Effect of breast milk oral care in infants who underwent surgical correction of ventricular septal defect

Abstract Objective: This study explored the clinical effect of employing breast milk oral care for infants who underwent surgical correction of ventricular septal defect. Methods: A prospective randomised controlled study was conducted in a provincial hospital between January, 2020 and July, 2020 in China. Patients were randomly divided into an intervention group (breast milk oral care, n = 28) and a control group (physiological saline oral care, n = 28). The intervention group was given oral nursing using breast milk for infants in the early post-operative period, and the control group was given oral nursing using physiological saline. Related clinical data were recorded and analysed. Results: There were no significant differences in age, gender, weight, operation time, cardiopulmonary bypass time, or aortic cross-clamping time between the two groups. Compared with the physiological saline oral care group, the mechanical ventilation duration, the length of ICU stay in the breast milk oral care group were significantly shorter. The time of start feeding and total enteral nutrition were significantly earlier in the intervention group than those in the control group. The incidence of post-operative pneumonia in the breast milk oral care group was 3.6%, which was significantly lower than that of the physiological saline oral care group. Conclusion: The use of breast milk for oral care in infants who underwent surgical correction of VSD can reduce the incidence of post-operative pneumonia and promote the recovery of gastrointestinal function.

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Effectiveness of the Oral Care Program in Type 2 Diabetic Elderly Patients with Periodontitis: A Clustered Randomised Controlled Study With 6-month Follow-Up

10.21203/rs.3.rs-74162/v1 ◽

2020 ◽

Author(s):

Namon Phetnin ◽

Vichayanrat Tippanart ◽

Anunmana Chuchai

Keyword(s):

Oral Health ◽

Oral Hygiene ◽

Oral Care ◽

Intervention Group ◽

Health Behaviours ◽

Care Program ◽

Controlled Study ◽

Control Group ◽

Oral Health Behaviours ◽

Oral Hygiene Instruction

Abstract Background: Diabetes mellitus and periodontal disease have a bidirectional relationship. This study aimed to assess the effectiveness of the oral care program in reducing glycaemic status and improving oral health behaviours and oral hygiene among type 2 diabetes mellitus (T2DM) older patients with periodontitis.Methods: A clustered randomised controlled study was conducted in Nakhon Ratchasima province between July 2019 and January 2020. The two health centres were randomly assigned to control and intervention groups, which thirty-five T2DM older patients with chronic periodontitis were recruited in each group. The intervention group received the program consisted of oral health education based on Health Belief Model (HBM), individual oral hygiene instruction and scaling and root planning at one month and followed by individual oral hygiene instruction at three months. The patients in the control group received the routine program provided by the health centre. Outcomes were measured using the interviewed questionnaire, simplified oral hygiene index, and the glycaemic status (HbA1c) at baseline, 3 months and 6 months, respectively. Data were analysed using a descriptive statistic, Chi-square test, t-test, repeated measure ANOVA at p-value = 0.05. Results: After the 3 and 6 months, the results showed that the intervention group significantly improved in the HBM scores, oral health behaviours scores, and decreased in OHI-S scores and HbA1c level (p < 0.05), while there was no significant difference in the control group.Conclusion: The findings suggested that the proposed program was effective among diabetic older people with periodontitis to improve oral health perception, behaviours, oral hygiene, and decreased glycaemic status at 3- and 6-month evaluation.Trial registration: Thai Clinical Trials Registry (TCTR), TCTR202004230005. Registered 22 April 2020 - Retrospectively registered.

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Effect of the Use of WeChat to Disseminate Preoperative Health Education to Parents of Children with Restrictive Ventricular Septal Defects: A Prospective Randomized Controlled Study

The Heart Surgery Forum ◽

10.1532/hsf.3323 ◽

2020 ◽

Vol 23 (6) ◽

pp. E897-E901

Author(s):

Qiliang Zhang ◽

Ning Xu ◽

Shuting Huang ◽

Qiang Chen ◽

Hua Cao

Keyword(s):

Health Education ◽

Ventricular Septal Defect ◽

Septal Defect ◽

Preoperative Care ◽

Randomized Controlled Study ◽

Controlled Study ◽

Control Group ◽

Loss To Follow Up ◽

Randomized Controlled

Background: This study explored the clinical effect of implementing WeChat-based preoperative health education for parents of children with restrictive ventricular septal defect. Methods: A prospective randomized controlled study was conducted in a provincial hospital on the southeast coast of China. Participants were randomly divided into an intervention (WeChat) group (n = 35) and a control group (leaflet) group (n = 35). The study explored the parents’ knowledge of preoperative care, the follow-up rate, and complications of children with restrictive ventricular septal defect. Results: The score of preoperative care knowledge of the WeChat group (66.9 ± 3.5) was significantly higher than that of the leaflet group (47.3 ± 6.3) (P = .006). Compared with the score of care knowledge at the first visit, the score of the WeChat group at the preoperation was significantly higher (P < .05), whereas the increase in the score of the leaflet group was not significant. The rate of lost follow-up in the WeChat group (0%) was significantly lower than in the leaflet group (16.7%) (P = .02). The complications in the leaflet group were significantly higher than in the WeChat group. Conclusions: Using WeChat to provide preoperative health education to parents of children with restrictive ventricular septal defect can effectively enhance the parents’ knowledge of preoperative care and reduce the occurrence of complications and loss to follow-up.

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The effects of surgically induced right bundle branch block on left ventricular function after closure of the ventricular septal defect

Cardiology in the Young ◽

10.1017/s1047951108002357 ◽

2008 ◽

Vol 18 (4) ◽

pp. 430-436 ◽

Cited By ~ 16

Author(s):

Thais A. L. Pedersen ◽

Niels H. Andersen ◽

Mette R. Knudsen ◽

Thomas D. Christensen ◽

Keld E. Sørensen ◽

...

Keyword(s):

Ventricular Septal Defect ◽

Left Ventricular Function ◽

Right Bundle Branch Block ◽

Septal Defect ◽

Left Ventricular ◽

Surgical Correction ◽

Control Group ◽

Bundle Branch Block ◽

Surgical Closure ◽

Control Subjects

AbstractObjectiveTo determine the long-term significance of right bundle branch block on left ventricular systolic and diastolic function in children subsequent to surgical closure of ventricular septal defect.MethodsWe studied 26 children who underwent surgical closure of a ventricular septal defect 11 ± 2 years postoperatively by use of conventional and tissue Doppler echocardiography, comparing the findings to those obtained from a control group. Of those having surgical correction 14 had postoperative right bundle branch block.ResultsIrrespective of the presence of right bundle branch block, the peak systolic velocity of the mitral ring was lower in those undergoing surgical correction, with values of 5.2 ± 1.4 cm/s in those with right bundle branch block, 5.4 ± 1.2 cm/s in those without right bundle branch block after surgical correction, and 6.6 ± 1.0 cm/s in the control subjects (p < 0.01). In terms of diastolic function, the early septal velocity of transmitral inflow divided by the early diastolic mitral annular velocity was significantly higher in children with right bundle branch block, at 12 ± 3.0 cm/s compared to 8.4 ± 1.5 cm/s in the control subjects (p < 0.01), but not significantly higher in the children without right bundle branch block after correction compared to the control group. The fractional shortening percentage was similar in both patients and control subjects. The changes noted in left ventricular function were not significantly related to age at surgery, the period of follow-up, or the surgical method.ConclusionsSystolic long axis function is significantly reduced in children after surgical closure of ventricular septal defects, irrespective of the presence of right bundle branch block. Diastolic dysfunction, in contrast, was observed primarily in children with post-operative right bundle branch block.

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Effectiveness of the eCARE programme: a short message service for asthma monitoring

BMJ Health & Care Informatics ◽

10.1136/bmjhci-2019-100007 ◽

2019 ◽

Vol 26 (1) ◽

pp. e100007

Author(s):

Lathy Prabhakaran ◽

Yap Chun Wei

Keyword(s):

Asthma Control ◽

Short Message Service ◽

Intervention Group ◽

Routine Care ◽

Controlled Study ◽

Care Group ◽

Control Group ◽

Short Message ◽

Message Service ◽

Randomised Controlled

ObjectiveTo evaluate the effectiveness of the upgraded eCARE monitoring system on asthma control in discharged emergency department (ED) patients.MethodsA multicentre randomised controlled study (randomised controlled trial) was done for patients with a primary diagnosis of asthma seen at the EDs in Singapore between 1 March 2013 and 28 February 2015. Those who met the inclusion criteria were randomised into a control group (routine care, n=212) and intervention group (eCARE, n=212). Patients in the intervention group received short message service (SMS) messages according to a structured workﬂow, while patients in the control group did not receive SMS support.ResultsFor patients with poorly controlled asthma at recruitment, the results at 5 weeks showed no statistical difference in the proportion of patients who attained well-controlled asthma between the eCARE and routine care groups. At 3 months, the routine care group had a higher proportion of patients with well-controlled asthma but this was not statistically significant after adjustment for baseline differences using logistic regression. Approximately 95% of patients under the eCARE programme were satisfied with the SMS service.DiscussionPatients in the eCARE programme did not have better asthma control than those receiving routine care. Conversely, patients in the eCARE programme appeared to have poorer asthma control, though a larger sample size will be required to confirm this finding.

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A Randomized Controlled Study of the Effectiveness of Electrophysiological Monitoring of Dexmedetomidine in Patients with Brain Damage of Various Origins

Annals of the Russian academy of medical sciences ◽

10.15690/vramn1271 ◽

2020 ◽

Vol 75 (5) ◽

pp. 490-499

Author(s):

Yuri Y. Kiryachkov ◽

Marina V. Petrova ◽

Bagautdin G. Muslimov ◽

Sergey A. Bosenko ◽

Mikhail M. Gorlachev

Keyword(s):

Intervention Group ◽

Clinical Effectiveness ◽

Protective Role ◽

Digital Data ◽

Controlled Study ◽

Control Group ◽

Average Dose ◽

Autonomic Nervous System Dysfunction ◽

Sympathetic Hyperactivity ◽

Starting Dose

Background.At the same time, the main effect of the use of this drug is the elimination of the autonomic nervous system dysfunction and sympatholysis. It seems important to search for a method of indications and selection of a dose of dexmedetomidine in intensive care.Aims to improve the clinical effectiveness of the electrophysiological navigation of the prolonged use of dexmedetomidine in patients with brain pathology of various origins.Methods.The study included 83 patients 2050 days after the traumatic brain injury, anoxic damage; consequences of acute disorders of cerebral. 37 patients comprised the 1st intervention group with a clinical course of dexmedetomidine (male 28; female 9; average age 49.62.3 years) and 46 patients comprised the 2nd control group without pharmacological correction with dexmedetomidine (male 23; female 23, average age 512.5 years). Criteria for the inclusion of prolonged infusion of the drug dexmedetomidine (Orion Pharma, Finland) are based on heart rate variability (HRV) indicators characteristic of sympathetic hyperactivity, the target task of titration of doses of dexmedetomidine served as the parameters for achieving normal HRV indicators, the appearance of parasympathetic hyperactivity served as the basis for reducing the dosage of the drug or stopping it of application. HRV parameters were recorded before dexmetomedine infusion-initially, on 13; 45; 910; 1520 days of drug administration.Results.The starting dose of dexmedetomidine with sympathetic hyperactivity in patients was 0.12 to 0.24 g.kg1.hr1(average dose 0.160.01; total 200 mg/day). According to digital data from HRV, the effective dose of dexmedetomidine ED50 was 0.260.03 g.kg1.hr1(total daily 353.835.1 g) and was achieved on day 910 using dexmedetomidine.Conclusions.The protective role of dexmedetomidine with correction of sympathetic hyperactivity based on electrophysiological navigation according to the HRV is reliable in the following indicators: The improvement of consciousness; a significant decrease in the incidence of distress lung syndrome; septic shock; mortality.

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Effectiveness of Medication Review Services on Diabetes Self-Care in Primary Care Patients (Preprint)

10.2196/preprints.23269 ◽

2020 ◽

Author(s):

Tay Siew Cheng Sarah ◽

Lim Jit Fan Christina ◽

Tan Soo Chieng Daphne ◽

Tan Seok Yee Maureen ◽

Chen Jieying Cordelia ◽

...

Keyword(s):

Physical Activity ◽

Primary Healthcare ◽

Medication Review ◽

Intervention Group ◽

Self Care ◽

Effective Intervention ◽

Controlled Study ◽

Control Group ◽

Dietary Control ◽

Glucose Management

BACKGROUND Diabetes is one of the most common medical conditions referred to medication review service run by pharmacists, OBJECTIVE This study aims to determine whether pharmacist-run MRS can be an effective intervention tool to improve patients’ participation in self-care of diabetes. METHODS This randomised controlled study was conducted in five public primary healthcare centres from December 2014 to October 2016. Participants were 40 to 80 years of age and had been diagnosed with type 2 diabetes. These participants were prescribed with five or more chronic medications, of which at least one was an antidiabetic medication, by the primary healthcare centres’ doctors. The participants were randomly recruited into the intervention or control arm. A self-developed questionnaire which incorporated the validated Diabetes Self-Management Questionnaire (DSMQ) was administered face-to-face by the study team to the participants prior to and after MRS. MRS was not administered to participants in the control group. RESULTS A total of 221 participants completed the follow up. There were 105 participants in the control arm and 116 in the intervention arm. The DSMQ Sum Scale score of the control group improved by 0.16 ± 1.11 (p= 0.136) while the intervention group improved by 0.40 ± 0.99 (p=0.000). Participants in the intervention group reported a better improvement in their self-care of diabetes, specifically in glucose management (0.38± 1.35, p=0.003), dietary control (0.26±1.66, p=0.096) and physical activity (0.67±2.36, p=0.003). CONCLUSIONS Pharmacist-run MRS is an effective intervention tool to improve participants’ self-care of diabetes, particularly in glucose management, dietary control and physical activity.

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Echocardiographic evaluation of ventricular septal defect haemodynamics

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0710541m ◽

2007 ◽

Vol 135 (9-10) ◽

pp. 541-546

Author(s):

Vesna Miranovic

Keyword(s):

Ventricular Septal Defect ◽

Pulmonary Artery ◽

Body Surface ◽

Septal Defect ◽

Left Ventricular ◽

The Body ◽

Control Group ◽

Healthy Children ◽

And Control ◽

The Relationship

Introduction Ventricular septal defect (VSD) is an opening in the interventricular septum. 30-50% of patients with congenital heart disease have VSD. Objective The aim of the study was to determine the dependence of the left ventricular diastolic dimension (LVD), left ventricular systolic dimension (LVS), shortening fraction (SF), left atrium (LA), pulmonary artery truncus (TPA) on the body surface and compare their values among experimental, control and a group of healthy children. Values of maximal systolic gradient pressure (Pvsd) of VSD were compared with children from one experimental and control group. Method Children were divided into three groups: experimental (32 children with VSD that were to go to surgery), control (20 children with VSD who did not require surgery) and 40 healthy children. Measurements of LVD, LVS, SF, LA, TPA were performed in accordance to recommendations of the American Echocardiographic Association. The value of Pvsd was calculated from the maximal flow velocity (V) in VSD using the following formula: Pvsd=4xV? (mm Hg). Results For children from the experimental group, the relationship between the body surface and the variability of the LVD was explained with 56.85%, LVS with 66.15%, SF with 4.9%, TPA with 58.92%. For children from the control group, the relationship between the body surface and the variability of LVD was explained with 88.8%, LVS with 72.5%, SF with 0.42%, PA with 58.92%. For healthy children, the relationship between the body surface and the variabilitiy of the LVD was explained with 88.8%, LVS with 88.78%, SF with 5.25% and PA with 84.75%. There was a significant statistical difference between average values of Pvsd in the experimental and control group (p<0.02). Conclusion The presence of the large VSD has an influence on the enlargement of LVD, LVS, SF, TPA. The enlargement of the size of the pulmonary artery depends on the presence of VSD and there is a direct variation in the magnitude of the shunt. There is a relationship and significant dependence of the LVS and LVD on the body surface. There is no statistically significant dependence between SF and body surface.

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Administration of breast milk cell fractions to neonates with birthweight equal to or less than 1800 g: a randomized controlled trial

International Breastfeeding Journal ◽

10.1186/s13006-021-00405-0 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Minoo Fallahi ◽

Seyed Masoud Shafiei ◽

Naeeme Taslimi Taleghani ◽

Maryam Khoshnood Shariati ◽

Shamsollah Noripour ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Breast Milk ◽

Hospital Mortality ◽

Low Birthweight ◽

Controlled Trial ◽

Intervention Group ◽

Control Group ◽

Randomized Controlled ◽

Cell Fractions ◽

Breast Milk Cell

Abstract Background Most premature and very low birthweight infants cannot tolerate breast milk feeding in the first few days of life and are deprived of its benefits. This study evaluates the clinical outcomes of administering breast milk cell fractions to neonates with a birthweight of ≤1800 g. Methods We conducted a randomized controlled trial on 156 infants in the neonatal intensive care unit of Mahdieh Maternity Hospital in Tehran, Iran, from May 2019 to April 2020. All neonates with a birthweight ≤1800 g were enrolled and divided into intervention and control groups using stratified block randomization. Neonates in the intervention group received the extracted breast milk cell fractions (BMCFs) of their own mother’s milk after being centrifuged in the first 6 to 12 h after birth. The control group received routine care, and breastfeeding was started as soon as tolerated in both groups. Study outcomes were necrotizing enterocolitis (NEC), death, and in-hospital complications. Results We divided participants into two groups: 75 neonates in the intervention group and 81 neonates in the control group. The mean birthweight of neonates was 1390.1 ± 314.4 g, and 19 (12.2%) neonates deceased during their in-hospital stay. The incidence of NEC was similar in both groups. After adjustment for possible confounders in the multivariable model, receiving BMCFs were independently associated with lower in-hospital mortality (5 [26.3%] vs. 70 (51.1%]; odds ratio (OR): 0.24; 95% confidence interval [CI] 0.07, 0.86). Also, in a subgroup analysis of neonates with birthweight less than 1500 g, in-hospital mortality was significantly lower in the intervention group (4 [9.5%] vs. 13 [30.2%]; OR: 0.24; 95% CI 0.07, 0.82). There were no differences in major complications such as bronchopulmonary dysplasia and retinopathy of prematurity between the two groups. No adverse effects occurred. Conclusions Our research demonstrated a significantly lower mortality rate in neonates (with a birthweight of ≤1800 g) who received breast milk cell fractions on the first day of life. Since this is a novel method with minimal intervention, we are looking forward to developing and evaluating this method in larger studies. Trial registration IIranian Registry of Clinical Trials. Registered 25 May 2019, IRCT20190228042868N1.

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EVALUATION OF EFFECTIVENESS OF AROGYA KASHAYAM-20 IN COVID-19 CASES - A RANDOMIZED CONTROLLED STUDY

10.31219/osf.io/au3ct ◽

2021 ◽

Author(s):

Umesh Shukla ◽

Nitin Ujjaliya

Keyword(s):

Controlled Trial ◽

Care Center ◽

Large Population ◽

Intervention Group ◽

Controlled Study ◽

Control Group ◽

Rt Pcr ◽

Randomized Controlled ◽

Group A ◽

Negative Conversion

Introduction: The characteristic clinical features of Covid-19 disease range between asymptomatic to mild-moderate symptoms. Studies suggest that a large population (80%) presents its asymptomatic or milder form. Remaining 20 percent, owing to severity of the diseases, need hospital-based care. Many treatment protocols and strategies have been promoted and recommended by authorities including WHO, but nothing has actually been finalized till date. The present study was planned to evaluate the effectiveness of an Ayurvedic formulation viz. Arogya Kashayam-20 in the hospitalized cases of Covid-19.Aim: To evaluate the effectiveness of Arogya Kashayam-20 in the cases of COVID-19 particularly the negative conversion of RTPCR in 10 days duration.Material and Methods: This was a randomized controlled trial conducted at COVID-19 Care Center, Pt. Khushilal Sharma Government Ayurveda College & Institute, Bhopal, Madhya Pradesh with a sample size of 112 participants, aged between 16 to 60 years of either sex. Participants were divided in two groups viz. group A and B. Both the groups received Hydroxychloroquine (HCQ), vitamin C and Zinc as per the prevailing ICMR guidelines and group 'A' received additionally Arogya Kashayam-20 for 10 days. Outcome measure of the study was to see the negative conversion RT-PCR test after intervention period of 10 days. CTRI Registration: CTRI/2020/06/026221. Results: Among the 60 cases registered in study group (group A), 51 cases (85.00%) were reported with negative RTPCR on 10th day. Out of 52 cases registered in control group (group B); 39 cases (75.00%) were tested negative RTPCR on 10th day. In both the groups all the cases were discharged asymptomatically on 10th day as per the prevailing ICMR guidelines. No ADR/AE observed during the intervention period.Conclusion: The study observes that the add on intervention group has a better outcome in terms of RT-PCR negative reports after 10 days comparing to the control group.

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The effect of postoperative early mobilization on healing process and quality of life following radical cystectomy and ileal conduit: A randomized prospective controlled trial

10.22541/au.161545934.45040085/v1 ◽

2021 ◽

Author(s):

Sevgi Peker ◽

Özgür Çakmak ◽

Talha Muezzinoglu ◽

Guven Aslan ◽

Hakan Baydur

Keyword(s):

Quality Of Life ◽

Radical Cystectomy ◽

Ileal Conduit ◽

Healing Process ◽

Intervention Group ◽

Early Mobilization ◽

Controlled Study ◽

Control Group ◽

Sf 36

Aim: This study was conducted to evaluate the effect of postoperative early mobilization in patients who underwent radical cystectomy (RC) and ileal conduit in terms of healing process and QOL. Methods: This multicenter prospective randomized controlled study was conducted with 40 patients who were randomly divided into two groups. The intervention group was mobilized within the first 16 hours postoperatively in accordance with the mobilization procedure which determined according to literature. Data were collected using the case report form, HADS and SF-36 QoL scale. Results: Postoperative hospitalization, duration of narcotic analgesic administration, first oral food intake, flatus, defecation and NG tube termination time were shorter in the intervention group. In the control group blood glucose and pulse values were higher after mobilization. SF-36 physical function, physical role difficulty and general perception of health were higher in intervention group at the postoperative first and third month (p <0.05). Conclusion: Our study showed that early mobilization contributed to the healing process positively and improved the quality of life in the patients who underwent radical cystectomy (RC) and ileal conduit surgery. Keywords: Early Mobilization, Radical Cystectomy, Ileal conduit, Quality of Life, Convalescence

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