The Role of 5-HT1B/1D Receptors in the Treatment of Migraine

CNS Spectrums ◽  
1998 ◽  
Vol 3 (8) ◽  
pp. 30-39 ◽  
Author(s):  
Christian Waeber
Keyword(s):  
Sensory Neurons ◽  
Rodent Models ◽  
The One ◽  
The Relationship

AbstractOf all known neurotransmitters, 5-HT is the one most frequently mentioned in the pathophysiology of migraine. This review focuses on the relationship between the efficacy of sumatriptan and other migraine agents and their effects on specific 5-HT receptors in rodent models. These agents are seen to have effects on vascular constriction and the release of vasoactive and inflammatory peptides from trigeminovascular sensory neurons. Specific subtypes of the 5-HT1 receptors appear to mediate these effects.

scholarly journals Socio-legal studies and the humanities – law, interdisciplinarity and integrity

2009 ◽  
Vol 5 (3) ◽  
pp. 243-261 ◽  
Author(s):  
Melanie L. Williams
Keyword(s):  
Human Experience ◽  
Normative Values ◽  
Moral Sensibility ◽  
Hard Data ◽  
Legal Studies ◽  
Psychological Significance ◽  
The One ◽  
Relationship Of ◽  
The Relationship

This paper was delivered as a plenary lecture, designed to respond to the one-day special conference focus upon links between socio-legal studies and the humanities.1 The paper focuses in particular upon the relationship between law and the humanities. It may be argued that the role of empirically sourced socio-legal research is well accepted, given its tangible utility in terms of producing hard data which can inform and transform policy perspectives. However, scholarly speculation about the relationship between law and the humanities ranges from the indulgent to the hostile. In particular, legal scholars aligning themselves as ‘black letter’ commentators express strong opinions about such links, suggesting that scholarship purporting to establish links between the two fields is essentially spurious, bearing in mind the purposive role of law as a problem-solving mechanism. The paper sets out to challenge such assertions, indicating the natural connections between the two fields and the philosophical necessity of continued interaction, given the fact that certain aspects of human experience and nature cannot be plumbed by doctrine or empiricism or even by combinations of the two. Law must be understood to stand at the nexus of human experience, in a relationship of integrity, where the word is understood to mean both morally principled and culturally integrated. In particular, the development of human qualities, of character and moral sensibility informing normative values – and, ultimately, engagement with the world of law – is a process of subtle cultural as well as psychological significance, and may benefit from interrogation deriving from the wider fields of human discourse.

scholarly journals The Mediating Role of Competency on the Relationship between Training and Task Performance: Applied Study in Pharmacists

2017 ◽  
Vol 8 (7) ◽  
pp. 16
Author(s):  
Jih-Hua Yang ◽  
Shih-Chieh Fang ◽  
Ching-Ying Huang
Keyword(s):  
Task Performance ◽  
Core Competency ◽  
Professional Competency ◽  
Mediating Role ◽  
Technical Competency ◽  
Full Effect ◽  
The One ◽  
The Relationship ◽  
And Task

This study aimed to determine the mediating role of competency (professional competency, technical competency, and core competency) between training and task performance in pharmacists. Questionnaire was the tool of collecting data from a sample of (210) pharmacists. The results of the study indicated that there is a positive effect of training on task performance. Also, there is full effect of the two mediator variables (professional competency; technical competency) and partial effect of the one mediator variable (core competency) on the relationship between independent and dependent variables.

scholarly journals A European convergence towards a stare decisis model?

2015 ◽  
pp. 173 ◽  
Author(s):  
Stefano Civitarese
Keyword(s):  
Rule Of Law ◽  
Deep Understanding ◽  
The European Union ◽  
Stare Decisis ◽  
The Rule Of Law ◽  
Law System ◽  
Legal Space ◽  
The One ◽  
The Relationship

The article revolves around the doctrine of precedent within the so-called European legal space, wondering whether and to what extent we can speak of a convergence towards a stare decisis model boosted by the harmonizing role of the Court of Justice of the European Union. The article argues that although there are still some differences between civil law and common law legal systems they regard more the style of reasoning and the deep understanding of the relationship between the present decision of a court and past judicial decisions than the very existence of the constraints of the latter upon the former. The article concludes that a sort of mechanism of stare decisis has in fact been created, even though, on the one hand, uncertainty remains as to the way in which the binding force of a precedent concretely operates in the system, and on the other hand, this mechanism relates exclusively to the relationships between past and future decisions of higher courts (horizontal effect). This change, far from being a shift towards a truly judge-made law system or a consequence of the final abandonment of the dictates of the rule of law, enhances legal certainty contributing to the fundamental requirement of stability of law as a feature of the ideal of the rule of law.

scholarly journals “A Boot Stamping on a Human Face – For Ever”: George Orwell, Language, Literature, and Politics

2020 ◽  
Vol 39 ◽  
pp. 172-188
Author(s):  
Roberta Ferrari
Keyword(s):  
Spanish Civil War ◽  
George Orwell ◽  
The Political ◽  
Human Face ◽  
Literature And Politics ◽  
Language And Literature ◽  
The One ◽  
Historical Moment ◽  
The Relationship

"Britain experienced the harshness of 20th-century dictatorship and censorship only obliquely, as a reflection of what was happening in several “elsewheres”. Yet, events such as the Spanish Civil War deeply affected a whole generation of young British writers who, after the period of elitist Modernism, were trying to reassert the political import of literature through a redefinition of the role of the artist as politically and socially engagé. George Orwell figures as one of the most disenchanted and lucid witnesses of this particular historical moment. In both his essays and journalistic articles, as well as in his narrative work, he continuously ponders over the relationship between political power and society on the one hand, and language and literature on the other, providing a most interesting analysis of the mechanisms that preside over this interaction."

“Soviet mentality?” The role of shared political culture in relations between the Armenian state and Russia's Armenian diaspora

2013 ◽  
Vol 41 (5) ◽  
pp. 709-729 ◽  
Author(s):  
Kristin Cavoukian
Keyword(s):  
Soviet Union ◽  
Political Culture ◽  
Community Organization ◽  
The Soviet Union ◽  
Armenian Diaspora ◽  
The Difference ◽  
The One ◽  
Management Institutions ◽  
The Relationship

Russia's Armenians have begun to form diaspora institutions and engage in philanthropy and community organization, much as the pre-Soviet “established” diaspora in the West has done for years. However, the Russian Armenian diaspora is seen by Armenian elites as being far less threatening due to a shared “mentality.” While rejecting the mentality argument, I suggest that the relationship hinges on their shared political culture and the use of symbols inherited from the Soviet Union in the crafting of new diaspora and diaspora-management institutions. Specifically, “Friendship of the Peoples” symbolism appears to be especially salient on both sides. However, the difference between old and new diasporas may be more apparent than real. The Russian Armenian diaspora now engages in many of the same activities as the Western diaspora, including the one most troublesome to Armenia's elites: involvement in politics.

The Use of Blood Money in the Establishment of Non-Justice: Necrodomination and Resistance

2019 ◽  
pp. 160-186
Author(s):  
Cem Özatalay ◽  
Gözde Aytemur Nüfusçu ◽  
Gülistan Zeren
Keyword(s):  
Social Hierarchy ◽  
Judicial Process ◽  
The Social ◽  
Blood Money ◽  
Perpetrators And Victims ◽  
The One ◽  
The Right ◽  
Relationship Of ◽  
The Relationship

The use of blood money by powerful people during the judicial process following different kinds of homicides (workplace homicides, state homicides, gun homicides and so on) has become commonplace within the neoliberal context. Based on data obtained from five cases in Turkey, this chapter shows, on the one hand, how the use of blood money serves as an effective tool in the hands of powerful people to consolidate power relations, particularly necropower, as well as the relationship of domination, which rests upon class and identity-based inequalities. The analysis indicates that the blood money offers made by powerful people allows them to minimize potential penalties within penal courts and also to keep their privileged positions in the social hierarchy by purchasing the ‘right to kill’. On the other hand, the resistance of the oppressed and aggrieved people to the subjugation of life to the power of death is analysed with a particular focus on the role of power asymmetries between perpetrators and victims and their unequal positions in the social hierarchy. This conflictual relationship, which we qualify as an expression of necrodomination, offers novel insights into Turkey’s historically shaped system of domination.

scholarly journals How do conflict narratives shape conflict- and peace-related outcomes among majority group members? The role of competitive victimhood in intractable conflicts

2020 ◽  
pp. 136843022091577
Author(s):  
Özden Melis Uluğ ◽  
Brian Lickel ◽  
Bernhard Leidner ◽  
Gilad Hirschberger
Keyword(s):  
Violent Conflict ◽  
The Other ◽  
Intergroup Conflict ◽  
Majority Group ◽  
Group Members ◽  
The One ◽  
Kurdish Conflict ◽  
The Relationship ◽  
Conflict Narratives

Previous research in the Turkish–Kurdish conflict context highlighted two opposing conflict narratives: (a) a terrorism narrative and (b) an independence narrative. In this article, we argue that these narratives are relevant to protracted and asymmetrical intergroup conflict (e.g., independence struggles), and therefore have consequences for conflict- and peace-related outcomes regardless of conflict contexts. We tested this generalizability hypothesis in parallel studies in the context of Turkish–Kurdish (Study 1) and Israeli–Palestinian relations (Study 2) among majority group members (Turks and Jewish Israelis, respectively). We also investigated competitive victimhood as a potential mediating variable in the relationship between conflict narratives on the one side and support for non-violent conflict resolution, forgiveness, and support for aggressive policies on the other, in parallel studies with the two aforementioned contexts. We argue that the terrorism narrative is essentially a negation of the narrative of the other group, and the independence narrative is a consideration of that narrative; therefore, competitive victimhood would be lower/higher when the narrative of the other is acknowledged/denied. Results point to the crucial relationship between endorsing conflict narratives and conflict- and peace-related outcomes through competitive victimhood, and to the possibility that these conflict narratives may show some similarities across different conflict contexts.

Language Pangs

2019 ◽  
Author(s):  
Ilit Ferber
Keyword(s):  
The Other ◽  
Literary Texts ◽  
Close Reading ◽  
Philosophical Text ◽  
Origin Of Language ◽  
Pain Expression ◽  
The One ◽  
The Relationship

Language and pain are usually thought of as opposites, the one being about expression and communication, the other destructive, “beyond words,” and isolating. Language Pangs challenges these familiar conceptions and offers a reconsideration of the relationship between pain and language in terms of an essential interconnectedness rather than an exclusive opposition. The book’s premise is that the experience of pain cannot be probed without consideration of its inherent relation to language, and vice versa: understanding the nature of language essentially depends on an account of its relationship with pain. Language Pangs brings together discussions of philosophical as well as literary texts, an intersection especially productive in considering the phenomenology of pain and its bearing on language. The book’s first chapter presents a phenomenology of pain and its relation to language. Chapters 2 and 3 provide a close reading of Herder’s Treatise on the Origin of Language (1772), which was the first modern philosophical text to bring together language and pain, establishing the cry of pain as the origin of language. Herder also raises important claims regarding the relationship between human and animal, sympathy, and the role of hearing in the experience of pain. Chapter 4 is devoted to Heidegger’s seminar (1939) on Herder’s text about language, a relatively unknown seminar that raises important claims regarding pain, expression, and hearing. Chapter 5 focuses on Sophocles’ story of Philoctetes, important to Herder’s treatise, in terms of pain, expression, sympathy, and hearing, also referring to more thinkers such as Cavell and Gide.

scholarly journals Self-concept and Family: A study on Greek secondary school students

2016 ◽  
Vol 10 (1) ◽  
Author(s):  
Dimitris Kiritsis
Keyword(s):  
Sampling Technique ◽  
Self Concept ◽  
School Students ◽  
The Family ◽  
Major Variation ◽  
Essential Contribution ◽  
The One ◽  
High Degree ◽  
The Relationship

The aim of the study is twofold. On the one hand it concerns the measurement and the examination of the subjects’ self-concept and on the other the detection and justification of the role of family in its configuration. The study analyzed the data collected from the answers to a research questionnaire of 1344 15-and 16-year-old school students in the Prefecture of Thessaloniki, Greece) with the use of a stratified random sampling technique. The first important finding concerned the high degree of the general self-concept of the adolescents. Among the seven specific sectors of the general self-concept a major variation was noted, with the higher average to be traced in the relationship that the students have configured with their peers and the lower one in the valuation of their academic competence. The second important finding was the ascertainment of the essential contribution of the family.

Analyse Experimentale Du Role De L'Ovitube Dans Le Comportement De Ponte De La Bruche Du Haricot (Acanthoscelides Obtectus Say- Coleoptera, Bruchidae)

Behaviour ◽  
1975 ◽  
Vol 54 (3-4) ◽  
pp. 258-277 ◽  
Author(s):  
Jean Pouzat
Keyword(s):  
Mechanical Stimulus ◽  
Egg Laying ◽  
Acanthoscelides Obtectus ◽  
The One ◽  
The Relationship ◽  
Acanthoscelides Obtectus Say ◽  
Egg Laying Behaviour ◽  
Made In ◽  
Important Stimulus

AbstractA resume is made of the major sequences of egg-laying behaviour, both in nature and on stored seeds, of the bean weevil. An experimental analysis of the role of the ovipositor in the act of egg-laying is then undertaken by simple techniques. It is observed that an important stimulus, with respect to this, is mechanical in nature: resulting from contact between the setae of the ovipositor on the one hand, and the seed and the "ground" on the other. Simply suspending the seed instead of leaving it lie on the cage bottom, suffices to reduce egg-laying and production significantly. Examination of egg-laying, when the substratum furnished is a trellis with suitable sized mesh, shows that an important aspect of the mechanical stimulus is in its concentrical character, i.e., the fact that it is applied to a greater number of setae all around the ovipositor. The result enables us to understand better the behaviour in nature, where there is a boring of the bean pod followed by egg-laying inside that pod through through the hole made. In the course of the paper some connected problems are evoked: - The relationship between egg-laying and production; - The more or less necessary character of the succession of the different sequences in egg-laying behaviour. Existence of intermediary cases, between individuals which can lay eggs only in the pod and those laying in the apparent absence of any stimulus, particularly stimuli connected with the bean; - Links between the phytophage and its host, remarks on the apparently unfavourable peculiarity of laying a great number of eggs in the same place, the possible consequences with respect to population dynamics.

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