Peptide-Functionalized Amino Acid-Derived Pseudoprotein-Based Hydrogel with Hemorrhage Control and Antibacterial Activity for Wound Healing

2019 ◽  
Vol 31 (12) ◽  
pp. 4436-4450 ◽  
Author(s):  
Jie Zhu ◽  
Hua Han ◽  
Faxue Li ◽  
Xueli Wang ◽  
Jianyong Yu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Amino Acid ◽  
Hemorrhage Control

APPLICATIONS OF CHITOSAN-SULFATHIAZOLE AS ANTIMICROBIAL AGENT

2018 ◽  
Vol 28 (2) ◽  
pp. 429-432
Author(s):  
Dilyana Zvezdova
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Antimicrobial Agent ◽  
Defense Mechanisms ◽  
Solvent Casting ◽  
Casting Method ◽  
Gram Negative ◽  
Positively Charged

Chitosan, a hydrophilic biopolymer industrially obtained by N-deacetylation of chitin, can be applied as an antimicrobial agent. It highlights the applications of chitosan as an antimicrobial agent against fungi, bacteria, and viruses and as an elicitor of plant defense mechanisms. A series of novel chitosan-sulfathiazole nanocomposite (CSFZ) films were prepared by using solvent casting method for wound healing application. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the interaction between negatively charged sulfathiazole and positively charged chitosan. Moreover, the antibacterial activity of the films was investigated against gram positive and gram negative microorganisms. It was found that all CSFZ films showed good inhibitory activity against all the tested bacteria as compared to control. The above analysis suggested that the CSFZ films could be used as potential candidates for wound healing application.

Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies

2020 ◽  
Vol 17 (1) ◽  
pp. 71-84
Author(s):  
Riham M. Bokhtia ◽  
Siva S. Panda ◽  
Adel S. Girgis ◽  
Hitesh H. Honkanadavar ◽  
Tarek S. Ibrahim ◽  
...  
Keyword(s):  
Experimental Data ◽  
Antibacterial Activity ◽  
Amino Acid ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Antibacterial Properties ◽  
Computational Studies ◽  
Protecting Group ◽  
Amino Acid Conjugates ◽  
Molecular Modeling Studies

Background: Bacterial infections are considered as one of the major global health threats, so it is very essential to design and develop new antibacterial agents to overcome the drawbacks of existing antibacterial agents. Method: The aim of this work is to synthesize a series of new fluoroquinolone-3-carboxamide amino acid conjugates by molecular hybridization. We utilized benzotriazole chemistry to synthesize the desired hybrid conjugates. Result: All the conjugates were synthesized in good yields, characterized, evaluated for their antibacterial activity. The compounds were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Synthesized conjugates were tested for activity against medically relevant pathogens; Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27856) Staphylococcus aureus (ATCC 25923) and Enterococcus faecalis (ATCC 19433). Conclusion: The observed antibacterial experimental data indicates the selectivity of our synthesized conjugates against E.Coli. The protecting group on amino acids decreases the antibacterial activity. The synthesized conjugates are non-toxic to the normal cell lines. The experimental data were supported by computational studies.

A moisture balanced antibacterial dressing loaded with lysozyme possesses antibacterial activity and promotes wound healing

Soft Matter ◽  
2021 ◽  
Vol 17 (11) ◽  
pp. 3162-3173
Author(s):  
Ling Xiao ◽  
Wenqiang Ni ◽  
Xiaohong Zhao ◽  
Yicheng Guo ◽  
Xue Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Promote Wound Healing

An antibacterial moisture balanced dressing is designed to fight infection and promote wound healing.

scholarly journals Controlling Antibacterial Activity Exclusively with Visible Light: Introducing a Tetra‐ortho‐Chloro‐Azobenzene Amino Acid

2021 ◽  
Author(s):  
Xavier Just-Baringo ◽  
Alejandro Yeste-Vázquez ◽  
Javier Moreno-Morales ◽  
Clara Ballesté-Delpierre ◽  
Jordi Vila ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Amino Acid ◽  
Visible Light

A Fe3+-crosslinked pyrogallol-tethered gelatin adhesive hydrogel with antibacterial activity for wound healing

2020 ◽  
Vol 8 (11) ◽  
pp. 3164-3172 ◽  
Author(s):  
Ning Han ◽  
Ziyang Xu ◽  
Chunyan Cui ◽  
Yuan Li ◽  
Dongfei Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Strong Adhesion ◽  
Mixing Method ◽  
Antibacterial Capacity

A tunicate-inspired gelatin-based hydrogel prepared by a simple mixing method, exhibits strong adhesion and antibacterial capacity, and facilitates wound healing.

scholarly journals Differential Expression of System L Amino Acid Transporters during Wound Healing Process in the Skin of Young and Old Rats

2008 ◽  
Vol 31 (3) ◽  
pp. 395-399
Author(s):  
Moon-Jin Jeong ◽  
Chun Sung Kim ◽  
Joo-Cheol Park ◽  
Heung-Joong Kim ◽  
Yeong Mu Ko ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amino Acid ◽  
Differential Expression ◽  
Healing Process ◽  
Wound Healing Process ◽  
Amino Acid Transporters ◽  
System L ◽  
Old Rats

scholarly journals The Wound Healing and Antibacterial Activity of Five Ethnomedical Calophyllum inophyllum Oils: An Alternative Therapeutic Strategy to Treat Infected Wounds

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0138602 ◽  
Author(s):  
Teddy Léguillier ◽  
Marylin Lecsö-Bornet ◽  
Christelle Lémus ◽  
Delphine Rousseau-Ralliard ◽  
Nicolas Lebouvier ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Therapeutic Strategy ◽  
Calophyllum Inophyllum ◽  
Infected Wounds

scholarly journals SYNTHESIS AND ANTIMICROBIAL EVALUATION OF QUINAZOLINONE PEPTIDE DERIVATIVES

2017 ◽  
Vol 10 (16) ◽  
pp. 7 ◽  
Author(s):  
Bhupinder Kapoor ◽  
Arshid Nabi ◽  
Reena Gupta ◽  
Mukta Gupta
Keyword(s):  
Antibacterial Activity ◽  
Amino Acid ◽  
Antimicrobial Agents ◽  
Methyl Esters ◽  
Standard Drug ◽  
Amino Acid Peptide ◽  
Chemical Structures ◽  
1H Nuclear Magnetic Resonance ◽  
Peptide Derivatives ◽  
Derivatives Of

  Objective: The increased microbial resistance against commercially available drugs initiated the development of novel and safe antimicrobial agents in last few decades. In this view, a series of amino acid/dipeptide derivatives of quinazolin-3(4H)-one was synthesized and was evaluated for their antimicrobial potential.Method: Synthesis of amino acid/peptide derivatives were carried out by coupling 5-(2-(2-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)-2-hydroxy benzoic acid with amino acid/dipeptide methyl esters in the presence of dicyclohexylcarbodiimide and N-methylmorpholine. The chemical structures of synthesized compounds were characterized by 1H nuclear magnetic resonance and infrared spectroscopy and were screened for antibacterial activity by disc diffusion method.Results: All the synthesized derivatives exhibited moderate to significant antibacterial activity against both Gram-positive and Gram-negative bacteria. The potency of compound 5d was comparable to standard drug ciprofloxacin in all the strains of bacteria used. The compound 5a was found to be more active against Streptococcus pyogenes and Staphylococcus aureus while compound 5c against Pseudomonas aeruginosa and Escherichia coli. Conclusion: Peptide derivatives of quinazolinone are promising antimicrobial agent and can be used for the synthesis of other novel compounds.

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