Rational Design of Nanoparticles to Overcome Poor Tumor Penetration and Hypoxia-Induced Chemotherapy Resistance: Combination of Optimizing Size and Self-Inducing High Level of Reactive Oxygen Species

2019 ◽  
Vol 11 (35) ◽  
pp. 31743-31754 ◽  
Author(s):  
Liandong Deng ◽  
Zujian Feng ◽  
Hongzhang Deng ◽  
Yujia Jiang ◽  
Kun Song ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Rational Design ◽  
Chemotherapy Resistance ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tumor Penetration ◽  
High Level

scholarly journals Extremely high level of reactive oxygen species (ROS) production in a newly isolated strain of the dinoflagellate Karenia mikimotoi

2019 ◽  
Vol 54 (4) ◽  
pp. 632-640 ◽  
Author(s):  
Daekyung Kim ◽  
Li Wencheng ◽  
Yukihiko Matsuyama ◽  
Kichul Cho ◽  
Yasuhiro Yamasaki ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Ros Production ◽  
Oxygen Species ◽  
Karenia Mikimotoi ◽  
High Level

scholarly journals Reactive Oxygen Species, Metabolic Plasticity, and Drug Resistance in Cancer

2020 ◽  
Vol 21 (10) ◽  
pp. 3412 ◽  
Author(s):  
Vikas Bhardwaj ◽  
Jun He
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Tca Cycle ◽  
Metabolic Adaptation ◽  
Oxygen Species ◽  
Metabolic Plasticity ◽  
The Tca Cycle ◽  
Clinical Benefits ◽  
High Level

The metabolic abnormality observed in tumors is characterized by the dependence of cancer cells on glycolysis for their energy requirements. Cancer cells also exhibit a high level of reactive oxygen species (ROS), largely due to the alteration of cellular bioenergetics. A highly coordinated interplay between tumor energetics and ROS generates a powerful phenotype that provides the tumor cells with proliferative, antiapoptotic, and overall aggressive characteristics. In this review article, we summarize the literature on how ROS impacts energy metabolism by regulating key metabolic enzymes and how metabolic pathways e.g., glycolysis, PPP, and the TCA cycle reciprocally affect the generation and maintenance of ROS homeostasis. Lastly, we discuss how metabolic adaptation in cancer influences the tumor’s response to chemotherapeutic drugs. Though attempts of targeting tumor energetics have shown promising preclinical outcomes, the clinical benefits are yet to be fully achieved. A better understanding of the interaction between metabolic abnormalities and involvement of ROS under the chemo-induced stress will help develop new strategies and personalized approaches to improve the therapeutic efficiency in cancer patients.

Selective RNA interference and gene silencing using reactive oxygen species-responsive lipid nanoparticles

2019 ◽  
Vol 55 (56) ◽  
pp. 8170-8173 ◽  
Author(s):  
Chunjing Liang ◽  
Jin Chang ◽  
Ying Jiang ◽  
Ji Liu ◽  
Lanqun Mao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Lipid Nanoparticles ◽  
Oxygen Species ◽  
Efficient Delivery ◽  
Intracellular Ros ◽  
Cell Gene Expression ◽  
High Level ◽  
Cell Gene

The integration of reactive oxygen species (ROS)-responsive thioketal group into lipids nanoparticles enables the efficient delivery of siRNA into cells, and selectively cancer cell gene expression silencing in response to the high level of intracellular ROS in cancer cells.

A Luminol-Based Self-Illuminating Nanocage as a Reactive Oxygen Species Amplifier to Enhance Deep Tumor Penetration and Synergistic Therapy

ACS Nano ◽  
2021 ◽  
Author(s):  
Xiao-Ling Xu ◽  
Nan-Nan Zhang ◽  
Gao-Feng Shu ◽  
Di Liu ◽  
Jing Qi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tumor Penetration

High level of reactive oxygen species inhibits triacylglycerols accumulation in Chlamydomonas reinhardtii

2019 ◽  
Vol 38 ◽  
pp. 101400 ◽  
Author(s):  
Rongli Miao ◽  
Xiaocui Ma ◽  
Xuan Deng ◽  
Kaiyao Huang
Keyword(s):  
Reactive Oxygen Species ◽  
Chlamydomonas Reinhardtii ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
High Level

Bifunctional liposomes reduce the chemotherapy resistance of doxorubicin induced by reactive oxygen species

2019 ◽  
Vol 7 (11) ◽  
pp. 4782-4789
Author(s):  
Lei Xu ◽  
Zhicheng Zhang ◽  
Yawen Ding ◽  
Li Wang ◽  
Yali Cheng ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Chemotherapy Resistance ◽  
Reactive Oxygen ◽  
Oxygen Species

A biofunctional liposome containing acriflavine (ACF) and doxorubicin (DOX) for reducing the chemotherapy resistance of DOX induced by reactive oxygen species.

scholarly journals Elevated CO2 and Reactive Oxygen Species in Stomatal Closure

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 410
Author(s):  
Xiaonan Ma ◽  
Ling Bai
Keyword(s):  
Reactive Oxygen Species ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Stomatal Closure ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Important Regulator ◽  
Carbon Dioxide Co2 ◽  
High Level

Plant guard cell is essential for photosynthesis and transpiration. The aperture of stomata is sensitive to various environment factors. Carbon dioxide (CO2) is an important regulator of stomatal movement, and its signaling includes the perception, transduction and gene expression. The intersections with many other signal transduction pathways make the regulation of CO2 more complex. High levels of CO2 trigger stomata closure, and reactive oxygen species (ROS) as the key component has been demonstrated function in this regulation. Additional research is required to understand the underlying molecular mechanisms, especially for the detailed signal factors related with ROS in this response. This review focuses on Arabidopsis stomatal closure induced by high-level CO2, and summarizes current knowledge of the role of ROS involved in this process.

scholarly journals Screening Vitis Genotypes for Responses to Botrytis cinerea and Evaluation of Antioxidant Enzymes, Reactive Oxygen Species and Jasmonic Acid in Resistant and Susceptible Hosts

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 5 ◽  
Author(s):  
Mati Rahman ◽  
Muhammad Hanif ◽  
Ran Wan ◽  
Xiaoqing Hou ◽  
Bilal Ahmad ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Jasmonic Acid ◽  
Botrytis Cinerea ◽  
Reactive Oxygen ◽  
Fungal Growth ◽  
Ros Production ◽  
Oxygen Species ◽  
Fungal Phytopathogen ◽  
Vitis Davidii ◽  
High Level

Botrytis cinerea is a necrotrophic fungal phytopathogen with devastating effects on many Vitis genotypes. Here, a screening of 81 Vitis genotypes for leaf resistance to B. cinerea revealed two highly resistant (HR), twelve resistant (R), twenty-five susceptible (S) and forty-two highly susceptible (HS) genotypes. We focused on the HR genotype, ‘Zi Qiu’ (Vitis davidii), and the HS genotype ‘Riesling’ (V. vinifera), to elucidate mechanisms of host resistance and susceptibility against B. cinerea, using detached leaf assays. These involved a comparison of fungal growth, reactive oxygen species (ROS) responses, jasmonic acid (JA) levels, and changes in the anti-oxidative system between the two genotypes after inoculation with B. cinerea. Our results indicated that the high-level resistance of ‘Zi Qiu’ can be attributed to insignificant fungal development, low ROS production, timely elevation of anti-oxidative functions, and high JA levels. Moreover, severe fungal infection of ‘Riesling’ and sustained ROS production coincided with relatively unchanged anti-oxidative activity, as well as low JA levels. This study provides insights into B. cinerea infection in grape, which can be valuable for breeders by providing information for selecting suitable germplasm with enhanced disease resistance.

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