The Resuscitative and Pharmacokinetic Effects of Humeral Intraosseous Vasopressin in a Swine Model of Ventricular Fibrillation

2017 ◽  
Vol 32 (3) ◽  
pp. 305-310 ◽  
Author(s):  
James M. Burgert ◽  
Arthur D. Johnson ◽  
Jose Garcia-Blanco ◽  
Lawrence V. Fulton ◽  
Michael J. Loughren
Keyword(s):  
Ventricular Fibrillation ◽  
Analysis Of Variance ◽  
Repeated Measures ◽  
Control Group ◽  
Swine Model ◽  
Maximum Plasma ◽  
Publication Type ◽  
Treatment Groups ◽  
Significant Difference ◽  
And Control

AbstractIntroductionThe American Heart Association (AHA; Dallas, Texas USA) and European Resuscitation Council (Niel, Belgium) cardiac arrest (CA) guidelines recommend the intraosseous (IO) route when intravenous (IV) access cannot be obtained. Vasopressin has been used as an alternative to epinephrine to treat ventricular fibrillation (VF).Hypothesis/ProblemLimited data exist on the pharmacokinetics and resuscitative effects of vasopressin administered by the humeral IO (HIO) route for treatment of VF. The purpose of this study was to evaluate the effects of HIO and IV vasopressin, on the occurrence, odds, and time of return of spontaneous circulation (ROSC) and pharmacokinetic measures in a swine model of VF.MethodsTwenty-seven Yorkshire-cross swine (60 to 80 kg) were assigned randomly to three groups: HIO (n=9), IV (n=9), and a control group (n=9). Ventricular fibrillation was induced and untreated for two minutes. Chest compressions began at two minutes post-arrest and vasopressin (40 U) administered at four minutes post-arrest. Serial blood specimens were collected for four minutes, then the swine were resuscitated until ROSC or 29 post-arrest minutes elapsed.ResultsFisher’s Exact test determined ROSC was significantly higher in the HIO 5/7 (71.5%) and IV 8/11 (72.7%) groups compared to the control 0/9 (0.0%; P=.001). Odds ratios of ROSC indicated no significant difference between the treatment groups (P=.68) but significant differences between the HIO and control, and the IV and control groups (P=.03 and .01, respectively). Analysis of Variance (ANOVA) indicated the mean time to ROSC for HIO and IV was 621.20 seconds (SD=204.21 seconds) and 554.50 seconds (SD=213.96 seconds), respectively, with no significant difference between the groups (U=11; P=.22). Multivariate Analysis of Variance (MANOVA) revealed the maximum plasma concentration (Cmax) and time to maximum concentration (Tmax) of vasopressin in the HIO and IV groups was 71753.9 pg/mL (SD=26744.58 pg/mL) and 61853.7 pg/mL (SD=22745.04 pg/mL); 111.42 seconds (SD=51.3 seconds) and 114.55 seconds (SD=55.02 seconds), respectively. Repeated measures ANOVA indicated no significant difference in plasma vasopressin concentrations between the treatment groups over four minutes (P=.48).ConclusionsThe HIO route delivered vasopressin effectively in a swine model of VF. Occurrence, time, and odds of ROSC, as well as pharmacokinetic measurements of HIO vasopressin, were comparable to IV.BurgertJM, JohnsonAD, Garcia-BlancoJ, FultonLV, LoughrenMJ. The resuscitative and pharmacokinetic effects of humeral intraosseous vasopressin in a swine model of ventricular fibrillation. Prehosp Disaster Med. 2017;32(3):305–310.

Assessing the effectiveness of problem-based and lecture-based learning environments on students’ achievements in electronic works

2018 ◽  
Vol 55 (4) ◽  
pp. 334-353 ◽  
Author(s):  
Chibueze Tobias Orji ◽  
Theresa Chinyere Ogbuanya
Keyword(s):  
Learning Environments ◽  
Analysis Of Variance ◽  
Repeated Measures ◽  
Univariate Analysis ◽  
Control Group ◽  
Chi Square ◽  
Control Group Design ◽  
Repeated Measures Analysis ◽  
Significant Difference ◽  
And Control

The purpose of this study was to investigate the effectiveness of problem-based and lecture-based learning environments on students’ achievement in electronic works. The design was randomized subjects with pretest and posttest control group design. The participants ( N = 148) were randomized to treatment and control conditions. Repeated measures analysis of variance and univariate analysis of variance were conducted by the researchers to compare changes across the treatment and control group participants. To test for differences in categorical data representing characteristics of the participants, the researchers used Chi-square (χ2) statistic. Results show that the experimental group achieved higher achievement scores than the control group for electronic works achievement test at the posttest and follow-up test stages. Furthermore, the study found that there was no significant difference ( P > 0.05) in the achievement of students in the different ability levels and genders after the treatment. Hence, problem-based learning was advocated for teachers of electronic works in Nigeria.

Benefits of a Guided Motor-Mental Preperformance Routine on Learning the Basketball Free Throw

2019 ◽  
Vol 127 (1) ◽  
pp. 248-262
Author(s):  
Jalil Moradi
Keyword(s):  
Analysis Of Variance ◽  
Repeated Measures ◽  
Motor Pattern ◽  
Self Regulation ◽  
Past Research ◽  
Control Group ◽  
Free Throw ◽  
Significant Difference ◽  
Transfer Testing ◽  
And Control

While past research has shown the benefits of preperformance routines (PPRs) on athletes’ performances, only a few studies have addressed PPR effects on novices’ learning or performance. This study investigated the effect of motor-mental PPR on learning the basketball free throw. We categorized 45 undergraduate male students into three 15-session training groups receiving (a) a five-step PPR based on Singer’s model, (b) a self-regulation PPR, and (c) no PPR, but only a basketball free throw performance (control group). One week later, we conducted retention and transfer testing. A repeated measures analysis of variance and two-way mixed design analysis of variance showed that, in the acquisition and test phases, the five-step PPR group performed better than the other two groups ( p < .001), and there was no significant difference between the self-regulation PPR and control groups. The results also showed that, in accordance with the specificity of practice hypothesis, participants’ performance decreased significantly on transfer testing when PPR was removed from the experimental groups. A well-guided motor-mental PPR was superior to a self-regulated PPR for novices learning this basketball skill, probably because it increased the participants’ concentration during acquisition and helped them learn it as part of a motor pattern.

The comparison of humeral intraosseous and intravenous administration of vasopressin on return of spontaneous circulation and pharmacokinetics in a hypovolemic cardiac arrest swine model

2016 ◽  
Vol 11 (4) ◽  
pp. 237-242 ◽  
Author(s):  
Mark H. Wimmer, BSN ◽  
Kenneth Heffner, BSN ◽  
Michael Smithers, BSN ◽  
Richard Culley, BSN ◽  
Jennifer Coyner, PhD, CRNA ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Analysis Of Variance ◽  
Repeated Measures ◽  
Maximum Concentration ◽  
Life Support ◽  
Spontaneous Circulation ◽  
Control Group ◽  
Swine Model ◽  
Return Of Spontaneous Circulation ◽  
Significant Difference

Introduction: The American Heart Association (AHA) recommends intravenous (IV) or intraosseous (IO) vasopressin in Advanced Cardiac Life Support (ACLS). Obtaining IV access in hypovolemic cardiac arrest patients can be difficult, and IO access is often obtained in these life threatening situations. No studies have been conducted to determine the effects of humeral IO (HIO) access with vasopressin in the return of spontaneous circulation (ROSC). Our study compared the kinetics of vasopressin and ROSC with HIO with IV access in the hypovolemic swine model.Methods: Twenty-two Yorkshire swine were divided into three groups: HIO (n = 7), IV (n = 8), and a control group (n = 7). The IV and HIO group received vasopressin and cardiopulmonary resuscitation (CPR), while the control group received only CPR. All subjects were exsanguinated 31 percent of their blood volume, placed in cardiac arrest, and resuscitated per ACLS. Subjects that achieved ROSC were then monitored for 20 minutes. Blood samples (10 mL) collected at 0.5, 1, 1.5, 2, 2.5, 3, and 4 minutes after vasopressin injection and analyzed for maximum concentration (Cmax) and time to maximum concentration (Tmax). Data were analyzed using a multivariate analysis of variance (MANOVA) and a Fisher's Exact Test.Results: ROSC was achieved in every subject that received vasopressin via the HIO route. Data analysis using a MANOVA pairwise comparison revealed no difference between mean Cmax (p = 0.601) and Tmax (p = 0.771) of vasopressin administered IV versus HIO routes. Analysis of the mean serum concentrations at time intervals using a repeated measures analysis of variance found no difference (p 0.05). A Fisher's Exact Test revealed no difference in rate of ROSC between HIO and IV groups (p 0.05). Odds ratio determined that there was a 33 times higher chance of survival among HIO subjects versus control (CPR and Defibrillation; p = 0.03) and no difference in the survivability of the HIO or IV groups (p = 0.52). Conclusion: The data from this study strongly suggest that there is no significant difference in ROSC, time to ROSC, hemodynamics, or pharmacokinetics between HIO vasopressin and IV vasopressin. This research reinforces current AHA guidelines recommending the use of HIO route early over delaying care awaiting IV access.

scholarly journals Presurgical orthopedics by drink plates does not significantly normalize deglutition in infants with cleft lip and palate

2015 ◽  
Vol 86 (2) ◽  
pp. 315-323
Author(s):  
Michael Knösel ◽  
Christine Fendel ◽  
Klaus Jung ◽  
Paulo Sandoval ◽  
Wilfried G. Engelke
Keyword(s):  
Repeated Measures ◽  
Null Hypothesis ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Control Group ◽  
Treatment Groups ◽  
Significant Difference ◽  
And Control ◽  
Intraoral Pressure ◽  
Pressure Characteristics

ABSTRACT Objective:  To test the null hypothesis of no significant difference between intraoral pressure characteristics in infants with cleft lip and palate (CLP) with or without presurgical orthopedic (PSO) plates (groups CLP and CLP-PSO), compared with noncleft infants. Materials and Methods:  Intraoral atmospheric pressure assessments were performed on 17 subjects with preoperative CLP (m/f, 11/6; mean/SD, 4.76/0.92 months) and a matched control group (n = 24; m/f, 15/9; mean/SD, 4.88/0.9 months), for 200 seconds, simultaneously at the vestibulum (vestibular space [VS]) and at the palate (subpalatal space [SPS]), using a prepared pacifier connected to a digital manometer. Areas under the pressure curves (AUC), frequencies, durations, and magnitudes of swallowing peaks and pressure resting plateaus were compared between trial groups and locations (VS, SPS) using a two-factor analysis of variance for repeated measures, Kruskal-Wallis test, and Mann-Whitney U-test (α = .05). Results:  The null hypothesis was rejected: Globally, there were statistically significant differences in intraoral pressure characteristics between groups CLP, CLP-PSO, and control (all P &lt; .01), with significantly higher negative pressures (AUC) in the control subjects compared with those of CLP or CLP-PSO. There were significant effects by the location of pressure recordings (VS, SPS) and their interaction with all treatment groups. Differences between noncleft and CLP subjects were more pronounced in the VS than in the SPS. There was no significant effect by PSO. Conclusion:  PSO does not improve deviated swallowing characteristics during suction in CLP infants.

scholarly journals Effect of Carnatic Music Listening Training on Speech in Noise Performance in Adults

2021 ◽  
Vol 25 (1) ◽  
pp. 22-26
Author(s):  
Raksha Amemane ◽  
Archana Gundmi ◽  
Kishan Madikeri Mohan
Keyword(s):  
Repeated Measures ◽  
Functional Organization ◽  
Control Group ◽  
Music Listening ◽  
Noise Performance ◽  
Short Term ◽  
Speech In Noise ◽  
Carnatic Music ◽  
Significant Difference ◽  
And Control

Background and Objectives: Music listening has a concomitant effect on structural and functional organization of the brain. It helps in relaxation, mind training and neural strengthening. In relation to it, the present study was aimed to find the effect of Carnatic music listening training (MLT) on speech in noise performance in adults.Subjects and Methods: A total of 28 participants (40-70 years) were recruited in the study. Based on randomized control trial, they were divided into intervention and control group. Intervention group underwent a short-term MLT. Quick Speech-in-Noise in Kannada was used as an outcome measure.Results: Results were analysed using mixed method analysis of variance (ANOVA) and repeated measures ANOVA. There was a significant difference between intervention and control group post MLT. The results of the second continuum revealed no statistically significant difference between post training and follow-up scores in both the groups.Conclusions: In conclusion short-term MLT resulted in betterment of speech in noise performance. MLT can be hence used as a viable tool in formal auditory training for better prognosis.

scholarly journals Effects of Erythropoietin Administration on Adrenal Glands of Landrace/Large White Pigs after Ventricular Fibrillation

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Armando Faa ◽  
Gavino Faa ◽  
Apostolos Papalois ◽  
Eleonora Obinu ◽  
Giorgia Locci ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Adrenal Glands ◽  
Life Support ◽  
Advanced Life Support ◽  
Spontaneous Circulation ◽  
Control Group ◽  
Swine Model ◽  
Protective Effects ◽  
Large White ◽  
Significant Difference

Aim.To evaluate the effects of erythropoietin administration on the adrenal glands in a swine model of ventricular fibrillation and resuscitation.Methods. Ventricular fibrillation was inducedviapacing wire forwarded into the right ventricle in 20 female Landrace/Large White pigs, allocated into 2 groups: experimental group treated with bolus dose of erythropoietin (EPO) and control group which received normal saline. Cardiopulmonary resuscitation (CPR) was performed immediately after drug administrationas perthe 2010 European Resuscitation Council (ERC) guidelines for Advanced Life Support (ALS) until return of spontaneous circulation (ROSC) or death. Animals who achieved ROSC were monitored, mechanically ventilated, extubated, observed, and euthanized. At necroscopy, adrenal glands samples were formalin-fixed, paraffin-embedded, and routinely processed. Sections were stained with hematoxylin-eosin.Results.Oedema and apoptosis were the most frequent histological changes and were detected in all animals in the adrenal cortex and in the medulla. Mild and focal endothelial lesions were also detected. A marked interindividual variability in the degree of the intensity of apoptosis and oedema at cortical and medullary level was observed within groups. Comparing the two groups, higher levels of pathological changes were detected in the control group. No significant difference between the two groups was observed regarding the endothelial changes.Conclusions. In animals exposed to ventricular fibrillation, EPO treatment has protective effects on the adrenal gland.

scholarly journals Effectiveness of Training Based on Healthy Human Theory and Emotion-Focused Therapy in Marital Happiness

2021 ◽  
Vol 6 (3) ◽  
pp. 81-90
Author(s):  
Sara Moradi ◽  
◽  
Asghar Aghaei ◽  
Mohsen Golparvar ◽  
◽  
...  
Keyword(s):  
Marital Conflict ◽  
Repeated Measures ◽  
Control Group ◽  
Marital Happiness ◽  
Healthy Human ◽  
Statistical Population ◽  
Emotion Focused Therapy ◽  
Significant Difference ◽  
Effectiveness Of Training ◽  
And Control

Background: Psychological factors affect marital conflict and happiness; in other words, they strengthen and shape marital relations. The present study aimed to investigate the effectiveness of training based on Healthy Human Theory (HHT) and Emotion-Focused Therapy (EFT) in marital happiness of couples living in Isfahan City, Iran. Materials & Methods: This research has a pretest-posttest control group design. The statistical population included all couples referring to mental health centers in Isfahan in 2020. The study sample consisted of 39 couples selected by the convenience sampling method. The participants were randomly divided into two experimental groups (training based on HHT and EFT) and control group (n=13 couples per group). The research instrument included the marital satisfaction scale. Follow-up was performed after 90 days. Repeated-measures ANOVA in SPSS software was used to analyze the data. Results: The results showed that training based on HHT significantly affected marital happiness compared to EFT and control group (P=0.001). The Mean±SD of the posttest scores of marital happiness in the HHT-based training, EFT, and control groups were 97.92±1.54, 87.50±5.56, and 75.38±8.71, respectively. There was no significant difference between the effects of HHT-based training and EFT on happiness in couples. Conclusion: Based on the results, the HHT-based training and EFT are appropriate methods for improving marital happiness.

Efficacy of Fenbendazole and Ivermectin against Trichuris spp. in African Green Monkeys (Chlorocebus sabaeus) in Barbados West Indies

2021 ◽  
Author(s):  
Kamara JR Rhynd ◽  
Daniel P Walsh ◽  
Linnell CM Arthur-Banfield
Keyword(s):  
Natural Infection ◽  
Combined Treatment ◽  
Control Group ◽  
Treatment Groups ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Bayesian Generalized Linear Model ◽  
Proportional Reduction ◽  
Green Monkeys

Trichuris spp. are common helminths in NHP, and benzimidazoles and avermectins have both been used to treat theseintestinal parasites. The current study compared the efficacy of fenbendazole and ivermectin against natural infection ofTrichuris spp. in African green monkeys (Chlorocebus sabaeus). Anthelmintic-naive animals (n = 65) were randomly assignedto 4 groups: an untreated control group, and 3 groups treated with either fenbendazole, ivermectin, or both compounds. Fecalsamples were collected before treatment and on days 7, 14, 28, and 60 after treatment, and fecal egg counts (FEC) were determined by using fecal flotation. The mean percentages of FEC reduction at day 60 were 100%, 86%, and 100% for treatmentwith fenbendazole, ivermectin, and both compounds, respectively. Analyzing the time series of FEC by using a Bayesian generalized linear model showed no significant difference in the proportional reduction in FEC among the 3 treatment groups, although all FEC from treated groups were significantly lower than the FEC of the control group. In contrast, the probability of shedding was highest in the ivermectin group and the lowest in the animals treated with both compounds. The probability of shedding differed significantly between the fenbendazole and ivermectin groups and between the ivermectin and combined-treatment groups. In conclusion, both fenbendazole and ivermectin are effective anthelmintics in treating Trichuris spp. infection in African green monkeys. All treatment groups showed significant reductions in FEC when compared with baseline counts and control animals; however, fenbendazole may be more effective than ivermectin when used solely or in combination with other anthelmintic treatments.

Infant Walkers: Developmental Tool or Inherent Danger

1982 ◽  
Vol 55 (3_suppl) ◽  
pp. 1201-1202 ◽  
Author(s):  
Marcella V. Ridenour
Keyword(s):  
Analysis Of Variance ◽  
Onset Time ◽  
Control Group ◽  
Bipedal Locomotion ◽  
Control Groups ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Experimental Group

This study investigated the influence of pre-walking practice in an infant walker on the onset time of independent walking. 15 pairs of twins were randomly divided into experimental and control groups. Only the experimental group was exposed to an infant walker. This group spent a minimum of 1 hr. per day in an infant walker from 4 mo. of age until the onset of bipedal locomotion. The infants in the control group were not placed in infant walkers. A one-way analysis of variance indicated there was no significant difference between the mean ages of initial walking for the experimental and control groups. The use of the infant walker did not influence the onset of independent walking.

Efficacy of Imagery and Meditation Techniques in Treating Psoriasis

1989 ◽  
Vol 8 (1) ◽  
pp. 25-38 ◽  
Author(s):  
Louise Gaston ◽  
Jean-Charles Crombez ◽  
Jacques Joly ◽  
Sheilagh Hodgins ◽  
Marc Dumont
Keyword(s):  
Time Series ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Control Group ◽  
Control Groups ◽  
Treatment Groups ◽  
Series Design ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Using a dismantled time-series design, eighteen subjects were randomly assigned to three groups: meditation ( N = 5); meditation and imagery ( N = 4); waiting list ( N = 5). Treatment lasted twelve weeks, while pre- and post-baseline periods were of four weeks. An assessment control group control was also used during baseline periods ( N = 4). The severity of psoriasis symptoms was reliably rated by dermatologists. While controlling for extraneous factors influencing psoriasis symptoms, a time-series multivariate regression analysis revealed a significant difference between the mean psoriasis ratings of treatment and control groups after treatment (partial r = .30, p < .01). No additional impact was associated with the use of the imagery technique (partial r = − .06, p > .05). Four subjects in the treatment groups, two in each condition, succeeded in clinically improving their psoriasis symptoms, and none deteriorated. The practice of mediation may be clinically effective for some patients in reducing their psoriasis symptoms.

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