Longitudinal Consistency of the Relationship Between Depression Symptoms and Cognitive Functioning in Multiple Sclerosis

CNS Spectrums ◽  
2005 ◽  
Vol 10 (5) ◽  
pp. 372-382 ◽  
Author(s):  
Peter A. Arnett
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Dysfunction ◽  
Symptom Clusters ◽  
Cognitive Capacity ◽  
Depression Symptoms ◽  
Depression Symptom ◽  
Cognitive Domains ◽  
Mood Scale ◽  
The Relationship ◽  
Time Point

AbstractBackground: Lifetime prevalence rates of cognitive dysfunction and depression in multiple sclerosis (MS) have typically been reported to be ∼50%. However, an inconsistent relationship between these two common features of MS has been reported in the literature. Because neurovegetative depression symptoms overlap with MS symptoms, it may be that literature inconsistencies can partly be explained by the fact that only those depression symptom clusters unambiguously reflective of depression are associated with cognitive dysfunction.Objective: To explore the relationship between different depression symptom clusters and a battery of tests measuring cognitive domains commonly impaired in MS and was examined at two time points 3 years apart.Methods: The Chicago Multiscale Depression Inventory was employed to measure mood, negative evaluative, and neurovegetative symptom clusters in 53 MS patients who were also administered a battery of neuropsychological tests.Results: At time point 1, Mood and Evaluative Chicago Multiscale Depression Inventory scales were significantly associated with tasks of complex speeded attention, planning, and working memory. At time point 2, the Evaluative scale was still significantly associated with these domains, in addition to spatial memory; however, all of the significant correlations with the Mood scale dropped out.Conclusion: These results show that negative evaluative depression symptoms are most consistently predictive of cognitive dysfunction in MS. It may be that negative evaluative depression symptoms use up available cognitive capacity, thus compromising performance on cognitive capacity demanding tasks in MS patients.

scholarly journals Depression at Treatment Initiation Predicts HIV Antiretroviral Adherence in Uganda

2016 ◽  
Vol 16 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Glenn J. Wagner ◽  
Mary Slaughter ◽  
Bonnie Ghosh-Dastidar
Keyword(s):  
Depression Symptoms ◽  
Depression Symptom ◽  
Minor Depression ◽  
Antiretroviral Adherence ◽  
Logistic Regression Models ◽  
Treatment Of Depression ◽  
Patient Health ◽  
Hiv Antiretroviral Therapy ◽  
The Relationship ◽  
Predictors Of Adherence

We examined the relationship between depression (symptom type, diagnostic severity, and change over time) and adherence to HIV antiretroviral therapy (ART) with data from 3 longitudinal studies (N = 1021) of patients starting ART in Uganda. The Patient Health Questionnaire was used to assess depressive symptoms (total score; somatic and cognitive subscales) and categorize severity level. At baseline, 9% had major depression and 30% had minor depression; 82% were adherent (reported no missed ART doses in the past 7 days) at month 6 and 85% at month 12. Controlling for demographic and medical covariates, multivariate random-effects logistic regression models revealed that change in depression was not related to adherence; however, baseline total depression symptoms and cognitive symptoms in particular as well as major and minor depression were significant predictors of adherence. These findings highlight the need for early identification and aggressive treatment of depression to optimize ART adherence.

scholarly journals THE RELATIONSHIP BETWEEN MARITAL STATUS, COHORT, AND DEPRESSION SYMPTOMS IN TAIWAN

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S311-S312
Author(s):  
Fang-Yi Huang ◽  
Min Li
Keyword(s):  
Depressive Symptoms ◽  
Marital Status ◽  
Baby Boom ◽  
Depression Symptoms ◽  
Depression Symptom ◽  
Economic Decline ◽  
Logistic Regression Models ◽  
Financial Decline ◽  
Married Female ◽  
The Relationship

Abstract Objectives: The relationship between marital status and depression symptoms is well documented. However, how the negative economic shock affect relationship differ by gender and cohort is still indecisive. The dataset “2011 wave of the Taiwan Longitudinal Study in Aging” and logistic regression models were used in the study. The results: Marital status is related to depression symptoms, but it differs by gendered cohort. With considering financial shock, there is no difference of depressive symptom between divorced and married female. The divorced and widowed have 4.81 and 2.47 times higher of getting depression symptom than the married for baby boom female. Being divorced is 3.67 times higher of getting depressive symptoms than being married for baby boom male. For WWII female, the widows are 1.78 times higher to have depressive symptoms than the married. being divorced, widowers, and single are 3.32, 2.21 and 2.90 times higher of getting depressive symptoms than being married for WWII male. Being divorced is 3.67 times higher of getting depressive symptoms than being married for baby boom male. In conclusions, people with unstable marital statuses are more depressed than the married. In particular, the effect of unstable marital statuses on depression could be account for by financial decline for women but not men. Given the policy emphasis on those with unstable marital status and economic decline, divorce female and single baby boom female may represent particular groups in whom interventions designed to financially support.

scholarly journals Subjective cognitive concern in multiple sclerosis is associated with reduced thalamic and cortical gray matter volumes

2019 ◽  
Vol 5 (1) ◽  
pp. 205521731982761 ◽  
Author(s):  
Isaiah Kletenik ◽  
Enrique Alvarez ◽  
Justin M Honce ◽  
Brooke Valdez ◽  
Timothy L Vollmer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Dysfunction ◽  
Gray Matter ◽  
Brain Volume ◽  
Brain Magnetic Resonance Imaging ◽  
Regions Of Interest ◽  
Patient Reported ◽  
Cortical Gray Matter ◽  
Gray Matter Volumes ◽  
The Relationship

Objective Brain atrophy has been correlated with objective cognitive dysfunction in multiple sclerosis but few studies have explored self-reported subjective cognitive concerns and their relationship to brain volume changes. This study explores the relationship between subjective cognitive concerns in multiple sclerosis and reduced brain volume in regions of interest implicated in cognitive dysfunction. Methods A total of 158 patients with multiple sclerosis completed the Quality of Life in Neurologic Disorders Measures (Neuro-QoL) short forms to assess subjective cognitive concerns and underwent brain magnetic resonance imaging. Regional brain volumes from regions of interest implicated in cognitive dysfunction were measured using NeuroQuant automated volumetric quantitation. Linear regression was used to analyze the relationship between subjective cognitive concerns and brain volume. Results Controlling for age, disease duration, gender, depression and fatigue, increased subjective cognitive concerns were associated with reduced thalamic volume (standardized β = 0.223, t150 =2.406, P = 0.017) and reduced cortical gray matter volume (standardized β = 0.240, t150 = 2.777, P = 0.006). Increased subjective cognitive concerns were not associated with any other regions of interest that were analyzed. Conclusions Subjective cognitive concern in MS is associated with reduced thalamic and cortical gray matter volumes, areas of the brain that have been implicated in objective cognitive impairment. These findings may lend neuroanatomical significance to subjective cognitive concerns and patient-reported outcomes as measured by Neuro-QoL.

scholarly journals Endorsement of self-report neurovegetative items of depression is associated with multiple sclerosis disease symptoms

2008 ◽  
Vol 14 (6) ◽  
pp. 1057-1062 ◽  
Author(s):  
JOE E. BEENEY ◽  
PETER A. ARNETT
Keyword(s):  
Multiple Sclerosis ◽  
Self Report ◽  
Depression Symptom ◽  
Disease Symptoms ◽  
Symptoms Of Depression ◽  
Multiple Sclerosis Disease ◽  
Core Elements ◽  
Depression Scales ◽  
The Relationship ◽  
Symptom Overlap

AbstractSome researchers have suggested that general self-report depression scales may be inadequate for assessing depression among individuals with Multiple Sclerosis (MS), because many of such items represent MS disease symptoms. However, research has been mixed on this issue: whereas some studies provide support for symptom overlap, others have found opposing evidence. We investigated this issue in two different MS samples with three different strategies. We (1) examined reliable change in depression symptom categories at two time points over three years, (2) assessed the relationship between variables associated with depression and different depression symptom subscales, and (3) assessed the relationship between symptom subscales and physical disability. In each instance we found significant evidence that items meant to assess vegetative symptoms of depression may be influenced by presence of MS disease symptoms or were not associated with other core elements or central correlates of depression. (JINS, 2008, 14, 1057–1062.)

Cognitive Function in Patients with Multiple Sclerosis: Impairment and Treatment

2004 ◽  
Vol 6 (1) ◽  
pp. 9-22 ◽  
Author(s):  
Stephen M. Rao
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Cognitive Dysfunction ◽  
Disease Duration ◽  
Cognitive Domains ◽  
Neuropsychological Dysfunction ◽  
Visuospatial Abilities ◽  
Assessment And Treatment ◽  
Neurologic Disability ◽  
History Of

Cognitive impairment is common in multiple sclerosis (MS), with up to 65% of patients exhibiting some type of neuropsychological dysfunction. The cognitive domains most affected by MS are learning and memory, attention, information processing, visuospatial abilities, and executive functioning. It is difficult to detect cognitive dysfunction in patients with MS during routine neurologic examinations because conventional measures of neurologic disability are not sensitive enough to detect cognitive impairment. Furthermore, cognitive dysfunction is only weakly correlated with the type of MS, disease duration, or physical disability. However, brain imaging studies show that a relatively strong correlation exists between cognitive dysfunction and overall lesion burden and brain atrophy in MS. This paper reviews the natural history of cognitive dysfunction, areas of cognition affected, the correlation between MRI measures and cognitive dysfunction, issues related to neuropsychological assessment, and treatment of cognitive impairment with disease-modifying MS drugs.

Upper and Lower Extremity Motor Function and Cognitive Impairment in Multiple Sclerosis

2011 ◽  
Vol 17 (4) ◽  
pp. 643-653 ◽  
Author(s):  
Ralph H.B. Benedict ◽  
Roee Holtzer ◽  
Robert W. Motl ◽  
Frederick W. Foley ◽  
Sukhmit Kaur ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Motor Function ◽  
Linear Regression Analysis ◽  
Cognitive Capacity ◽  
Performance Indices ◽  
Motor Impairments ◽  
Assessment And Treatment ◽  
The Relationship ◽  
Nine Hole Peg Test ◽  
Better Than

AbstractMotor impairments and cognitive dysfunction are common in multiple sclerosis (MS). We aimed to delineate the relationship between cognitive capacity and upper and lower motor function in 211 MS patients, and 120 healthy volunteers. Lower and upper motor function were assessed with the Timed 25 Foot Walk (T25FW) and the Nine Hole Peg Test (NHPT) as implemented in the Multiple Sclerosis Functional Composite (MSFC). Subjects also underwent neuropsychological evaluation. Hierarchical linear regression analysis was conducted separately for the MS and healthy groups with the T25FW and NHPT serving as the outcome measures. Cognitive performance indices served as predictors. As expected, healthy subjects performed better than the MS group on all measures. Processing speed and executive function tests were significant predictors of lower and upper motor function in both groups. Correlations were more robust in the MS group, where cognitive tests predicted variability in motor function after controlling for disease duration and physical disability. In conclusion, we find evidence of higher order cognitive control of motor function that appears to be particularly salient in this large and representative MS sample. The findings may have implications for risk assessment and treatment of mobility dysfunction in MS. (JINS, 2011, 17, 643–653)

scholarly journals Changes in Activity Participation After Multiple Sclerosis Diagnosis

2020 ◽  
Vol 22 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Yael Goverover ◽  
Helen M. Genova ◽  
Angela Smith ◽  
Jeannie Lengenfelder ◽  
Nancy D. Chiaravalloti
Keyword(s):  
Multiple Sclerosis ◽  
Functional Status ◽  
Quantitative Measure ◽  
Activity Participation ◽  
Control Group ◽  
Depression Symptoms ◽  
Card Sort ◽  
Level Of Activity ◽  
Motor Tests ◽  
The Relationship

Abstract Background: Multiple sclerosis (MS) results in impairments in cognitive and motor skills, which may reduce the level of activity participation in people with MS. This study compares past and current levels of activity participation in adults with MS and controls. The relationship between retained activity participation (since diagnosis) and cognitive, motor, functional status, and depression symptoms of persons with MS was examined. Methods: Twenty-seven individuals with MS living in the community and 21 controls completed cognitive and motor tests and rated their activity participation (using the Activity Card Sort), depression symptoms, and functional status. Results: The MS group reported significantly lower current activity participation than the control group. Percentage of retained activity participation (from prediagnosis to current) in the MS group correlated with time since diagnosis, executive function and motor skill ability, depression symptoms, and current functional status. Conclusions: Persons with MS report negative changes in activity participation in most aspects of life after diagnosis. These findings call attention to changes in activity participation in people with MS that are directly related to disease symptoms. Therefore, using a quantitative measure of activity participation—the Activity Card Sort—can provide important information to aid the clinician in developing individualized treatment goals for people with MS.

Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis

2006 ◽  
Vol 12 (1) ◽  
pp. 77-87 ◽  
Author(s):  
U Nocentini ◽  
P Pasqualetti ◽  
S Bonavita ◽  
M Buccafusca ◽  
M F De Caro ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Cognitive Dysfunction ◽  
Processing Speed ◽  
Sample Selection ◽  
Large Sample Size ◽  
Clinical Markers ◽  
Information Processing Speed ◽  
Cognitive Domains ◽  
Relapsing Remitting

Cognitive dysfunction is considered one of the clinical markers of multiple sclerosis (MS). However, in the literature there are inconsistent reports on the prevalence of cognitive dysfunction, and separate data for the relapsing-remitting (RR) type of the disease are not always presented. In this study, we submitted 461 RRMS patients to a battery of neuropsychological tests to investigate their impairment in various cognitive domains. As a consequence of the exclusion criteria, the sample is not fully representative of the entire population of RRMS patients. In this selected sample, when only the eight scores of a core battery (Mental Deterioration Battery) were considered (with respective cutoffs), it emerged that 31% of the patients were affected by some degree of cognitive deficit. In particular, 15% had mild, 11.2% moderate and 4.8% had severe impairment. Information processing speed was the most frequently impaired area, followed by memory. When two other tests (SDMT and MCST) were added and cognitive domains were considered, it emerged that 39.3% of the patients were impaired in two or more domains. When four subgroups were obtained by means of cluster analysis and then compared, it emerged that information processing speed and memory deficits differentiated the still cognitively unimpaired from the mildly impaired MS patients. Significant associations were found between cognitive and clinical characteristics. However, due to the large sample size, clinically irrelevant relationships may also have emerged. Even with the limitations imposed by the sample selection and the possible underestimation of the prevalence and severity of cognitive dysfunction, these results seem to provide further evidence that information processing speed deficit may be an early and important marker of cognitive impairment in MS patients.

scholarly journals Facebook Depression Displays at Two Time Points: A Content Analysis (Preprint)

2020 ◽  
Author(s):  
Megan Moreno ◽  
Quintin Gaus ◽  
Megan Wilt ◽  
Alina Arseniev-Koehler ◽  
Adrienne Ton ◽  
...  
Keyword(s):  
Social Media ◽  
Young Adults ◽  
Content Analysis ◽  
Adolescent Depression ◽  
Depression Symptoms ◽  
Depression Symptom ◽  
Common Symptom ◽  
Time Points ◽  
Quantitative Descriptive ◽  
Time Point

BACKGROUND Depression is a prevalent and problematic mental disorder that often has its onset in adolescence. Despite this, depression screening of adolescents is not comprehensive. To aid in screenings, adolescent depression symptoms could be identified by viewing their social media as adolescents may use Facebook to disclose depression symptoms. OBJECTIVE To investigate displayed depression symptoms on Facebook at two time points. METHODS Content analysis of one year of Facebook data at two time points: Time 1 as adolescents (17-18 years) and Time 2 as young adults (20-22 years). Content analysis applied diagnostic criteria for depression to identify participants’ displayed depression symptoms. Qualitative and quantitative descriptive data for past 12 months at each time point, and non-parametric tests for comparisons. RESULTS A total of 78 participants’ Facebook profiles were examined, 51% were male. At Time 1, 48 of the 78 adolescents had a Facebook profile and 53.9% of adolescents displayed depression symptom references, with an average of 9.4 references and 3 symptom types. Common symptom types included sleep difficulties, an example post was “5 naps in a day, phew.” At Time 2, 44.9% of young adults displayed depression symptoms with an average of 4.6 references and 2 symptom types. Common symptom types included depressed mood, with example post “is really truly depressed.” There were no gender differences in prevalence or average number of displays at either time point. CONCLUSIONS Social media may be a valuable approach to observe and understand depression over the emerging adult developmental period.

Cognitive dysfunction in primary progressive multiple sclerosis: a neuropsychological and MRI study

2009 ◽  
Vol 15 (9) ◽  
pp. 1055-1061 ◽  
Author(s):  
M Ukkonen ◽  
T Vahvelainen ◽  
P Hämäläinen ◽  
P Dastidar ◽  
I Elovaara
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Cognitive Dysfunction ◽  
Neuropsychological Tests ◽  
Brain Lesion ◽  
Progressive Multiple Sclerosis ◽  
Primary Progressive Multiple Sclerosis ◽  
Cognitive Domains ◽  
Primary Progressive ◽  
Mri Study

Although cognitive dysfunction is known to occur in multiple sclerosis (MS), only few studies have reported cognitive performance in patients with primary progressive MS (PPMS). To find out the pattern of cognitive performance in PPMS, 28 PPMS patients underwent an extensive battery of neuropsychological tests. The results were compared to those of healthy controls ( n = 20) and patients with secondary progressive MS (SPMS, n = 28). Furthermore, the results of neuropsychological tests in PPMS were correlated to magnetic resonance imaging findings. Our study showed that the PPMS patients have deficits in several cognitive domains when compared to age-matched and education-matched controls, but the cognitive impairment in the PPMS and SPMS patients appeared to be similar. Cognitive deficits in PPMS patients correlated with diffuse brain lesion, T1- and T2-lesion load, but no correlations were found with atrophy.

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