scholarly journals Pregnancy outcomes in women with preexisting thyroid diseases: a French cohort study

Author(s):  
Marion Lecorguillé ◽  
Juliane Léger ◽  
Anne Forhan ◽  
Marie Cheminat ◽  
Marie-Noëlle Dufourg ◽  
...  

Abstract Women with thyroid diseases at the beginning of pregnancy may have suboptimal thyroid hormone levels because of potential difficulties in compensating for the physiological thyroid hormone changes occurring in pregnancy. Our objective was to study the association between preexisting thyroid diseases, pregnancy complications, and neonatal anthropometry. In total, 16,395 women from the ELFE French longitudinal birth cohort were included, and 273 declared pre-pregnancy thyroid diseases. Associations were investigated with multivariable regression models, with adjustment for relevant potential confounders. Body mass index (BMI) was additionally adjusted for in a second stage. As compared with other women, women with pre-pregnancy thyroid diseases were more frequently obese (19.6% vs. 9.8%) and had greater odds of gestational diabetes development (odds ratio [OR] = 1.58 [95% confidence interval [CI] 1.08, 2.30]) or had undergone treatment for infertility (OR = 1.57 [95% CI 1.07, 2.31]). After adjustment for BMI, the association with gestational diabetes was no longer significant (OR = 1.27 [95% CI 0.86, 1.88]). After excluding women with another medical history, those with pre-pregnancy thyroid diseases had increased odds of premature rupture of membranes (OR = 1.51 [95% CI 1.01, 2.25]). Children born from mothers with hypothyroidism before conception due to a disease or as a potential side effect of treatment had a smaller head circumference at birth than other children (β = −0.23 [95% CI −0.44, −0.01] cm). In conclusion, pre-pregnancy thyroid diseases were associated with risk of infertility treatment, gestational diabetes, and premature rupture of membranes. The association between history of hypothyroidism and moderate adverse effects on fetal head circumference growth needs replication.

2019 ◽  
Vol 8 (11) ◽  
pp. 1987 ◽  
Author(s):  
Damien Bouvier ◽  
Jean-Claude Forest ◽  
Loïc Blanchon ◽  
Emmanuel Bujold ◽  
Bruno Pereira ◽  
...  

We revisited risk factors and outcomes related to the preterm premature rupture of membranes (PPROM). A total of 7866 pregnant women were recruited during 5 years at their first prenatal visit to the perinatal clinic of the institution. We compared three groups (women without prematurity, women with spontaneous preterm labor with intact membranes (sPL with IM), women with PPROM) regarding 60 criteria about characteristics, lifestyle, medical, gynecological, obstetrical history of mothers, medication during pregnancy, events at delivery, and complications in neonates. Logistic regression analyses adjusting for potential confounding factors were used. Of the 6968 women selected, 189 (2.8%) presented a PPROM, and 225 (3.2%) an sPL with IM. The specific risk factors for PPROM were body mass index (BMI) <18.5 kg/m2 (adjusted odds ratio, aOR: 2.00 (1.09–3.67)), history of PPROM (aOR: 2.75 (1.19–6.36)), nulliparity (aOR: 2.52 (1.77–3.60)), gestational diabetes (aOR: 1.87 (1.16–2.99)), and low level of education (aOR: 2.39 (1.20–4.78)). The complications associated with PPROM were abruption placentae, cesarean, APGAR 5′ <4, birth weight <2500 g, stillbirth, neonatal jaundice, and hospitalization of mother and neonates. All these complications were also associated with sPL with IM. Our study confirms some of the risk factors of PPROM and highlights a new one: gestational diabetes. Outcomes of PPROM are related to prematurity.


2018 ◽  
Vol 2 (1) ◽  
pp. 59-67
Author(s):  
Lailatul Hafidah

Early Rupture of membranes is a rupture of the membranes when inpartu with opening at primipara less than 3 cm and in multiparas less than 5 cm, without depending on gestational age. Some factors which are suspected to be the cause of premature rupture of membranes are parity, history of KPD, sexual status and anemia. The purpose of this study is to analyze the determinant factor of premature rupture of membranes on the inpartu mother in the Inpatient Installation Room 1 RSU Moh. Noer Pamekasan.  The type of research is quantitative research with cross sectional research design. The study was conducted on January 30 to March 15, 2018 in the Inpatient Installation Room 1 RSU Moh. Noer Pamekasan. The sample is 59 respondents taken with simple random sampling. The independent variables are parity, history of premature rupture of membranes, sexual status and anemia. Dependent variable is premature rupture of membranes. The data was analyzed by using logistic regression test with p = 0,05. The results showed that the variable X1 (parity) with p = 0.037; OR = 0,008, variable X2 (history of KPD) with p = 0,049; OR = 23.736), Variable X3 (sexual relationship status) with p = 0,064; OR = 19.770; Variable X4 (anemia) with p = 0,628; OR = 2,132. So it can be concluded that the factors which affect Y (the incidence of premature rupture of membranes) is a parity factor and history of KPD and the most dominant factor is the parity with the effect of 0.008.The high parity or parity of grandemultipara and the history of KPD to the previous labor affects the occurrence of premature rupture of membranes in the Inpatient Installation Room 1 RSU Moh.Noer.  So it is necessary to do health education about the factors which affect the occurrence of premature rupture of membranes to prevent premature rupture of membranes recurring at the next labor


1998 ◽  
Vol 29 (4) ◽  
pp. 311-313 ◽  
Author(s):  
Maria Stella G. Raddi ◽  
Nancy C. Lorencetti

Microbiological routine exams of endocervix and vaginal specimens of 22 women with clinical history of recent spontaneous abortion or premature rupture of membranes were accomplished. Chlamydia trachomatis, Streptococcus pyogenes, Streptococcus agalactiae, Candida sp and Gardnerella vaginalis were recovered from 54.5% (12) of the women. Ureaplasma urealyticum was frequently isolated (45.5%) but 5 out of 22 had U. urealyticum only. Our report stands for the importance of quantitative as well as qualitative investigation on genital microflora in pregnant women, since it is likely to influence on pregnancy outcome.


2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Yasmine El-Masry ◽  
Ahmed M. E. Ossman ◽  
Mohammed El-Namoury ◽  
Sameh Sarsik

A case of a 19-year-old female with class U3b/C2/V1 uterus conceived a twin pregnancy with a fetus in each horn after spontaneous conception. She referred to our department with presentation of premature rupture of membranes, with a history of cesarean delivery of a single full term living fetus a year and a half before this delivery. Examination revealed two completely separate uterine horns with a fetus in each horn, two distinct externally rounded cervices, and a single vagina with a short nonobstructing vaginal septum in the upper part of the vagina. And as the appropriate mode of delivery is still unclear, each case should be managed as the condition requires, and in our case urgent bilateral caesarean sections were performed.


2019 ◽  
Vol 2 (2) ◽  
pp. 37-39
Author(s):  
Rahmawati .

Premature rupture of membranes is rupture of membranes before there are signs of labor and after waiting for an hour before the start of labor. World Health Organization (WHO) in 2015 there were 303,000 women died during childbirth and as many as 20% caused by premature rupture of membranes. The incidence of maternity with premature rupture of membranes in Sayang Hospital Cianjur in 2016 was 1151 maternity with premature rupture of membranes from 6814 births while in 2017 there were 1272 births with premature rupture of 5887 births. This study aims to determine the relationship between premature rupture of membranes with age, parity, education, and history of premature rupture of membranes. Statistical test results obtained that there is a relationship between premature rupture of membranes with age with a P value = 0.008 OR value of 0.556. Statistical test results obtained that there is a relationship between premature rupture of membranes with parity with a P value = 0,000 OR value of 3.336. Statistical test results obtained that there is a relationship between premature rupture of membranes with education with a P value = 0.001 OR value of 2.431. Statistical test results obtained that there is no relationship between premature rupture of membranes with a history of premature rupture of membranes with a P value = 0.949 OR value of 2.431. It is recommended for health workers to increase their preventive efforts so that pregnant women get clear information about premature rupture of membranes and anticipate problems that can arise in labor


2016 ◽  
Vol 30 (15) ◽  
pp. 1829-1835 ◽  
Author(s):  
Mia Kibel ◽  
Jon Barrett ◽  
Carly Tward ◽  
Alex Pittini ◽  
Michael Kahn ◽  
...  

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