scholarly journals Insufficient autumn vitamin D intake and low vitamin D status in 7-year-old Icelandic children

2014 ◽  
Vol 18 (2) ◽  
pp. 208-217 ◽  
Author(s):  
Adda Bjarnadottir ◽  
Asa Gudrun Kristjansdottir ◽  
Hannes Hrafnkelsson ◽  
Erlingur Johannsson ◽  
Kristjan Thor Magnusson ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cardiorespiratory Fitness ◽  
Sunlight Exposure ◽  
Vitamin D Status ◽  
Blood Samples ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
School Based ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements

AbstractObjectiveThe aim was to investigate autumn vitamin D intake and status in 7-year-old Icelanders, fitting BMI and cardiorespiratory fitness as predictors.DesignThree-day food records and fasting blood samples were collected evenly from September to November, and cardiorespiratory fitness was measured with an ergometer bike. Food and nutrient intakes were calculated, and serum 25-hydroxyvitamin D (s-25(OH)D) and serum parathyroid hormone were analysed. Suboptimal vitamin D status was defined s-25(OH)D <50 nmol/l, and deficient status as s-25(OH)D <25 nmol/l.SettingSchool-based study in Reykjavik, Iceland in 2006.SubjectsOf the 7-year-olds studied (n 265), 165 returned valid intake information (62 %), 158 gave blood samples (60 %) and 120 gave both (45 %).ResultsRecommended vitamin D intake (10 μg/d) was reached by 22·4 % of the children and 65·2 % had s-25(OH)D <50 nmol/l. Median s-25(OH)D was higher for children taking vitamin D supplements (49·2 nmol/l v. 43·2 nmol/l, respectively; P < 0·0 0 1). Median s-25(OH)D was lower in November (36·7 nmol/l) than in September (59·9 nmol/l; P < 0·001). The regression model showed that week of autumn accounted for 18·9 % of the variance in s-25(OH)D (P < 0·001), vitamin D intake 5·2 % (P < 0·004) and cardiorespiratory fitness 4·6 % (P < 0·005).ConclusionsA minority of children followed the vitamin D recommendations and 65 % had suboptimal vitamin D status during the autumn. Week of autumn was more strongly associated with vitamin D status than diet or cardiorespiratory fitness, which associated with vitamin D status to a similar extent. These results demonstrate the importance of sunlight exposure during summer to prevent suboptimal vitamin D status in young schoolchildren during autumn in northern countries. An increased effort is needed for enabling adherence to the vitamin D recommendations and increasing outdoor activities for sunlight exposure.

Unzureichende Vitamin-D-Versorgung im Alter: Konsequenzen und Lösungsansätze für die Praxis

2021 ◽  
Vol 46 (06) ◽  
pp. 397-400
Author(s):  
Armin Zittermann
Keyword(s):  
Vitamin D ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements

ZusammenfassungVitamin D ist eine für den Menschen essenzielle Substanz, die eine zentrale Rolle bei der Regulation des Kalzium- und Phosphathaushalts spielt, aber auch für eine normale Immunfunktion und Zellteilung wichtig ist. Als essenzielle Substanz muss Vitamin D dem Körper lebenslang in ausreichender Menge zur Verfügung gestellt werden. In Deutschland liegt bei Senioren ähnlich wie in der jüngeren Allgemeinbevölkerung der Blutspiegel an 25-Hydroxyvitamin D (Indikator des Vitamin-D-Status) zu über 50 % im defizitären/insuffizienten Bereich (< 50 nmol/L), wobei die unzureichende Versorgungslage deutliche saisonale Schwankungen aufweist (41 % am Ende des Sommers und 75 % am Ende des Winters). Im klinischen Bereich können Vitamin-D-Supplemente bei Personen mit defizitärer Vitamin-D-Versorgung zu einer Reduktion des Risikos von osteoporotischen Frakturen und akuten Atemwegsinfekte beitragen sowie möglicherweise bei einigen Erkrankungen wie Asthma und chronisch obstruktiver Lungenerkrankung die Krankheitsschübe reduzieren. Ein Vitamin-D-Mangel kann in der Regel durch die tägliche Einnahme eines Vitamin-D-Supplements in Höhe von 800–1000 IE (20–25 µg) effektiv verhindert werden. Von hochdosierten, intermittierenden Vitamin-D-Gaben, die zu 25OHD-Spiegeln > 125 nmol/L führen, ist abzuraten. Vitamin-D-Tests werden im klinischen Bereich häufig zur Beurteilung der Versorgungslage von Einzelpersonen durchgeführt. Hier sind sie zur Bestätigung eines Verdachts auf eine Vitamin-D-Intoxikation hilfreich. Ansonsten sind sie aber als Screening auf einen Vitamin-D-Mangel meist unnötig und manchmal verunsichernd.

scholarly journals Recommended intakes of vitamin D to optimise health, associated circulating 25-hydroxyvitamin D concentrations, and dosing regimens to treat deficiency: workshop report and overview of current literature

2015 ◽  
Vol 4 ◽  
Author(s):  
Michiel G. J. Balvers ◽  
Elske M. Brouwer-Brolsma ◽  
Silvia Endenburg ◽  
Lisette C. P. G. M. de Groot ◽  
Frans J. Kok ◽  
...  
Keyword(s):  
Vitamin D ◽  
The Netherlands ◽  
Vitamin D Deficiency ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Skeletal Disease ◽  
Health Council ◽  
Dosing Regimens ◽  
25 Hydroxyvitamin D

AbstractVitamin D is a fat-soluble hormone that traditionally has been linked to bone health. Recently, its involvement has been extended to other (extra-skeletal) disease areas, such as cancer, CVD, energy metabolism and autoimmune diseases. Vitamin D deficiency is a worldwide problem, and several recommendation-setting bodies have published guidelines for adequate vitamin D intake and status. However, recommendations from, for example, the Health Council of the Netherlands do not provide advice on how to treat vitamin D deficiency, a condition that is often encountered in the clinic. In addition, these recommendations provide guidelines for the maintenance of ‘minimum levels’, and do not advise on ‘optimum levels’ of vitamin D intake/status to further improve health. The NutriProfiel project, a collaboration between the Gelderse Vallei Hospital (Ede, the Netherlands) and the Division of Human Nutrition of Wageningen University (Wageningen, the Netherlands), was initiated to formulate a protocol for the treatment of vitamin deficiency and for the maintenance of optimal vitamin D status. To discuss the controversies around treatment of deficiency and optimal vitamin D status and intakes, a workshop meeting was organised with clinicians, scientists and dietitians. In addition, a literature review was conducted to collect recent information on optimal intake of vitamins, their optimal circulating concentrations, and effective dosing regimens to treat deficiency. This information has been translated into the NutriProfiel advice, which is outlined in this article.

Vitamin D Status in Irish Children and Adolescents

2014 ◽  
Vol 53 (14) ◽  
pp. 1345-1351 ◽  
Author(s):  
Aoife Carroll ◽  
Chike Onwuneme ◽  
Malachi J. McKenna ◽  
Philip D. Mayne ◽  
Eleanor J. Molloy ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Formula Milk ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Mean ◽  
Vitamin D Supplements

Background. Vitamin D has important skeletal and extraskeletal roles but those living at northerly latitudes are at risk of suboptimal levels because of reduced sunlight exposure. Aim. To describe the vitamin D status of Irish children and identify factors predictive of vitamin D status. Methods. A prospective cross sectional study was undertaken over a 12 month period. Two hundred and fifty two healthy children attending for minor medical or surgical procedures were recruited. All had 25-hydroxyvitamin D (25OHD), parathyroid hormone and bone profiles measured. Results. The mean (standard deviation) for 25OHD was 51(25) nmol/L (20.4 (10) ng/mL). Forty-five percent had levels >50 nmol/L (20 ng/mL). The following variables were significantly associated with 25OHD levels >50 nmol/L (20 ng/mL): sample drawn in April-September, use of vitamin D supplements, consumption of formula milk, and non-African ethnicity. Conclusion. More than half of the children in this study had 25OHD levels less than 50 nmol/L (20 ng/mL). Vitamin D status was significantly improved by augmented oral vitamin D intake.

scholarly journals Determinants of changes in vitamin D status postpartum in Swedish women

2015 ◽  
Vol 115 (3) ◽  
pp. 422-430 ◽  
Author(s):  
Petra Brembeck ◽  
Anna Winkvist ◽  
Mari Bååth ◽  
Linnea Bärebring ◽  
Hanna Augustin
Keyword(s):  
Vitamin D ◽  
Sun Exposure ◽  
Activity Level ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Food Diaries ◽  
Main Determinants ◽  
Vitamin D Supplements

AbstractLow vitamin D status has been associated with unfavourable health outcomes. Postpartum, it is speculated that maternal vitamin D status decreases due to transfer of vitamin D from mother to child through breast milk. A few studies have investigated changes in maternal vitamin D postpartum and possible determinants. Thus, the aims of the present study were to determine changes in serum concentrations of 25-hydroxyvitamin D (25(OH)D) between 2 weeks and 12 months postpartum in Swedish women and to evaluate lactation and other determinants for changes in 25(OH)D concentration postpartum. In total, seventy-eight women were studied at 2 weeks, 4 months and 12 months postpartum. Data collection included measurements of weight and height as well as information about lactation, sun exposure, use of oestrogen contraceptives and physical activity level. Blood samples were collected and serum 25(OH)D levels were analysed using liquid chromatography-tandem MS. Dietary intake of vitamin D was recorded using 4-d food diaries. For all the women studied, mean serum 25(OH)D did not change between 2 weeks and 12 months postpartum (67 (sd 23) v. 67 (sd 19) nmol/l). No association was found between lactation and changes in serum 25(OH)D concentration postpartum. Significant determinants for postpartum changes in 25(OH)D concentration were use of vitamin D supplements (P=0·003), use of oestrogen contraceptives (P=0·013) and season (P=0·005). In conclusion, no changes were observed in 25(OH)D concentrations during the 1st year postpartum in these women and no association was found between lactation and changes in 25(OH)D concentration postpartum. The main determinants for the variation in changes in 25(OH)D concentrations postpartum were use of vitamin D supplements, use of oestrogen contraceptives and season.

scholarly journals Vitamin D status in children and adults in Sweden: dietary intake and 25-hydroxyvitamin D concentrations in children aged 10–12 years and adults aged 18–80 years

2020 ◽  
Vol 9 ◽  
Author(s):  
Cecilia Nälsén ◽  
Wulf Becker ◽  
Monika Pearson ◽  
Peter Ridefelt ◽  
Anna Karin Lindroos ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dietary Intake ◽  
Dietary Factors ◽  
Winter Period ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Dietary Record ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements

Abstract The study aimed to estimate vitamin D intake and plasma/serum 25-hydroxyvitamin D (25(OH)D) concentrations, investigate determinants of 25(OH)D concentrations and compare two 25(OH)D assays. We conducted two nationwide cross-sectional studies in Sweden with 206 school children aged 10–12 years and 1797 adults aged 18–80 years (n 268 provided blood samples). A web-based dietary record was used to assess dietary intake. Plasma/serum 25(OH)D was analysed by liquid chromatography-mass spectrometry (LC-MS) and immunoassay in adults and LC-MS/MS in children. Most participants reported a vitamin D intake below the average requirement (AR), 16 % of children and 33 % of adults met the AR (7⋅5 μg). In adults, plasma 25(OH)D below 30 and 50 nmol/l were found in 1 and 18 % of participants during the summer period and in 9 and 40 % of participants during the winter period, respectively. In children, serum 25(OH)D below 30 and 50 nmol/l were found in 5 and 42 % of participants (samples collected March–May), respectively. Higher 25(OH)D concentrations were associated with the summer season, vacations in sunny locations (adults), and dietary intake of vitamin D and use of vitamin D supplements, while lower concentrations were associated with a higher BMI and an origin outside of Europe. Concentrations of 25(OH)D were lower using the immunoassay than with the LC-MS assay, but associations with dietary factors and seasonal variability were similar. In conclusion, vitamin D intake was lower than the AR, especially in children. The 25(OH)D concentrations were low in many participants, but few participants had a concentration below 30 nmol/l.

Vitamin D - From Essentiality to Functionality

2012 ◽  
Vol 82 (5) ◽  
pp. 321-326 ◽  
Author(s):  
Heike Bischoff-Ferrari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Severe Deficiency ◽  
Normal Vitamin ◽  
25 Hydroxyvitamin D ◽  
Muscle Health

Vitamin D is essential in bone and muscle health. Severe deficiency (25-hydroxyvitamin D serum levels < 25 nmol/l) can result in rickets and osteomalacia, fractures, myopathy and falls. All recent recommendations on vitamin D agree that children and adults should reach a target 25-hydroxyvitamin D range of at least 50 nmol/l (threshold for normal vitamin D status) and 50 % of the population may be below that threshold. A vitamin D intake of 600 to 800 IU per day as recommended today will prevent about 97 % of children and adults from vitamin D deficiency. Notably, a higher 25-hydroxyvitamin D threshold of more than 60 nmol/l is needed for optimal functionality, fall and fracture in adults age 65 and older.

scholarly journals UV and dietary predictors of serum 25-hydroxyvitamin D concentrations among young shift-working nurses and implications for bone density and skin cancer

2013 ◽  
Vol 17 (4) ◽  
pp. 772-779 ◽  
Author(s):  
Sarah C Wallingford ◽  
Glenville Jones ◽  
Lindsay C Kobayashi ◽  
Anne Grundy ◽  
Qun Miao ◽  
...  
Keyword(s):  
Vitamin D ◽  
White Women ◽  
Full Time ◽  
Institute Of Medicine ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Supplement Use ◽  
Tanning Bed ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements

AbstractObjectiveIn 2011, the US Institute of Medicine updated the definition of vitamin D inadequacy to serum 25-hydroxyvitamin D (25(OH)D) concentration of 30–<50 nmol/l and of deficiency to serum 25(OH)D < 30 nmol/l. We describe the prevalence of these conditions according to these definitions, seasonal variation in 25(OH)D and predictors of serum 25(OH)D concentrations among working, white women.DesignParticipants recorded lifestyle factors and dietary intake and provided fasting blood samples for measurement of serum 25(OH)D in both summer and winter. Predictors of serum 25(OH)D variation were analysed using linear regression and generalized linear mixed models.SettingKingston General Hospital in Kingston, Ontario, Canada, from April 2008 to July 2009.SubjectsFemale premenopausal nurses (n83) working full-time rotating shifts.ResultsDeficient or inadequate vitamin D status was observed in 9 % of participants following summer/autumn and in 13 % following winter/spring. Predictors of serum 25(OH)D concentration were vitamin D supplement use, tanning bed use and season. Tanning bed use increased serum 25(OH)D by 23·24 nmol/l (95 % CI 8·78, 37·69 nmol/l,P= 0·002) on average.ConclusionsAccording to the 2011 Institute of Medicine bone health guidelines, over 10 % of nurses had deficient or inadequate vitamin D status following winter. Higher serum concentrations were associated with use of tanning beds and vitamin D supplements. As health promotion campaigns and legal restrictions are successful in reducing tanning bed use among women, our data suggest that increased prevalence of vitamin D inadequacy and deficiency may be a consequence, and that low vitamin D status will need to be countered with supplementation.

scholarly journals Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein Polymorphisms

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 90
Author(s):  
Spyridon N. Karras ◽  
Erdinç Dursun ◽  
Merve Alaylıoglu ◽  
Duygu Gezen-Ak ◽  
Fatme Al Anouti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Serum Biomarkers ◽  
Vitamin D Status ◽  
Vitamin D Binding Protein ◽  
Northern Greece ◽  
Blood Samples ◽  
Hydroxyvitamin D ◽  
Genotype Iii ◽  
25 Hydroxyvitamin D

Dyshomeostasis of vitamin D-binding protein (VDBP) has been implicated in the pathogenesis of various pregnancy complications, including preeclampsia, preterm birth, gestational diabetes, and adverse metabolic profiles in the offspring. VDBP polymorphisms have been consistently reported to contribute to this intriguing interplay. Until recently, the effects of VDBP polymorphism heterogeneity on maternal and neonatal adipomyokine profiles have not been investigated, specifically after incorporating the different maternal and neonatal 25-hydroxyvitamin D concentration cut-offs at birth. We aimed to investigate the potential effects of maternal and neonatal VDBP polymorphisms on adiponectin, irisin, and VDBP concentrations at birth, according to different cut-offs of vitamin D status, in maternal–neonatal dyads recruited from the sunny region of Northern Greece. We obtained blood samples from 66 mother–child pairs at birth. Results indicated that (i) Neonatal serum biomarkers were not affected by any included neonatal VDBP polymorphism according to different cut-offs of neonatal vitamin D status at birth, (ii) neonatal VDBP concentration was elevated in neonates with maternal rs7041 GG genotype, (iii) maternal 25(OH)D at ≤75 nmol/L resulted in increased concentrations of maternal VBDP and irisin concentrations in women with CC genotype for rs2298850 and rs4588,whereas this effect was also evident for this cut-off for neonatal VDBP concentrations at birth for GC genotype for rs 7041, and iv) no significant effect of neonatal VDBP polymorphisms was observed on neonatal VDBP, adiponectin, or irisin levels when stratified according to maternal 25(OH)D cut-offs. In conclusion, these findings confirm that among women with the combination of CC genotype for rs2298850 and rs4588, a specific high cut-off of maternal 25(OH)D results in increasing maternal VBDP concentrations, hence providing a mechanistic rationale for aiming for specific cut-offs of vitamin D after supplementation during pregnancy, in daily clinical practice.

scholarly journals Determinants of serum 25-hydroxyvitamin D concentration in Finnish children: the Physical Activity and Nutrition in Children (PANIC) study

2016 ◽  
Vol 115 (6) ◽  
pp. 1080-1091 ◽  
Author(s):  
Sonja Soininen ◽  
Aino-Maija Eloranta ◽  
Virpi Lindi ◽  
Taisa Venäläinen ◽  
Nina Zaproudina ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Vitamin D ◽  
Population Sample ◽  
Daily Intake ◽  
Milk Products ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements

AbstractWe studied vitamin D intake, serum 25-hydroxyvitamin D (S-25(OH)D) concentration, determinants of S-25(OH)D and risk factors for S-25(OH)D <50 nmol/l in a population sample of Finnish children. We studied 184 girls and 190 boys aged 6–8 years, analysed S-25(OH)D by chemiluminescence immunoassay and assessed diet quality using 4-d food records and other lifestyle factors by questionnaires. We analysed the determinants of S-25(OH)D using linear regression and risk factors for S-25(OH)D <50 nmol/l using logistic regression. Mean dietary intake of vitamin D was 5·9 (sd 2·1) µg/d. Altogether, 40·8 % of children used no vitamin D supplements. Of all children, 82·4 % did not meet the recommended total vitamin D intake of 10 µg/d. Milk fortified with vitamin D was the main dietary source of vitamin D, providing 48·7 % of daily intake. S-25(OH)D was <50 nmol/l in 19·5 % of children. Consumption of milk products was the main determinant of S-25(OH)D in all children (standardised regression coefficient β=0·262; P<0·001), girls (β=0·214; P=0·009) and boys (β=0·257; P=0·003) in multivariable models. Vitamin D intake from supplements (β=0·171; P=0·035) and age (β=−0·198; P=0·015) were associated with S-25(OH)D in girls. Children who drank ≥450 g/d of milk, spent ≥2·2 h/d in physical activity, had ≥13·1 h/d of daylight time or were examined in autumn had reduced risk for S-25(OH)D <50 nmol/l. Insufficient vitamin D intake was common among Finnish children, one-fifth of whom had S-25(OH)D <50 nmol/l. More attention should be paid to the sufficient intake of vitamin D from food and supplements, especially among children who do not use fortified milk products.

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