foe?

2018 ◽  
Vol 14 (1) ◽  
pp. 49-52
Author(s):  
Awaj Kafle ◽  
Vikas Gupta
Keyword(s):  
Operative Procedure ◽  
Pancreatic Head ◽  
Cross Sectional Study ◽  
High Morbidity ◽  
Chi Square ◽  
Pancreatic Anastomosis ◽  
Cross Sectional ◽  
The Past ◽  
Periampullary Region ◽  
Malignant Lesions

Background & Objectives:Pancreaticoduodenectomy (PD) has become a standard operative procedure for both benign and malignant lesions of pancreatic head and periampullary region. Pancreatic Fistula (PF) is the most troublesome complication and heralds the development of other complications. The procedure was associated with high morbidity and mortality in the past but with the identification of various risk factors associated with the development of PF, the management has changed dramatically. Similarly, Diabetes mellitus (DM) and poor glycemic control is associated with various adverse postoperative events. So, the objective of this study was to identify the association between DM and postoperative occurrence of PF.Materials & Methods:This was a prospective cross-sectional study enrolling a total of 72 patients. Patients were screened for the presence or absence of DM based on guidelines by American Diabetes Association in January 2009. After surgery, patients were observed for the development of PF. The association between these two was assessed using Chi-Square test.Results:Out of 72 patients, 12 had DM. All the patients who had DM did not develop PF; in contrast 15 patients who developed PF were non-diabetic.Conclusion:Diabetes Mellitus was found to be protective in preventing the occurrence of PF postoperatively.

scholarly journals Kratom from Head to Toe—Case Reviews of Adverse Events and Toxicities

2019 ◽  
Vol 7 (4) ◽  
pp. 141-168 ◽  
Author(s):  
Emad Alsarraf ◽  
Jamie Myers ◽  
Sarah Culbreth ◽  
John Fanikos
Keyword(s):  
Adverse Events ◽  
Case Reports ◽  
In Vivo Studies ◽  
Poison Control ◽  
Cross Sectional ◽  
Randomized Controlled ◽  
Reversible Encephalopathy ◽  
Neonatal Withdrawal

Abstract Purpose of Review This review describes case reports for patients with kratom-associated adverse events in order to assist clinicians with patient management. A stepwise approach is proposed for assessing active kratom users as well as considerations for the management of toxicities or withdrawal. Recent Findings Multiple in vitro and in vivo studies illustrate the pharmacologic and toxicologic effects of kratom extract. No randomized controlled trials in humans exist that assess the safety and efficacy of the substance. Cross-sectional surveys from active users and reports from poison control centers have shown acute and chronic physiological and psychological adverse events. Summary Reports of adverse effects associated with kratom use have demonstrated hypothyroidism, hypogonadism, hepatitis, acute respiratory distress syndrome, posterior reversible encephalopathy syndrome, seizure, and coma. Overdose toxidrome leads to respiratory failure, cardiac arrest, and fatalities. Adult and neonatal withdrawal symptoms have also occurred. Clinicians should be aware of the risks and benefits of kratom use.

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