Near-IR/Visible-Emitting Thiophenyl-Based Ru(II) Complexes: Efficient Photodynamic Therapy, Cellular Uptake, and DNA Binding

2019 ◽  
Vol 58 (20) ◽  
pp. 14244-14259 ◽  
Author(s):  
Si-Qi Zhang ◽  
Ting-Ting Meng ◽  
Jia Li ◽  
Fan Hong ◽  
Jin Liu ◽  
...  
2021 ◽  
Vol 2021 (9) ◽  
pp. 831-839
Author(s):  
Vanitha Ramu ◽  
Paramita Kundu ◽  
Aarti Upadhyay ◽  
Paturu Kondaiah ◽  
Akhil R. Chakravarty

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1345
Author(s):  
Sherif Ashraf Fahmy ◽  
Hassan Mohamed El-Said Azzazy ◽  
Jens Schaefer

Photodynamic therapy (PDT) is a promising non-invasive strategy in the fight against that which circumvents the systemic toxic effects of chemotherapeutics. It relies on photosensitizers (PSs), which are photoactivated by light irradiation and interaction with molecular oxygen. This generates highly reactive oxygen species (such as 1O2, H2O2, O2, ·OH), which kill cancer cells by necrosis or apoptosis. Despite the promising effects of PDT in cancer treatment, it still suffers from several shortcomings, such as poor biodistribution of hydrophobic PSs, low cellular uptake, and low efficacy in treating bulky or deep tumors. Hence, various nanoplatforms have been developed to increase PDT treatment effectiveness and minimize off-target adverse effects. Liposomes showed great potential in accommodating different PSs, chemotherapeutic drugs, and other therapeutically active molecules. Here, we review the state-of-the-art in encapsulating PSs alone or combined with other chemotherapeutic drugs into liposomes for effective tumor PDT.


2020 ◽  
Vol 11 (33) ◽  
pp. 8928-8935
Author(s):  
Kirsty L. Smitten ◽  
Paul A. Scattergood ◽  
Charlotte Kiker ◽  
Jim A. Thomas ◽  
Paul I. P. Elliott

Cellular uptake, luminescence imaging and antimicrobial activity of facial and meridional isomers of Os(ii) triazole-based complexes against methicillin-resistant S. aureus, MRSA.


2020 ◽  
Vol 49 (43) ◽  
pp. 15180-15183
Author(s):  
Balaji Babu ◽  
John Mack ◽  
Tebello Nyokong
Keyword(s):  

The utility of NIR absorbing Sn(iv) N-confused porphyrins for use as photosensitizer dyes in photodynamic therapy is assessed.


2020 ◽  
Vol 15 (2) ◽  
pp. 334-341
Author(s):  
Casey J. Adams ◽  
Ruby Krueger ◽  
Thomas J. Meade

2001 ◽  
Vol 8 (1) ◽  
pp. 29-37 ◽  
Author(s):  
José M. Pérez ◽  
Eva I. Montero ◽  
Adoración G. Quiroga ◽  
Miguel A Fuertes ◽  
Carlos Alonso ◽  
...  

Trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] is a novel trans-platinum compound that shows cytotoxic activity in several cisplatin resistant cell lines. The aim of this paper was to analyse, by means of molecular cell biology techniques and total reflection X-ray fluorescence (TXRF), the cytotoxic activity, the induction of apoptosis, the cellular uptake and the DNA binding of trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] in the cisplatin resistant cell line A2780cisR. The results show that this drug is more cytotoxic and induces a higher amount of apoptotic cells than cisplatin in A2780cisR cells. However, the intracellular accumulation and extent of binding to DNA of trans-[PtCl2(N,N-dimethylamine)( isopropylamine)] is lower than that of cis-DDP. Moreover, trans-[PtCl2(N,N-dimethylamine)(isopropylaminae)] is partially inactivated by intracellular levels of glulathione. The result suggest that circumvention of ciplatin resistance by trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] in A2780cisR cells might be related with the ability of this drug to induce apoptosis.


2011 ◽  
Vol 30 (10) ◽  
pp. 829-838 ◽  
Author(s):  
Yun-Jun Liu ◽  
Zhen-Hua Liang ◽  
Zheng-Zheng Li ◽  
Jun-Hua Yao ◽  
Hong-Liang Huang

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