Starting from Styrene: A Unified Protocol for Hydrotrifluoromethylation of Diversified Alkenes

2021 ◽  
Author(s):  
Yi-Fei Yang ◽  
Jin-Hong Lin ◽  
Ji-Chang Xiao
Keyword(s):  
2020 ◽  
Vol 86 (7) ◽  
pp. 12-19
Author(s):  
I. V. Plyushchenko ◽  
D. G. Shakhmatov ◽  
I. A. Rodin

A viral development of statistical data processing, computing capabilities, chromatography-mass spectrometry, and omics technologies (technologies based on the achievements of genomics, transcriptomics, proteomics, metabolomics) in recent decades has not led to formation of a unified protocol for untargeted profiling. Systematic errors reduce the reproducibility and reliability of the obtained results, and at the same time hinder consolidation and analysis of data gained in large-scale multi-day experiments. We propose an algorithm for conducting omics profiling to identify potential markers in the samples of complex composition and present the case study of urine samples obtained from different clinical groups of patients. Profiling was carried out by the method of liquid chromatography mass spectrometry. The markers were selected using methods of multivariate analysis including machine learning and feature selection. Testing of the approach was performed using an independent dataset by clustering and projection on principal components.


Emotion dysregulation—which is often defined as the inability to modulate strong affective states including impulsivity, anger, fear, sadness, and anxiety—is observed in nearly all psychiatric disorders. These include internalizing disorders such as panic disorder and major depression, externalizing disorders such as conduct disorder and antisocial personality disorder, and various other disorders including schizophrenia, autism, and borderline personality disorder. Among many affected individuals, precursors to emotion dysregulation appear early in development, and often predate the emergence of diagnosable psychopathology. Collaborative work by Drs. Crowell and Beauchaine, and work by many others, suggests that emotion dysregulation arises from both familial (coercion, invalidation, abuse, neglect) and extrafamilial (deviant peer group affiliations, social reinforcement) mechanisms. These studies point toward strategies for prevention and intervention. The Oxford Handbook of Emotion Dysregulation brings together experts whose work cuts across levels of analysis, including neurobiological, cognitive, and social, in studying emotion dysregulation. Contributing authors describe how early environmental risk exposures shape emotion dysregulation, how emotion dysregulation manifests in various forms of mental illness, and how emotion dysregulation is most effectively assessed and treated. This is the first text to assemble a highly accomplished group of authors to address conceptual issues in emotion dysregulation research; define the emotion dysregulation construct at levels of cognition, behavior, and social dynamics; describe cutting-edge assessment techniques at neural, psychophysiological, and behavioral levels of analysis; and present contemporary treatment strategies. Conceptualizing emotion dysregulation as a core vulnerability to psychopathology is consistent with modern transdiagnostic approaches to diagnosis and treatment, including the Research Domain Criteria and the Unified Protocol, respectively.


2021 ◽  
Author(s):  
Shannon Sauer-Zavala ◽  
Anthony J. Rosellini ◽  
Kate H. Bentley ◽  
Amantia A. Ametaj ◽  
James F. Boswell ◽  
...  

2012 ◽  
Vol 36 (4) ◽  
pp. 482-508 ◽  
Author(s):  
K. K. Ellard ◽  
T. Deckersbach ◽  
L. G. Sylvia ◽  
A. A. Nierenberg ◽  
D. H. Barlow

2020 ◽  
pp. 014544552098256
Author(s):  
Sara Rodriguez-Moreno ◽  
Todd J. Farchione ◽  
Pablo Roca ◽  
Carolina Marín ◽  
Ana I. Guillén ◽  
...  

The purpose of this study is to evaluate the effectiveness of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders adapted for homeless women (UPHW). Eighty-one homeless women participated in this single-blinded quasi-experimental clinical trial, involving up to 12 sessions of group treatment, and 3-and 6-month follow-ups. The participants received either immediate treatment with the UPHW ( n = 46) or delayed treatment, following a 12-week wait-list control period (WLC; n = 35). Primary outcomes included depression and anxiety. Secondary measures comprised positive and negative affect, psychological well-being, health perception, and social support. The UPHW resulted in significant improvement on measures of anxiety, depression and negative affect. Improvements in anxiety and depression were maintained over a 3-month follow-up period, but not at 6-month. The reliability of the clinical changes showed significant differences between UPHW and WLC for depression. Moreover, the inter-session assessment in the UPHW group showed a linear trend reduction for depression and anxiety scores along the 12 sessions. The clinical implications on the UPHW in social settings are also discussed.


2017 ◽  
Vol 42 (2) ◽  
pp. 210-230 ◽  
Author(s):  
Ruth L. Varkovitzky ◽  
Andrew M. Sherrill ◽  
Greg M. Reger

Effective treatment options are needed for veterans who do not participate in trauma-focused psychotherapy. Research has yet to examine the effectiveness of transdiagnostic psychotherapy in veterans with posttraumatic stress disorder (PTSD) and co-occurring psychological disorders. This pilot study examined the effectiveness of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) delivered in a 16-week group format. We examined treatment outcomes in male and female veterans ( n = 52) in an outpatient specialty PTSD clinic at a large Veterans Affairs (VA) medical center. We hypothesized significant decreases in emotion regulation difficulty (Difficulties in Emotion Regulation Scale), PTSD symptom severity (PTSD Checklist for DSM-5), and depressive symptom severity (Patient Health Questionnaire–9). In addition, we hypothesized that reductions in emotion regulation difficulty across treatment would negatively predict PTSD and depressive symptoms at posttreatment. PTSD symptoms, depressive symptoms, and emotion regulation difficulty all evidenced significant improvements at the end of treatment relative to baseline ( ps < .001). In addition, reductions in emotion regulation across treatment were associated with lower PTSD and depressive symptoms at posttreatment ( ps < .001). This pilot study provides preliminary evidence supporting use of UP among veterans with PTSD and co-occurring disorders. Well-designed clinical trials evaluating efficacy of UP among veterans are needed.


2020 ◽  
Author(s):  
Carmen Schaeuffele ◽  
Sophie Luise Homeyer ◽  
Luis Perea ◽  
Lisa Scharf ◽  
Ava Schulz ◽  
...  

The Unified Protocol (UP) as a transdiagnostic intervention has primarily been applied in the treatment of anxiety disorders and in face-to-face-settings. The current study investigated the efficacy of a 10-week internet-based adaptation of the UP for anxiety, depressive, and somatic symptom disorders. N=132 participants were randomized to treatment or waitlist control. Linear mixed effect models revealed significant treatment effects for symptom distress, satisfaction with life, positive/negative affect and markers of anxiety, depression, and somatic symptom burden (within-group Hedges’ g = 0.32-1.38 and between-group g = 0.20-1.11). Treatment gains were maintained at 1- and 6-month-follow-up. Subgroup analyses showed comparable effects in participants with anxiety and depressive disorders. The results strengthen the application of the UP as an internet-based treatment for alleviating symptom distress across emotional disorders. More research on the applicability for single disorders and the mechanisms underlying the effects is needed.


Electronics ◽  
2021 ◽  
Vol 10 (20) ◽  
pp. 2550
Author(s):  
Jean Park ◽  
Juyeop Kim

LoRa Wide Area Networks (LoRaWAN) can provide a connectivity service to Internet of Things (IoT) for an extremely long run-time and with low power consumption. As the LoRaWAN is extensively applied to various IoT scenarios, LoRaWAN solutions face a flexibility issue in terms of inter-operating with various kinds of LoRa modem hardware and protocol scenarios. In this regard, we design a unified protocol architecture for LoRaWAN physical layer, which can flexibly correspond to various deployment and operational cases. The new protocol architecture includes a hardware abstraction sub-layer, which contains generalized handlers for configuring various kinds of the LoRa modem, and a physical procedure sub-layer that structurally models the physical layer procedures of the LoRaWAN based on Finite State Machine(FSM). We illustrate the flexibility of the new protocol architecture by implementing an extensive feature that enhances the packet reception ratio based on the status of preamble detection. For evaluating the new protocol architecture, we implement the LoRaWAN physical layer protocol on real-time embedded systems and conduct experiments. The experimental results show that the proposed protocol robustly transmits and receives packets and generates little amount of additional burden compared with the conventional open source protocol provided by SemTech.


Sign in / Sign up

Export Citation Format

Share Document